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Quality of Life Research
Gepubliceerd in: Quality of Life Research 4/2014

01-05-2014

Gender-specific quality of life after cancer in young adulthood: a comparison with the general population

Auteurs: Kristina Geue, Annekathrin Sender, Ricarda Schmidt, Diana Richter, Andreas Hinz, Thomas Schulte, Elmar Brähler, Yve Stöbel-Richter

Gepubliceerd in: Quality of Life Research | Uitgave 4/2014

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Abstract

Purpose

Over the last years, adolescents and young adults with cancer (AYA) have moved strongly into scientific focus. However, there have only been a few studies about the quality of life of the AYA group, and gender differences have very rarely been examined.

Methods

A cross-sectional study was conducted with young adult cancer patients who were aged 18–39 years at the time of survey and had completed their acute treatment. We used the quality of life questionnaire European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). The EORTC QLQ-C30 contains five function scales (physical, role, emotional, cognitive and social), nine symptom scales and a global quality of life scale. The patient sample was compared to a gender- and age-matched representative sample (REP).

Results

Compared to the general population (N = 585), significantly poorer quality of life (p = .001) was observed for the 117 young cancer patients (40 male, 77 female) on all scales and items of the EORTC QLQ-C30. Analyses of variance with the factors group (AYA vs. REP) and gender showed interaction effects for the physical (p < .012), emotional (p < .029) and cognitive function scales (p < .008) and fatigue (p < .026) as well as for the items insomnia (p < .011), constipation (p < .037) and financial difficulties (p < .026). The pattern of the interaction was that female cancer patients reported the lowest quality of life outcomes. The same effects were found for the three calculated sum scales function, symptom and total.

