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Gepubliceerd in: Quality of Life Research 3/2011

01-04-2011

Patient-reported outcomes in clinical trials of inhaled asthma medications: systematic review and research needs

Auteurs: Geoff K. Frampton, Jonathan Shepherd

Gepubliceerd in: Quality of Life Research | Uitgave 3/2011

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Abstract

Purpose

To assess the diversity, application, analysis and interpretation of patient-reported outcomes (PROs) in asthma clinical trials.

Methods

We critically appraised the use of asthma-specific PROs in 87 randomised controlled trials (RCTs) of inhaled asthma medications published during 1985–2006.

Results

A total of 79 RCTs reported PROs, of which 78 (99%) assessed symptom scores and seven (9%) assessed asthma quality of life scores. Only eight (10%) used validated instruments and five (6%) provided clinical interpretation of scores. Due to heterogeneity in the reporting of symptom measures, it is not possible to determine how many discrete symptom assessment instruments have been used. Only 26 (33%) of the RCTs that measured symptom scores reported the scores for follow-up. Limited improvement occurred over time: fewer than 30% of the RCTs used validated PRO measures in any individual year.

Conclusion

Numerous validated PRO instruments are available but it is unclear why few are used in asthma clinical trials. Problems include poor reporting, and uncritical analysis and interpretation of PRO scores. Research needs include identifying and recommending a set of PROs for use in asthma clinical research and providing guidance for researchers on the application, analysis and interpretation of PRO measures in clinical trials.
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Literatuur
1.
go back to reference Rosenzweig, J. R., Edwards, L., Lincourt, W., Dorinsky, P., & ZuWallack, R. L. (2004). The relationship between health-related quality of life, lung function and daily symptoms in patients with persistent asthma. Respiratory Medicine, 98(12), 1157–1165. Rosenzweig, J. R., Edwards, L., Lincourt, W., Dorinsky, P., & ZuWallack, R. L. (2004). The relationship between health-related quality of life, lung function and daily symptoms in patients with persistent asthma. Respiratory Medicine, 98(12), 1157–1165.
2.
go back to reference Jenkins, C. R., Thien, F. C. K., Wheatley, J. R., & Reddel, H. K. (2005). Traditional and patient-centred outcomes with three classes of asthma medication. European Respiratory Journal, 26(1), 36–44.PubMed Jenkins, C. R., Thien, F. C. K., Wheatley, J. R., & Reddel, H. K. (2005). Traditional and patient-centred outcomes with three classes of asthma medication. European Respiratory Journal, 26(1), 36–44.PubMed
3.
go back to reference Atherton, H. A., White, P. T., Hewett, G., & Howells, K. (1996). Relationship of daytime asthma symptom frequency to morning peak expiratory flow. European Respiratory Journal, 9(2), 232–236.PubMed Atherton, H. A., White, P. T., Hewett, G., & Howells, K. (1996). Relationship of daytime asthma symptom frequency to morning peak expiratory flow. European Respiratory Journal, 9(2), 232–236.PubMed
4.
go back to reference Brand, P. L. P., Duiverman, E. J., Postma, D. S., Waalkens, H. J., Kerrebijn, K. F., & van Essen-Zandvliet, E. E. M. (1997). Peak flow variation in childhood asthma: Relationship to symptoms, atopy, airways obstruction and hyperresponsiveness. European Respiratory Journal, 10(6), 1242–1247.PubMed Brand, P. L. P., Duiverman, E. J., Postma, D. S., Waalkens, H. J., Kerrebijn, K. F., & van Essen-Zandvliet, E. E. M. (1997). Peak flow variation in childhood asthma: Relationship to symptoms, atopy, airways obstruction and hyperresponsiveness. European Respiratory Journal, 10(6), 1242–1247.PubMed
5.
go back to reference Brand, P. L. P., Duiverman, E. J., Waalkens, H. J., van Essen-Zandvliet, E. E. M., & Kerrebijn, K. F. (1999). Peak flow variation in childhood asthma: Correlation with symptoms, airways obstruction, and hyperresponsiveness during long term treatment with inhaled corticosteroids. Thorax, 54(2), 103–107.PubMed Brand, P. L. P., Duiverman, E. J., Waalkens, H. J., van Essen-Zandvliet, E. E. M., & Kerrebijn, K. F. (1999). Peak flow variation in childhood asthma: Correlation with symptoms, airways obstruction, and hyperresponsiveness during long term treatment with inhaled corticosteroids. Thorax, 54(2), 103–107.PubMed
6.
go back to reference Ståhl, E. (2000). Correlation between objective measures of airway calibre and clinical symptoms in asthma: A systematic review of clinical studies. Respiratory Medicine, 94(8), 735–741.PubMed Ståhl, E. (2000). Correlation between objective measures of airway calibre and clinical symptoms in asthma: A systematic review of clinical studies. Respiratory Medicine, 94(8), 735–741.PubMed
7.
go back to reference Leone, F. T., Mauger, E. A., Peters, S. P., Chinchilli, V. M., Fish, J. E., Boushey, H. A., et al. (2001). The utility of peak flow, symptom scores, and β-agonist use as outcome measures in asthma clinical research. Chest, 119(4), 1027–1033.PubMed Leone, F. T., Mauger, E. A., Peters, S. P., Chinchilli, V. M., Fish, J. E., Boushey, H. A., et al. (2001). The utility of peak flow, symptom scores, and β-agonist use as outcome measures in asthma clinical research. Chest, 119(4), 1027–1033.PubMed
8.
go back to reference Kuntz, K. M., Kitch, B. T., Fuhlbrigge, A. L., Paltiel, A. D., & Weiss, S. T. (2002). A novel approach to defining the relationship between lung function and symptom status in asthma. Journal of Clinical Epidemiology, 55(1), 11–18.PubMed Kuntz, K. M., Kitch, B. T., Fuhlbrigge, A. L., Paltiel, A. D., & Weiss, S. T. (2002). A novel approach to defining the relationship between lung function and symptom status in asthma. Journal of Clinical Epidemiology, 55(1), 11–18.PubMed
9.
go back to reference Mitra, A. D., Ogston, S., Crighton, A., & Mukhopadhyay, S. (2002). Lung function and asthma symptoms in children: Relationships and response to treatment. Acta Paediatrica, 91(7), 789–792.PubMed Mitra, A. D., Ogston, S., Crighton, A., & Mukhopadhyay, S. (2002). Lung function and asthma symptoms in children: Relationships and response to treatment. Acta Paediatrica, 91(7), 789–792.PubMed
10.
go back to reference Aburuz, S., McElnay, J., Gamble, M., Millership, J., & Heaney, L. (2005). Relationship between lung function and asthma symptoms in patients with difficult to control asthma. Journal of Asthma, 42(10), 859–864.PubMed Aburuz, S., McElnay, J., Gamble, M., Millership, J., & Heaney, L. (2005). Relationship between lung function and asthma symptoms in patients with difficult to control asthma. Journal of Asthma, 42(10), 859–864.PubMed
11.
go back to reference Wildhaber, J. H., Sznitman, J., Harpes, P., Straub, D., Möller, A., Basek, P., et al. (2007). Correlation of spirometry and symptom scores in childhood asthma and the usefulness of curvature assessment in expiratory flow-volume curves. Respiratory Care, 52(12), 1744–1752.PubMed Wildhaber, J. H., Sznitman, J., Harpes, P., Straub, D., Möller, A., Basek, P., et al. (2007). Correlation of spirometry and symptom scores in childhood asthma and the usefulness of curvature assessment in expiratory flow-volume curves. Respiratory Care, 52(12), 1744–1752.PubMed
12.
go back to reference Juniper, E. F., Wisniewski, M. E., Cox, F. M., Emmett, A. H., Nielsen, K. E., & O’Byrne, P. M. (2004). Relationship between quality of life and clinical status in asthma: A factor analysis. European Respiratory Journal, 23(2), 287–291.PubMed Juniper, E. F., Wisniewski, M. E., Cox, F. M., Emmett, A. H., Nielsen, K. E., & O’Byrne, P. M. (2004). Relationship between quality of life and clinical status in asthma: A factor analysis. European Respiratory Journal, 23(2), 287–291.PubMed
13.
go back to reference Strunk, R. C., & Korenblat, P. E. (2002). Choice of medication to treat asthma: Is an improvement in symptoms sufficient for deciding? Journal of Allergy and Clinical Immunology, 110(6), 832–833.PubMed Strunk, R. C., & Korenblat, P. E. (2002). Choice of medication to treat asthma: Is an improvement in symptoms sufficient for deciding? Journal of Allergy and Clinical Immunology, 110(6), 832–833.PubMed
14.
go back to reference Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., Casale, T. B., et al. (2008). A new perspective on concepts of asthma severity and control. European Respiratory Journal, 32(3), 545–554.PubMed Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., Casale, T. B., et al. (2008). A new perspective on concepts of asthma severity and control. European Respiratory Journal, 32(3), 545–554.PubMed
15.
go back to reference Gill, T. M., & Feinstein, R. (1994). A critical appraisal of the quality of quality-of-life measurements. JAMA, 272(8), 619–626.PubMed Gill, T. M., & Feinstein, R. (1994). A critical appraisal of the quality of quality-of-life measurements. JAMA, 272(8), 619–626.PubMed
16.
go back to reference European Medicines Agency (EMEA). (2004). Reflection paper on the regulatory guidance for the use of health-related quality of life (HRQL) measures in the evaluation of medicinal products. London: EMEA Committee for Medicinal Products for Human Use (CHMP). Report number EMEA/CHMP/EWP/139391/2004. European Medicines Agency (EMEA). (2004). Reflection paper on the regulatory guidance for the use of health-related quality of life (HRQL) measures in the evaluation of medicinal products. London: EMEA Committee for Medicinal Products for Human Use (CHMP). Report number EMEA/CHMP/EWP/139391/2004.
