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Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

  • Bone and Joint Pain (PW Mantyh and TJ Schnitzer, Section Editors)
  • Published:
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Abstract

Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanisms are not fully understood, and safe and efficient analgesic drugs are not available. The pain associated with joint pain is highly individual, and features from radiological imaging have not demonstrated robust associations with the pain manifestations. In recent years, a variety of human quantitative pain assessment tools (quantitative sensory testing (QST)) have been developed providing new opportunities for profiling patients and reaching a greater understanding of the mechanisms involved in chronic joint pain. As joint pain is a complex interaction between many different pain mechanisms, available tools are important for patent profiling and providing the basic knowledge for development of new drugs and for developing pain management regimes.

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L Arendt-Nielsen, ST Skou, TA Nielsen, and KK Petersen all declare no conflicts of interest.

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All studies by the authors involving animal and/or human subjects were performed after approval by the appropriate institutional review boards. When required, written informed consent was obtained from all participants.

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Correspondence to Lars Arendt-Nielsen.

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This article is part of the Topical Collection on Bone and Joint Pain

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Arendt-Nielsen, L., Skou, S.T., Nielsen, T.A. et al. Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain. Curr Osteoporos Rep 13, 225–234 (2015). https://doi.org/10.1007/s11914-015-0276-x

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