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Default mode network activity and neuropsychological profile in male children and adolescents with attention deficit hyperactivity disorder and conduct disorder

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Abstract

It is known that patients with Attention Deficit and Hyperactivity disorder (ADHD) and Conduct disorder (CD) commonly shows greater symptom severity than those with ADHD alone and worse outcomes. This study researches whether Default mode network (DMN) is altered in adolescents with ADHD + CD, relative to ADHD alone and controls or not. Ten medication-naïve boys with ADHD + CD, ten medication-naïve boys with ADHD and 10-age-matched typically developing (TD) controls underwent functional magnetic resonance imaging (fMRI) scans in the resting state and neuropsychological tasks such as the Wisconsin Card Sorting Test (WCST), Stroop Test TBAG Form (STP), Auditory Verbal learning Test (AVLT), Visual Auditory Digit Span B (VADS B) were applied to all the subjects included. fMRI scans can be used only nine patients in each groups. The findings revealed group differences between cingulate cortex and primary mortor cortex; cingulate cortex and somatosensory association cortex; angular gyrus (AG) and dorsal posterior cingulate cortex, in these networks increased activity was observed in participants with ADHD + CD compared with the ADHD. We found that lower resting state (rs)-activity was observed between left AG and dorsal posterior cingulate cortex, whereas higher rs-activity connectivity were detected between right AG and somatosensory association cortex in ADHD relative to the ones with ADHD + CD. In neuropsyhcological tasks, ADHD + CD group showed poor performance in WISC-R, WCST, Stroop, AVLT tasks compared to TDs. The ADHD + CD group displayed rs-functional abnormalities in DMN. Our results suggest that abnormalities in the intrinsic activity of resting state networks may contribute to the etiology of CD and poor prognosis of ADHD + CD.

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References

  • Andrews-Hanna, J. R. (2012). The brain’s default network and its adaptive role in internal mentation. The Neuroscientist, 18(3), 251–270.

    Article  PubMed  Google Scholar 

  • Ansari, D. (2008). Effects of development and enculturation on number representation in the brain. Nature Reviews. Neuroscience, 9(4), 278–291. doi:10.1038/nrn2334.

    Article  CAS  PubMed  Google Scholar 

  • Aronowitz, B., Liebowitz, M., Hollander, E., Fazzini, E., Durlach-Misteli, C., Frenkel, M., … et al. (1994). Neuropsychiatric and neuropsychological findings in conduct disorder and attention-deficit hyperactivity disorder. Journal of Neuropsychiatry and Clinical Neurosciences, 6(3), 245–249.

  • Baker, K. (2009). Conduct disorders in children and adolescents. Paediatrics & Child Health, 19(2), 73–78.

    Article  Google Scholar 

  • Banich, M. T., Milham, M. P., Atchley, R., Cohen, N. J., Webb, A., Wszalek, T., … Magin, R. (2000). fMri studies of Stroop tasks reveal unique roles of anterior and posterior brain systems in attentional selection. Journal of Cognitive Neuroscience, 12(6), 988–1000.

  • Berg, E. A. (1948). A simple objective technique for measuring flexibility in thinking. The Journal of General Psychology, 39(1), 15–22.

    Article  CAS  PubMed  Google Scholar 

  • Biederman, J., Newcorn, J., & Sprich, S. (1991). Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. The American Journal of Psychiatry, 148(5), 564–577. doi:10.1176/ajp.148.5.564.

    Article  CAS  PubMed  Google Scholar 

  • Binder, J. R., Frost, J. A., Hammeke, T. A., Bellgowan, P. S., Rao, S. M., & Cox, R. W. (1999). Conceptual processing during the conscious resting state. A functional MRI study. Journal of Cognitive Neuroscience, 11, 80–95.

    Article  CAS  PubMed  Google Scholar 

  • Can, P. H., Doğutepe, P. E., Yazıhan, P. N. T., Korkman, P. H., & Bakar, P. E. E. (2015). Construct validity of auditory verbal learning test. Journal of Turkish Psychiatry, 26, 1–9.

    CAS  Google Scholar 

  • Dehaene, S., Piazza, M., Pinel, P., & Cohen, L. (2003). Three parietal circuits for number processing. Cognitive Neuropsychology, 20(3), 487–506. doi:10.1080/02643290244000239.

