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Measuring health-related quality of life in bipolar disorder: Relationship of the EuroQol (EQ-5D) to condition-specific measures

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Abstract

Generic utility measures of health-related quality of life provide an independent net valuation of health states. They are increasingly used with condition-specific outcome measures in assessing treatments. In Bipolar Disorder, a few studies indicate poorer quality of life for depressed vs. euthymic patients. A single study suggests mania is less negative than depression. This analysis examines the relationship of one such scale, the EuroQol (EQ-5D), to objective and subjective measures of depression and mania in 221 Bipolar subjects, recently or still in an episode of illness. Results: Depressed patients showed a very poor quality of life (median EQ-5D Index score 0.41). Index and Visual Analogue scores improved significantly as level of depression decreased (Jonckheere–Terpstra test p<0.001). Both scores were significantly negatively related to all depression measures. Patients reported problems across all areas of life covered by the EQ-5D. No such relationships were observed between EQ-5D scores and mania measures, though all mania measures were inter-related. However, the range of mania shown was quite restricted. Conclusions: The EQ-5D is a useful measure of quality of life for Bipolar patients suffering from depression. Conclusions about the role of the EQ-5D in mania are restricted by the limited range of mania observed.

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Abbreviations

ASRM:

Altman Self Rating scale for Mania

BDI:

Beck Depression Inventory

BRMS:

Bech-Rafaelsen Mania Rating Scale – Modified version

EQ-5D:

EuroQol

HRSD:

Hamilton Rating Scale for Depression

HUI:

Health Utilities Index

LIFE:

Longitudinal Interval Follow-up Evaluation

MID:

Minimally important difference

SAS:

Social Adjustment Scale

SF-20:

20-item version of Medical Outcomes Study Short Form-36

SF-36:

Medical Outcomes Study Short Form-36

VAS:

EQ-5D Visual Analogue Scale Score

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Authors and Affiliations

  1. Department of Psychiatry, Cambridge University, Box 189, Addenbrookes Hospital, Cambridge, CB2 2QQ, UK

    Hazel Hayhurst & Rosemary Abbott

  2. Centre for Health Economics, University of York, Alcuin Block ‘A’, Heslington, York, YO10 5DD, UK

    Stephen Palmer

  3. Medical Research Council Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK

    Tony Johnson

  4. Department of Psychological Medicine, Institute of Psychiatry, PO Box 96, De Crespigny Park, London, SE5 8AF, UK

    Jan Scott

Authors
  1. Hazel Hayhurst
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  2. Stephen Palmer
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  3. Rosemary Abbott
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  4. Tony Johnson
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  5. Jan Scott
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Correspondence to Hazel Hayhurst.

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Hayhurst, H., Palmer, S., Abbott, R. et al. Measuring health-related quality of life in bipolar disorder: Relationship of the EuroQol (EQ-5D) to condition-specific measures. Qual Life Res 15, 1271–1280 (2006). https://doi.org/10.1007/s11136-006-0059-z

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