Skip to main content
Top
Gepubliceerd in: Quality of Life Research 4/2017

14-10-2016

Gastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders

Auteurs: James W. Varni, Robert J. Shulman, Mariella M. Self, Samuel Nurko, Miguel Saps, Shehzad A. Saeed, Ashish S. Patel, Chelsea Vaughan Dark, Cristiane B. Bendo, John F. Pohl, on behalf of the Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms Module Testing Study Consortium

Gepubliceerd in: Quality of Life Research | Uitgave 4/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Objectives

To investigate the patient-reported multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with functional gastrointestinal disorders (FGIDs).

Methods

The Pediatric Quality of Life Inventory™ (PedsQL™) Gastrointestinal Symptoms Scales and PedsQL™ 4.0 Generic Core Scales were completed in a 9-site study by 259 pediatric patients with functional constipation, functional abdominal pain (FAP), or irritable bowel syndrome (IBS). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL.

Results

Gastrointestinal symptoms were differentially associated with decreased HRQOL in bivariate analyses for the three FGIDs. In predictive models utilizing hierarchical multiple regression analyses controlling for age, gender, and race/ethnicity, gastrointestinal symptoms differentially accounted for an additional 47, 40, and 60 % of the variance in patient-reported HRQOL for functional constipation, FAP, and IBS, respectively, reflecting large effect sizes. Significant individual gastrointestinal symptoms predictors were identified after controlling for the other gastrointestinal symptoms in the FGID-specific predictive models.