Conclusions

Results clearly indicate that young adult cancer patients have a reduced quality of life in comparison with the general population even long after the treatment of their disease is complete. Women had a lower quality of life than men. Age-specific interventions should be offered that lead to improvements in quality of life for this age group. And future studies should clarify what factors lead to women’s quality of life being worse than men’s.
vorige artikel The impact of weight loss on health-related quality-of-life: implications for cost-effectiveness analyses
volgende artikel Health-related quality of life among breast, prostate, and colorectal cancer patients with end-stage disease
Literatuur
1.
Midtgaard, J., & Quist, M. (2008). Proof of Life: A theoretical and empirical outline of a community and exercise based rehabilitation initiative developed by and for young adult cancer survivors. Recent Advances and Research Updates, 9(1), 63–71.
2.
De, P., Ellison, L. F., Barr, R. D., Semenciw, R., Marrett, L. D., Weir, H. K., et al. (2011). Canadian adolescents and young adults with cancer: Opportunity to improve coordination and level of care. CMAJ: Canadian Medical Association Journal, 183(3), 187–194.CrossRef
3.
Furlong, W., Rae, C., Greenberg, M. L., & Barr, R. D. (2012). Surveillance and survival among adolescents and young adults with cancer in Ontario, Canada. International Journal, 131, 2660–2667.
4.
5.
Krebs in Deutschland 2005/2006 (2010). Häufigkeiten und Trends. 7. Ausgabe. Robert Koch-Institut, Hrsg. Und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V., Hrsg. Berlin.
6.
7.
Engel, J., Freund, M., & Hölzel, D. (2011). Brauchen wir ein AYA-Netzwerk? Onkologie, 34(suppl. 5), 2–5.PubMedCrossRef
8.
Hilgendorf, I., Freund, M., Kroop, P., Hartmann, S., Krogmann, D., Daunke, A., et al. (2011). Onkologische Erkrankungen bei Jugendlichen und jungen Erwachsenen – Zahlen aus dem Klinischen Krebsregister Rostock als Arbeitsgrundlage für eine interdisziplinäre Herausforderung. Tumor Diagn und Therapie, 32(2), 85–92.CrossRef
9.
Ramphal, R., Meyer, R., Schacter, B., Rogers, P., & Pinkerton, R. (2011). Active therapy and models of care for adolescents and young adults with cancer. Cancer, 117(suppl. 10), 2316–2322.PubMedCrossRef
10.
Zebrack, B. (2011). Psychological, social, and behavioral issues for young adults with cancer. Cancer, 117(suppl. 10), 2289–2294.PubMedCrossRef
11.
Thomas, D. M., Seymour, J. F., O’Brien, T., Sawyer, S. M., & Ashley, D. M. (2006). Adolescent and young adult cancer: A revolution in evolution? Internal Medicine Journal, 36(5), 302–307.PubMedCrossRef
12.
Pentheroudakis, G., & Pavlidis, N. (2005). Juvenile cancer: Improving care for adolescents and young adults within the frame of medical oncology. Annals of Oncology, 16(2), 181–188.PubMedCrossRef
13.
Haase, J. E., & Phillips, C. R. (2004). The adolescent/young adult experience. Journal of Pediatric Oncology Nursing, 21(3), 145–149.PubMedCrossRef
14.
Loren, A. W., Mangu, P. B., Nohr Beck, L., Brennan, L., Magdalinski, A. J., Partridge, A. H. et al. (2013). Fertility preservation for patients with cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. Journal of Clinical Oncology, 1–12. doi:10.​1200/​JCO.​2013.​49.​2678.
15.
Lawrenz, B., Fehm, T., Neunhoeffer, E., Krämer, B., Soekler, M., Kanz, L., et al. (2011). Fertility preservation in young female lymphoma patients: Review of available options and initial experiences with their implementation in clinical routine. Onkologie, 34, 88–93.PubMedCrossRef
16.
Ferrari, A., Thomas, D., Franklin, A. R. K., Hayes-Lattin, B. M., Mascarin, M., van der Graaf, W., et al. (2010). Starting an adolescent and young adult program: Some success stories and some obstacles to overcome. Journal of Clinical Oncology, 28(32), 4850–4857.PubMedCrossRef
17.
Gondos, A., Hiripi, E., Holleczek, B., Luttmann, S., Eberle, A., & Brenner, H. (2013). Survival among Adolescents and young adults with cancer in Germany and the United States: An international comparison. International Journal of Cancer 1–9. doi:10.​1002/​ijc.​28231.
18.
Enskär, K., & von Essen, L. (2007). Prevalence of aspects of distress, coping, support and care among adolescents and young adults undergoing and being off cancer treatment. European Journal of Oncology Nursing, 11, 400–408.PubMedCrossRef
19.