17.
go back to reference Hays, R. D., & Hadorn, D. (1992). Responsiveness to change: An aspect of validity, not a separate dimension. Quality of Life Research, 1(1), 73–75.PubMed Hays, R. D., & Hadorn, D. (1992). Responsiveness to change: An aspect of validity, not a separate dimension. Quality of Life Research, 1(1), 73–75.PubMed
18.
go back to reference Fitzpatrick, R., Davey, C., Buxton, M. J., & Jones, D. R. (1998). Evaluating patient-based outcome measures for use in clinical trials. Health Technology Assessment, 2(14), 1–74.PubMed Fitzpatrick, R., Davey, C., Buxton, M. J., & Jones, D. R. (1998). Evaluating patient-based outcome measures for use in clinical trials. Health Technology Assessment, 2(14), 1–74.PubMed
19.
go back to reference Juniper, E. F. (1998). Quality of life questionnaires: Does statistically significant = clinically important? Journal of Allergy and Clinical Immunology, 102(1), 16–17.PubMed Juniper, E. F. (1998). Quality of life questionnaires: Does statistically significant = clinically important? Journal of Allergy and Clinical Immunology, 102(1), 16–17.PubMed
20.
go back to reference Wang, S. T., Yu, M. L., Wang, C. J., & Huang, C. C. (1999). Bridging the gap between the pros and cons in treating ordinal scales as interval scales from an analysis point of view. Nursing Research, 48(4), 226–229.PubMed Wang, S. T., Yu, M. L., Wang, C. J., & Huang, C. C. (1999). Bridging the gap between the pros and cons in treating ordinal scales as interval scales from an analysis point of view. Nursing Research, 48(4), 226–229.PubMed
21.
go back to reference Kampen, J., & Swyngedouw, M. (2000). The ordinal controversy revisited. Quality & Quantity, 34(1), 87–102. Kampen, J., & Swyngedouw, M. (2000). The ordinal controversy revisited. Quality & Quantity, 34(1), 87–102.
22.
go back to reference Jamieson, S. (2004). Likert scales: How to (ab)use them. Medical Education, 38(12), 1212–1218. Jamieson, S. (2004). Likert scales: How to (ab)use them. Medical Education, 38(12), 1212–1218.
23.
go back to reference Kahler, E., Rogausch, A., Brunner, E., & Himmel, W. (2008). A parametric analysis of ordinal quality-of-life data can lead to erroneous results. Journal of Clinical Epidemiology, 61(5), 475–480.PubMed Kahler, E., Rogausch, A., Brunner, E., & Himmel, W. (2008). A parametric analysis of ordinal quality-of-life data can lead to erroneous results. Journal of Clinical Epidemiology, 61(5), 475–480.PubMed
24.
go back to reference Shepherd, J., Rogers, G., Anderson, R., Main, C., Thompson Coon, J., Hartwell, D., et al. (2008). Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta-2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over. Health Technology Assessment, 12(20), 1–274.PubMed Shepherd, J., Rogers, G., Anderson, R., Main, C., Thompson Coon, J., Hartwell, D., et al. (2008). Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta-2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over. Health Technology Assessment, 12(20), 1–274.PubMed
25.
go back to reference Main, C., Shepherd, J., Anderson, R., Rogers, G., Thompson Coon, J., Liu, Z., et al. (2008). Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta-2 agonists for the treatment of chronic asthma in children under the age of 12 years. Health Technology Assessment, 12(19), 1–192.PubMed Main, C., Shepherd, J., Anderson, R., Rogers, G., Thompson Coon, J., Liu, Z., et al. (2008). Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta-2 agonists for the treatment of chronic asthma in children under the age of 12 years. Health Technology Assessment, 12(19), 1–192.PubMed
26.
go back to reference National Institute for Health and Clinical Excellence (NICE). (2008). Corticosteroids for the treatment of chronic asthma in adults and children aged 12 years and over. NICE Technology Appraisal Report 138. London: National Institute for Health and Clinical Excellence. http://www.nice.org.uk/TA138 (Accessed July 2010). National Institute for Health and Clinical Excellence (NICE). (2008). Corticosteroids for the treatment of chronic asthma in adults and children aged 12 years and over. NICE Technology Appraisal Report 138. London: National Institute for Health and Clinical Excellence. http://​www.​nice.​org.​uk/​TA138 (Accessed July 2010).
27.
go back to reference National Institute for Health and Clinical Excellence (NICE). (2007). Inhaled corticosteroids for the treatment of chronic asthma in children under the age of 12 years. NICE Technology Appraisal Report 131. London: National Institute for Health and Clinical Excellence. http://www.nice.org.uk/TA131 (Accessed July 2010). National Institute for Health and Clinical Excellence (NICE). (2007). Inhaled corticosteroids for the treatment of chronic asthma in children under the age of 12 years. NICE Technology Appraisal Report 131. London: National Institute for Health and Clinical Excellence. http://​www.​nice.​org.​uk/​TA131 (Accessed July 2010).
28.
go back to reference Frampton, G. K., Shepherd, J., & Dorne, J. L. C. M. (2009). Demographic data in asthma clinical trials: a systematic review with implications for generalizing trial findings and tackling health disparities. Social Science and Medicine, 69(8), 1147–1154.PubMed Frampton, G. K., Shepherd, J., & Dorne, J. L. C. M. (2009). Demographic data in asthma clinical trials: a systematic review with implications for generalizing trial findings and tackling health disparities. Social Science and Medicine, 69(8), 1147–1154.PubMed
29.
go back to reference Jarjour, N. N. (1999). Circadian variation in allergen and non-specific bronchial responsiveness in asthma. Chronobiology International, 16(5), 631–639.PubMed Jarjour, N. N. (1999). Circadian variation in allergen and non-specific bronchial responsiveness in asthma. Chronobiology International, 16(5), 631–639.PubMed
30.
go back to reference Brennan, R. L., & Prediger, D. J. (1981). Coefficient kappa: Some uses, misuses, and alternatives. Educational and Psychological Measurement, 41(3), 687–699. Brennan, R. L., & Prediger, D. J. (1981). Coefficient kappa: Some uses, misuses, and alternatives. Educational and Psychological Measurement, 41(3), 687–699.
31.
go back to reference Emery, M.-P., Perrier, L.-L., & Acquadro, C. (2005). Patient-reported outcome and quality of life instruments database (PROQOLID): Frequently asked questions. Health and Quality of Life Outcomes, 3:12 (6 pp). (details of instruments at www.proqolid.org) (Accessed July 2010). Emery, M.-P., Perrier, L.-L., & Acquadro, C. (2005). Patient-reported outcome and quality of life instruments database (PROQOLID): Frequently asked questions. Health and Quality of Life Outcomes, 3:12 (6 pp). (details of instruments at www.​proqolid.​org) (Accessed July 2010).
33.
go back to reference Rafferty, P., Tucker, L. G., & Frame, M. H. (1985). Comparison of budesonide and beclomethasone dipropionate in patients with severe chronic asthma: Assessment of relative prednisolone-sparing effects. British Journal of Diseases of the Chest, 79(3), 244–250.PubMed Rafferty, P., Tucker, L. G., & Frame, M. H. (1985). Comparison of budesonide and beclomethasone dipropionate in patients with severe chronic asthma: Assessment of relative prednisolone-sparing effects. British Journal of Diseases of the Chest, 79(3), 244–250.PubMed
34.
go back to reference Ebden, P., Jenkins, A., Houston, G., & Davies, B. H. (1986). Comparison of two high dose corticosteroid aerosol treatments, beclomethasone dipropionate (1500 mug/day) and budesonide (1600 mug/day), for chronic asthma. Thorax, 41(11), 869–874.PubMed Ebden, P., Jenkins, A., Houston, G., & Davies, B. H. (1986). Comparison of two high dose corticosteroid aerosol treatments, beclomethasone dipropionate (1500 mug/day) and budesonide (1600 mug/day), for chronic asthma. Thorax, 41(11), 869–874.PubMed
35.
go back to reference Bisgaard, H., Nielsen, M. D., Andersen, B., Andersen, P., Foged, N., Fuglsang, G., et al. (1988). Adrenal function in children with bronchial asthma treated with beclomethasone dipropionate or budesonide. Journal of Allergy and Clinical Immunology, 81(6), 1088–1095.PubMed Bisgaard, H., Nielsen, M. D., Andersen, B., Andersen, P., Foged, N., Fuglsang, G., et al. (1988). Adrenal function in children with bronchial asthma treated with beclomethasone dipropionate or budesonide. Journal of Allergy and Clinical Immunology, 81(6), 1088–1095.PubMed
36.
go back to reference Pedersen, S., & Fuglsang, G. (1988). Urine cortisol excretion in children treated with high doses of inhaled corticosteroids: A comparison of budesonide and beclomethasone. European Respiratory Journal, 1(5), 433–435.PubMed Pedersen, S., & Fuglsang, G. (1988). Urine cortisol excretion in children treated with high doses of inhaled corticosteroids: A comparison of budesonide and beclomethasone. European Respiratory Journal, 1(5), 433–435.PubMed
37.