Conclusions

Gastrointestinal symptoms represent potentially modifiable predictors of generic HRQOL in pediatric patients with FGIDs. Identifying the condition-specific gastrointestinal symptoms that are the most important predictors from the patient perspective facilitates a patient-centered approach to targeted interventions designed to ameliorate impaired overall HRQOL.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
1.
go back to reference Rasquin, A., Di Lorenzo, C., Forbes, D., Guiraldes, E., Hyams, J. S., Staiano, A., et al. (2006). Childhood functional gastrointestinal disorders: Child/adolescent. Gastroenterology, 130, 1527–1537.CrossRefPubMed Rasquin, A., Di Lorenzo, C., Forbes, D., Guiraldes, E., Hyams, J. S., Staiano, A., et al. (2006). Childhood functional gastrointestinal disorders: Child/adolescent. Gastroenterology, 130, 1527–1537.CrossRefPubMed
2.
go back to reference Varni, J. W., Bendo, C. B., Nurko, S., Shulman, R. J., Self, M. M., Franciosi, J. P., et al. (2015). Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases. Journal of Pediatrics, 166, 85–90.CrossRefPubMed Varni, J. W., Bendo, C. B., Nurko, S., Shulman, R. J., Self, M. M., Franciosi, J. P., et al. (2015). Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases. Journal of Pediatrics, 166, 85–90.CrossRefPubMed
3.
go back to reference Youssef, N. N., Murphy, T. G., Langseder, A. L., & Rosh, J. R. (2006). Quality of life for children with functional abdominal pain: A comparison study of patients’ and parents’ perceptions. Pediatrics, 117, 54–59.CrossRefPubMed Youssef, N. N., Murphy, T. G., Langseder, A. L., & Rosh, J. R. (2006). Quality of life for children with functional abdominal pain: A comparison study of patients’ and parents’ perceptions. Pediatrics, 117, 54–59.CrossRefPubMed
4.
go back to reference Varni, J. W., Lane, M., Burwinkle, T., Fontaine, E., Youssef, N., Schwimmer, J., et al. (2006). Health-related quality of life in pediatric patients with irritable bowel syndrome: A comparative analysis. Journal of Developmental and Behavioral Pediatrics, 27, 451–458.CrossRefPubMed Varni, J. W., Lane, M., Burwinkle, T., Fontaine, E., Youssef, N., Schwimmer, J., et al. (2006). Health-related quality of life in pediatric patients with irritable bowel syndrome: A comparative analysis. Journal of Developmental and Behavioral Pediatrics, 27, 451–458.CrossRefPubMed
5.
go back to reference Hyams, J. S., Burke, G., Davis, P. M., Rzepski, B., & Andrulonis, P. A. (1996). Abdominal pain and irritable bowel syndrome in adolescents: A community-based study. Journal of Pediatrics, 129, 220–226.CrossRefPubMed Hyams, J. S., Burke, G., Davis, P. M., Rzepski, B., & Andrulonis, P. A. (1996). Abdominal pain and irritable bowel syndrome in adolescents: A community-based study. Journal of Pediatrics, 129, 220–226.CrossRefPubMed
6.
go back to reference Mohammad, S., Di Lorenzo, C., Youssef, N. N., Miranda, A., Nurko, S., Hyman, P., et al. (2014). Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: Are we ready for change? Journal of Pediatric Gastroenterology and Nutrition, 58, 46–50.CrossRefPubMedPubMedCentral Mohammad, S., Di Lorenzo, C., Youssef, N. N., Miranda, A., Nurko, S., Hyman, P., et al. (2014). Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: Are we ready for change? Journal of Pediatric Gastroenterology and Nutrition, 58, 46–50.CrossRefPubMedPubMedCentral
8.
go back to reference Czyzewski, D. I., Lane, M. M., Weidler, E. M., Williams, A. E., Swank, P. R., & Shulman, R. J. (2011). The interpretation of Rome III criteria and method of assessment affect the irritable bowel syndrome classification of children. Alimentary Pharmacology & Therapeutics, 33, 403–411.CrossRef Czyzewski, D. I., Lane, M. M., Weidler, E. M., Williams, A. E., Swank, P. R., & Shulman, R. J. (2011). The interpretation of Rome III criteria and method of assessment affect the irritable bowel syndrome classification of children. Alimentary Pharmacology & Therapeutics, 33, 403–411.CrossRef
9.
go back to reference Self, M. M., Czyzewski, D. I., Chumpitazi, B. P., Weidler, E. M., & Shulman, R. J. (2014). Subtypes of irritable bowel syndrome in children and adolescents. Clinical Gastroenterology and Hepatology, 12, 1468–1473.CrossRefPubMedPubMedCentral Self, M. M., Czyzewski, D. I., Chumpitazi, B. P., Weidler, E. M., & Shulman, R. J. (2014). Subtypes of irritable bowel syndrome in children and adolescents. Clinical Gastroenterology and Hepatology, 12, 1468–1473.CrossRefPubMedPubMedCentral
10.