    Article  PubMed  Google Scholar 

  • Dery, M., Toupin, J., Pauze, R., Mercier, H., & Fortin, L. (1999). Neuropsychological characteristics of adolescents with conduct disorder: association with attention-deficit–hyperactivity and aggression. Journal of Abnormal Child Psychology, 27(3), 225–236.

    Article  CAS  PubMed  Google Scholar 

  • Fairchild, G., Passamonti, L., Hurford, G., Hagan, C. C., von dem Hagen, E. A., van Goozen, S. H., … Calder, A. J. (2011). Brain structure abnormalities in early-onset and adolescent-onset conduct disorder. American Journal of Psychiatry, 168(6), 624–633. doi: 10.1176/appi.ajp.2010.10081184

  • Fassbender, C., Zhang, E., Buzy, W. M., Cortes, C. R., Mizuiri, D., Beckett, L., & Schweitzer, J. B. (2009). A lack of default network suppression is linked to increased distractibility in ADHD. Brain Research, 1273, 114–128. doi:10.1016/j.brainres.2009.02.070.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gökler, B., Ünal, F., Pehlivantürk, B., Kültür, E. Ç., Akdemir, D., & Taner, Y. (2004). Reliability and validity of schedule for affective disorders and schizophrenia for school age children-present and lifetime version-Turkish version (K-SADS-PL-T). Çocuk ve Gençlik Ruh Sağlığı Dergisi/Turkish Journal of Child and Adolescent Mental Health, 11(3), 109–116.

    Google Scholar 

  • Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences of the United States of America, 100(1), 253–258. doi:10.1073/pnas.0135058100.

    Article  CAS  PubMed  Google Scholar 

  • Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001). Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 7, 4259–4264.

    Article  Google Scholar 

  • Heaton, R. K. (1981). A manual for the Wisconsin card sorting test. Odessa: Western Psycological Services.

    Google Scholar 

  • Herba, C. M., Tranah, T., Rubia, K., & Yule, W. (2006). Conduct problems in adolescence: three domains of inhibition and effect of gender. Developmental Neuropsychology, 30(2), 659–695.

    Article  PubMed  Google Scholar 

  • Hill, J. (2002). Biological, psychological and social processes in the conduct disorders. Journal of Child Psychology and Psychiatry, 43(1), 133–164.

    Article  PubMed  Google Scholar 

  • Huebner, T., Vloet, T. D., Marx, I., Konrad, K., Fink, G. R., Herpertz, S. C., & Herpertz-Dahlmann, B. (2008). Morphometric brain abnormalities in boys with conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 47(5), 540–547. doi:10.1097/CHI.0b013e3181676545.

    Article  PubMed  Google Scholar 

  • Karakas, S., & Kitabı, E. (2006). Nöropsikolojik Testler İçin Araştırma ve Geliştirme Çalışmaları (2. Baskı ed.). Ankara: Eryılmaz Ofset.

    Google Scholar 

  • Karakaş, S., & Yalın, A. (1993). Görssel İşitsel Sayı DizileriTesti B formu (GİSD:B). Ankara: Medikomat.

    Google Scholar 

  • Karakaş, S., Eski, R., & Başar, E. (1996). Türk kültürü için standardizasyonu yapılmış nöropsikolojik testler topluluğu: BİLNOT Bataryası. 32. İstanbul: Ulusal Nöroloji Kongresi Kitabı. Türk Nöroloji Dergisi ve Bakırköy Ruh ve Sinir Hastalıkları Hastanesi.

    Google Scholar 

  • Kelly, A. M. C., Uddin, L. Q., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2008). Competition between functional brain networks mediates behavioral variability. NeuroImage, 39, 527–537. doi:10.1016/j.neuroimage.2007.08.008.

    Article  PubMed  Google Scholar 

  • Kılıç, B., Koçkar, A., Irak, M., Şener, Ş., & Karakaş, S. (2002a). Stroop Testi TBAG Formunun 6-11 yaş grubu çocuklarda standardizasyon çalışması. Turkish Journal of Child and Adolescent Mental Health, 9(2), 86–99.

