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Bone and the Innate Immune System

  • Osteoimmunology (D Novack and G Schett, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

The immune system and bone are intimately linked with significant physical and functionally related interactions. The innate immune system functions as an immediate response system to initiate protections against local challenges such as pathogens and cellular damage. Bone is a very specific microenvironment, in which infectious attack is less common but repair and regeneration are ongoing and important functions. Thus, in the bone the primary goal of innate immune and bone interactions is to maintain tissue integrity. Innate immune signals are critical for removal of damaged and apoptotic cells and to stimulate normal tissue repair and regeneration. In this review we focus on the innate immune mechanisms that function to regulate bone homeostasis.

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Conflict of Interest

J.F. Charles declares that she has no conflicts of interest. M.C. Nakamura has received research support from the NIH, VA, and Arthritis Foundation; speaker honorarium from the University of Oklahoma; and travel reimbursement from the International Osteo-Immunology Conference and Rheumatology Research Foundation.

Human and Animal Rights and Informed Consent

All studies by the authors involving animal and/or human subjects were performed after approval by the appropriate institutional review boards. When required, written informed consent was obtained from all participants.

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Authors and Affiliations

  1. Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Julia F. Charles

  2. Department of Medicine, Division of Rheumatology, University of California, 513 Parnassus Avenue, San Francisco, CA, 94143, USA

    Mary C. Nakamura

  3. Arthritis/Immunology Section, Veterans Affairs Medical Center, 4150 Clement Street, 111R, San Francisco, CA, 94121, USA

    Mary C. Nakamura

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  1. Julia F. Charles
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Charles, J.F., Nakamura, M.C. Bone and the Innate Immune System. Curr Osteoporos Rep 12, 1–8 (2014). https://doi.org/10.1007/s11914-014-0195-2

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