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Update on beta-lactam allergy diagnosis

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Abstract

Allergic reactions to penicillin and cephalosporin antibiotics are common. The mechanisms involved are heterogeneous and not yet completely understood. However, clinical and immunologic studies suggest that type I (IgE-mediated) and type IV (cellmediated) pathogenic mechanisms are involved in most immediate and non-immediate reactions, respectively. The diagnostic procedure has recently been standardized under the aegis of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interest group on drug hypersensitivity. In this review, we describe the general guidelines for evaluating subjects in whom there is suspicion of allergic reactions to β-lactams.

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Authors and Affiliations

  1. Exploration des Allergies, Maladies Respiratoires, INSERM U454-IFR3, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, 34295, Montpellier Cedex 5, France

    Pascal Demoly MD, PhD & Antonino Romano MD, PhD

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  1. Pascal Demoly MD, PhD
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  2. Antonino Romano MD, PhD
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Demoly, P., Romano, A. Update on beta-lactam allergy diagnosis. Curr Allergy Asthma Rep 5, 9–14 (2005). https://doi.org/10.1007/s11882-005-0048-2

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  • DOI: https://doi.org/10.1007/s11882-005-0048-2

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