    Google Scholar 

  • Kılıç, B. G., Koçkar, A. İ., Irak, M., Şener, Ş., & Karakaş, S. (2002b). Görsel işitsel sayı dizileri testi B formu kullanılarak ölçülen bellek uzamının Türk ilkokul çocuklarında gelişimi. Journal of Psychiatry Psychol Psychopharmacol (in Turkish), 10, 243–224254.

    Google Scholar 

  • Koppitz, E. M. (1977). The visual aural digit span test. San Antonio: Psychological Corp.

    Google Scholar 

  • Langleben, D. D., Monterosso, J., Elman, I., Ash, B., Krikorian, G., & Austin, G. (2006). Effect of methylphenidate on stroop color-word task performance in children with attention deficit hyperactivity disorder. Psychiatry Research, 141(3), 315–320. doi:10.1016/j.psychres.2005.09.007.

    Article  CAS  PubMed  Google Scholar 

  • Leech, R., & Sharp, D. J. (2014). The role of the posterior cingulate cortex in cognition and disease. Brain, 137(Pt 1), 12–32. doi:10.1093/brain/awt162.

    Article  PubMed  Google Scholar 

  • MacLeod, C. M. (1991). Half a century of research on the stroop effect: an integrative review. Psychological Bulletin, 109(2), 163.

    Article  CAS  PubMed  Google Scholar 

  • Marsh, A. A., Finger, E. C., Fowler, K. A., Adalio, C. J., Jurkowitz, I. T., Schechter, J. C., … Blair, R. J. (2013). Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits. Journal of Child Psychology and Psychiatry, 54(8), 900–910. doi: 10.1111/jcpp.12063

  • McAlonan, G. M., Cheung, V., Cheung, C., Chua, S. E., Murphy, D. G., Suckling, J., … Ho, T. P. (2007). Mapping brain structure in attention deficit-hyperactivity disorder: a voxel-based MRI study of regional grey and white matter volume. Psychiatry Research, 154(2), 171–180. doi: 10.1016/j.pscychresns.2006.09.006

  • Moffitt, T. E. (1993). Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychological Review, 100(4), 674–701.

    Article  CAS  PubMed  Google Scholar 

  • Morgan, A. B., & Lilienfeld, S. O. (2000). A meta-analytic review of the relation between antisocial behavior and neuropsychological measures of executive function. Clinical Psychology Review, 20(1), 113–136.

    Article  CAS  PubMed  Google Scholar 

  • Pennington, B. F., & Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry, 37(1), 51–87.

    Article  CAS  PubMed  Google Scholar 

  • Price, C. J. (2000). The anatomy of language: contributions from functional neuroimaging. Journal of Anatomy, 197(Pt 3), 335–359.

    Article  PubMed  PubMed Central  Google Scholar 

  • Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001). A default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 98, 676–682.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rey, A. (1941). L’examen psychologique dans les cas d’encephalopathie traumatique. (Les problems). Archives de psychologie, 28, 215–285.

  • Sasayama, D., Hayashida, A., Yamasue, H., Harada, Y., Kaneko, T., Kasai, K., … Amano, N. (2010). Neuroanatomical correlates of attention-deficit-hyperactivity disorder accounting for comorbid oppositional defiant disorder and conduct disorder. Psychiatry and Clinical Neurosciences, 64(4), 394–402. doi:10.1111/j.1440-1819.2010.02102.x

  • Séguin, J. R., Pihl, R. O., Harden, P. W., Tremblay, R. E., & Boulerice, B. (1995). Cognitive and neuropsychological characteristics of physically aggressive boys. Journal of Abnormal Psychology, 104(4), 614.

    Article  PubMed  Google Scholar 

  • Shallice, T., Marzocchi, G. M., Coser, S., Del Savio, M., Meuter, R. F., & Rumiati, R. I. (2002). Executive function profile of children with attention deficit hyperactivity disorder. Developmental Neuropsychology, 21(1), 43–71. doi:10.1207/S15326942DN2101_3.

    Article  PubMed  Google Scholar 

  • Sonuga-Barke, E. J., & Castellanos, F. X. (2007). Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neuroscience and Biobehavioral Reviews, 31, 977–986. doi:10.1016/j.neurobiorev.2007.02.005.

