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Quality of Life Research

Gepubliceerd in:

01-04-2008

The effects of exercise training on quality of life in HAART-treated HIV-positive Rwandan subjects with body fat redistribution

Auteurs: Eugene Mutimura, Aimee Stewart, Nigel J. Crowther, Kevin E. Yarasheski, W. Todd Cade

Gepubliceerd in: Quality of Life Research | Uitgave 3/2008

Abstract

Objective

Our objective was to examine the effects of exercise training (EXS) on quality of life (QoL) in highly active antiretroviral therapy (HAART)-treated HIV-positive (HIV+) subjects with body fat redistribution (BFR) in Rwanda.

Methods

The effects of a randomised controlled trial of EXS on QoL were measured using World Health Organisation Quality of Life (WHOQOL)-BREF in HIV+ subjects with BFR randomised to EXS (n = 50; BFR + EXS) or no exercise training (n = 50; BFR + noEXS).

Results

At 6 months, scores on the psychological [1.3 (0.3) vs. 0.5 (0.1); P < 0.0001], independence [0.6 (0.1) vs. 0.0 (0.0); P < 0.0001], social relationships [0.6 (0.2) vs. 0.0 (0.0); P < 0.0001] and HIV HAART-specific QoL domains [1.4 (0.2) vs. −0.1 (0.2); P < 0.0001] improved more in BFR + EXS than BFR + noEXS group, respectively. Self-esteem [1.3 (0.8) vs. 0.1 (0.6); P < 0.001], body image [1.5 (0.6) vs. 0.0 (0.5); P < 0.001] and emotional stress [1.6 (0.7) vs. 0.2 (0.5); P < 0.001] improved more in the BFR + EXS group than BFR + noEXS group, respectively. Psychological [1.5 (0.2) vs. 1.1 (0.3); P < 0.0001], social relationship [0.8 (0.2) vs. 0.4 (0.2); P < 0.0001], and HIV HAART-specific well-being [1.8 (0.2) vs. 1.0 (0.0); P < 0.0001] improved more in BFR + EXS female than male subjects.

Conclusions

Exercise training improved several components of QoL in HAART-treated HIV+ African subjects with BFR. Exercise training is an inexpensive and efficacious strategy for improving QoL in HIV+ African subjects, which may improve HAART adherence and treatment initiatives in resource-limited areas of sub-Saharan Africa.

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Egger, M., May, M., Chene, G., et al. (2002). Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet, 360, 119–129.PubMedCrossRef

Chen, D., Mistra, A., & Garg, A. (2002). Lipodystrophy in human immunodeficiency virus-infected patients. The Journal of Clinical Endocrinology and Metabolism, 87, 4845–4856.PubMedCrossRef

Pujari, S. N., Dravid, A., Naik, E., et al. (2005). Lipodystrophy and dyslipidaemia among patients taking first-line, World Health Organisation-recommended highly active antiretroviral therapy regimens in Western India. Journal of Acquired Immune Deficiency Syndromes, 39, 199–202.PubMed

Reynolds, N. R., Neidig, J. L., Wu, A. W., et al. (2006). Balancing disfigurement and fear of disease progression: Patient perceptions of HIV fat redistribution. AIDS Care, 18, 663–673.PubMedCrossRef

Beck, E. J., Vitoria, M., Mandalia, S., et al. (2006). National adult antiretroviral therapy guidelines in resource-limited countries: Concordance with 2003 WHO guidelines? AIDS, 11, 1497–1502.CrossRef

Ammassari, A., Antinori, A., Cozzi-Lepri, A., et al. (2002). Relationship Between HAART Adherence and Adipose Tissue Alterations. Journal of Acquired Immune Deficiency Syndromes, 31, S140–S144.PubMed

Tramarin, A., Campostrini, S., Postma, M. J., et al. (2004). A multicentre study of patient survival, disability, quality of life and cost of care: Among patients with AIDS in northern Italy. Pharmacoeconomics, 22, 43–53.PubMedCrossRef

Steel, J. L., Landsittel, D., Calhoun, B., et al. (2006). Effects of lipodystrophy on quality of life and depression in HIV-infected men on HAART. AIDS Patient Care and STDs, 20, 565–575.PubMedCrossRef

Blanch, J., Rousaud, A., Martinez, E., et al. (2004). Factors associated with severe impact of lipodystrophy on quality of life of patients infected with HIV-1. Clinical Infectious Disease, 38, 1464–1470.CrossRef

10.

Jacobson, D. L., Knox, T., Spiegelman, D., et al. (2005). Prevalence of, evolution of, and risk factors for fat atrophy and fat deposition in a cohort of HIV-infected men and women. Clinical Infectious Disease, 40, 1837–1845.CrossRef

11.

