Skip to main content

Advertisement

Log in

Mental Stress and Ventricular Arrhythmias

  • Psychological Aspects of Cardiovascular Diseases (A Steptoe, Section Editor)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Anger and other negative emotions can precipitate sudden death, as shown in studies of population stressors. Clinical studies of patients with implantable defibrillators demonstrate that anger can trigger ventricular arrhythmias. Long-term negative emotions also increase vulnerability to arrhythmias. Mechanisms linking anger and arrhythmias include autonomic changes, which alter repolarization, possibly enhanced in patients with sympathetic denervation, which in turn trigger potentially lethal polymorphic ventricular tachycardias. Interventions which decrease negative emotions and resultant autonomic responses may be therapeutic in patients with implantable cardioverter defibrillators.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Rashbaum W, New York Times. Woman dies after police mistakenly raid her apartment. 2003.

    Google Scholar 

  2. Engel GL. Sudden and rapid death during psychological stress. Annal Int Med. 1971;74:771–82.

    Article  CAS  Google Scholar 

  3. Leor J, Poole WK, Kloner RA. Sudden cardiac death triggered by an earthquake. N Engl J Med. 1996;334:413–9. This study is among the first and most rigorous to demonstrate an association between a population stressor and sudden cardiac death.

    Article  CAS  PubMed  Google Scholar 

  4. Kitamura T, Kiyohara K, Iwami T. The great east Japan earthquake and out-of-hospital cardiac arrest. N Engl J Med. 2013;369:2165–7.

    Article  CAS  PubMed  Google Scholar 

  5. Kiyohara K, Kitamura T, Iwami T, Nishiyama C, Kawamura T. Impact of the Great East Japan earthquake on out-of-hospital cardiac arrest with cardiac origin in non-disaster areas [corrected]. J Epidemiol Community Health (1979). 2015;69:185–8.

    Article  Google Scholar 

  6. Meisel SR, Kutz I, Dayan KI, et al. Effect of Iraqi missile war on incidence of acute myocardial infarction and sudden death in Israeli civilians. Lancet. 1991;338:660–1.

    Article  CAS  PubMed  Google Scholar 

  7. Ma W, Chen H, Jiang L, Song G, Kan H. Stock volatility as a risk factor for coronary heart disease death. Eur Heart J. 2011;32:1006–11.

    Article  PubMed  Google Scholar 

  8. Katz E, Metzger J-T, Marazzi A, Kappenberger L. Increase of sudden cardiac deaths in Switzerland during the 2002 FIFA World Cup. Int J Cardiol. 2006;107:132–3.

    Article  PubMed  Google Scholar 

  9. Sweeney MO, Quill TE. Clustering of sudden death and aborted cardiac arrest associated with a family grief reaction. Heart Rhythm. 2007;4:952–55.

    Article  PubMed  Google Scholar 

  10. Steinberg JS, Arshad A, Kowalski M, et al. Increased incidence of life-threatening ventricular arrhythmias in implantable defibrillator patients after the World Trade Center attack. J Am Coll Cardiol. 2004;44:1261–4.

    Article  PubMed  Google Scholar 

  11. Shedd OL, Sears SF, Harvill JL, et al. The World Trade Center attack: increased frequency of defibrillator shocks for ventricular arrhythmias in patients living remotely from New York City. J Am Coll Cardiol. 2004;44:1265–7.

    Article  PubMed  Google Scholar 

  12. Nakano M, Kondo M, Wakayama Y, et al. Increased incidence of tachyarrhythmias and heart failure hospitalization in patients with implanted cardiac devices after the Great East Japan earthquake disaster. Circ J. 2012;76:1283–5.

    Article  PubMed  Google Scholar 

  13. Wilbert-Lampen U, Leistner D, Greven S, et al. Cardiovascular events during World Cup soccer. [see comment]. N Engl J Med. 2008;358:475–83.

    Article  CAS  PubMed  Google Scholar 

  14. Kondo Y, Linhart M, Schwab JO, Andrie RP. Incidence of ventricular arrhythmias during World Cup football 2014 in patients with implantable cardioverter defibrillator. Int J Cardiol. 2015;187:307–8.

    Article  PubMed  Google Scholar 

  15. Lampert R. Behavioral influences on cardiac arrhythmias. Trends Cardiovasc Med. 2016;26:68–77.

    Article  PubMed  Google Scholar 

  16. Lampert R, Joska T, Burg M, Batsford W, McPherson C, Jain D. Emotional and physical precipitants of ventricular arrhythmia. Circulation. 2002;106:1800–5. This study was the first to demonstrate the association between anger and ventricular arrhythmias, in patients with implantable cardioverter-defibrillators.

    Article  PubMed  Google Scholar 

  17. Stopper M, Joska T, Burg MM, et al. Electrophysiologic characteristics of anger-triggered arrhythmias. Heart Rhythm. 2007;4:268–73. see comment.