go back to reference Fitzgerald, D., Van Asperen, P., Mellis, C., Honner, M., Smith, L., & Ambler, G. (1998). Fluticasone propionate 750 μg/day versus beclomethasone dipropionate 1500 mug/day: Comparison of efficacy and adrenal function in paediatric asthma. Thorax, 53(8), 656–661.PubMed Fitzgerald, D., Van Asperen, P., Mellis, C., Honner, M., Smith, L., & Ambler, G. (1998). Fluticasone propionate 750 μg/day versus beclomethasone dipropionate 1500 mug/day: Comparison of efficacy and adrenal function in paediatric asthma. Thorax, 53(8), 656–661.PubMed
38.
go back to reference Fabbri, L., Burge, P. S., Croonenborgh, L., Warlies, F., Weeke, B., Ciaccia, A., et al. (1993). Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one year. Thorax, 48(8), 817–823.PubMed Fabbri, L., Burge, P. S., Croonenborgh, L., Warlies, F., Weeke, B., Ciaccia, A., et al. (1993). Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one year. Thorax, 48(8), 817–823.PubMed
39.
go back to reference Barnes, N. C., Marone, G., Di Maria, G. U., Visser, S., Utama, I., & Payne, S. L. (1993). A comparison of fluticasone propionate, 1 mg daily, with beclomethasone dipropionate, 2 mg daily, in the treatment of severe asthma. European Respiratory Journal, 6(6), 877–885.PubMed Barnes, N. C., Marone, G., Di Maria, G. U., Visser, S., Utama, I., & Payne, S. L. (1993). A comparison of fluticasone propionate, 1 mg daily, with beclomethasone dipropionate, 2 mg daily, in the treatment of severe asthma. European Respiratory Journal, 6(6), 877–885.PubMed
40.
go back to reference Lundback, B., Alexander, M., Day, J., Hebert, J., Holzer, R., et al. (1993). Evaluation of fluticasone propionate (500 μg day-1) administered either as dry powder via a Diskhaler(TM) inhaler or pressurized inhaler and compared with beclomethasone dipropionate (1000 μg day-1) administered by pressurized inhaler. Respiratory Medicine, 87(8), 609–620.PubMed Lundback, B., Alexander, M., Day, J., Hebert, J., Holzer, R., et al. (1993). Evaluation of fluticasone propionate (500 μg day-1) administered either as dry powder via a Diskhaler(TM) inhaler or pressurized inhaler and compared with beclomethasone dipropionate (1000 μg day-1) administered by pressurized inhaler. Respiratory Medicine, 87(8), 609–620.PubMed
41.
go back to reference Gustafsson, P., Tsanakas, J., Gold, M., Primhak, R., Radford, M., & Gillies, E. (1993). Comparison of the efficacy and safety of inhaled fluticasone propionate 200 μg/day with inhaled beclomethasone dipropionate 400 μg/day in mild and moderate asthma. Archives of Disease in Childhood, 69(2), 206–211.PubMed Gustafsson, P., Tsanakas, J., Gold, M., Primhak, R., Radford, M., & Gillies, E. (1993). Comparison of the efficacy and safety of inhaled fluticasone propionate 200 μg/day with inhaled beclomethasone dipropionate 400 μg/day in mild and moderate asthma. Archives of Disease in Childhood, 69(2), 206–211.PubMed
42.
go back to reference Langdon, C. G., & Capsey, L. J. (1994). Fluticasone propionate and budesonide in adult asthmatics: A comparison using dry powder inhaler devices. British Journal of Clinical Research, 5, 85–89. Langdon, C. G., & Capsey, L. J. (1994). Fluticasone propionate and budesonide in adult asthmatics: A comparison using dry powder inhaler devices. British Journal of Clinical Research, 5, 85–89.
43.
go back to reference Langdon, C. G., & Thompson, J. (1994). A multicentre study to compare the efficacy and safety of inhaled fluticasone propionate and budesonide via metered-dose inhalers in adults with mild-to-moderate asthma. British Journal of Clinical Research, 5, 73–84. Langdon, C. G., & Thompson, J. (1994). A multicentre study to compare the efficacy and safety of inhaled fluticasone propionate and budesonide via metered-dose inhalers in adults with mild-to-moderate asthma. British Journal of Clinical Research, 5, 73–84.
44.
go back to reference Boe, J., Bakke, P., Rodolen, T., Skovlund, E., & Gulsvik, A. (1994). High-dose inhaled steroids in asthmatics: Moderate efficacy gain and suppression of the hypothalamic-pituitary-adrenal (HPA) axis. European Respiratory Journal, 7(12), 2179–2184.PubMed Boe, J., Bakke, P., Rodolen, T., Skovlund, E., & Gulsvik, A. (1994). High-dose inhaled steroids in asthmatics: Moderate efficacy gain and suppression of the hypothalamic-pituitary-adrenal (HPA) axis. European Respiratory Journal, 7(12), 2179–2184.PubMed
45.
go back to reference Tjwa, M. K. T. (1995). Budesonide inhaled via Turbuhaler: A more effective treatment for asthma than beclomethasone dipropionate via Rotahaler. Annals of Allergy, Asthma & Immunology, 75(2), 107–112. Tjwa, M. K. T. (1995). Budesonide inhaled via Turbuhaler: A more effective treatment for asthma than beclomethasone dipropionate via Rotahaler. Annals of Allergy, Asthma & Immunology, 75(2), 107–112.
46.
go back to reference Connolly, A. (1995). A comparison of fluticasone propionate 100 μg twice daily with budesonide 200 μg twice daily via their respective powder devices in the treatment of mild asthma. A UK Study Group. European Journal of Clinical Research, 7, 15–29. Connolly, A. (1995). A comparison of fluticasone propionate 100 μg twice daily with budesonide 200 μg twice daily via their respective powder devices in the treatment of mild asthma. A UK Study Group. European Journal of Clinical Research, 7, 15–29.
47.
go back to reference Bootsma, G. P., Dekhuijzen, P. N. R., Festen, J., Mulder, P. J. H., & van Herwaarden, C. L. A. (1995). Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma. Thorax, 50(10), 1044–1050.PubMed Bootsma, G. P., Dekhuijzen, P. N. R., Festen, J., Mulder, P. J. H., & van Herwaarden, C. L. A. (1995). Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma. Thorax, 50(10), 1044–1050.PubMed
48.
go back to reference Ayres, J. G., Bateman, E. D., Lundback, B., & Harris, T. A. J. (1995). High-dose fluticasone propionate, 1 mg daily, versus fluticasone propionate, 2 mg daily, or budesonide, 1.6 mg daily, in patients with chronic severe asthma. European Respiratory Journal, 8(4), 579–586.PubMed Ayres, J. G., Bateman, E. D., Lundback, B., & Harris, T. A. J. (1995). High-dose fluticasone propionate, 1 mg daily, versus fluticasone propionate, 2 mg daily, or budesonide, 1.6 mg daily, in patients with chronic severe asthma. European Respiratory Journal, 8(4), 579–586.PubMed
49.
go back to reference Lorentzen, K. A., Van Helmond, J. L. M., Bauer, K., Langaker, K. E., Bonifazi, F., & Harris, T. A. J. (1996). Fluticasone propionate 1 mg daily and beclomethasone dipropionate 2 mg daily: A comparison over 1 yr. Respiratory Medicine, 90(10), 609–617.PubMed Lorentzen, K. A., Van Helmond, J. L. M., Bauer, K., Langaker, K. E., Bonifazi, F., & Harris, T. A. J. (1996). Fluticasone propionate 1 mg daily and beclomethasone dipropionate 2 mg daily: A comparison over 1 yr. Respiratory Medicine, 90(10), 609–617.PubMed
50.
go back to reference Ringdal, N., Swinburn, P., Backman, R., Plaschke, P., Sips, A. P., Kjaersgaard, P., et al. (1996). A blinded comparison of fluticasone propionate with budesonide via powder devices in adult patients with moderate-to-severe asthma: A clinical evaluation. Mediators of Inflammation, 5(5), 382–389.PubMed Ringdal, N., Swinburn, P., Backman, R., Plaschke, P., Sips, A. P., Kjaersgaard, P., et al. (1996). A blinded comparison of fluticasone propionate with budesonide via powder devices in adult patients with moderate-to-severe asthma: A clinical evaluation. Mediators of Inflammation, 5(5), 382–389.PubMed
51.
go back to reference Hoekx, J. C., Hedlin, G., Pedersen, W., Sorva, R., Hollingworth, K., & Efthimiou, J. (1996). Fluticasone propionate compared with budesonide: A double-blind trial in asthmatic children using powder devices at a dosage of 400 micrograms day-1. European Respiratory Journal, 9(11), 2263–2272.PubMed Hoekx, J. C., Hedlin, G., Pedersen, W., Sorva, R., Hollingworth, K., & Efthimiou, J. (1996). Fluticasone propionate compared with budesonide: A double-blind trial in asthmatic children using powder devices at a dosage of 400 micrograms day-1. European Respiratory Journal, 9(11), 2263–2272.PubMed
52.
go back to reference Basran, G., Campbell, M., Knox, A., Scott, R., Smith, R., Vernon, J., et al. (1997). An open study comparing equal doses of budesonide via Turbohaler with fluticasone propionate via Diskhaler in the treatment of adult asthmatic patients. European Journal of Clinical Research, 9, 185–197. Basran, G., Campbell, M., Knox, A., Scott, R., Smith, R., Vernon, J., et al. (1997). An open study comparing equal doses of budesonide via Turbohaler with fluticasone propionate via Diskhaler in the treatment of adult asthmatic patients. European Journal of Clinical Research, 9, 185–197.
