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Quality of Life Research

Gepubliceerd in:

01-06-2013

An assessment of the external validity of mapping QLQ-C30 to EQ-5D preferences

Auteurs: Ralph Crott, Matthijs Versteegh, Carin Uyl-de-Groot

Gepubliceerd in: Quality of Life Research | Uitgave 5/2013

Abstract

Background

Although cancer-specific Health-related Quality-of-Life measures are commonly included in randomized clinical trials or other prospective non-randomized clinical studies, it is rare that preference-based instruments are used, which allow the calculation of a Utility weight suitable for estimating Quality-adjusted Life-Years gained.

Objective

To test the external validity of a previously published mapping algorithm to transform the EORTC QLQ-C30 questionnaire responses into EQ-5D-derived utilities by predicting EQ-5D utilities from QLQ-C30 scores.

Study design and methods

Comparative retrospective data analysis of four multicentre, prospective clinical trials in Breast, Multiple Myeloma, Non-Hodgkin Lymphoma and Non-Small-Cell Lung cancer patients with, respectively, 219, 172, 132 and 172 patients. Regression analysis of individual pairs of EQ-5D and QLQ-C30 scores.

Results

Although the internal predictive power of a previously published mapping equation was high, its external validity when tested on a set of unrelated external data sets in other cancers proved to underestimate both the mean and variance of the mapped EQ-5D utilities. Furthermore, it appears that the relationship between QLQ-C30 scores and EQ-5D values is not stable across the different data sets.

Conclusions

Validation of the proposed algorithm in other external clinical data sets should be encouraged as well as the application of other more complex mapping methods to enhance accuracy of mapping. In the meanwhile, direct mapping from QLQ-C30 profiles to EQ-5D utilities using published algorithms should be performed with reservations.

vorige artikel Determinants of health-related quality of life after aneurysmal subarachnoid hemorrhage: a systematic review

volgende artikel Usefulness of EQ-5D for evaluation of health-related quality of life in young adults with first-episode psychosis

Note: Utilities were transformed to disutilities because this results in a right-skewed distribution bounded by zero at the left. This in fact only changes the sign of the coefficients in the regressions and the size of the constant.

OLS does not request a particular distribution of the dependent or independent variable. It does request, however, normality of the residuals with zero mean or more generally that “the mean of the distribution from which the disturbance term is drawn is zero” (Kennedy P, A Guide to Econometrics, 2003).

Note: No formal econometric structural test based on individual data, like the Chow test or Wald test, could be performed, as the individual patient data are residing in different institutions, and no pooled data set could be constructed due to patient data confidentiality and ownership constraints.

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Titel: An assessment of the external validity of mapping QLQ-C30 to EQ-5D preferences
Auteurs: Ralph Crott
Matthijs Versteegh
Carin Uyl-de-Groot
Publicatiedatum: 01-06-2013
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 5/2013
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-012-0220-9

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Abstract

Background

Objective

Study design and methods

Results

Conclusions

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