Erickson, J. M., Beck, S. L., Christian, B. R., Dudley, W., Hollen, P. J., Albritton, K. A., et al. (2011). Fatigue, sleep-wake disturbances, and quality of life in adolescents receiving chemotherapy. Journal of Pediatric Hematology/Oncology, 33(1), 17–25.CrossRef
20.
Odo, R., & Potter, C. (2009). Understanding the needs of young adult cancer survivors: A clinical perspective. Oncology Nurse Edition, 23(11), 1–7.
21.
Bleyer, A. (2002). Cancer in older adolescents and young adults: Epidemiology, diagnosis, treatment, survival, and importance of clinical trials. Medical and Pediatric Oncology, 38(1), 1–10.PubMedCrossRef
22.
von Essen, L., Enskär, K., Kreuger, A., Larsson, B., & Sjöden, P. O. (2000). Self-esteem, depression and anx-iety among Swedish children and adolescents on and off cancer treatment. Acta Paediatrica, 89, 229–236.CrossRef
23.
Pendley, J. S., Dahlquist, L. M., & Dreyer, Z. (1997). Body image and psychosocial adjustment in adolescent cancer survivors. Journal of Pediatric Psychology, 22(1), 29–43.PubMedCrossRef
24.
Larsson, G., Mattsson, E., & von Essen, L. (2010). Aspects of quality of life, anxiety, and depression among persons diagnosed with cancer during adolescence: a long-term follow-up study. European Journal of Cancer, 46, 1062–1068.PubMedCrossRef
25.
Dyson, G. J., Thompson, K., Palmer, S., Thomas, D. M., & Schofield, P. (2012). The relationship between unmet needs and distress amongst young people with cancer. Supportive Care in Cancer, 2012(20), 75–85.CrossRef
26.
Krüger, A., Leibbrand, B., Barth, J., Berger, D., Lehmann, C., Koch, U., et al. (2009). Verlauf der psychosozialen Belastung und gesundheitsbezogenen Lebensqualität bei Patienten verschiedener Altersgruppen in der onkologischen Rehabilitation. Zeitschrift für Psychosomatische Medizin und Psychotherapie, 55(2), 141–161.PubMed
27.
Seitz, D. C. M., Besier, T., Debatin, K. M., Grabow, D., Dieluweit, U., Hinz, A., et al. (2010). Posttraumatic stress, depression and anxiety among adult long-term survivors of cancer in adolescence. European Journal of Cancer, 46(9), 1596–1606.PubMedCrossRef
28.
Ladehoff, N., Koch, U., & Mehnert, A. (2011). Körperliche und psychosoziale Belastungen bei Jugendlichen und jungen Erwachsenen mit einer Krebserkrankung. Zeitschrift für Gesundheitspsychologie, 19(1), 43–64.CrossRef
29.
Greenfield, D. M., Walters, S. J., Coleman, R. E., Hancock, B. W., Snowden, J. A., Shalet, S. M., et al. (2010). Quality of life, self-esteem, fatigue, and sexual function in young men after cancer: A controlled cross-sectional study. Cancer, 116(6), 1592–1601.PubMedCrossRef
30.
Hall, A. E., Boyes, A. W., Bowman, J., Walsh, R. A., James, E. L., & Girgis, A. (2012). Young adult cancer survivors’ psychosocial well-being: A cross-sectional study assessing quality of life, unmet needs, and health behaviors. Supportive Care in Cancer, 20, 1333–1341.PubMedCrossRef
31.
McDougall, J., & Tsonis, M. (2009). Quality of life in survivors of childhood cancer: A systematic review of the literature (2001–2008). Supportive Care in Cancer, 17, 1231–1246.PubMedCrossRef
32.
Hjermstadt, M. J., Fayers, P. M., Bjordal, K., & Kaasa, S. (1998). Using reference data on quality of life—The importance of adjusting for age and gender, exemplified by the EORTC QLQ-C30 (+3). European Journal of Cancer, 34, 1381–1389.CrossRef
33.
Schwarz, R., & Hinz, A. (2001). Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. European Journal of Cancer, 37, 1345–1351.PubMedCrossRef
34.
van de Poll-Franse, L. V., Mols, F., Gundy, C. M., Creutzberg, C. L., Nout, R. A., Leeuw, I. M. V., et al. (2011). Normative data for the EORTC QLQ-C30 and EORTC-sexuality items in the general Dutch population. European Journal of Cancer, 47, 667–675.PubMedCrossRef
35.
Jensen, R. E., Arora, N. K., Bellizzi, K. M., Rowland, J. H., Hamilton, A. S., Aziz, N. M., et al. (2013). Health-related quality of life among survivors of aggressive non-Hodgkin lymphoma. Cancer,. doi:10.​1002/​cncr.​27781.
36.
Smith, A. W., Bellizzi, K. M., Keegan, T. H. M., Zebrack, B., Chen, V. W., Neale, A. V., et al. (2013). Health-related quality of life of adolescent and young adult patients with cancer in the United States: The adolescent and young adult health outcomes and patient experience study. Journal of Clinical Oncology, 31(17), 2136–2148.PubMedCrossRef
37.
Hauser, W., Schmutzer, G., Brähler, E., & Glaesmer, H. (2011). Maltreatment in childhood and adolescence: Results from a survey of a representative sample of the German population. Deutsches Ärzteblatt International, 108, 287–294.PubMedCentralPubMed
