Abstract
Quality of life as an outcome variable has become an important measure in clinical research. Making a transition from a ‘biomedical model’ of health to one that incorporates the social aspects of disease, clinicians and researchers dealing with chronic illness now incorporate quality-oflife measures into clinical practice and research. Chronic liver disease has shown a significant impact on the wellbeing of patients and contributes to the significant morbidity associated with these conditions. In this article, we review the recent research that has examined the impact of chronic liver disease on health-related quality of life.
Similar content being viewed by others
References and Recommended Reading
Marchesini G, Amodio P, Salerno F, et al.: Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology 2001, 120:305–307. This is an excellent large-scale study assessing the factors associated with poor perceived health in a population where this has not been documented previously.
Ware JE Jr, Bayliss MS, Mannocchia M, Davis GL: Healthrelated quality of life in chronic hepatitis C: impact of disease and treatment response. Hepatology 1999, 30:550–555.
Younossi ZM, Guyatt G, Kiwi M, et al.: Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease. Gut 1999, 45:295–300.
Gralnek IM, Hays RD, Kilbourne A, et al.: Development and evaluation of the Liver Disease Quality of Life instrument in persons with advanced, chronic liver disease: the LDQOL 1.0. Am J Gastroenterol 2000, 95:3552–3565.
Younossi ZM, Kiwi ML, Boparai, et al.: Cholestatic liver diseases and health-related quality of life. Am J Gastroenterol 2000, 95:497–502.
Lawrence, SP: Advances in the treatment of hepatitis C. Adv Intern Med 2000, 45:65–105.
Schwimmer JB, Balistreri WF: Transmission, natural history, and treatment of hepatitis C virus infection in the pediatric population. Semin Liver Dis 2000, 20:37–46.
Midgley DE, Bradlee TA, Donohoe C, et al.: Health-related quality of life in long-term survivors of pediatric liver transplantation. Liver Transplant 2000, 6:333–339.
Younossi ZM, Boparai N, Price LL, et al.: Health-related quality of life in chronic liver disease: the impact of type and severity of disease. Am J Gastroenterol 2001, 96:2199–2205. The authors address an important question and provide a comprehensive study on chronic liver disease and health-related quality of life.
Marchesini G, Amodio P, Salerno F, et al.: Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology 2001, 120:305–307. This is an excellent large-scale study assessing the factors associated with poor perceived health in a population where this has not been documented previously.
Fontana RJ, Moyer CA, Sonnad S, et al.: Comorbidities and quality of life in patients with interferon-refractory chronic hepatitis C. Am J Gastroenterol 2001, 96:170–178.
Obhrai J, Hall Y, Anand BS: Assessment of fatigue and psychologic disturbances in patients with hepatitis C virus infection. J Clin Gastroenterol 2001, 32:413–417.
Huet PM, Deslauriers J, Tran A, et al.: Impact of fatigue on the quality of life of patients with primary biliary cirrhosis. Am J Gastroenterol 2000, 95:760–767.
Rodger AJ, Jolley D, Thompson SC, et al.: The impact of diagnosis of hepatitis C virus on quality of life. Hepatology 1999, 30:1299–1301.
Singer ME, Younossi ZM: Cost effectiveness of screening for hepatitis C virus in asymptomatic, average-risk adults. Am J Med 2001, 111:25–30. This paper documents the cost-effectiveness of not screening adults in the general population for hepatitis C.
Younossi ZM, McCormick M, Price LL, et al.: Impact of liver transplantation on health-related quality of life. Liver Transplant 2000, 6:784–785.
Pereira SP, Howard LM, Muiesan P, et al.: Quality of life after liver transplantation for alcoholic liver disease. Liver Transplant 2000, 6:762–768.
De Bona M, Ponton P, Ermani M, et al.: The impact of liver disease and medical complications on quality of life and psychological distress before and after liver transplantation. J Hepatol 2000, 33:609–615.
Paterson DL, Gayowski T, Wannstedt CF, et al.: Quality of life in long-term survivors after liver transplantation: impact of recurrent viral hepatitis C virus hepatitis. Clin Transplant 2000, 14:48–54. This is an important topic. The study goes beyond the impact of liver transplantation and assesses the issue of recurring hepatitis C virus after transplant.
McHutchison JG, Ware JE Jr, Bayliss MS, et al.: The effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity. J Hepatol 2001, 34:140–147.
Zeuzem S, Teuber G, Naumann U, et al.: Randomized, doubleblind, placebo-controlled trial of interferon alfa2a with and without amantadine as initial treatment for chronic hepatitis C. Hepatology 2000, 32:835–841.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Martin, L.M., Sheridan, M.J. & Younossi, Z.M. The impact of liver disease on health-related quality of life: A review of the literature. Curr Gastroenterol Rep 4, 79–83 (2002). https://doi.org/10.1007/s11894-002-0041-z
Issue Date:
DOI: https://doi.org/10.1007/s11894-002-0041-z