go back to reference Nurko, S., & Zimmerman, L. A. (2014). Evaluation and treatment of constipation in children and adolescents. American Family Physician, 90, 82–90.PubMed Nurko, S., & Zimmerman, L. A. (2014). Evaluation and treatment of constipation in children and adolescents. American Family Physician, 90, 82–90.PubMed
11.
go back to reference Youssef, N. N., Langseder, A. L., Verga, B. J., Mones, R. L., & Rosh, J. R. (2005). Chronic childhood constipation is associated with impaired quality of life: A case-controlled study. Journal of Pediatric Gastroenterology and Nutrition, 41, 56–60.CrossRefPubMed Youssef, N. N., Langseder, A. L., Verga, B. J., Mones, R. L., & Rosh, J. R. (2005). Chronic childhood constipation is associated with impaired quality of life: A case-controlled study. Journal of Pediatric Gastroenterology and Nutrition, 41, 56–60.CrossRefPubMed
12.
go back to reference Hartman, E. E., Pawaskar, M., Williams, V., McLeod, L., Dubois, D., Benninga, M. A., et al. (2014). Psychometric properties of the PedsQL Generic Core Scales for children with functional constipation in the Netherlands. Journal of Pediatric Gastroenterology and Nutrition, 59, 739–747.CrossRefPubMed Hartman, E. E., Pawaskar, M., Williams, V., McLeod, L., Dubois, D., Benninga, M. A., et al. (2014). Psychometric properties of the PedsQL Generic Core Scales for children with functional constipation in the Netherlands. Journal of Pediatric Gastroenterology and Nutrition, 59, 739–747.CrossRefPubMed
13.
go back to reference Varni, J. W., Shulman, R. J., Self, M. M., Nurko, S., Saps, M., Saeed, S., et al. (2015). Symptom profiles in patients with irritable bowel syndrome or functional abdominal pain compared to healthy controls. Journal of Pediatric Gastroenterology and Nutrition, 61, 323–329.CrossRefPubMed Varni, J. W., Shulman, R. J., Self, M. M., Nurko, S., Saps, M., Saeed, S., et al. (2015). Symptom profiles in patients with irritable bowel syndrome or functional abdominal pain compared to healthy controls. Journal of Pediatric Gastroenterology and Nutrition, 61, 323–329.CrossRefPubMed
14.
go back to reference Varni, J. W., Nurko, S., Shulman, R. J., Self, M. M., Saps, M., Bendo, C. B., et al. (2015). Pediatric functional constipation gastrointestinal symptom profile compared to healthy controls. Journal of Pediatric Gastroenterology and Nutrition, 61, 424–430.CrossRefPubMed Varni, J. W., Nurko, S., Shulman, R. J., Self, M. M., Saps, M., Bendo, C. B., et al. (2015). Pediatric functional constipation gastrointestinal symptom profile compared to healthy controls. Journal of Pediatric Gastroenterology and Nutrition, 61, 424–430.CrossRefPubMed
15.
go back to reference Fayers, P. M., & Hand, D. J. (1997). Factor analysis, causal indicators and quality of life. Quality of Life Research, 6, 139–150.PubMed Fayers, P. M., & Hand, D. J. (1997). Factor analysis, causal indicators and quality of life. Quality of Life Research, 6, 139–150.PubMed
16.
go back to reference Varni, J. W., Bendo, C. B., Denham, J., Shulman, R. J., Self, M. M., Neigut, D. A., et al. (2014). PedsQL™ gastrointestinal symptoms module: Feasibility, reliability, and validity. Journal of Pediatric Gastroenterology and Nutrition, 59, 347–355.CrossRefPubMed Varni, J. W., Bendo, C. B., Denham, J., Shulman, R. J., Self, M. M., Neigut, D. A., et al. (2014). PedsQL™ gastrointestinal symptoms module: Feasibility, reliability, and validity. Journal of Pediatric Gastroenterology and Nutrition, 59, 347–355.CrossRefPubMed
17.
go back to reference Varni, J. W., Bendo, C. B., Denham, J., Shulman, R. J., Self, M. M., Neigut, D. A., et al. (2015). PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls. Quality of Life Research, 24, 363–378.CrossRefPubMed Varni, J. W., Bendo, C. B., Denham, J., Shulman, R. J., Self, M. M., Neigut, D. A., et al. (2015). PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls. Quality of Life Research, 24, 363–378.CrossRefPubMed
18.
go back to reference Varni, J. W., Franciosi, J. P., Shulman, R. J., Saeed, S., Nurko, S., Neigut, D. A., et al. (2015). PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with inflammatory bowel disease in comparison to healthy controls. Inflammatory Bowel Diseases, 21, 1115–1124.CrossRefPubMed Varni, J. W., Franciosi, J. P., Shulman, R. J., Saeed, S., Nurko, S., Neigut, D. A., et al. (2015). PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with inflammatory bowel disease in comparison to healthy controls. Inflammatory Bowel Diseases, 21, 1115–1124.CrossRefPubMed
19.