53.
go back to reference Agertoft, L., & Pedersen, S. (1997). A randomized, double-blind dose reduction study to compare the minimal effective dose of budesonide Turbuhaler and fluticasone propionate Diskhaler. Journal of Allergy and Clinical Immunology, 99(6 I Suppl), 773–780.PubMed Agertoft, L., & Pedersen, S. (1997). A randomized, double-blind dose reduction study to compare the minimal effective dose of budesonide Turbuhaler and fluticasone propionate Diskhaler. Journal of Allergy and Clinical Immunology, 99(6 I Suppl), 773–780.PubMed
54.
go back to reference Yiallouros, P. K., Milner, A. D., Conway, E., & Honour, J. W. (1997). Adrenal function and high dose inhaled corticosteroids for asthma. Archives of Disease in Childhood, 76(5), 405–410.PubMed Yiallouros, P. K., Milner, A. D., Conway, E., & Honour, J. W. (1997). Adrenal function and high dose inhaled corticosteroids for asthma. Archives of Disease in Childhood, 76(5), 405–410.PubMed
55.
go back to reference Pauwels, R. A., Yernault, J. C., Demedts, M. G., & Geusens, P. (1998). Safety and efficacy of fluticasone and beclomethasone in moderate to severe asthma. American Journal of Respiratory and Critical Care Medicine, 157(3 I), 827–832.PubMed Pauwels, R. A., Yernault, J. C., Demedts, M. G., & Geusens, P. (1998). Safety and efficacy of fluticasone and beclomethasone in moderate to severe asthma. American Journal of Respiratory and Critical Care Medicine, 157(3 I), 827–832.PubMed
56.
go back to reference Bateman, E. D., Britton, M., Carrillo, J., Almeida, J., & Wixon, C. (1998). Salmeterol/fluticasone combination inhaler. A new, effective and well tolerated treatment for asthma. Clinical Drug Investigation, 16(3), 193–201.PubMed Bateman, E. D., Britton, M., Carrillo, J., Almeida, J., & Wixon, C. (1998). Salmeterol/fluticasone combination inhaler. A new, effective and well tolerated treatment for asthma. Clinical Drug Investigation, 16(3), 193–201.PubMed
57.
go back to reference Dal Negro, R., Micheletto, C., Tognella, S., Mauroner, L., Burti, E., Turco, P., et al. (1999). Effect of inhaled beclomethasone dipropionate and budesonide dry powder on pulmonary function and serum eosinophil cationic protein in adult asthmatics. Journal of Investigational Allergology and Clinical Immunology, 9(4), 241–247.PubMed Dal Negro, R., Micheletto, C., Tognella, S., Mauroner, L., Burti, E., Turco, P., et al. (1999). Effect of inhaled beclomethasone dipropionate and budesonide dry powder on pulmonary function and serum eosinophil cationic protein in adult asthmatics. Journal of Investigational Allergology and Clinical Immunology, 9(4), 241–247.PubMed
58.
go back to reference Raphael, G. D., Lanier, R. Q., Baker, J., Edwards, L., Rickard, K., & Lincourt, W. R. (1999). A comparison of multiple doses of fluticasone propionate and beclomethasone dipropionate in subjects with persistent asthma. Journal of Allergy and Clinical Immunology, 103(5 I), 796–803.PubMed Raphael, G. D., Lanier, R. Q., Baker, J., Edwards, L., Rickard, K., & Lincourt, W. R. (1999). A comparison of multiple doses of fluticasone propionate and beclomethasone dipropionate in subjects with persistent asthma. Journal of Allergy and Clinical Immunology, 103(5 I), 796–803.PubMed
59.
go back to reference Egan, J. J., Maden, C., Kalra, S., Adams, J. E., Eastell, R., & Woodcock, A. A. (1999). A randomized, double-blind study comparing the effects of beclomethasone and fluticasone on bone density over two years. European Respiratory Journal, 13(6), 1267–1275.PubMed Egan, J. J., Maden, C., Kalra, S., Adams, J. E., Eastell, R., & Woodcock, A. A. (1999). A randomized, double-blind study comparing the effects of beclomethasone and fluticasone on bone density over two years. European Respiratory Journal, 13(6), 1267–1275.PubMed
60.
go back to reference Malo, J.-L., Cartier, A., Ghezzo, H., Mark, S., Brown, J., Laviolette, M., et al. (1999). Skin bruising, adrenal function and markers of bone metabolism in asthmatics using inhaled beclomethasone and fluticasone. European Respiratory Journal, 13(5), 993–998.PubMed Malo, J.-L., Cartier, A., Ghezzo, H., Mark, S., Brown, J., Laviolette, M., et al. (1999). Skin bruising, adrenal function and markers of bone metabolism in asthmatics using inhaled beclomethasone and fluticasone. European Respiratory Journal, 13(5), 993–998.PubMed
61.
go back to reference Heinig, J. H., Boulet, L. P., Croonenborghs, L., & Mollers, M. J. (1999). The effect of high-dose fluticasone propionate and budesonide on lung function and asthma exacerbations in patients with severe asthma. Respiratory Medicine, 93(9), 613–620.PubMed Heinig, J. H., Boulet, L. P., Croonenborghs, L., & Mollers, M. J. (1999). The effect of high-dose fluticasone propionate and budesonide on lung function and asthma exacerbations in patients with severe asthma. Respiratory Medicine, 93(9), 613–620.PubMed
62.
go back to reference Hughes, J. A., Conry, B. G., Male, S. M., & Eastell, R. (1999). One year prospective open study of the effect of high dose inhaled steroids, fluticasone propionate, and budesonide on bone markers and bone mineral density. Thorax, 54(3), 223–229.PubMed Hughes, J. A., Conry, B. G., Male, S. M., & Eastell, R. (1999). One year prospective open study of the effect of high dose inhaled steroids, fluticasone propionate, and budesonide on bone markers and bone mineral density. Thorax, 54(3), 223–229.PubMed
63.
go back to reference Aubier, M., Pieters, W. R., Schlosser, N. J. J., & Steinmetz, K.-O. (1999). Salmeterol/fluticasone propionate (50/500 μg) in combination in a Diskus(TM) inhaler (Seretide(TM)) is effective and safe in the treatment of steroid-dependent asthma. Respiratory Medicine, 93(12), 876–884.PubMed Aubier, M., Pieters, W. R., Schlosser, N. J. J., & Steinmetz, K.-O. (1999). Salmeterol/fluticasone propionate (50/500 μg) in combination in a Diskus(TM) inhaler (Seretide(TM)) is effective and safe in the treatment of steroid-dependent asthma. Respiratory Medicine, 93(12), 876–884.PubMed
64.
go back to reference Chapman, K. R., Ringdal, N., Backer, V., Palmqvist, M., Saarelainen, S., & Briggs, M. (1999). Salmeterol and fluticasone propionate (50/250 μg) administered via combination Diskus inhaler: As effective as when given via separate Diskus inhalers. Canadian Respiratory Journal, 6(1), 45–51.PubMed Chapman, K. R., Ringdal, N., Backer, V., Palmqvist, M., Saarelainen, S., & Briggs, M. (1999). Salmeterol and fluticasone propionate (50/250 μg) administered via combination Diskus inhaler: As effective as when given via separate Diskus inhalers. Canadian Respiratory Journal, 6(1), 45–51.PubMed
65.
go back to reference Rao, R., Gregson, R. K., Jones, A. C., Miles, E. A., Campbell, M. J., & Warner, J. O. (1999). Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: A comparison of fluticasone with beclomethasone. European Respiratory Journal, 13(1), 87–94.PubMed Rao, R., Gregson, R. K., Jones, A. C., Miles, E. A., Campbell, M. J., & Warner, J. O. (1999). Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: A comparison of fluticasone with beclomethasone. European Respiratory Journal, 13(1), 87–94.PubMed
66.
go back to reference Ferguson, A. C., Spier, S., Manjra, A., Versteegh, F. G. A., Mark, S., & Zhang, P. (1999). Efficacy and safety of high-dose inhaled steroids in children with asthma: A comparison of fluticasone propionate with budesonide. Journal of Pediatrics, 134(4), 422–427.PubMed Ferguson, A. C., Spier, S., Manjra, A., Versteegh, F. G. A., Mark, S., & Zhang, P. (1999). Efficacy and safety of high-dose inhaled steroids in children with asthma: A comparison of fluticasone propionate with budesonide. Journal of Pediatrics, 134(4), 422–427.PubMed
67.
go back to reference Jäger, L., Laurikainen, K., Leinonen, M., & Silvasti, M. (2000). Beclomethasone dipropionate Easyhaler(TM) is as effective as budesonide Turbohaler(TM) in the control of asthma and is preferred by patients. International Journal of Clinical Practice, 54(6), 368–372.PubMed Jäger, L., Laurikainen, K., Leinonen, M., & Silvasti, M. (2000). Beclomethasone dipropionate Easyhaler(TM) is as effective as budesonide Turbohaler(TM) in the control of asthma and is preferred by patients. International Journal of Clinical Practice, 54(6), 368–372.PubMed
68.
go back to reference Medici, T. C., Grebski, E., Hacki, M., Ruegsegger, P., Maden, C., & Efthimiou, J. (2000). Effect of one year treatment with inhaled fluticasone propionate or beclomethasone dipropionate on bone density and bone metabolism: A randomised parallel group study in adult asthmatic subjects. Thorax, 55(5), 375–382.PubMed Medici, T. C., Grebski, E., Hacki, M., Ruegsegger, P., Maden, C., & Efthimiou, J. (2000). Effect of one year treatment with inhaled fluticasone propionate or beclomethasone dipropionate on bone density and bone metabolism: A randomised parallel group study in adult asthmatic subjects. Thorax, 55(5), 375–382.PubMed
69.