Wohl, D. A. (2004). Diagnosis and management of body morphology changes and lipid abnormalities associated with HIV Infection and its therapies. Topics in HIV Medicine, 12, 89–93.PubMed

12.

Dube, M. P., Stein, J. H., Aberg, J. A., et al. (2003). Guidelines for the evaluation and management of dyslipidemia in human immunodeficiency virus (HIV)-infected adults receiving antiretroviral therapy: Recommendations of the HIV Medicine Association of America and the Adult AIDS Clinical Trials Group. Clinical Infectious Disease, 37, 613–627.CrossRef

13.

Ciccolo, J. T., Jowers, E. M., & Bartholomew, J. B. (2004). The benefits of exercise training for quality of life in HIV/AIDS in the post-HAART era. Sports Medicine, 34, 487–499.PubMedCrossRef

14.

Stringer, W. W., Berezovskava, M., O’Brien WA, et al. (1998). The effects of exercise training on aerobic fitness, immune indices, and quality of life in HIV positive patients. Medicine and Science in Sports and Exercise, 30, 11–16.PubMed

15.

Bartholomew, J. B., & Miller, B. M. (2002). Affective responses to an aerobic dance class: the impact of perceived performance. Research Quarterly for Exercise and Sport, 73, 301–309.PubMed

16.

Burnham, T. R., & Wilcox, A. (2002). Effects of exercise on physiological and psychological variables in cancer survivors. Medicine and Science in Sports and Exercise, 34, 1863–1867.PubMedCrossRef

17.

Lichtenstein, K. A., Ward, D. J., & Moorman, A. C. (2001). Clinical assessment of HIV-associated lipodystrophy in an ambulatory population. AIDS, 15, 1389–1398.PubMedCrossRef

18.

Carr, A., Emery, S., Law, M., et al. (2003). An objective case definition of lipodystrophy in HIV-infected adults: A case-control study. Lancet, 361, 726–735.PubMedCrossRef

19.

Wilkinson, D. M., Fallowfield, J. L., & Myers, S. D. (1999). A modified incremental shuttle run test for the determination of peak shuttle running speed and the prediction of maximal oxygen uptake. Journal of Sports Sciences, 17, 413–419.PubMedCrossRef

20.

Flouris, A. D., Metsios, G. S., & Koutedakis, Y. (2005). Enhancing the efficacy of the 20 m Multi-stage run test. British Journal of Sports Medicine, 39, 166–170.PubMedCrossRef

21.

Hsiung, P., Fang, C., Chang, Y. Y., et al. (2005). Comparison of WHOQOL-BREF and SF-36 in patients with HIV infection. Quality of Life Research, 14, 141–150.PubMedCrossRef

22.

O’Connell, K., Saxena, S., Skevington, S., et al. (2004). WHOQOL-HIV Quality of Life assessment among people living with HIV and AIDS: results from the field test. AIDS Care, 16, 882–889.CrossRef

23.

Guaraldi, G., Orlando, G., Murri, R., et al. (2006). Quality of life and body image in the assessment of psychological impact of lipodystrophy: Validation of the Italian version of Assessment of Body Change and Distress questionnaire. Quality of Life Research, 15, 173–178.PubMedCrossRef

24.

Durnin, J. V. G. A., & Rahaman, M. M. (1967). The assessment of the amount of fat in the human body from measurements of skinfold thickness. The British Journal of Nutrition, 21, 681–689.PubMedCrossRef

25.

Durnin, J. V. G. A., & Womersley, J. (1974). Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16–72 years. The British Journal of Nutrition, 32, 77–97.PubMedCrossRef

26.

Zillikens, M. C., Conway, J. M. (1990). Anthropometry in blacks: Applicability of generalized skinfold equations and differences in fat patterning between blacks and whites. The American Journal of Clinical Nutrition, 52, 45–51.PubMed

27.

Mutimura, E., Stewart, A., Rheeder, P., et al. (2007). Metabolic function and the prevalence of lipodystrophy in a population of HIV-infected African subjects receiving highly active antiretroviral therapy (HAART). Journal of Acquired Immune Deficiency Syndromes, 46, 451–455.PubMedCrossRef

28.

Liu, C., Ostrow, D., Detels, R., et al. (2006). Impacts of HIV infection and HAART use on quality of life. Quality of Life Research, 15, 941–949.PubMedCrossRef

29.

Holmes, W. C., & Shea, J. A. (1997). Performance of a new HIV/AIDS-targeted quality of life (HAT-QoL) instrument in asymptomatic seropositive individuals. Quality of Life Research, 6, 561–571.PubMedCrossRef

30.