go back to reference Varni, J. W., Bendo, C. B., Shulman, R. J., Self, M. M., Nurko, S., Franciosi, J. P., et al. (2015). Interpretability of the PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases. Journal of Pediatric Psychology, 40, 591–601.CrossRefPubMedPubMedCentral Varni, J. W., Bendo, C. B., Shulman, R. J., Self, M. M., Nurko, S., Franciosi, J. P., et al. (2015). Interpretability of the PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases. Journal of Pediatric Psychology, 40, 591–601.CrossRefPubMedPubMedCentral
20.
go back to reference Varni, J. W., Kay, M. T., Limbers, C. A., Franciosi, J. P., & Pohl, J. F. (2012). PedsQL™ Gastrointestinal Symptoms Module item development: Qualitative methods. Journal of Pediatric Gastroenterology and Nutrition, 54, 664–671.CrossRefPubMed Varni, J. W., Kay, M. T., Limbers, C. A., Franciosi, J. P., & Pohl, J. F. (2012). PedsQL™ Gastrointestinal Symptoms Module item development: Qualitative methods. Journal of Pediatric Gastroenterology and Nutrition, 54, 664–671.CrossRefPubMed
21.
go back to reference Varni, J. W., Seid, M., & Kurtin, P. S. (2001). PedsQL™ 4.0: Reliability and validity of the Pediatric Quality of Life Inventory™ Version 4.0 Generic Core Scales in healthy and patient populations. Medical Care, 39, 800–812.CrossRefPubMed Varni, J. W., Seid, M., & Kurtin, P. S. (2001). PedsQL™ 4.0: Reliability and validity of the Pediatric Quality of Life Inventory™ Version 4.0 Generic Core Scales in healthy and patient populations. Medical Care, 39, 800–812.CrossRefPubMed
22.
go back to reference Varni, J. W., Thompson, K. L., & Hanson, V. (1987). The Varni/Thompson Pediatric Pain Questionnaire: I. Chronic musculoskeletal pain in juvenile rheumatoid arthritis. Pain, 28, 27–38.CrossRefPubMed Varni, J. W., Thompson, K. L., & Hanson, V. (1987). The Varni/Thompson Pediatric Pain Questionnaire: I. Chronic musculoskeletal pain in juvenile rheumatoid arthritis. Pain, 28, 27–38.CrossRefPubMed
23.
go back to reference Fairclough, D. L. (2002). Design and analysis of quality of life studies in clinical trials: Interdisciplinary statistics. New York: Chapman & Hall/CRC. Fairclough, D. L. (2002). Design and analysis of quality of life studies in clinical trials: Interdisciplinary statistics. New York: Chapman & Hall/CRC.
24.
go back to reference Varni, J. W., & Limbers, C. A. (2009). The Pediatric Quality of Life Inventory™: Measuring pediatric health-related quality of life from the perspective of children and their parents. Pediatric Clinics of North America, 56, 843–863.CrossRefPubMed Varni, J. W., & Limbers, C. A. (2009). The Pediatric Quality of Life Inventory™: Measuring pediatric health-related quality of life from the perspective of children and their parents. Pediatric Clinics of North America, 56, 843–863.CrossRefPubMed
25.
go back to reference Varni, J. W., Limbers, C. A., & Burwinkle, T. M. (2007). How young can children reliably and validly self-report their health-related quality of life?: An analysis of 8,591 children across age subgroups with the PedsQL™ 4.0 Generic Core Scales. Health and Quality of Life Outcomes, 5(1), 1–13.CrossRefPubMedPubMedCentral Varni, J. W., Limbers, C. A., & Burwinkle, T. M. (2007). How young can children reliably and validly self-report their health-related quality of life?: An analysis of 8,591 children across age subgroups with the PedsQL™ 4.0 Generic Core Scales. Health and Quality of Life Outcomes, 5(1), 1–13.CrossRefPubMedPubMedCentral
26.
go back to reference Norman, G. R., Sloan, J. A., & Wyrwich, K. W. (2003). Interpretation of changes in health-related quality of life: The remarkable universality of half a standard deviation. Medical Care, 41, 582–592.PubMed Norman, G. R., Sloan, J. A., & Wyrwich, K. W. (2003). Interpretation of changes in health-related quality of life: The remarkable universality of half a standard deviation. Medical Care, 41, 582–592.PubMed
27.
go back to reference Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Erlbaum. Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Erlbaum.
28.
go back to reference Cohen, J., Cohen, P., West, S. G., & Aiken, L. S. (2003). Applied multiple regression/correlation analysis for the behavioral sciences (3rd ed.). Mahwah, NJ: Erlbaum. Cohen, J., Cohen, P., West, S. G., & Aiken, L. S. (2003). Applied multiple regression/correlation analysis for the behavioral sciences (3rd ed.). Mahwah, NJ: Erlbaum.
29.
go back to reference Varni, J. W., Limbers, C. A., & Burwinkle, T. M. (2007). Impaired health-related quality of life in children and adolescents with chronic conditions: A comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales. Health and Quality of Life Outcomes, 5(43), 1–15.CrossRefPubMedPubMedCentral Varni, J. W., Limbers, C. A., & Burwinkle, T. M. (2007). Impaired health-related quality of life in children and adolescents with chronic conditions: A comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales. Health and Quality of Life Outcomes, 5(43), 1–15.CrossRefPubMedPubMedCentral