38.
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of National Cancer Institute, 85, 365–376.CrossRef
39.
Hinz, A., Einenkel, J., Stolzenburg, J. U., Papsdorf, K., & Singer, S. (2012). Is it useful to calculate sum scores of the quality of life questionnaire EORTC QLQ-C30? European Journal of Cancer Care, 21, 677–683.PubMedCrossRef
40.
Cocks, K., King, M. T., Velikova, G., Martyn St-James, M., Fayers, P. M., & Brown, J. M. (2011). Evidence-based guidelines for determination of sample size and interpretation of the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Journal of Clinical Oncology, 29(1), 89–96.PubMedCrossRef
41.
Schumacher, J., Klaiberg, A., & Brähler, E. (2003). Diagnostische Verfahren zu Lebensqualität und Wohlbefinden. Bern, Toronto: Hogrefe Göttingen.
42.
Howard-Anderson, J., Ganz, P. A., Bower, J. E., & Stanton, A. L. (2012). Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: A systematic review. Journal of National Cancer Institute, 104, 386–405.CrossRef
43.
Barrera, M., Teall, T., Barr, R., Silva, M., & Greenberg, M. (2012). Health related quality of life in adolescent and young adult survivors of lower extremity bone tumors. Pediatric Blood & Cancer, 2012(58), 265–273.CrossRef
44.
Jörngården, A., Mattsson, E., & von Essen, L. (2007). Health-related quality of life, anxiety and depression among adolescents and young adults with cancer: A prospective longitudinal study. European Journal of Cancer, 43, 1952–1958.PubMedCrossRef
45.
Osoba, D., Rodrigues, G., Myles, J., Zee, B., & Pater, J. (1998). Interpreting the significance of changes in health-related quality-of-life scores. Journal of Clinical Oncology, 16(1), 139–144.PubMed
46.
Dunn, J., & Steginga, S. K. (2000). Young women’s experience of breast cancer: Defining young and identifying concerns. Psycho-Oncology, 9, 137–146.PubMedCrossRef
47.
Armuand, G. M., Rodriguez-Wallberg, K. A., Wettergren, L., Ahkgren, J., Enblad, G., Höglund, M., et al. (2012). Sex differences in fertility-related information received by young adult cancer survivors. Journal of Clinical Oncology, 30, 2147–2153.PubMedCrossRef
48.
Peddie, V. L., Porter, M. A., Barbour, R., Culligan, D., MacDonald, G., Kind, D., et al. (2012). Factors affecting decision making about fertility preservation after cancer diagnosis: A qualitative study. Journal of Obstretrics and Gynaecology. doi:10.​1111/​j.​1471-0528.​2012.​03368.​x.
49.
Jenskins, V., Shilling, V., Fallowfield, L., Howell, A., & Hutton, S. (2004). Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study. Psycho-Oncology, 13, 61–66.CrossRef
50.
Prue, G., Rankin, J., Allen, J., et al. (2006). Cancer-related fatigue: A critical appraisal. European Journal of Cancer, 42, 846–863.PubMedCrossRef
51.
Servaes, P., Verhagen, C., & Bleijenberg, G. (2002). Fatigue in cancer Patients during and after treatment: Prevalence, correlates and interventions. European Journal of Cancer, 38, 27–43.PubMedCrossRef
52.
Zebrack, B. (2008). Information and service needs for young adult cancer patients. Supportive Care in Cancer, 16, 1353–1360.PubMedCrossRef
53.
D’Agostino, N. M., Penney, A., & Zebrack, B. (2011). Providing developmentally appropriate psychosocial care to adolescent and young adult cancer survivors. Cancer, 117(suppl. 10), 2329–2334.PubMedCrossRef
54.
Dieluweit, U., Seitz, D. C. M., Besier, T., Debatin, K. M., Grabow, D., Kaatsch, P., et al. (2011). Utilization of psychosocial care and oncological follow-up assessments among German long-term survivors of cancer with onset during adolescence. Klinische Pädiatrie, 223(3), 152–158.PubMedCrossRef
55.
Phillips-Salami, C. R., & Andrykowski, M. A. (2013). Physical and mental health status of female adolescent/young adult survivors of breast and gynaecological cancer: A national, population-based, case–control study. Supportive Care in Cancer, 21, 1597–1604.CrossRef
56.
Metagegevens
Titel
Gender-specific quality of life after cancer in young adulthood: a comparison with the general population
Auteurs
Kristina Geue
Annekathrin Sender
Ricarda Schmidt
Diana Richter
Andreas Hinz
Thomas Schulte
Elmar Brähler
Yve Stöbel-Richter
Publicatiedatum
01-05-2014
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 4/2014
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-013-0559-6

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