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Prospective evaluation of sleep disturbances in chronic pancreatitis and its impact on quality of life: a pilot study

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Background

Patients with chronic pancreatitis (CP) have poor quality of life (QOL). Sleep disorders affect QOL when associated with chronic pain and opioid use. Hence patients with CP may have unrecognized sleep disturbances.

Aims

The aim of the study was to evaluate sleep disturbances in CP and its impact on QOL.

Methods

Established CP patients were prospectively enrolled after exclusion of patients with co-morbidities known to negatively affect sleep and QOL. Three questionnaires were used to identify sleep disturbances, PROMISv1SF8, Insomnia Severity Index, and Epworth Sleepiness Scale, and one for restless leg syndrome (RLS). PANQOLI and SF12 questionnaires were used to evaluate QOL. Two blinded sleep pulmonologists evaluated the responses. QOL assessments were then analyzed in patients with and without sleep disturbances.

Results

Of 89 patients, 48 met exclusion criteria, 41 were eligible, and 28 completed the study. Twenty patients (71%) had sleep disturbances with significantly worse scores across all 3 sleep questionnaires and also had lower scores on both PANQOLI (50 vs 76, p = 0.002) and SF-12 (physical component 29.3 vs 53.9, p < 0.001; mental component 36.4 vs 46.1, p = 0.03). Eleven patients (39%) had RLS and sleep disturbances.

Conclusion

In patients with established CP there was a high prevalence of sleep disturbances and RLS with worse QOL representing a potential therapeutic target to improve QOL.

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Acknowledgements

Awais Ahmed MD and Ishani Shah are fellows of the Barbara Janson and Arthur Hilsinger Pancreatology Fellowship at Beth Israel Deaconess Medical Center.

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Author notes

  1. Awais Ahmed and Amit N. Anand contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Rabb 423, Boston, MA, USA

    Awais Ahmed, Ishani Shah, William Yakah, Steven D. Freedman & Sunil G. Sheth

  2. Department of Medicine, Division of Pulmonology, St. Elizabeth Medical Center, Boston, MA, USA

    Amit N. Anand

  3. Department of Medicine, Division of Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Robert Thomas

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  1. Awais Ahmed
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Ahmed, A., Anand, A.N., Shah, I. et al. Prospective evaluation of sleep disturbances in chronic pancreatitis and its impact on quality of life: a pilot study. Sleep Breath 26, 1683–1691 (2022). https://doi.org/10.1007/s11325-021-02541-7

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  • DOI: https://doi.org/10.1007/s11325-021-02541-7

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