30.
go back to reference Colombo, J. M., Wassom, M. C., & Rosen, J. M. (2015). Constipation and encopresis in childhood. Pediatrics in Review, 36, 392–401.CrossRefPubMed Colombo, J. M., Wassom, M. C., & Rosen, J. M. (2015). Constipation and encopresis in childhood. Pediatrics in Review, 36, 392–401.CrossRefPubMed
31.
go back to reference Cushing, C. C., Martinez-Leo, B., Bischoff, A., Hall, J., Helmrath, M., Hsi Dickie, B., Levitt, M. A., Peña, A., Zeller, M. H., & Frischer, J. S. (in press). Health related quality of life and parental stress in children with fecal incontinence: A normative comparison. Journal of Pediatric Gastroenterology & Nutrition. Cushing, C. C., Martinez-Leo, B., Bischoff, A., Hall, J., Helmrath, M., Hsi Dickie, B., Levitt, M. A., Peña, A., Zeller, M. H., & Frischer, J. S. (in press). Health related quality of life and parental stress in children with fecal incontinence: A normative comparison. Journal of Pediatric Gastroenterology & Nutrition.
32.
go back to reference Rajindrajith, S., Devanarayana, N. M., & Benninga, M. A. (2016). Fecal incontinence in adolescents is associated with child abuse, somatization, and poor health-related quality of life. Journal of Pediatric Gastroenterology and Nutrition, 62, 698–703.CrossRefPubMed Rajindrajith, S., Devanarayana, N. M., & Benninga, M. A. (2016). Fecal incontinence in adolescents is associated with child abuse, somatization, and poor health-related quality of life. Journal of Pediatric Gastroenterology and Nutrition, 62, 698–703.CrossRefPubMed
33.
go back to reference Böhn, L., Störsrud, S., Törnblom, H., Bengtsson, U., & Simrén, M. (2013). Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life. American Journal of Gastroenterology, 108, 634–641.CrossRefPubMed Böhn, L., Störsrud, S., Törnblom, H., Bengtsson, U., & Simrén, M. (2013). Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life. American Journal of Gastroenterology, 108, 634–641.CrossRefPubMed
34.
go back to reference Arsie, E., Coletta, M., Cesana, B. M., & Basilisco, G. (2015). Symptom-association probability between meal ingestion and abdominal pain in patients with irritable bowel syndrome. Does somatization play a role? Neurogastroenterology and Motility, 27, 416–422.CrossRefPubMed Arsie, E., Coletta, M., Cesana, B. M., & Basilisco, G. (2015). Symptom-association probability between meal ingestion and abdominal pain in patients with irritable bowel syndrome. Does somatization play a role? Neurogastroenterology and Motility, 27, 416–422.CrossRefPubMed
35.
go back to reference Carlson, M. J., Moore, C. E., Tsai, C. M., Shulman, R. J., & Chumpitazi, B. P. (2014). Child and parent perceived food-induced gastrointestinal symptoms and quality of life in children with functional gastrointestinal disorders. Journal of the Academy of Nutrition and Dietetics, 114, 403–413.CrossRefPubMed Carlson, M. J., Moore, C. E., Tsai, C. M., Shulman, R. J., & Chumpitazi, B. P. (2014). Child and parent perceived food-induced gastrointestinal symptoms and quality of life in children with functional gastrointestinal disorders. Journal of the Academy of Nutrition and Dietetics, 114, 403–413.CrossRefPubMed
36.
go back to reference Chumpitazi, B. P., Weidler, E. M., Lu, D. Y., Tsai, C. M., & Shulman, R. J. (in press). Self-perceived food intolerances are common and associated with clinical severity in childhood irritable bowel syndrome. Journal of the Academy of Nutrition and Dietetics. Chumpitazi, B. P., Weidler, E. M., Lu, D. Y., Tsai, C. M., & Shulman, R. J. (in press). Self-perceived food intolerances are common and associated with clinical severity in childhood irritable bowel syndrome. Journal of the Academy of Nutrition and Dietetics.
37.
go back to reference Reed-Knight, B., Squires, M., Chitkara, D. K., & van Tilburg, M. A. (in press). Adolescents with irritable bowel syndrome report increased eating-associated symptoms, changes in dietary composition, and altered eating behaviors: A pilot comparison study to healthy adolescents. Neurogastroenterology & Motility. Reed-Knight, B., Squires, M., Chitkara, D. K., & van Tilburg, M. A. (in press). Adolescents with irritable bowel syndrome report increased eating-associated symptoms, changes in dietary composition, and altered eating behaviors: A pilot comparison study to healthy adolescents. Neurogastroenterology & Motility.
38.