    Article  PubMed  Google Scholar 

  18. Sgoifo A, Stilli D, Aimi B, Parmigiani S, Manghi M, Musso E. Behavioral and electrocardiographic responses to social stress in male rats. Physiol Behav. 1994;55:209–16.

    Article  CAS  PubMed  Google Scholar 

  19. Stamler JS, Goldman ME, Gomes J, Matz D, Horowitz SF. The effect of stress and fatigue on cardiac rhythm in medical interns. J Electrocardiography. 1992;25:333–8.

    Article  CAS  Google Scholar 

  20. Albert CM, Lampert R, Conti JB, et al. Episodes of anger trigger ventricular arrhythmias in patients with implantable cardioverter defibrillators. Circulation. 2006;114:II–831.

    Article  Google Scholar 

  21. Lown B, Verrier R, Corbalan R. Psychologic stress and threshold for repetitive ventricular response. Science. 1973;182:834–6.

    Article  CAS  PubMed  Google Scholar 

  22. Lampert R, Jain D, Burg MM, Batsford WP, McPherson CA. Destabilizing effects of mental stress on ventricular arrhythmias in patients with implantable cardioverter-defibrillators. Circulation. 2000;101:158–64.

    Article  CAS  PubMed  Google Scholar 

  23. Lane RD, Reis HT, Peterson DR, Zareba W, Moss AJ. Happiness and stress alter susceptibility to cardiac events in Long QT Syndrome. Ann Noninvasive Electrocardiol. 2009;14:193–200.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lampert R, Jamner L, Burg M, et al. Triggering of symptomatic atrial fibrillation by negative emotion. J Am Coll Cardiol. 2014;64:1533–4.

    Article  PubMed  Google Scholar 

  25. Tindle HA, Chang YF, Kuller LH, et al. Optimism, cynical hostility, and incident coronary heart disease and mortality in the Women’s Health Initiative. Circulation. 2009;120:656–62.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Chida Y, Steptoe A. Positive psychological well-being and mortality: a quantitative review of prospective observational studies. Psychosom Med. 2008;70:741–56.

    Article  PubMed  Google Scholar 

  27. Dockray S, Steptoe A. Positive affect and psychobiological processes. Neurosci Biobehav Rev. 2010;35:69–75. This article describes the importance of positive affect in influencing health outcomes.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Whang W, Albert CM, Sears Jr SF, et al. Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators: results from the Triggers of Ventricular Arrhythmias (TOVA) study. J Am Coll Cardiol. 2005;45:1090–5.

    Article  PubMed  Google Scholar 

  29. Habibović M, Pedersen SS, Van Den Broek KC, et al. Anxiety and risk of ventricular arrhythmias or mortality in patients with an implantable cardioverter defibrillator. Psychosom Med. 2013;75:36–41.

    Article  PubMed  Google Scholar 

  30. van den Broek KC, Nyklicek I, van der Voort PH, Alings M, Meijer A, Denollet J. Risk of ventricular arrhythmia after implantable defibrillator treatment in anxious type d patients. J Am Coll Cardiol. 2009;54:531–7.

    Article  PubMed  Google Scholar 

  31. Burg MM, Lampert R, Joska T, Batsford W, Jain D. Psychological traits and emotion-triggering of ICD shock-terminated arrhythmias. Psychosom Med. 2004;66:898–902.

    Article  PubMed  Google Scholar 

  32. Bernardi L, Wdowczyk-Szulc J, Valenti C, et al. Effects of controlled breathing, mental activity, and mental stress with or without verbalization on heart rate variability. J Am Coll Cardiol. 2000;35:1462–9.

    Article  CAS  PubMed  Google Scholar 

  33. Vaccarino V, Lampert R, Bremner JD, et al. Depressive symptoms and heart rate variability: evidence for a shared genetic substrate in a study of twins. Psychosom Med. 2008;70:628–36.

    Article  PubMed  Google Scholar 

  34. Han J, Garcia de Jalon P, Moe GK. Adrenergic effects on ventricular vulnerability. Circ Res. 1964;14:516–24.

    Article  CAS  PubMed  Google Scholar 

  35. Cerati D, Schwartz PJ. Single cardiac vagal fiber activity, acute myocardial ischemia, and risk for sudden death. Circ Res. 1991;69:1389–401.

    Article  CAS  PubMed  Google Scholar 

  36. Toivonen L, Helenius K, Viitasalo M. Electrocardiographic repolarization during stress from awakening on alarm call. J Am Coll Cardiol. 1997;30:774–9.

    Article  CAS  PubMed  Google Scholar 

  37. Kop WJ, Krantz DS, Nearing BD, et al. Effects of acute mental stress and exercise on T-wave alternans in patients with implantable cardioverter defibrillators and controls. Circulation. 2004;109:1864–9. This study demonstrates that anger increases T-wave alternans, a measure of repolarization heterogeneity, likely an important mechanism in the effect of anger on arrhythmogenesis.

