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An assessment of the long-term health outcome of renal transplant recipients in Ireland

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Abstract

Background

Renal transplantation remains the preferred method of renal replacement therapy in terms of patient survival, quality of life and cost. However, patients have a high risk of complications ranging from rejection episodes, infection and cancer, amongst others.

Aims and methods

In this study, we sought to determine the long-term health outcomes and preventive health measures undertaken for the 1,536 living renal transplant patients in Ireland using a self-reported questionnaire. Outcomes were divided into categories, namely, general health information, allograft-related information, immunosuppression-related complications and preventive health measures.

Results

The results demonstrate a high rate of cardiovascular, neoplastic and infectious complications in our transplant patients. Moreover, preventive health measures are often not undertaken by patients and lifestyle choices can be poor.

Conclusions

This study highlights the work needed by the transplantation community to improve patient education, adjust immunosuppression where necessary and aggressively manage patient risk factors.

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References

  1. Loubeau PR, Loubeau JM, Jantzen R (2001) The economics of kidney transplantation versus hemodialysis. Prog Transplant 11(4):291–297

    CAS  PubMed  Google Scholar 

  2. Port F, Wolfe R, Mauger E, Berling D, Jiang K (1993) Comparison of survival probabilities for dialysis patients vs cadaveric renal transplant recipients. JAMA 270:1339–1343. doi:10.1001/jama.270.11.1339

    Article  CAS  PubMed  Google Scholar 

  3. Tomasz W, Piotr S (2003) A trial of objective comparison of quality of life between chronic renal failure patients treated with hemodialysis and renal transplantation. Ann Transplant 8(2):47–53

    PubMed  Google Scholar 

  4. Heisel O, Heisel R, Balshaw R, Keown P (2004) New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and meta-analysis. Am J Transplant 4(4):583–595. doi:10.1046/j.1600-6143.2003.00372.x

    Article  PubMed  Google Scholar 

  5. Textor SC, Canzanello VJ, Taler SJ et al (1994) Cyclosporine-induced hypertension after transplantation. Mayo Clin Proc 69(12):1182–1193

    CAS  PubMed  Google Scholar 

  6. Braun WE (1990) Long-term complications of renal transplantation. Kidney Int 37(5):1363–1378. doi:10.1038/ki.1990.123

    Article  CAS  PubMed  Google Scholar 

  7. United States Renal Data System 2007 Annual Data Report. http://www.usrds.org

  8. Gray DS, Fujioka K (1991) Use of relative weight and body mass index for the determination of adiposity. J Clin Epidemiol 44(6):545–550. doi:10.1016/0895-4356(91)90218-X

    Article  CAS  PubMed  Google Scholar 

  9. Kasiske BL, Guijarro C, Massy ZA, Wiederkehr MR, Ma JZ (1996) Cardiovascular disease after renal transplantation. J Am Soc Nephrol 7(1):158–165

    CAS  PubMed  Google Scholar 

  10. Aker S, Ivens K, Grabensee B, Heering P (1998) Cardiovascular risk factors and diseases after renal transplantation. Int Urol Nephrol 30(6):777–788. doi:10.1007/BF02564867

    Article  CAS  PubMed  Google Scholar 

  11. Office of Tobacco Control Annual Report 2007, Appendix A. http://www.otc.ie/uploads/Annual_Report_2007.pdf

  12. Shah T, Bunnapradist S, Hutchinson I et al (2008) The evolving notion of “senior” kidney transplant recipients. Clin Transplant 22:794–802 (18 Aug)

    Google Scholar 

  13. Hartevelt MM, Bavinck JN, Kootte AM, Vermeer BJ, Vandenbroucke JP (1990) Incidence of skin cancer after renal transplantation in The Netherlands. Transplantation 49(3):506–509. doi:10.1097/00007890-199003000-00006

    Article  CAS  PubMed  Google Scholar 

  14. Ducloux D, Carron PL, Rebibou JM et al (1998) CD4 lymphocytopenia as a risk factor for skin cancers in renal transplant recipients. Transplantation 65(9):1270–1272. doi:10.1097/00007890-199805150-00022

    Article  CAS  PubMed  Google Scholar 

  15. Kasiske BL, Snyder JJ, Gilbertson DT, Wang C (2004) Cancer after kidney transplantation in the United States. Am J Transplant 4(6):905–913. doi:10.1111/j.1600-6143.2004.00450.x