go back to reference Simrén, M., Månsson, A., Langkilde, A. M., Svedlund, J., Abrahamsson, H., Bengtsson, U., et al. (2001). Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion, 63, 108–115.CrossRefPubMed Simrén, M., Månsson, A., Langkilde, A. M., Svedlund, J., Abrahamsson, H., Bengtsson, U., et al. (2001). Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion, 63, 108–115.CrossRefPubMed
39.
go back to reference Le Nevé, B., Brazeilles, R., Derrien, M., Tap, J., Guyonnet, D., Ohman, L., et al. (2016). Lactulose challenge determines visceral sensitivity and severity of symptoms in patients with irritable bowel syndrome. Clinical Gastroenterology and Hepatology, 14, 226–233.CrossRefPubMed Le Nevé, B., Brazeilles, R., Derrien, M., Tap, J., Guyonnet, D., Ohman, L., et al. (2016). Lactulose challenge determines visceral sensitivity and severity of symptoms in patients with irritable bowel syndrome. Clinical Gastroenterology and Hepatology, 14, 226–233.CrossRefPubMed
40.
go back to reference Ragnarsson, G., & Bodemar, G. (1998). Pain is temporally related to eating but not to defaecation in the irritable bowel syndrome (IBS): Patients’ description of diarrhea, constipation and symptom variation during a prospective 6-week study. European Journal of Gastroenterology and Hepatology, 10, 415–421.CrossRefPubMed Ragnarsson, G., & Bodemar, G. (1998). Pain is temporally related to eating but not to defaecation in the irritable bowel syndrome (IBS): Patients’ description of diarrhea, constipation and symptom variation during a prospective 6-week study. European Journal of Gastroenterology and Hepatology, 10, 415–421.CrossRefPubMed
41.
go back to reference Gibson, P. R., Varney, J., Malakar, S., & Muir, J. G. (2015). Food components and irritable bowel syndrome. Gastroenterology, 148, 1158–1174.CrossRefPubMed Gibson, P. R., Varney, J., Malakar, S., & Muir, J. G. (2015). Food components and irritable bowel syndrome. Gastroenterology, 148, 1158–1174.CrossRefPubMed
42.
go back to reference Capili, B., Anastasi, J. K., & Chang, M. (2016). Addressing the role of food in irritable bowel syndrome symptom management. Journal for Nurse Practitioners, 12, 324–329.CrossRefPubMed Capili, B., Anastasi, J. K., & Chang, M. (2016). Addressing the role of food in irritable bowel syndrome symptom management. Journal for Nurse Practitioners, 12, 324–329.CrossRefPubMed
43.
go back to reference McKenzie, Y. A., Bowyer, R. K., Leach, H., Gulia, P., Horobin, J., O’Sullivan, N. A., Pettitt, C., Reeves, L. B., Seamark, L., Williams, M., Thompson, J., & Lomer, M. C. E. (in press). British Dietetic Association systematic review and evidence based practice guidelines for the dietary management of irritable bowel syndrome in adults (2016 update). Journal of Human Nutrition and Dietetics. McKenzie, Y. A., Bowyer, R. K., Leach, H., Gulia, P., Horobin, J., O’Sullivan, N. A., Pettitt, C., Reeves, L. B., Seamark, L., Williams, M., Thompson, J., & Lomer, M. C. E. (in press). British Dietetic Association systematic review and evidence based practice guidelines for the dietary management of irritable bowel syndrome in adults (2016 update). Journal of Human Nutrition and Dietetics.
44.
go back to reference Shah, S. L., & Lacy, B. E. (2016). Dietary interventions and irritable bowel syndrome: A review of the evidence. Current gastroenterology reports, 18, 41.CrossRefPubMed Shah, S. L., & Lacy, B. E. (2016). Dietary interventions and irritable bowel syndrome: A review of the evidence. Current gastroenterology reports, 18, 41.CrossRefPubMed
45.
go back to reference Van Oudenhove, L., Törnblom, H., Störsrud, S., Tack, J., & Simrén, M. (2016). Depression and somatization are associated with increased postprandial symptoms in patients with irritable bowel syndrome. Gastroenterology, 150, 866–874.CrossRefPubMed Van Oudenhove, L., Törnblom, H., Störsrud, S., Tack, J., & Simrén, M. (2016). Depression and somatization are associated with increased postprandial symptoms in patients with irritable bowel syndrome. Gastroenterology, 150, 866–874.CrossRefPubMed
Metagegevens
Titel
Gastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders
Auteurs
James W. Varni
Robert J. Shulman
Mariella M. Self
Samuel Nurko
Miguel Saps
Shehzad A. Saeed
Ashish S. Patel
Chelsea Vaughan Dark
Cristiane B. Bendo
John F. Pohl
on behalf of the Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms Module Testing Study Consortium
Publicatiedatum
14-10-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 4/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1430-3

Andere artikelen Uitgave 4/2017

Quality of Life Research 4/2017 Naar de uitgave