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Quality of Life Research
Gepubliceerd in: Quality of Life Research 4/2021

14-01-2021

Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors

Auteurs: Elizabeth J. Siembida, Ashley Wilder Smith, Arnold L. Potosky, Kristi D. Graves, Roxanne E. Jensen

Gepubliceerd in: Quality of Life Research | Uitgave 4/2021

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Abstract

Purpose

Older cancer survivors (≥ 65 years at diagnosis) are at high-risk for multimorbidity (2 + comorbid conditions). However, few studies have utilized a generalizable sample of older cancer survivors to understand how individual comorbid conditions, as opposed to total comorbidity burden, are associated with health-related quality of life (HRQOL). We examined associations between HRQOL outcomes (pain, fatigue, physical function), individual comorbidities (cardiovascular disease [CVD], lung disease, diabetes, arthritis) and total comorbidity (cancer-only, cancer + 1 condition, cancer + 2 or more conditions).

Methods

Utilizing a population-based sample of 2019 older cancer survivors, we tested associations between comorbid conditions and the HRQOL outcomes using generalized linear models. HRQOL domains were assessed using Patient-Reported Outcome Measurement Information System® (PROMIS®) measures. Comorbidity was assessed via self-report.

Results

Cancer survivors with lung disease reported significantly worse physical functioning (β = − 4.96, p < 0.001), survivors with arthritis reported significantly higher pain (β = 4.37, p < 0.001), and survivors with CVD reported significantly higher fatigue (β = 3.45, p < 0.001) compared to survivors without each condition. Having cancer + 1 condition was not as strongly associated with all outcomes as when individual conditions were tested (e.g. pain: β = 3.09, p < 0.001). Having 2+ comorbidities had a stronger association with all outcomes (e.g. physical function: β = − 7.51, p < 0.001) than examining conditions individually.