go back to reference Bousquet, J., D’Urzo, A., Hebert, J., Barraza, C. H., Boulet, L.-P., Suarez-Chacon, R., et al. (2000). Comparison of the efficacy and safety of mometasone furoate dry powder inhaler to budesonide Turbuhaler(TM). European Respiratory Journal, 16(5), 808–816.PubMed Bousquet, J., D’Urzo, A., Hebert, J., Barraza, C. H., Boulet, L.-P., Suarez-Chacon, R., et al. (2000). Comparison of the efficacy and safety of mometasone furoate dry powder inhaler to budesonide Turbuhaler(TM). European Respiratory Journal, 16(5), 808–816.PubMed
70.
go back to reference Jenkins, C., Woolcock, A. J., Saarelainen, P., Lundbäck, B., & James, M. H. (2000). Salmeterol/fluticasone propionate combination therapy 50/250 μg twice daily is more effective than budesonide 800 μg twice daily in treating moderate to severe asthma. Respiratory Medicine, 94(7), 715–723.PubMed Jenkins, C., Woolcock, A. J., Saarelainen, P., Lundbäck, B., & James, M. H. (2000). Salmeterol/fluticasone propionate combination therapy 50/250 μg twice daily is more effective than budesonide 800 μg twice daily in treating moderate to severe asthma. Respiratory Medicine, 94(7), 715–723.PubMed
71.
go back to reference Kavuru, M., Melamed, J., Gross, G., LaForce, C., House, K., Prillaman, B., et al. (2000). Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: A randomized, double-blind, placebo-controlled trial. Journal of Allergy and Clinical Immunology, 105(6 I), 1108–1116.PubMed Kavuru, M., Melamed, J., Gross, G., LaForce, C., House, K., Prillaman, B., et al. (2000). Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: A randomized, double-blind, placebo-controlled trial. Journal of Allergy and Clinical Immunology, 105(6 I), 1108–1116.PubMed
72.
go back to reference Shapiro, G., Lumry, W., Wolfe, J., Given, J., White, M. V., Woodring, A., et al. (2000). Combined salmeterol 50 μg and fluticasone propionate 250 μg in the Diskus device for the treatment of asthma. American Journal of Respiratory and Critical Care Medicine, 161(2 I), 527–534.PubMed Shapiro, G., Lumry, W., Wolfe, J., Given, J., White, M. V., Woodring, A., et al. (2000). Combined salmeterol 50 μg and fluticasone propionate 250 μg in the Diskus device for the treatment of asthma. American Journal of Respiratory and Critical Care Medicine, 161(2 I), 527–534.PubMed
73.
go back to reference Van den Berg, N. J., Ossip, M. S., Hederos, C. A., Anttila, H., Ribeiro, B. L., & Davies, P. I. (2000). Salmeterol/fluticasone propionate (50/100 μg) in combination in a Diskus(TM) inhaler (Seretide(TM)) is effective and safe in children with asthma. Pediatric Pulmonology, 30(2), 97–105.PubMed Van den Berg, N. J., Ossip, M. S., Hederos, C. A., Anttila, H., Ribeiro, B. L., & Davies, P. I. (2000). Salmeterol/fluticasone propionate (50/100 μg) in combination in a Diskus(TM) inhaler (Seretide(TM)) is effective and safe in children with asthma. Pediatric Pulmonology, 30(2), 97–105.PubMed
74.
go back to reference O’Connor, B., Bonnaud, G., Haahtela, T., Luna, M. J., Querfurt, H., Wegener, T., et al. (2001). Dose-ranging study of mometasone furoate dry powder inhaler in the treatment of moderate persistent asthma using fluticasone propionate as an active comparator. Annals of Allergy, Asthma & Immunology, 86(4), 397–404. O’Connor, B., Bonnaud, G., Haahtela, T., Luna, M. J., Querfurt, H., Wegener, T., et al. (2001). Dose-ranging study of mometasone furoate dry powder inhaler in the treatment of moderate persistent asthma using fluticasone propionate as an active comparator. Annals of Allergy, Asthma & Immunology, 86(4), 397–404.
75.
go back to reference Aubier, M., Wettenger, R., & Gans, S. J. M. (2001). Efficacy of HFA-beclomethasone dipropionate extra-fine aerosol (800 μg day-1) versus HFA-fluticasone propionate (1000 μg day-1) in patients with asthma. Respiratory Medicine, 95(3), 212–220.PubMed Aubier, M., Wettenger, R., & Gans, S. J. M. (2001). Efficacy of HFA-beclomethasone dipropionate extra-fine aerosol (800 μg day-1) versus HFA-fluticasone propionate (1000 μg day-1) in patients with asthma. Respiratory Medicine, 95(3), 212–220.PubMed
76.
go back to reference Johansson, G., McIvor, R. A., D’Ambrosio, F. P., Gratziou, C., & James, M. H. (2001). Comparison of salmeterol/fluticasone propionate combination with budesonide in patients with mild-to-moderate asthma. Clinical Drug Investigation, 21(9), 633–642. Johansson, G., McIvor, R. A., D’Ambrosio, F. P., Gratziou, C., & James, M. H. (2001). Comparison of salmeterol/fluticasone propionate combination with budesonide in patients with mild-to-moderate asthma. Clinical Drug Investigation, 21(9), 633–642.
77.
go back to reference Zetterström, O., Buhl, R., Mellem, H., Perpiñá, M., Hedman, J., O’Neill, S., et al. (2001). Improved asthma control with budesonide/formeterol in a single inhaler, compared with budesonide alone. European Respiratory Journal, 18(2), 262–268.PubMed Zetterström, O., Buhl, R., Mellem, H., Perpiñá, M., Hedman, J., O’Neill, S., et al. (2001). Improved asthma control with budesonide/formeterol in a single inhaler, compared with budesonide alone. European Respiratory Journal, 18(2), 262–268.PubMed
78.
go back to reference De Benedictis, F. M., Teper, A., Green, R. J., Boner, A. L., Williams, L., & Medley, H. (2001). Effects of 2 inhaled corticosteroids on growth: Results of a randomized controlled trial. Archives of Pediatrics and Adolescent Medicine, 155(11), 1248–1254.PubMed De Benedictis, F. M., Teper, A., Green, R. J., Boner, A. L., Williams, L., & Medley, H. (2001). Effects of 2 inhaled corticosteroids on growth: Results of a randomized controlled trial. Archives of Pediatrics and Adolescent Medicine, 155(11), 1248–1254.PubMed
79.
go back to reference Szefler, S. J., Martin, R. J., King, T. S., Boushey, H. A., Cherniack, R. M., Chinchilli, V. M., et al. (2002). Significant variability in response to inhaled corticosteroids for persistent asthma. Journal of Allergy and Clinical Immunology, 109(3), 410–418.PubMed Szefler, S. J., Martin, R. J., King, T. S., Boushey, H. A., Cherniack, R. M., Chinchilli, V. M., et al. (2002). Significant variability in response to inhaled corticosteroids for persistent asthma. Journal of Allergy and Clinical Immunology, 109(3), 410–418.PubMed
80.
go back to reference Ige, O. M., & Sogaolu, O. M. (2002). The clinical efficacy of fluticasone propionate (Fluvent) compared with beclomethasone dipropionate (Becotide) in patients with mild to moderate bronchial asthma at the University College Hospital, Ibadan, Nigeria. West African Journal of Medicine, 21(4), 297–301.PubMed Ige, O. M., & Sogaolu, O. M. (2002). The clinical efficacy of fluticasone propionate (Fluvent) compared with beclomethasone dipropionate (Becotide) in patients with mild to moderate bronchial asthma at the University College Hospital, Ibadan, Nigeria. West African Journal of Medicine, 21(4), 297–301.PubMed
81.
go back to reference Ringdal, N., Chuchalin, A., Chovan, L., Tudoric, N., Maggi, E., Whitehead, P. J., et al. (2002). Evaluation of different inhaled combination therapies (EDICT): A randomised, double-blind comparison of Seretide (50/250 μg bd Diskus) vs. formoterol (12 μg bd) and budesonide (800 μg bd) given concurrently (both via Turbuhaler) in patients with moderate-to-severe asthma. Respiratory Medicine, 96(11), 851–861.PubMed Ringdal, N., Chuchalin, A., Chovan, L., Tudoric, N., Maggi, E., Whitehead, P. J., et al. (2002). Evaluation of different inhaled combination therapies (EDICT): A randomised, double-blind comparison of Seretide (50/250 μg bd Diskus) vs. formoterol (12 μg bd) and budesonide (800 μg bd) given concurrently (both via Turbuhaler) in patients with moderate-to-severe asthma. Respiratory Medicine, 96(11), 851–861.PubMed
82.
go back to reference Rosenhall, L., Heinig, J. H., Lindqvist, A., Leegaard, J., Stahl, E., & Bergqvist, P. B. F. (2002). Budesonide/formoterol (symbicort) is well tolerated and effective in patients with moderate persistent asthma. International Journal of Clinical Practice, 56(6), 427–433.PubMed Rosenhall, L., Heinig, J. H., Lindqvist, A., Leegaard, J., Stahl, E., & Bergqvist, P. B. F. (2002). Budesonide/formoterol (symbicort) is well tolerated and effective in patients with moderate persistent asthma. International Journal of Clinical Practice, 56(6), 427–433.PubMed
83.
go back to reference Kannisto, S., Voutilainen, R., Remes, K., & Korppi, M. (2002). Efficacy and safety of inhaled steroid and cromone treatment in school-age children: A randomized pragmatic pilot study. Pediatric Allergy & Immunology, 13(1), 24–30. Kannisto, S., Voutilainen, R., Remes, K., & Korppi, M. (2002). Efficacy and safety of inhaled steroid and cromone treatment in school-age children: A randomized pragmatic pilot study. Pediatric Allergy & Immunology, 13(1), 24–30.