    Article  PubMed  Google Scholar 

  38. Nearing BD, Huang AH, Verrier RL. Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave. Science. 1991;252:437–40.

    Article  CAS  PubMed  Google Scholar 

  39. Hohnloser SH, Klingenheben T, Zabel M, Yg L, Albrecht P, Cohen RJ. T wave alternans during exercise and atrial pacing in humans. J Cardiovasc Electrophysiol. 1997;8:987–93.

    Article  CAS  PubMed  Google Scholar 

  40. Rashba EJ, Cooklin M, MacMurdy K, et al. Effects of selective autonomic blockade on T-wave alternans in humans. Circulation. 2002;105:837–42.

    Article  PubMed  Google Scholar 

  41. Child N, Hanson B, Bishop M, et al. Effect of mental challenge induced by movie clips on action potential duration in normal human subjects independent of heart rate. Circ Arrhythm Electrophysiol. 2014;7:518–23.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Finlay MC, Lambiase PD, Ben-Simon R, Taggart P. Effect of mental stress on dynamic electrophysiological properties of the endocardium and epicardium in humans. Heart Rhythm. 2016;13:175–82.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Jacobson AF, Senior R, Cerqueira MD, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010;55:2212–21.

    Article  PubMed  Google Scholar 

  44. Rubart M, Zipes DP. Mechanisms of sudden cardiac death. J Clin Investig. 2005;115:2305–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Gardner RT, Wang L, Lang BT, et al. Targeting protein tyrosine phosphatase sigma after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias. Nat Commun. 2015;6:6235.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Hashemi Zanouz T, Liu YH, Sandoval V, et al. Cardiac sympathetic heterogeneity as measured by I-123 MIBG imaging in patients with ischemic cardiomyopathy. Society for Nuclear Medicine and Molecular Imaging. 2015. abstract.

  47. Lampert R, Shusterman V, Burg M, Batsford W, McPherson C, Soufer R. Anger-induced T-wave alternans predicts future ventricular arrhythmias in patients with implantable cardioverter-defibrillators. J Am Coll Cardiol. 2009;53:774–8.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Verrier RL, Klingenheben T, Malik M, et al. Microvolt T-wave alternans physiological basis, methods of measurement, and clinical utility—consensus guideline by International Society for Holter and Noninvasive Electrocardiology. J Am Coll Cardiol. 2011;58:1309–24.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Moss AJ, Schuger C, Beck CA, et al. Reduction in inappropriate therapy and mortality through ICD programming. N Eng J Med. 2012;367:2275–83.

    Article  CAS  Google Scholar 

  50. Dunbar SB, Dougherty CM, Sears SF, et al. Educational and psychological interventions to improve outcomes for recipients of implantable cardioverter defibrillators and their families. Circulation. 2012;126:2146–72.

    Article  PubMed  Google Scholar 

  51. Toise SC, Sears SF, Schoenfeld MH, et al. Psychosocial and cardiac outcomes of yoga for ICD patients: a randomized clinical control trial. Pacing Clin Electrophysiol. 2014;37:48–62.

    Article  PubMed  Google Scholar 

  52. Freedenberg VA, Thomas SA, Friedmann E. A pilot study of a mindfulness based stress reduction program in adolescents with implantable cardioverter defibrillators or pacemakers. Pediatr Cardiol. 2015;36:786–95.

    Article  PubMed  Google Scholar 

  53. Serber ER, Fava JL, Christon LM, et al. Positive psychotherapy to improve autonomic function and mood in ICD patients (PAM-ICD): rationale and design of an RCT currently underway. Pace-Pacing and Clin Electrophysiol. 2016;39:458–70.

    Article  Google Scholar 

  54. Chevalier P, Cottraux J, Mollard E, et al. Prevention of implantable defibrillator shocks by cognitive behavioral therapy: a pilot trial. Am Heart J. 2006;151:191e1–6.

    Article  Google Scholar 

  55. Donahue RG, Lampert R, Dornelas E, Clemow L, Burg MM, Investigators R. Rationale and design of a randomized clinical trial comparing stress reduction treatment to usual cardiac care: the Reducing Vulnerability to Implantable Cardioverter Defibrillator Shock-Treated Ventricular Arrhythmias (RISTA) trial. Psychosom Med. 2010;72:172–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rachel Lampert.

Ethics declarations

Conflict of Interest

Rachel Lampert declares that she has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain primary reports of any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Psychological Aspects of Cardiovascular Diseases

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lampert, R. Mental Stress and Ventricular Arrhythmias. Curr Cardiol Rep 18, 118 (2016). https://doi.org/10.1007/s11886-016-0798-6

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11886-016-0798-6

Keywords

Navigation