Smith, K. W., Avis, N. E., Mayer, K. H., & Awislow, L. (1997). Use of the MQoL-HIV with asymptomatic HIV-positive patients. Quality of Life Research, 6, 555–560.PubMedCrossRef

31.

Kuyken, W., Orley, J., Sartorius, N., Power, M., Herrman, H., Schofield, H., WHO Group. (1995). The World Health Organisation Quality of life Assessment (WHOQOL): Position paper from the World Health Organisation. Social Science and Medicine, 41, 1403–1409.

32.

Galantino, M. L., Shepard, K., Krafft, L., et al. (2005). The effect of group aerobic exercise and t’ai chi on functional outcomes and quality of life for persons living with acquired immunodeficiency syndrome. Journal of Alternative and Complementary Medicine, 11, 1085–1092.CrossRef

33.

Burgoyne, R., & Renwick, R. (2004). Social support and quality of life over time among adults living with HIV in the HAART era. Social Science and Medicine, 58, 1353–1366.PubMedCrossRef

34.

Preau, M., Leport, C., Salmon-Ceron, D., et al. (2004). Health-related quality of life and patient-provider relationships in HIV-infected patients during the first three years after starting PI-containing antiretroviral treatment. AIDS Care, 16, 649–661.PubMedCrossRef

35.

Fillipas, S., Oldmeadow, L. B., Bailey, M. J., et al. (2006). A six-month, supervised, aerobic and resistance exercise program improves self-efficacy in people with human immunodeficiency virus: A randomized controlled trial. The Australian Journal of Physiotherapy, 52, 185–190.PubMed

36.

Scevola, D., Di Matteo, A., Lanzarini, P., et al. (2003). Effect of exercise and strength training on cardiovascular status in HIV-infected patients receiving highly active antiretroviral therapy. AIDS, 17, 123–129.CrossRef

37.

Korzeniowska-Kubacka, I., Bilińska, M., & Piotrowicz, R. (2007). Influence of physical training on cardiac performance in patients with coronary artery disease and exercise-induced left ventricular dysfunction. Acta Cardiologica, 62, 573–578.PubMed

38.

O’Connor, P. J., & Puetz, T. W. (2005). Chronic physical activity and feelings of energy and fatigue. Medicine and Science in Sports and Exercise, 37, 299–305.PubMedCrossRef

39.

Nicholas, P. K., Kirksey, K. M., Corless, I. B., et al. (2005). Lipodystrophy and quality of life in HIV: Symptom management issues. Applied Nursing Research, 18, 55–58.PubMedCrossRef

40.

Galli, M., Veglia, F., Angarano, G., et al. (2003). Gender differences in antiretroviral drug-related adipose tissue alterations. Women are at higher risk than men to develop particular lipodystrophy patterns. Journal of Acquired Immune Deficiency Syndromes, 34, 58–61.PubMedCrossRef

41.

Kayirangwa, E., Hanson, J., Munyakazi, L., et al. (2006). Current trends in Rwanda’s HIV/AIDS epidemic. Sexually Transmitted Infections, 82, 27–31.CrossRef

42.

Corless, I. B., Kirksey, K. M., Kemppainen, J., et al. (2005). Lipodystrophy-associated symptoms and medication Adherence in HIV/AIDS. AIDS Patient Care and STDs, 19, 577–586.PubMedCrossRef

43.

Connors, J., & Casey, P. (2006). Sex, body-esteem and self-esteem. Psychological Reports, 98, 699–704.PubMedCrossRef

44.

Jones, S. P., Doran, D., Leatt, P. B., et al. (2001). Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy. AIDS, 15, 2049–2051.PubMedCrossRef

45.

Fitch, K., Anderson, E. J., Hubbard, J. L., et al. (2006). Effects of a lifestyle modification program in HIV-infected patients with metabolic syndrome. AIDS, 20, 1843–1850.PubMedCrossRef

46.

Dolan, S. E., Frontera, W., Librizzi, J., et al. (2006). Effects of a supervised home-based aerobic and progressed resistance regimen in women infected with human immunodeficiency virus. Archives of Internal Medicine, 166, 1225–1231.PubMedCrossRef

Titel: The effects of exercise training on quality of life in HAART-treated HIV-positive Rwandan subjects with body fat redistribution
Auteurs: Eugene Mutimura
Aimee Stewart
Nigel J. Crowther
Kevin E. Yarasheski
W. Todd Cade
Publicatiedatum: 01-04-2008
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 3/2008
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-008-9319-4

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Abstract

Objective

Methods

Results

Conclusions

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