Conclusions

Knowing the specific comorbid condition profile of an older cancer survivor provides insight into specific HRQOL outcomes that may be impaired in cancer survivorship, but understanding total comorbidity burden, regardless of the specific conditions, sheds light on survivors at-risk for multiple impairments in HRQOL. This information, taken together, can inform risk-stratified survivorship care.
vorige artikel How do the influencing factors of health-related quality of life of the injured patient differ according to activity limitations?
volgende artikel Rural–urban differences in health-related quality of life: patterns for cancer survivors compared to other older adults
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Literatuur
1.
Centers for Medicare and Medicaid Services. (2012). Chronic conditions among Medicare beneficiaries. Chartbook. Baltimore, MD.
2.
Huang, I., Hudson, M. M., Robison, L. L., & Krull, K. R. (2017). Differential impact of symptom prevalence and chronic conditions on quality of life in cancer survivors and non-cancer individuals: A population study. Cancer Epidemiology, Biomarkers & Prevention, 26, 1124–1132.CrossRef
3.
Ng, H. S., Roder, D., Koczwara, B., & Vitry, A. (2018). Comorbidity, physical and mental health among cancer patients and survivors: An Australian population-based study. Asia-Pacific Journal of Clinical Oncology, 14, e181–e192.PubMedCrossRef
4.
Yamagishi, A., Morita, T., Miyashita, M., & Kimura, F. (2009). Symptom prevalence and longitudinal follow-up in cancer outpatients receiving chemotherapy. Journal of Pain and Symptom Management, 37, 823–830.PubMedCrossRef
5.
Brant, J. M., Beck, S. L., Dudley, W. N., Cobb, P., Pepper, G., & Miaskowski, C. (2011). Symptom trajectories during chemotherapy in outpatients with lung cancer, colorectal cancer, or lymphoma. European Journal of Oncology Nursing, 15, 470–477.PubMedCrossRef
6.
Freak-Poli, R., Ikram, M. A., Franco, O. H., Hofman, A., & Tiemeier, H. (2018). Depressive symptoms prior to and after incident cardiovascular disease and long-term survival: A population-based study of older persons. Depression & Anxiety, 35, 18–31.PubMedCrossRef
7.
Servaes, P., Gielissen, M. F. M., Verhagen, S., & Bleijenberg, G. (2007). The course of severe fatigue in disease-free breast cancer patients: A longitudinal study. Psycho-Oncology, 16, 787–795.PubMedCrossRef
8.
Wang, X. S., Zhao, F., Fisch, M. J., O’Mara, A. M., Cella, D., Mendoza, T. R., et al. (2014). Prevalence and characteristics of moderate to severe fatigue: A multicenter study in cancer patients and survivors. Cancer, 120, 425–432.PubMedPubMedCentralCrossRef
9.
Pandya, C., Magnuson, A., Flannery, M., Zittel, J., Duberstein, P., Loh, K. P., et al. (2019). Association between symptom burden and physical function in older patients with cancer. Journal of the American Geriatrics Society, 67, 998–1004.PubMedPubMedCentralCrossRef
10.
Laroche, F., Perrot, S., Medkour, T., Cottu, P., Plerga, J., Beerblock, K., et al. (2017). Quality of life and impact of pain in women treated with aromatase inhibitors for breast cancer: A multicenter cohort study. PLoS ONE, 12(1), e0187165.PubMedPubMedCentralCrossRef
11.
Curt, G. A., Breitbart, W., Cella, D., Groopman, J. E., Horning, S. J., Itri, L. M., et al. (2000). Impact of cancer-related fatigue on the lives of patients: New findings from the fatigue coalition. The Oncologist, 5, 353–360.PubMedCrossRef
12.
Fleming, S. T., Sabatino, S. A., Kimmick, G., Cress, R., Wu, X., Trentham-Dietz, A., et al. (2011). Developing a claim-based version of the ACE-27 comorbidity index: A comparison with medical record review. Medical Care, 49, 752–760.PubMedCrossRef
13.
Elixhauser, A., Steiner, C., Harris, D. R., & Coffey, R. M. (1998). Comorbidity measures for use with administrative data. Medical Care, 36(1), 8–27.PubMedCrossRef
14.
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987). A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. Journal of Chronic Disease, 40, 373–383.CrossRef
15.
Klabunde, C. N., Legler, J. M., Warren, J. L., Baldwin, L., & Schrag, D. (2007). A refined comorbidity measurement algorithm for claims-based studies of breast, prostate, colorectal, and lung cancer patients. Annals of Epidemiology, 17, 584–590.PubMedCrossRef
16.
Koroukian, S. M., Bakaki, P. M., Schluchter, M. D., & Owusu, C. (2011). Treatment and survival patterns in relation to multimorbidity in patients with locoregional breast and colorectal cancer. Journal of Geriatric Oncology, 2(3), 200–208.PubMedPubMedCentralCrossRef
17.
Koroukian, S. M., Xu, F., Bakaki, P. M., Diaz-Insua, M., Towe, T. P., & Owusu, C. (2010). Comorbidities, functional limitations, and geriatric syndromes in relation to treatment and survival patterns among elders with colorectal cancer. Journal of Gerontology: Medical Sciences, 65A(3), 322–329.
18.
Ording, A. G., Boffetta, P., Garne, J. P., Nyström, P. M. W., Cronin-Fenton, D., Frøslev, T., et al. (2015). Relative mortality rates from incident chronic diseases among breast cancer survivors – A 14 year follow-up of five-year survivors diagnosed in Denmark between 1994 and 2007. European Journal of Cancer, 51, 767–775.PubMedCrossRef
19.
Aarts, M. J., Aerts, J. F., van den Borne, B. E., Biesma, B., Lemmens, V. E. P. P., & Kloover, J. S. (2015). Comorbidity in patients with small-cell lung cancer: Trends and prognostic impact. Clinical Lung Cancer, 16(4), 282–291.PubMedCrossRef
20.
Sarfati, D., Koczwara, B., & Jackson, C. (2016). The impact of comorbidity on cancer and its treatment. CA: A Cancer Journal for Clinicians, 66, 337–350.
21.
Edwards, B. K., Noone, A., Mariotto, A. B., Simard, E. P., Boscoe, F. P., Henley, S. J., et al. (2014). Annual report to the nation on the status of cancer, 1975–2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer, 120, 1290–1314.PubMedCrossRef
22.
Nilsson, J., Berglund, A., Bergström, S., Bergqvist, M., & Lambe, M. (2017). The role of comorbidity in the management and prognosis in nonsmall cell lung cancer: A population-based study. Acta Oncologica, 56(7), 949–956.PubMedCrossRef