    Article  PubMed  Google Scholar 

  16. Caillard S, Agodoa LY, Bohen EM, Abbott KC (2006) Myeloma, Hodgkin disease, and lymphoid leukemia after renal transplantation: characteristics, risk factors and prognosis. Transplantation 81(6):888–895. doi:10.1097/01.tp.0000203554.54242.56

    Article  PubMed  Google Scholar 

  17. Fishman JA (2007) Infection in solid-organ transplant recipients. N Engl J Med 357(25):2601–2614. doi:10.1056/NEJMra064928

    Article  CAS  PubMed  Google Scholar 

  18. Horber FF, Casez JP, Steiger U, Czerniak A, Montandon A, Jaeger P (1994) Changes in bone mass early after kidney transplantation. J Bone Miner Res 9(1):1–9

    Article  CAS  PubMed  Google Scholar 

  19. Braith RW, Mills RM, Welsch MA, Keller JW, Pollock ML (1996) Resistance exercise training restores bone mineral density in heart transplant recipients. J Am Coll Cardiol 28(6):1471–1477. doi:10.1016/S0735-1097(96)00347-6

    Article  CAS  PubMed  Google Scholar 

  20. Kessler M, Jay N, Molle R, Guillemin F (2006) Excess risk of cancer in renal transplant patients. Transpl Int 19(11):908–914. doi:10.1111/j.1432-2277.2006.00383.x

    Article  PubMed  Google Scholar 

  21. Kasiske BL, Snyder JJ, Gilbertson DT, Wang C (2004) Cancer after kidney transplantation in the United States. Am J Transplant 4(6):905–913. doi:10.1111/j.1600-6143.2004.00450.x

    Article  PubMed  Google Scholar 

  22. (2004) Guidelines for vaccination of solid organ transplant candidates and recipients. Am J Transplant 4(Suppl 10):160–163

  23. Kasiske BL, Anjum S, Shah R, Skogen J, Kandaswamy C, Danielson B, O’Shaughnessy EA, Dahl DC, Silkensen JR, Sahadevan M, Snyder JJ (2004) Hypertension after kidney transplantation. Am J Kidney Dis 43(6):1071–1081. doi:10.1053/j.ajkd.2004.03.013

    Article  PubMed  Google Scholar 

  24. K/DOQI Clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease-guideline 12. http://www.kidney.org/Professionals/kdoqi/guidelines_bp/guide_12.htm

  25. Rigatto C, Parfrey P, Foley R, Negrijn C, Tribula C, Jeffery J (2002) Congestive heart failure in renal transplant recipients: risk factors, outcomes, and relationship with ischemic heart disease. J Am Soc Nephrol 13(4):1084–1090

    PubMed  Google Scholar 

  26. Fan X, Miller BC et al (2006) An exploratory study about inaccuracy and invalidity in adolescent self-report surveys. Field Methods 18(3):223–244. doi:10.1177/152822X06289161

    Article  Google Scholar 

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Conflict of interest statement

There are no potential conflicts of interest reported.

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Authors and Affiliations

  1. Department of Nephrology, Beaumont Hospital, Dublin 9, Ireland

    A. Al-Aradi, P. J. Phelan, P. O’Kelly, A. H. Khan, M. A. Rahman, A. Hanley, C. Ho, F. Kheradmand, D. Hickey, S. Spencer, C. Magee, J. J. Walshe, N. Morgan & P. J. Conlon

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  1. A. Al-Aradi
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  2. P. J. Phelan
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  3. P. O’Kelly
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  4. A. H. Khan
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  5. M. A. Rahman
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  6. A. Hanley
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  7. C. Ho
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  8. F. Kheradmand
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  9. D. Hickey
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  10. S. Spencer
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  11. C. Magee
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  12. J. J. Walshe
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  13. N. Morgan
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  14. P. J. Conlon
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Corresponding author

Correspondence to P. J. Phelan.

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Al-Aradi, A., Phelan, P.J., O’Kelly, P. et al. An assessment of the long-term health outcome of renal transplant recipients in Ireland. Ir J Med Sci 178, 407–412 (2009). https://doi.org/10.1007/s11845-009-0363-z

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  • DOI: https://doi.org/10.1007/s11845-009-0363-z

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