01-11-2013 | Commentary
Pitfalls in subgroup analysis based on growth mixture models: a commentary on van Leeuwen et al. (2012)
Gepubliceerd in: Quality of Life Research | Uitgave 9/2013
Log in om toegang te krijgenAbstract
Objectives
This article is a brief commentary in response to “van Leeuwen et al. (Qual Life Res 21:1499–1508, 2012)”
Methods and results
The commentary argues that in the context of mixture modeling, assigning individuals to specific subgroups for conducting a secondary set of analyses ignores the original uncertainty in group membership, thereby biasing any subsequent results and inference.
Conclusions
Alternative approaches to subgroup analysis that attempt to preserve uncertainty in group membership are discussed and illustrated.