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Quality of Life Research

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01-09-2015

Health-related quality of life in young survivors of childhood cancer

Auteurs: L. Wengenroth, M. E. Gianinazzi, C. S. Rueegg, S. Lüer, E. Bergstraesser, C. E. Kuehni, G. Michel

Gepubliceerd in: Quality of Life Research | Uitgave 9/2015

Abstract

Purpose

Childhood cancer and its treatment may affect health-related quality of life (HRQoL) in childhood cancer survivors, but population-based studies in young survivors are scarce. We aimed to: (1) compare HRQoL between young survivors and population norms and (2) find factors that influence parent-reported HRQoL in survivors.

Methods

As part of the Swiss Childhood Cancer Survivor Study, a questionnaire was mailed to parents of survivors aged 8–16 years, registered in the Swiss Childhood Cancer Registry, ≥5 years after diagnosis. We used the KIDSCREEN-27 instrument to compare self- and parent-reported HRQoL between survivors (N = 425) and standardized norms in the five dimensions of physical well-being, psychological well-being, autonomy, peers and school environment (mean = 50, SD = 10). We then used multivariable linear regressions to test the influence of socio-demographic and cancer-related factors on HRQoL.

Results

Self-reported physical well-being was comparable to norms. Other HRQoL dimensions were higher than norms, with the highest mean = 52.2 (p < 0.001) for school environment. Parent-reported HRQoL in survivors was comparable to population norms; only physical well-being was lower (mean = 47.1, p < 0.001), and school environment was higher (mean = 51.1, p = 0.035). Parent-reported HRQoL was lower for survivors of CNS tumors (physical well-being: β = −5.27, p = 0.007; psychological well-being: β = −4.39, p = 0.044; peers β = −5.17, p = 0.028), survivors of neuroblastoma (psychological well-being β = −5.20, p = 0.047), and survivors who had had a relapse (physical well-being β = −5.41, p = 0.005).

Conclusions

Assessing HRQoL during follow-up care, with a focus on physical well-being, specific diagnoses (e.g., CNS tumor) and late complications (e.g., relapse) might help to early identify problems and offer support to survivors with reduced HRQoL.

vorige artikel Gender role orientation is associated with health-related quality of life differently among African-American, Hispanic, and White youth

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Titel: Health-related quality of life in young survivors of childhood cancer
Auteurs: L. Wengenroth
M. E. Gianinazzi
C. S. Rueegg
S. Lüer
E. Bergstraesser
C. E. Kuehni
G. Michel
Publicatiedatum: 01-09-2015
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 9/2015
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-015-0961-3

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