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Quality of Life Research

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24-06-2016

Association of circulating 25-hydroxyvitamin D with mental well-being in a population-based, nationally representative sample of German adolescents

Auteurs: Theresa Katharina Schäfer, Christoph Herrmann-Lingen, Thomas Meyer

Gepubliceerd in: Quality of Life Research | Uitgave 12/2016

Abstract

Objective

Numerous studies have linked vitamin D to health-related quality of life (hrQoL) in chronically ill adults or elderly subjects. The aim of this study was to evaluate the association between 25-hydroxyvitamin D (25(OH)D) and hrQoL in a population-based sample of German adolescents.

Methods

A total of n = 5066 study participants from the nationwide, representative German Health Interview and Examination Survey for Children and Adolescents (Kinder- und Jugendgesundheitssurvey) aged 11–17 years were included in this post hoc analysis. HrQoL was measured using the well-validated self- and parent-rated Children’s Quality of Life questionnaires (KINDL-R), while the level of distress was assessed using the self- and proxy version of the Strengths and Difficulties Questionnaire (SDQ). Serum 25(OH)D concentrations were determined using a commercially available chemiluminescence immunoassay.

Results

Bivariate analyses demonstrated a significant positive association between 25(OH)D and hrQoL for both self- [estimate (E) = 0.82, 95 % confidence interval (95 % CI) 0.35–1.30, p = 0.001] and parent ratings (E = 1.33, 95 % CI 0.83–1.83, p < 0.001). In addition, we found negative correlations between 25(OH)D and self- (E = −0.34, 95 % CI −0.58 to −0.11, p = 0.005) and parent-reported total SDQ scores (E = −0.70, 95 % CI −1.03 to −0.37, p < 0.001). Generalized linear models adjusted for age, sex, body mass index, systolic blood pressure, migration background, socio-economic status, and sedentary screen time confirmed that 25(OH)D independently and significantly predicted better hrQoL (p ≤ 0.004).

Conclusions

These findings linking 25(OH)D to better well-being in a nationally representative sample of German children and adolescents suggest beneficial effects of vitamin D on mental health. However, recommendations for vitamin supplementation in healthy children and adolescents are not warranted from our data.

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Titel: Association of circulating 25-hydroxyvitamin D with mental well-being in a population-based, nationally representative sample of German adolescents
Auteurs: Theresa Katharina Schäfer
Christoph Herrmann-Lingen
Thomas Meyer
Publicatiedatum: 24-06-2016
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 12/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-016-1334-2

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Abstract

Objective

Methods

Results

Conclusions

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