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Increased risks of healthcare-seeking behaviors of anxiety, depression and insomnia among patients with bladder pain syndrome/interstitial cystitis: a nationwide population-based study

  • Urology - Original Paper
  • Published:
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Abstract

Purpose

To explore the association between bladder pain syndrome/interstitial cystitis (BPS/IC) and the risk of subsequent healthcare-seeking behavior for common mental disorders in Taiwan using a population-based administrative database.

Materials and methods

Both BPS/IC subjects and their age- and sex-matched non-BPS/IC control subjects who had no previous insomnia and mental diseases, including anxiety, depression, were subsequent serviced for these mental disorders by psychiatrists from the recruited date between 2002 and 2010. The risk of outcomes was assessed with Kaplan–Meier curves; and the impact of BPS/IC was estimated with Poisson regression analysis and Cox proportional hazards models.

Results

We included 16,185 BPS/IC subjects and 32,370 non-BPS/IC subjects, with a mean age of 46 years and 73.5 % of women. Difference of the prevalence of hypertension, diabetes, chronic kidney disease, and hyperlipidemia between groups was not significant difference. Subjects with BPS/IC had a significant higher incidence rate of anxiety, depression, and insomnia than the matched controls (92.9 vs 38.4, 101.0 vs 42.2, 47.5 vs 23.0; per 10,000 person-year). After adjusting for age, sex, and common comorbidities in multivariable analysis, BPS/IC remained a significant predictor with hazard ratio and 95 % confidence incidence, 2.4 (2.2–2.7), 2.4 (2.2–2.6), and 2.1 (1.8–2.4) for anxiety, depression, and insomnia, respectively.

Conclusion

Patients with BPS/IC are at risk of development of anxiety, depression, and insomnia. These findings can help guide urologists, urogynecologists, and psychiatrists toward early identification and treatment of psychological complications that may develop in BPS/IC patients.

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Acknowledgments

This study is based in part on data from the National Health Insurance Research Database provided by the National Health Insurance Administration, Ministry of Health and Welfare and managed by National Health Research Institutes (Registered number NHIRD-102-044_). The interpretation and conclusions contained herein do not represent those of National Health Insurance Administration, Ministry of Health and Welfare or National Health Research Institutes.

Conflict of interest

All authors declare no conflict of interest.

Author information

Author notes

    Authors and Affiliations

    1. Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan

      Yao-Chi Chuang

    2. Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan

      Shih-Feng Weng & Ya-Wen Hsu

    3. Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan

      Shih-Feng Weng & Ya-Wen Hsu

    4. Department of Psychiatry, Chi Mei Medical Center, Tainan, Taiwan

      Charles Lung-Cheng Huang

    5. Department of Social Worker, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan

      Charles Lung-Cheng Huang

    6. Division of Urogynecology and Pelvic Floor Reconstruction, Department of Obstetrics and Gynecology, Chi Mei Medical Center, 901 Chung-Hwa Road, Yong-Kang, Tainan, 710, Taiwan

      Ming-Ping Wu

    7. Center of General Education, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan

      Ming-Ping Wu

    8. Department of Obstetrics and Gynecology, College of Medicine, Taipei Medical University, Taipei, Taiwan

      Ming-Ping Wu

    Authors
    1. Yao-Chi Chuang
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    2. Shih-Feng Weng
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    3. Ya-Wen Hsu
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    4. Charles Lung-Cheng Huang
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    Corresponding authors

    Correspondence to Charles Lung-Cheng Huang or Ming-Ping Wu.

    Additional information

    Charles Lung-Cheng Huang and Ming-Ping Wu have contributed equally to this work.

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    Chuang, YC., Weng, SF., Hsu, YW. et al. Increased risks of healthcare-seeking behaviors of anxiety, depression and insomnia among patients with bladder pain syndrome/interstitial cystitis: a nationwide population-based study. Int Urol Nephrol 47, 275–281 (2015). https://doi.org/10.1007/s11255-014-0908-6

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    • DOI: https://doi.org/10.1007/s11255-014-0908-6

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