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The effect of intradialytic combined exercise on hemodialysis efficiency in end-stage renal disease patients: a randomized-controlled trial

  • Nephrology - Original Paper
  • Published:
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Abstract

Purpose

Insufficient dialysis is a difficult problem for patients undergoing hemodialysis, and causes cardiovascular complications and increases mortality. Increasing aerobic exercise and resistance exercise have been shown to be beneficial to physical fitness of patients undergoing hemodialysis, but a few studies have focused on combined exercise (combination of aerobic and resistance exercise training) and the interaction effect of combined exercise and intervention duration on hemodialysis efficiency. This study aimed to investigate the effects of 24-week combined exercise on hemodialysis efficiency, blood pressure, exercise capacity, and quality of life in patients undergoing hemodialysis.

Methods

In total, 47 eligible subjects were randomly allocated to exercise group and control group. The intervention group performed a 24-week, three times weekly, and moderate-intensity intradialytic combined exercise. Patients in the control group received usual care. The primary outcome was hemodialysis efficiency, which recorded every 4 weeks. Secondary outcomes included blood pressure, exercise capacity, and quality of life, measured at baseline and after 24 weeks of intervention.

Results

In intervention group, sp Kt/V significantly improved by 13.2%, and systolic blood pressure and diastolic blood pressure significantly decreased by 8.5 mmHg and 6.5 mmHg, respectively. The 6-min walking distance increased significantly by 43 m (9.8%), but there was no significant change in quality of life.

Conclusion

Combined exercise and intervention duration had an interaction effect on hemodialysis efficiency. Combined exercise improved blood pressure and physical fitness for patients undergoing hemodialysis, but did not affect quality of life. The extensive benefits of combined exercise provide evidence for the exercise development for patients undergoing hemodialysis.

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Funding

This study received no specific funding.

Author information

Authors and Affiliations

  1. Health Science Center, Xi’an Jiaotong University, No. 76 Yanta West Road, Xi’an, 710061, Shaan Xi, China

    Mei Huang, Aili Lv, Jing Wang, Bin Zhang, Na Xu, Zhonghui Zhai & Tianzi Li

  2. Blood Purification Department, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaan Xi, China

    Julin Gao & Yu Wang

  3. Nursing Department, Air Force Medical University, Xi’an, Shaan Xi, China

    Chunping Ni

Authors
  1. Mei Huang
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  2. Aili Lv
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  3. Jing Wang
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  4. Bin Zhang
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  5. Na Xu
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  6. Zhonghui Zhai
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  7. Julin Gao
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  8. Yu Wang
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  9. Tianzi Li
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  10. Chunping Ni
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Contributions

Conceptualization: AL, MH, JW, and ZZ; methodology: MH, BZ, and ZZ; formal analysis and investigation: NX, JG, YW, TL, and CN; writing—original draft preparation: MH and AL; writing—review and editing: JW. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Aili Lv.

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The subjects have given their written informed consent and the study protocol was approved by the institute’s committee on human research.

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Huang, M., Lv, A., Wang, J. et al. The effect of intradialytic combined exercise on hemodialysis efficiency in end-stage renal disease patients: a randomized-controlled trial. Int Urol Nephrol 52, 969–976 (2020). https://doi.org/10.1007/s11255-020-02459-1

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  • DOI: https://doi.org/10.1007/s11255-020-02459-1

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