84.
go back to reference Kannisto, S., Korppi, M., Remes, K., & Voutilainen, R. (2000). Adrenal suppression, evaluated by a low dose adrenocorticotropin test, and growth in asthmatic children treated with inhaled steroids. Journal of Clinical Endocrinology and Metabolism, 85(2), 652–657.PubMed Kannisto, S., Korppi, M., Remes, K., & Voutilainen, R. (2000). Adrenal suppression, evaluated by a low dose adrenocorticotropin test, and growth in asthmatic children treated with inhaled steroids. Journal of Clinical Endocrinology and Metabolism, 85(2), 652–657.PubMed
85.
go back to reference Tal, A., Simon, G., Vermeulen, J. H., Petru, V., Cobos, N., Everard, M. L., et al. (2002). Budesonide/formoterol in a single inhaler versus inhaled corticosteroids alone in the treatment of asthma. Pediatric Pulmonology, 34(5), 342–350.PubMed Tal, A., Simon, G., Vermeulen, J. H., Petru, V., Cobos, N., Everard, M. L., et al. (2002). Budesonide/formoterol in a single inhaler versus inhaled corticosteroids alone in the treatment of asthma. Pediatric Pulmonology, 34(5), 342–350.PubMed
86.
go back to reference Corren, J., Berkowitz, R., Murray, J. J., & Prenner, B. (2003). Comparison of once-daily mometasone furoate versus once-daily budesonide in patients with moderate persistent asthma. International Journal of Clinical Practice, 57(7), 567–572.PubMed Corren, J., Berkowitz, R., Murray, J. J., & Prenner, B. (2003). Comparison of once-daily mometasone furoate versus once-daily budesonide in patients with moderate persistent asthma. International Journal of Clinical Practice, 57(7), 567–572.PubMed
87.
go back to reference Kuna, P. (2003). A randomized, double-blind, double-dummy, parallel-group, multicenter, dose-reduction trial of the minimal effective doses of budesonide and fluticasone dry-powder inhalers in adults with mild to moderate asthma. Clinical Therapeutics, 25(8), 2182–2197.PubMed Kuna, P. (2003). A randomized, double-blind, double-dummy, parallel-group, multicenter, dose-reduction trial of the minimal effective doses of budesonide and fluticasone dry-powder inhalers in adults with mild to moderate asthma. Clinical Therapeutics, 25(8), 2182–2197.PubMed
88.
go back to reference Busse, W., Koenig, S. M., Oppenheimer, J., Sahn, S. A., Yancey, S. W., Reilly, D., et al. (2003). Steroid-sparing effects of fluticasone propionate 100 μg and salmeterol 50 μg administered twice daily in a single product in patients previously controlled with fluticasone propionate 250 μg administered twice daily. Journal of Allergy and Clinical Immunology, 111(1), 57–65.PubMed Busse, W., Koenig, S. M., Oppenheimer, J., Sahn, S. A., Yancey, S. W., Reilly, D., et al. (2003). Steroid-sparing effects of fluticasone propionate 100 μg and salmeterol 50 μg administered twice daily in a single product in patients previously controlled with fluticasone propionate 250 μg administered twice daily. Journal of Allergy and Clinical Immunology, 111(1), 57–65.PubMed
89.
go back to reference Bateman, E. D., Bantje, T. A., Gomes, M. J., Toumbis, M. G., Huber, R. M., & Naya, I. (2003). Combination therapy with single inhaler budesonide/formoterol compared with high dose of fluticasone propionate alone in patients with moderate persistent asthma. American Journal of Respiratory Medicine, 2(3), 275–281.PubMed Bateman, E. D., Bantje, T. A., Gomes, M. J., Toumbis, M. G., Huber, R. M., & Naya, I. (2003). Combination therapy with single inhaler budesonide/formoterol compared with high dose of fluticasone propionate alone in patients with moderate persistent asthma. American Journal of Respiratory Medicine, 2(3), 275–281.PubMed
90.
go back to reference Lalloo, U. G., Malolepszy, J., Kozma, D., Krofta, K., Ankerst, J., Johansen, B., et al. (2003). Budesonide and formoterol in a single inhaler improves asthma control compared with increasing the dose of corticosteroid in adults with mild-to-moderate asthma. Chest, 123(5), 1480–1487.PubMed Lalloo, U. G., Malolepszy, J., Kozma, D., Krofta, K., Ankerst, J., Johansen, B., et al. (2003). Budesonide and formoterol in a single inhaler improves asthma control compared with increasing the dose of corticosteroid in adults with mild-to-moderate asthma. Chest, 123(5), 1480–1487.PubMed
91.
go back to reference Buhl, R., Creemers, J. P. H. M., Vondra, V., Martinelli, N. A., Naya, I. P., & Ekstrom, T. (2003). Once-daily budesonide/formoterol in a single inhaler in adults with moderate persistent asthma. Respiratory Medicine, 97(4), 323–330.PubMed Buhl, R., Creemers, J. P. H. M., Vondra, V., Martinelli, N. A., Naya, I. P., & Ekstrom, T. (2003). Once-daily budesonide/formoterol in a single inhaler in adults with moderate persistent asthma. Respiratory Medicine, 97(4), 323–330.PubMed
92.
go back to reference Parakh, U., Gupta, K., Sharma, S., & Gaur, N. (2004). A comparative evaluation of the efficacy of inhaled beclomethasone dipropionate, budesonide and fluticasone propionate in the management of bronchial asthma. Indian Journal of Allergy, Asthma and Immunology, 18(1), 33–38. Parakh, U., Gupta, K., Sharma, S., & Gaur, N. (2004). A comparative evaluation of the efficacy of inhaled beclomethasone dipropionate, budesonide and fluticasone propionate in the management of bronchial asthma. Indian Journal of Allergy, Asthma and Immunology, 18(1), 33–38.
93.
go back to reference Prasad, R., Bandhu, M., Kant, S., Pandey, U., Ahuja, R., & Agarwal, G. (2004). A comparative study on efficacy of inhaled fluticasone propionate and beclomethasone dipropionate in patients of bronchial asthma. Indian Journal of Allergy, Asthma and Immunology, 18(2), 73–77. Prasad, R., Bandhu, M., Kant, S., Pandey, U., Ahuja, R., & Agarwal, G. (2004). A comparative study on efficacy of inhaled fluticasone propionate and beclomethasone dipropionate in patients of bronchial asthma. Indian Journal of Allergy, Asthma and Immunology, 18(2), 73–77.
94.
go back to reference Bergmann, K.-C., Lindemann, L., Braun, R., & Steinkamp, G. (2004). Salmeterol/fluticasone propionate (50/250 μg) combination is superior to double dose fluticasone (500 μg) for the treatment of symptomatic moderate asthma: A prospective, double-blind trial. Swiss Medical Weekly, 134(3–4), 50–58.PubMed Bergmann, K.-C., Lindemann, L., Braun, R., & Steinkamp, G. (2004). Salmeterol/fluticasone propionate (50/250 μg) combination is superior to double dose fluticasone (500 μg) for the treatment of symptomatic moderate asthma: A prospective, double-blind trial. Swiss Medical Weekly, 134(3–4), 50–58.PubMed
95.
go back to reference Zhong, N. S., Ping, Z. J., Humphries, M. J., & Xin, D. (2004). Salmeterol/fluticasone propionate in a single inhaler is superior to budesonide alone in control of Chinese asthmatic adults–An open-label, randomised, 6-week study. Clinical Drug Investigation, 24(10), 583–592.PubMed Zhong, N. S., Ping, Z. J., Humphries, M. J., & Xin, D. (2004). Salmeterol/fluticasone propionate in a single inhaler is superior to budesonide alone in control of Chinese asthmatic adults–An open-label, randomised, 6-week study. Clinical Drug Investigation, 24(10), 583–592.PubMed
96.
go back to reference Scicchitano, R., Aalbers, R., Ukena, D., Manjra, A., Fouquert, L., Centann, S., et al. (2004). Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Current Medical Research and Opinion, 20(9), 1403–1418.PubMed Scicchitano, R., Aalbers, R., Ukena, D., Manjra, A., Fouquert, L., Centann, S., et al. (2004). Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Current Medical Research and Opinion, 20(9), 1403–1418.PubMed
97.
go back to reference Bateman, E. D., Boushey, H. A., Bousquet, J., Busse, W. W., Clark, T. J. H., Pauwels, R. A., et al. (2004). Can guideline-defined asthma control be achieved? The gaining optimal asthma control study. American Journal of Respiratory and Critical Care Medicine, 170(8), 836–844.PubMed Bateman, E. D., Boushey, H. A., Bousquet, J., Busse, W. W., Clark, T. J. H., Pauwels, R. A., et al. (2004). Can guideline-defined asthma control be achieved? The gaining optimal asthma control study. American Journal of Respiratory and Critical Care Medicine, 170(8), 836–844.PubMed
98.
