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Treatment of middle/late stage primary hepatic carcinoma by Chinese medicine comprehensive therapy: A prospective randomized controlled study

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Abstract

Objective

To observe the efficacy of Chinese medicine comprehensive therapeutic project in treating the middle/late stage primary hepatic carcinoma (PHC).

Methods

With prospective randomized controlled design, 97 patients with PHC were assigned to the test group (49 cases) treated with Chinese medicine comprehensive therapy using Oleum fructus bruceas intervention combining oral intake of Ganji Decoction (肝积方) and external application of Ailitong (癌理通), and the control group (48 cases) treated with chemotherapeutic agents combining iodized oil chemo-embolization and analgesics. The immediate and long-term efficacy, adverse reaction, pain-relieving initial time (PRIT) and pain-relieving sustained time (PRST) of the treatment, as well as the change in relieving patients’ quality of life (QOL) were observed.

Results

The difference between the two groups in illness control rate was statistically insignificant (P>0.05), but the adverse reaction occurence rate in the test group was lesser than that in the control group (P<0.05). PRIT was insignificantly different in the two groups (P>0.05), but the PRST was significantly superior in the test group than that in the control group (10.37±2.18 h vs 7.78±1.95 h, P<0.01). After treatment, the increased Karnofsky scores in the test group indicated that the patients’ somatic activity, symptoms and QOL were improved significantly, which were significantly superior to those in the control group (P<0.05). The survival rate in the two groups was similar at the 3rd month after treatment, but the test group did show superiority in terms of half- and 1-year survival rate (65.9% vs 42.5% and 38.6% vs 18.1%, respectively, P<0.05). The median survival time in the test group was 8.9 months and that in the control group was 5.3 months.

Conclusion

Chinese medicine comprehensive therapy is an effective treatment for the middle/late stage patients of PHC, and it could extend the PRST, improve the patients’ QOL and long-term survival with less adverse reaction.

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Authors and Affiliations

  1. Department of Oncology, Foshan Municipal Hospital of Traditional Chinese Medicine, Guangdong, 528000, China

    Hua-qin Tian  (田华琴), Hong-liang Li  (李宏良), Bin Wang  (王 斌), Gui-wen Liang  (梁贵文), Xiao-qing Huang  (黄小青), Zhi-qing Huang  (黄志庆), Jiang-ming Lang  (郎江明), Yu-ping Zhang  (张玉萍), Xue-zhang Chen  (陈学彰) & Yin-song Chen  (陈银崧)

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  1. Hua-qin Tian  (田华琴)
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  2. Hong-liang Li  (李宏良)
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  3. Bin Wang  (王 斌)
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  4. Gui-wen Liang  (梁贵文)
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  5. Xiao-qing Huang  (黄小青)
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  6. Zhi-qing Huang  (黄志庆)
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  7. Jiang-ming Lang  (郎江明)
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  8. Yu-ping Zhang  (张玉萍)
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  9. Xue-zhang Chen  (陈学彰)
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  10. Yin-song Chen  (陈银崧)
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Corresponding author

Correspondence to Bin Wang  (王 斌).

Additional information

Supported by Guangdong Administration of Sciences and Technology (No. 2005B36001012)

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Tian, Hq., Li, Hl., Wang, B. et al. Treatment of middle/late stage primary hepatic carcinoma by Chinese medicine comprehensive therapy: A prospective randomized controlled study. Chin. J. Integr. Med. 16, 102–108 (2010). https://doi.org/10.1007/s11655-010-0102-3

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  • DOI: https://doi.org/10.1007/s11655-010-0102-3

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