23.
Edwards, M. J., Campbell, I. D., Lawrenson, R. A., & Kuper-Hommel, M. J. (2017). Influence of comorbidity on chemotherapy use for early breast cancer: A systematic review and meta-analysis. Breast Cancer Research and Treatment, 165, 17–39.PubMedCrossRef
24.
Chang, H., Shih, S., & Lin, F. (2012). Impact of comorbidities on the outcomes of older patients receiving rectal cancer surgery. International Journal of Gerontology, 6, 285–289.CrossRef
25.
Wollschläger, D., Meng, X., Wӧckel, A., Janni, W., Kreienberg, R., Blettner, M., et al. (2018). Comorbidity-dependent adherence to guidelines and survival in breast cancer – Is there a role for guideline adherence in comorbid breast cancer patients? A retrospective study with 2137 patients. The Breast Journal, 24, 120–127.PubMedCrossRef
26.
Sabatino, S. A., Thompson, T. D., Wu, X., Fleming, S. T., Kimmick, G. G., Trentham-Dietz, A., et al. (2014). The influence of diabetes severity on receipt of guideline-concordant treatment for breast cancer. Breast Cancer Research and Treatment, 146, 199–209.PubMedPubMedCentralCrossRef
27.
Kimmick, G., Fleming, S. T., Sabatino, S. A., Wu, X., Hwang, W., Wilson, J. F., et al. (2014). Comorbidity burden and guideline-concordant care for breast cancer. Journal of American Geriatrics Society, 62, 482–488.CrossRef
28.
Smith, A. W., Reeve, B. B., Bellizzi, K. M., Harlan, L. C., Klabunde, C. N., Amsellem, M., et al. (2008). Cancer, comorbidities, and health-related quality of life of older adults. Health Care Financing Review, 29(4), 41–56.PubMedPubMedCentral
29.
Portz, J. D., Kutner, J. S., Blatchford, P. J., & Ritchie, C. S. (2017). High symptom burden and low functional status in the setting of multimorbidity. Journal of American Geriatrics Society, 65, 2285–2289.CrossRef
30.
Davis, L. E., Bubis, L. D., Mahar, A. L., Li, Q., Sussman, J., Moody, L., et al. (2018). Patient-reported symptoms after breast cancer diagnosis and treatment: A retrospective cohort study. European Journal of Cancer, 101, 1–11.PubMedCrossRef
31.
Jensen, R. E., Moinpour, C. M., Keegan, T. H. M., Cress, R. D., Wu, X., Paddock, L. E., et al. (2016). The measuring your health study: Leveraging community-based cancer registry recruitment to establish a large, diverse cohort of cancer survivors for analyses of measurement equivalence and validity of the Patient Reported Outcomes Measurement Information System® (PROMIS®) short form items. Psychological Test and Assessment Modeling, 58(1), 99–117.
32.
Cella, D., Riley, W., Stone, A., Rothrock, N., Reeve, B., Yount, S., et al. (2010). The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005–2008. Journal of Clinical Epidemiology, 63, 1179–1194.PubMedPubMedCentralCrossRef
33.
Yost, K. J., Eton, D. T., Garcia, S. F., & Cella, D. (2011). Minimally important differences were estimated for six Patient-Reported Outcomes Measurement Information System-Cancer scales in advanced stage cancer patients. Journal of Clinical Epidemiology, 64, 507–516.PubMedPubMedCentralCrossRef
34.
Cummings, A., Grimmett, C., Calman, L., Patel, M., Permyakova, N. V., Winter, J., et al. (2018). Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study. Psycho-Oncology, 27, 2427–2435.PubMedPubMedCentralCrossRef
35.
Yi, Y., Ban, W. H., & Sohng, K. (2018). Effect of COPD on symptoms, quality of life and prognosis in patients with advanced non-small cell lung cancer. BMC Cancer, 18, 1053.PubMedPubMedCentralCrossRef
36.
Wang, J., Sun, L., Li, J., Cong, X., Chen, X., Tang, Z., et al. (2015). Comorbid chronic diseases and their associations with quality of life among gynecological cancer survivors. BMC Public Health, 15, 965.PubMedPubMedCentralCrossRef
37.
Wang, J., Sun, L., Ding, N., Li, J., Gong, X., Chen, X., et al. (2016). The association between comorbidities and the quality of life among colorectal cancer survivors in the People’s Republic of China. Patient Preference and Adherence, 10, 1071–1077.PubMedPubMedCentralCrossRef
38.
Boakye, D., Rillmann, B., Walter, V., Jansen, L., Hoffmeister, M., & Brenner, H. (2018). Impact of comorbidity and frailty on prognosis in colorectal cancer patients: A systematic review and meta-analysis. Cancer Treatment Reviews, 64, 30–39.PubMedCrossRef
39.
Williams, G. R., Deal, A. M., Lund, J. L., Chang, Y., Muss, H. B., Pergolotti, M., et al. (2017). Patient-reported comorbidity and survival in older adults with cancer. The Oncologist, 22, 1–7.
40.
41.
Mayer, D. K., & Alfano, C. M. (2019). Personalized risk-stratified cancer follow-up care: Its potential for healthier survivors, happier clinicians and lower costs. Journal of National Cancer Institute, 11, 442–448.CrossRef
42.
Shao, S., Gill, A. A., Zahm, S. H., Jatoi, I., Shriver, C. D., McGlynn, K. A., et al. (2017). Diabetes and overall survival among breast cancer patients in the U.S. military health system. Cancer Epidemiology, Biomarkers & Prevention, 27, 50–57.CrossRef
43.
Austin, S. R., Wong, Y., Uzzo, R. G., Beck, J. R., & Egleston, B. L. (2015). Why summary comorbidity measures such as the Charlson comorbidity index and Elixhauser score work. Medical Care, 53, e65–e72.PubMedPubMedCentralCrossRef
44.
Yabroff, K. R., Gansler, T., Wender, R. C., Cullen, K. J., & Brawley, O. W. (2019). Minimizing the burden of cancer in the United States: Goals for a high-performing health care system. CA: A Cancer Journal for Clinicians, 69, 166–183.
45.
Naylor, M., & Berlinger, N. (2016). Transitional care: A priority for health care organizational ethics. Hastings Center Report, 46, S39–S42.CrossRef
Metagegevens
Titel
Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors
Auteurs
Elizabeth J. Siembida
Ashley Wilder Smith
Arnold L. Potosky
Kristi D. Graves
Roxanne E. Jensen
Publicatiedatum
14-01-2021
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 4/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02713-0

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