go back to reference Aalbers, R., Backer, V., Kava, T. T. K., Omenaas, E. R., Sandstrom, T., Jorup, C., et al. (2004). Adjustable maintenance dosing with budesonide/formoterol compared with fixed-dose salmeterol/fluticasone in moderate to severe asthma. Current Medical Research and Opinion, 20(2), 225–240.PubMed Aalbers, R., Backer, V., Kava, T. T. K., Omenaas, E. R., Sandstrom, T., Jorup, C., et al. (2004). Adjustable maintenance dosing with budesonide/formoterol compared with fixed-dose salmeterol/fluticasone in moderate to severe asthma. Current Medical Research and Opinion, 20(2), 225–240.PubMed
99.
go back to reference Niphadkar, P., Jagannath, K., Joshi, J. M., Awad, N., Boss, H., Hellbardt, S., et al. (2005). Comparison of the efficacy of ciclesonide 160 μg QD and budesonide 200 μg BID in adults with persistent asthma: A phase III, randomized, double-dummy, open-label study. Clinical Therapeutics, 27(11), 1752–1763.PubMed Niphadkar, P., Jagannath, K., Joshi, J. M., Awad, N., Boss, H., Hellbardt, S., et al. (2005). Comparison of the efficacy of ciclesonide 160 μg QD and budesonide 200 μg BID in adults with persistent asthma: A phase III, randomized, double-dummy, open-label study. Clinical Therapeutics, 27(11), 1752–1763.PubMed
100.
go back to reference Kaur, C., Bansal, S. K., & Chhabra, S. K. (2005). Study on serum and urinary cortisol levels of asthmatic patients after treatment with high dose inhaled beclomethasone dipropionate or budesonide. Indian Journal of Chest Diseases and Allied Sciences, 47(2), 89–95.PubMed Kaur, C., Bansal, S. K., & Chhabra, S. K. (2005). Study on serum and urinary cortisol levels of asthmatic patients after treatment with high dose inhaled beclomethasone dipropionate or budesonide. Indian Journal of Chest Diseases and Allied Sciences, 47(2), 89–95.PubMed
101.
go back to reference Molimard, M., Martinat, Y., Rogeaux, Y., Moyse, D., Pello, J.-Y., & Giraud, V. (2005). Improvement of asthma control with beclomethasone extrafine aerosol compared to fluticasone and budesonide. Respiratory Medicine, 99(6), 770–778.PubMed Molimard, M., Martinat, Y., Rogeaux, Y., Moyse, D., Pello, J.-Y., & Giraud, V. (2005). Improvement of asthma control with beclomethasone extrafine aerosol compared to fluticasone and budesonide. Respiratory Medicine, 99(6), 770–778.PubMed
102.
go back to reference FitzGerald, J. M., Boulet, L.-P., & Follows, R. M. A. (2005). The CONCEPT trial: A 1-year, multicenter, randomized, double-blind, double-dummy comparison of a stable dosing regimen of salmeterol/fluticasone propionate with an adjustable maintenance dosing regimen of formoterol/budesonide in adults with persistent asthma. Clinical Therapeutics, 27(4), 393–406.PubMed FitzGerald, J. M., Boulet, L.-P., & Follows, R. M. A. (2005). The CONCEPT trial: A 1-year, multicenter, randomized, double-blind, double-dummy comparison of a stable dosing regimen of salmeterol/fluticasone propionate with an adjustable maintenance dosing regimen of formoterol/budesonide in adults with persistent asthma. Clinical Therapeutics, 27(4), 393–406.PubMed
103.
go back to reference Vogelmeier, C., D’Urzo, A., Pauwels, R., Merino, J. M., Jaspal, M., Boutet, S., et al. (2005). Budesonide/formoterol maintenance and reliever therapy: An effective asthma treatment option? European Respiratory Journal, 26(5), 819–828.PubMed Vogelmeier, C., D’Urzo, A., Pauwels, R., Merino, J. M., Jaspal, M., Boutet, S., et al. (2005). Budesonide/formoterol maintenance and reliever therapy: An effective asthma treatment option? European Respiratory Journal, 26(5), 819–828.PubMed
104.
go back to reference O’Byrne, P. M., Bisgaard, H., Godard, P. P., Pistolesi, M., Palmqvist, M., Zhu, Y., et al. (2005). Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. American Journal of Respiratory and Critical Care Medicine, 171(2), 129–136.PubMed O’Byrne, P. M., Bisgaard, H., Godard, P. P., Pistolesi, M., Palmqvist, M., Zhu, Y., et al. (2005). Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. American Journal of Respiratory and Critical Care Medicine, 171(2), 129–136.PubMed
105.
go back to reference Altintas, D. U., Karakoc, G. B., Can, S., Yilmaz, M., & Kendirli, S. G. (2005). The effects of long term use of inhaled corticosteroids on linear growth, adrenal function and bone mineral density in children. Allergologia et Immunopathologia, 33(4), 204–209.PubMed Altintas, D. U., Karakoc, G. B., Can, S., Yilmaz, M., & Kendirli, S. G. (2005). The effects of long term use of inhaled corticosteroids on linear growth, adrenal function and bone mineral density in children. Allergologia et Immunopathologia, 33(4), 204–209.PubMed
106.
go back to reference Malone, R., LaForce, C., Nimmagadda, S., Schoaf, L., House, K., Ellsworth, A., et al. (2005). The safety of twice-daily treatment with fluticasone propionate and salmeterol in pediatric patients with persistent asthma. Annals of Allergy, Asthma & Immunology, 95(1), 66–71. Malone, R., LaForce, C., Nimmagadda, S., Schoaf, L., House, K., Ellsworth, A., et al. (2005). The safety of twice-daily treatment with fluticasone propionate and salmeterol in pediatric patients with persistent asthma. Annals of Allergy, Asthma & Immunology, 95(1), 66–71.
107.
go back to reference Pohl, W. R., Vetter, N., Zwick, H., & Hrubos, W. (2006). Adjustable maintenance dosing with budesonide/formoterol or budesonide: Double-blind study. Respiratory Medicine, 100(3), 551–560.PubMed Pohl, W. R., Vetter, N., Zwick, H., & Hrubos, W. (2006). Adjustable maintenance dosing with budesonide/formoterol or budesonide: Double-blind study. Respiratory Medicine, 100(3), 551–560.PubMed
108.
go back to reference Buhl, R., Vinkler, I., Magyar, P., Györi, Z., Rybacki, C., Middle, M. V., et al. (2006). Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma. Pulmonary Pharmacology and Therapeutics, 19(6), 404–412.PubMed Buhl, R., Vinkler, I., Magyar, P., Györi, Z., Rybacki, C., Middle, M. V., et al. (2006). Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma. Pulmonary Pharmacology and Therapeutics, 19(6), 404–412.PubMed
109.
go back to reference Koopmans, J. G., Lutter, R., Jansen, H. M., & van der Zee, J. S. (2006). Adding salmeterol to an inhaled corticosteroid: Long term effects on bronchial inflammation in asthma. Thorax, 61(4), 306–312.PubMed Koopmans, J. G., Lutter, R., Jansen, H. M., & van der Zee, J. S. (2006). Adding salmeterol to an inhaled corticosteroid: Long term effects on bronchial inflammation in asthma. Thorax, 61(4), 306–312.PubMed
110.
go back to reference Lundbäck, B., Rönmark, E., Lindberg, A., Jonsson, A.-C., Larsson, L.-G., Petavy, F., et al. (2006). Control of mild to moderate asthma over 1-year with the combination of salmeterol and fluticasone propionate. Respiratory Medicine, 100(1), 2–10.PubMed Lundbäck, B., Rönmark, E., Lindberg, A., Jonsson, A.-C., Larsson, L.-G., Petavy, F., et al. (2006). Control of mild to moderate asthma over 1-year with the combination of salmeterol and fluticasone propionate. Respiratory Medicine, 100(1), 2–10.PubMed
111.
go back to reference Kuna, P., Creemers, J. P., Vondra, V., Black, P. N., Lindqvist, A., Nihlen, U., et al. (2006). Once-daily dosing with budesonide/formoterol compared with twice-daily budesonide/formoterol and once-daily budesonide in adults with mild to moderate asthma. Respiratory Medicine, 100(12), 2151–2159.PubMed Kuna, P., Creemers, J. P., Vondra, V., Black, P. N., Lindqvist, A., Nihlen, U., et al. (2006). Once-daily dosing with budesonide/formoterol compared with twice-daily budesonide/formoterol and once-daily budesonide in adults with mild to moderate asthma. Respiratory Medicine, 100(12), 2151–2159.PubMed
112.
go back to reference Nathan, R. A., Rooklin, A., Schoaf, L., Scott, C., Ellsworth, A., House, K., et al. (2006). Efficacy and tolerability of fluticasone propionate/salmeterol administered twice daily via hydrofluoroalkane 134a metered-dose inhaler in adolescent and adult patients with persistent asthma: A randomized, double-blind, placebo-controlled, 12-week study. Clinical Therapeutics, 28(1), 73–85.PubMed Nathan, R. A., Rooklin, A., Schoaf, L., Scott, C., Ellsworth, A., House, K., et al. (2006). Efficacy and tolerability of fluticasone propionate/salmeterol administered twice daily via hydrofluoroalkane 134a metered-dose inhaler in adolescent and adult patients with persistent asthma: A randomized, double-blind, placebo-controlled, 12-week study. Clinical Therapeutics, 28(1), 73–85.PubMed
113.
go back to reference Dahl, R., Chuchalin, A., Gor, D., Yoxall, S., & Sharma, R. (2006). EXCEL: A randomised trial comparing salmeterol/fluticasone propionate and formoterol/budesonide combinations in adults with persistent asthma. Respiratory Medicine, 100(7), 1152–1162.PubMed Dahl, R., Chuchalin, A., Gor, D., Yoxall, S., & Sharma, R. (2006). EXCEL: A randomised trial comparing salmeterol/fluticasone propionate and formoterol/budesonide combinations in adults with persistent asthma. Respiratory Medicine, 100(7), 1152–1162.PubMed
114.
