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Addressing challenges in underactive bladder: recommendations and insights from the Congress on Underactive Bladder (CURE-UAB)

  • Urology - Review
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Abstract

Underactive bladder (UAB) is an expanding troublesome health issue, exerting a major influence on the health and independence of older people with a disproportionally low level of attention received. The 2nd International Congress on Underactive Bladder (CURE-UAB 2) convened in Denver, CO on December 3 and 4, 2015, and comprised of top clinicians, scientists, and other stakeholders to address the challenges in UAB. A series of workshops aimed to define UAB and its phenotype, define detrusor underactivity (DU) and create a subtyping of DU, evaluate existing animal models for DU, and lastly to establish research priorities for UAB.

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Acknowledgements

We would like to thank JoAnne Lake, The Underactive Bladder Foundation, Aikens Neurourology Research Center at Beaumont Health and the Society for Women’s Health Research for sharing patient experiences. We acknowledge all the participants of CURE-UAB for their insights, questions, and sharing their research.

Funding

Funding support was in parts sponsored by the National Institute on Aging (NIA), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the Underactive Bladder Foundation (www.underactivebladder.org), and the Aikens Neurourology Research Center at Beaumont Health (Royal Oak, MI). The views and opinions of authors expressed do not necessarily state or reflect those of the US government.

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    Authors and Affiliations

    1. Laboratory for Experimental Urology, Organ Systems Department of Development and Regeneration, University of Leuven, Leuven, Belgium

      Karel Dewulf & Dirk De Ridder

    2. Department of Urology, Montefiore Medical Center, Bronx, NY, USA

      Nitya Abraham

    3. Department of Urology, Beaumont Health System, 3811 West 13 Mile Road, Royal Oak, MI, 48073, USA

      Laura E. Lamb, Andrew Veerecke, Sarah N. Bartolone, Bernadette M. M. Zwaans, Ananias Diokno & Michael B. Chancellor

    4. Department of Urology, University of Kansas School of Medicine, Kansas City, KS, USA

      Tomas L. Griebling

    5. Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA

      Naoki Yoshimura & Pradeep Tyagi

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    1. Karel Dewulf
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    Correspondence to Michael B. Chancellor.

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    Conflict of interest

    There are no conflicts of interest for Karel Dewulf, Nitya Abraham, Laura E. Lamb, Naoki Yoshimura, Pradeep Tyagi, Tomas L. Griebling, Andrew Veerecke, Sarah N. Bartolone, Bernadette M.M. Zwanns, and Dirk De Ridder. Ananias Diokno is the principal investigator of Clinical Trial NCT02463448. Michael B. Chancellor has financial interest and a consultant relationship with Cook Myosite.

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    Karel Dewulf, Nitya Abraham, and Laura E. Lamb contributed equally to this manuscript. Michael B. Chancellor and Ananias Diokno contributed equally to this manuscript.

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    Dewulf, K., Abraham, N., Lamb, L.E. et al. Addressing challenges in underactive bladder: recommendations and insights from the Congress on Underactive Bladder (CURE-UAB). Int Urol Nephrol 49, 777–785 (2017). https://doi.org/10.1007/s11255-017-1549-3

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