    Article  PubMed  Google Scholar 

  • Sterzer, P., Stadler, C., Poustka, F., & Kleinschmidt, A. (2007). A structural neural deficit in adolescents with conduct disorder and its association with lack of empathy. NeuroImage, 37(1), 335–342. doi:10.1016/j.neuroimage.2007.04.043.

    Article  PubMed  Google Scholar 

  • Stroop, J. R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18(6), 643.

    Article  Google Scholar 

  • Swanson, J., Baler, R. D., & Volkow, N. D. (2011). Understanding the effects of stimulant medications on cognition in individuals with attention-deficit hyperactivity disorder: a decade of progress. Neuropsychopharmacology, 36(1), 207–226. doi:10.1038/npp.2010.160.

    Article  CAS  PubMed  Google Scholar 

  • Thapar, A., Langley, K., Owen, M. J., & O'Donovan, M. C. (2007). Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine, 37(12), 1681–1692. doi:10.1017/S0033291707000773.

    Article  PubMed  Google Scholar 

  • Tian, L., Jiang, T., Liang, M., Zang, Y., He, Y., Sui, M., & Wang, Y. (2008). Enhanced resting-state brain activities in ADHD patients: a fMRI study. Brain Dev, 30(5), 342–348. doi:10.1016/j.braindev.2007.10.005.

    Article  PubMed  Google Scholar 

  • Vogt, B. A., Finch, D. M., & Olson, C. R. (1992). Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cerebral Cortex, 2(6), 435–443.

    CAS  PubMed  Google Scholar 

  • Whitfield-Gabrieli, S., & Ford, J. M. (2012). Default mode network activity and connectivity in psychopathology. Annual Review of Clinical Psychology, 8, 49–76.

    Article  PubMed  Google Scholar 

  • Zang, Y. F., He, Y., Zhu, C. Z., Cao, Q. J., Sui, M. Q., Liang, M., … Wang, Y. F. (2007). Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Development, 29(2), 83–91. doi:10.1016/j.braindev.2006.07.002

  • Zhou, J., Yao, N., Fairchild, G., Cao, X., Zhang, Y., Xiang, Y. T., … Wang, X. (2015a). Disrupted default mode network connectivity in male adolescents with conduct disorder. Brain Imaging and Behavior. doi:10.1007/s11682-015-9465-6

  • Zhou, J., Yao, N., Fairchild, G., Zhang, Y., & Wang, X. (2015b). Altered hemodynamic activity in conduct disorder: a resting-state FMRI investigation. PloS One, 10(3), e0122750. doi:10.1371/journal.pone.0122750.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgment

We thank to MR technician Irfan Kiziloz at Erciyes University, Children’s Hospital pediatric radiology department for his help in image acquisition.

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Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry, Kayseri Research and Training Hospital, Emel-Mehmet Tarman Child Hospital, Erkilet, Kayseri, Turkey

    Merve Cikili Uytun

  2. Department of Child and Adolescent Psychiatry, Erciyes University, Faculty of Medicine, Kayseri, Turkey

    Emel Karakaya, Sevgi Ozmen & Esra Demirci

  3. Department of Child and Adolescent Psychiatry, Surp Birgic Armenian Hospital, Istanbul, Turkey

    Didem Behice Oztop

  4. Faculty of Engineering, Biomedical Engineering, Erciyes University, Kayseri, Turkey

    Serife Gengec & Semra Icer

  5. Biomedical Imaging Research Center, Erciyes University, Kayseri, Turkey

    Kazım Gumus

  6. Faculty of Medicine, Radiology, Erciyes University, Kayseri, Turkey

    Selim Doğanay

  7. Faculty of Medicine, Department of Psychiatry, Erciyes University, Kayseri, Turkey

    Saliha Demirel Ozsoy

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  1. Merve Cikili Uytun
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Correspondence to Merve Cikili Uytun.

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This work was supported by research grants from: Erciyes University Scientific Research Project Comission, Kayseri, Turkey (Project number: TCD-2015-5605).

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All of the authors reported no biomedical financial interests or potential conflicts of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

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Uytun, M.C., Karakaya, E., Oztop, D.B. et al. Default mode network activity and neuropsychological profile in male children and adolescents with attention deficit hyperactivity disorder and conduct disorder. Brain Imaging and Behavior 11, 1561–1570 (2017). https://doi.org/10.1007/s11682-016-9614-6

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