go back to reference Jenkins, C., Kolarikova, R., Kuna, P., Caillaud, D., Sanchis, J., Popp, W., et al. (2006). Efficacy and safety of high-dose budesonide/formoterol (Symbicort) compared with budesonide administered either concomitantly with formoterol or alone in patients with persistent symptomatic asthma. Respirology, 11(3), 276–286.PubMed Jenkins, C., Kolarikova, R., Kuna, P., Caillaud, D., Sanchis, J., Popp, W., et al. (2006). Efficacy and safety of high-dose budesonide/formoterol (Symbicort) compared with budesonide administered either concomitantly with formoterol or alone in patients with persistent symptomatic asthma. Respirology, 11(3), 276–286.PubMed
115.
go back to reference Bateman, E. D., Jacques, L., Goldfrad, C., Atienza, T., Mihaescu, T., & Duggan, M. (2006). Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down. Journal of Allergy and Clinical Immunology, 117(3), 563–570.PubMed Bateman, E. D., Jacques, L., Goldfrad, C., Atienza, T., Mihaescu, T., & Duggan, M. (2006). Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down. Journal of Allergy and Clinical Immunology, 117(3), 563–570.PubMed
116.
go back to reference Zietkowski, Z., Bodzenta-Lukaszyk, A., Tomasiak, M. M., Szymanski, W., & Skiepko, R. (2006). Effect of ciclesonide and fluticasone on exhaled nitric oxide in patients with mild allergic asthma. Respiratory Medicine, 100(9), 1651–1656.PubMed Zietkowski, Z., Bodzenta-Lukaszyk, A., Tomasiak, M. M., Szymanski, W., & Skiepko, R. (2006). Effect of ciclesonide and fluticasone on exhaled nitric oxide in patients with mild allergic asthma. Respiratory Medicine, 100(9), 1651–1656.PubMed
117.
go back to reference Horiguchi, T., Hayashi, N., Ohira, D., Torigoe, H., Ito, T., Hirose, M., et al. (2006). Usefulness of HFA-BDP for adult patients with bronchial Asthma: Randomized crossover study with Fluticasone. Journal of Asthma, 43(7), 509–512.PubMed Horiguchi, T., Hayashi, N., Ohira, D., Torigoe, H., Ito, T., Hirose, M., et al. (2006). Usefulness of HFA-BDP for adult patients with bronchial Asthma: Randomized crossover study with Fluticasone. Journal of Asthma, 43(7), 509–512.PubMed
118.
go back to reference Rabe, K. F., Pizzichini, E., Ställberg, B., Romero, S., Balanzat, A. M., Atienza, T., et al. (2006). Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma – A randomized, double-blind trial. Chest, 129(2), 246–256.PubMed Rabe, K. F., Pizzichini, E., Ställberg, B., Romero, S., Balanzat, A. M., Atienza, T., et al. (2006). Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma – A randomized, double-blind trial. Chest, 129(2), 246–256.PubMed
119.
go back to reference Jarjour, N. N., Wilson, S. J., Koenig, S. M., Laviolette, M., Moore, W. C., Davis, W. B., et al. (2006). Control of airway inflammation maintained at a lower steroid dose with 100/50 μg of fluticasone propionate/salmeterol. Journal of Allergy and Clinical Immunology, 118(1), 44–52.PubMed Jarjour, N. N., Wilson, S. J., Koenig, S. M., Laviolette, M., Moore, W. C., Davis, W. B., et al. (2006). Control of airway inflammation maintained at a lower steroid dose with 100/50 μg of fluticasone propionate/salmeterol. Journal of Allergy and Clinical Immunology, 118(1), 44–52.PubMed
120.
go back to reference Pohunek, P., Kuna, P., Jorup, C., & de Boeck, K. (2006). Budesonide/formoterol improves lung function compared with budesonide alone in children with asthma. Pediatric Allergy & Immunology, 17(6), 458–465. Pohunek, P., Kuna, P., Jorup, C., & de Boeck, K. (2006). Budesonide/formoterol improves lung function compared with budesonide alone in children with asthma. Pediatric Allergy & Immunology, 17(6), 458–465.
121.
go back to reference Eisner, C., & Morse, R. (2001). Quality-of-life measures in chronic diseases of childhood. Health Technology Assessment, 5(4), 1–148. Eisner, C., & Morse, R. (2001). Quality-of-life measures in chronic diseases of childhood. Health Technology Assessment, 5(4), 1–148.
122.
go back to reference Santanello, N. C., Barber, B. L., Reiss, T. F., Friedman, B. S., Juniper, E. F., & Zhang, J. (1997). Measurement characteristics of two asthma symptom diary scales for use in clinical trials. European Respiratory Journal, 10(3), 646–651.PubMed Santanello, N. C., Barber, B. L., Reiss, T. F., Friedman, B. S., Juniper, E. F., & Zhang, J. (1997). Measurement characteristics of two asthma symptom diary scales for use in clinical trials. European Respiratory Journal, 10(3), 646–651.PubMed
123.
go back to reference Juniper, E. F., Guyatt, G. H., Epstein, R. S., Ferrie, P. J., Jaeschke, R., & Hiller, T. K. (1992). Evaluation of impairment of health related quality of life in asthma: Development of a questionnaire for use in clinical trials. Thorax, 47(2), 76–83.PubMed Juniper, E. F., Guyatt, G. H., Epstein, R. S., Ferrie, P. J., Jaeschke, R., & Hiller, T. K. (1992). Evaluation of impairment of health related quality of life in asthma: Development of a questionnaire for use in clinical trials. Thorax, 47(2), 76–83.PubMed
124.
go back to reference Juniper, E. F., Guyatt, G. H., Feeny, D. H., Ferrie, P. J., Griffith, L. E., & Townsend, M. (1996). Measuring quality of life in children with asthma. Quality of Life Research, 5(1), 35–46.PubMed Juniper, E. F., Guyatt, G. H., Feeny, D. H., Ferrie, P. J., Griffith, L. E., & Townsend, M. (1996). Measuring quality of life in children with asthma. Quality of Life Research, 5(1), 35–46.PubMed
125.
go back to reference Juniper, E. F., Guyatt, G. H., Cox, F. M., Ferrie, P. J., & King, D. R. (1999). Development and validation of the Mini Asthma Quality of Life Questionnaire. European Respiratory Journal, 14(1), 32–38.PubMed Juniper, E. F., Guyatt, G. H., Cox, F. M., Ferrie, P. J., & King, D. R. (1999). Development and validation of the Mini Asthma Quality of Life Questionnaire. European Respiratory Journal, 14(1), 32–38.PubMed
126.
go back to reference Hyland, M. E. (1991). The living with asthma questionnaire. Respiratory Medicine, 85(Supp B), 13–16.PubMed Hyland, M. E. (1991). The living with asthma questionnaire. Respiratory Medicine, 85(Supp B), 13–16.PubMed
127.
go back to reference Ware, J. E., Kemp, J. P., Buchner, D. A., Singer, A. E., Nolop, K. B., & Goss, T. F. (1998). The responsiveness of disease-specific and generic health measures to changes in the severity of asthma among adults. Quality of Life Research, 7(3), 235–244.PubMed Ware, J. E., Kemp, J. P., Buchner, D. A., Singer, A. E., Nolop, K. B., & Goss, T. F. (1998). The responsiveness of disease-specific and generic health measures to changes in the severity of asthma among adults. Quality of Life Research, 7(3), 235–244.PubMed
128.
go back to reference Put, C., Demedts, M., van den Bergh, O., Demyttenaere, K., & Verleden, G. (1999). Asthma symptoms: Influence of personality versus clinical status. European Respiratory Journal, 13(4), 751–756.PubMed Put, C., Demedts, M., van den Bergh, O., Demyttenaere, K., & Verleden, G. (1999). Asthma symptoms: Influence of personality versus clinical status. European Respiratory Journal, 13(4), 751–756.PubMed
129.
go back to reference Rietveld, S., & Prins, P. J. M. (1998). The relationship between negative emotions and acute subjective and objective symptoms of childhood asthma. Psychological Medicine, 28(2), 407–415.PubMed Rietveld, S., & Prins, P. J. M. (1998). The relationship between negative emotions and acute subjective and objective symptoms of childhood asthma. Psychological Medicine, 28(2), 407–415.PubMed
130.
go back to reference Efficace, F., Bottomley, A., Osoba, D., Gotay, C., Flechtner, H., D’haese, S., et al. (2003). Beyond the development of health-related quality-of-life (HRQOL) measures: A checklist for evaluating HRQOL outcomes in cancer clinical trials – does HRQOL evaluation in prostate cancer research inform clinical decision making? Journal of Clinical Oncology, 21(18), 3502–3511.PubMed Efficace, F., Bottomley, A., Osoba, D., Gotay, C., Flechtner, H., D’haese, S., et al. (2003). Beyond the development of health-related quality-of-life (HRQOL) measures: A checklist for evaluating HRQOL outcomes in cancer clinical trials – does HRQOL evaluation in prostate cancer research inform clinical decision making? Journal of Clinical Oncology, 21(18), 3502–3511.PubMed
Metagegevens
Titel
Patient-reported outcomes in clinical trials of inhaled asthma medications: systematic review and research needs
Auteurs
Geoff K. Frampton
Jonathan Shepherd
Publicatiedatum
01-04-2011
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 3/2011
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-010-9750-1

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