Skip to main content

Advertisement

Log in

Psychosocial Functioning and Depressive Symptoms Among HIV-Positive Persons Receiving Care and Treatment in Kenya, Namibia, and Tanzania

  • Published:
Prevention Science Aims and scope Submit manuscript

Abstract

In sub-Saharan Africa, the prevalence of depressive symptoms among people living with HIV (PLHIV) is considerably greater than that among members of the general population. It is particularly important to treat depressive symptoms among PLHIV because they have been associated with poorer HIV care-related outcomes. This study describes overall psychosocial functioning and factors associated with depressive symptoms among PLHIV attending HIV care and treatment clinics in Kenya, Namibia, and Tanzania. Eighteen HIV care and treatment clinics (six per country) enrolled approximately 200 HIV-positive patients (for a total of 3,538 participants) and collected data on patients’ physical and mental well-being, medical/health status, and psychosocial functioning. Although the majority of participants did not report clinically significant depressive symptoms (72 %), 28 % reported mild to severe depressive symptoms, with 12 % reporting severe depressive symptoms. Regression models indicated that greater levels of depressive symptoms were associated with: (1) being female, (2) younger age, (3) not being completely adherent to HIV medications, (4) likely dependence on alcohol, (5) disclosure to three or more people (versus one person), (6) experiences of recent violence, (7) less social support, and (8) poorer physical functioning. Participants from Kenya and Namibia reported greater depressive symptoms than those from Tanzania. Approximately 28 % of PLHIV reported clinically significant depressive symptoms. The scale-up of care and treatment services in sub-Saharan Africa provides an opportunity to address psychosocial and mental health needs for PLHIV as part of comprehensive care.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ammassari, A., Trotta, M. P., Murri, R., Castelli, F., Narciso, P., Noto, P., et al. (2002). Correlates and predictors of adherence to highly active antiretroviral therapy: Overview of published literature. Journal of Acquired Immune Deficiency Syndromes, 31, S123–S127. doi:10.1097/00126334-200212153-00007.

    Article  PubMed  Google Scholar 

  • Antelman, G., Kaaya, S., Wei, R., Mbwambo, J., Msamanga, G. I., Fawzi, W. W., et al. (2007). Depressive symptoms increase risk of HIV disease progression and mortality among women in Tanzania. Journal of Acquired Immune Deficiency Syndromes, 44, 470–477. doi:10.1097/QAI.0b013e31802f1318.

    Article  PubMed  Google Scholar 

  • Babor, T. F., Higgins-Biddle, J. C., Saunders, J. B., & Monteiro, M. G. (2001). The Alcohol Use Disorders Identification Test: Guidelines for use in primary care. Geneva: World Health Organization.

    Google Scholar 

  • Bennett-Murphy, L., Koranyi, K., Crim, L., & Whited, S. (1999). Disclosure, stress and psychological adjustment among mothers affected by HIV. AIDS Patient Care and STDs, 13, 111–119.

    Article  Google Scholar 

  • Brandt, R. (2009). Putting mental health on the agenda for HIV + women: A review of evidence from Sub-Saharan Africa. Women and Health, 49, 215–228. doi:10.1080/03630240902915044.

    Article  PubMed  Google Scholar 

  • Breur, E., Myer, L., Struthers, H., & Joska, J. A. (2011). HIV/AIDS and mental health research in sub-Saharan Africa: A systematic review. African Journal of AIDS Research, 10, 101–122. doi:10.2989/16085906.2011.593373.

    Article  Google Scholar 

  • Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., & Zwickl, B. (2000). Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG adherence instruments. AIDS Care: Psychological and Socio-medical Aspects of HIV/AIDS, 12, 255–266. doi:10.1080/09540120050042891.

    Article  CAS  Google Scholar 

  • Collins, P. Y., Holman, A. R., Freeman, M. C., & Patel, V. (2006). What is the relevance of mental health to HIV/AIDS care and treatment programs in developing countries? A systematic review. AIDS, 20, 1571–1582. doi:10.1097/01.aids.0000238402.70379.d4.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ensel, W. (1986). Measuring depression: The CES-D scale. In N. Lin, A. Dean, & W. M. Ensel (Eds.), Social support, life events, and depression. New York: Academic Press.

    Google Scholar 

  • Farley, J., Miller, E., Zamani, A., Tepper, V., Morris, C., Oyegunle, M., et al. (2010). Screening for hazardous alcohol use and depressive symptomatology among HIV-infected patients in Nigeria: Prevalence, predictors, and association with adherence. Journal of the International Association of Physicians in AIDS Care, 9, 218–226. doi:10.1177/1545109710371133.

    Article  PubMed Central  PubMed  Google Scholar 

  • Freeman, M., Nkomo, N., Kafaar, Z., & Kelly, K. (2007). Factors associated with prevalence of mental disorder in people living with HIV/AIDS in South Africa. AIDS Care, 19, 1201–1209. doi:10.1080/09540120701426482.

    Article  CAS  PubMed  Google Scholar 

  • Freeman, M. C., Patel, V., & Collins, P. Y. (2005). Integrating mental health in global initiatives for HIV/AIDS. British Journal of Psychiatry, 187, 1–3. doi:10.1192/bjp.187.1.1.

    Article  PubMed  Google Scholar 

  • Gonzalez, J. S., Batchelder, A. W., Psaros, C., & Safren, S. A. (2011). Depression and HIV/AIDS treatment nonadherence: A review and meta-analysis. Journal of Acquired Immune Deficiency Syndromes, 58, 181–187. doi:10.1097/QAI.0b013e31822d490a.

    PubMed  Google Scholar 

  • Greeff, M., Phetlhu, R., Makoae, L. N., Dlamini, P. S., Holzemer, W. L., Naidoo, J. R., et al. (2008). Disclosure of HIV status: Experiences and perceptions of persons living with HIV/AIDS and nurses involved in their care in Africa. Qualitative Health Research, 18, 311–324. doi:10.1177/1049732307311118.

    Article  PubMed  Google Scholar 

  • Green, G., & Smith, R. (2004). The psychosocial and healthcare needs of HIV-positive people in the UK: A review. HIV Medicine, 5, 5–46.

    PubMed  Google Scholar 

  • Gureje, O., Uwakweb, R., Oladejic, B., Makanjuolac, V. O., & Esan, O. (2010). Depression in adult Nigerians: Results from the Nigerian Survey of Mental Health and Well-being. Journal of Affective Disorders, 120, 158–164. doi:10.1016/j.jad.2009.04.030.

    Article  PubMed  Google Scholar 

  • Ickovics, J. R., Hamburger, M. E., Vlahov, D., Schoenbaum, E. E., Schuman, P., Boland, R. J., et al. (2001). Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: Longitudinal analysis from the HIV Epidemiology Research Study. Journal of the American Medical Association, 285, 1466–1474. doi:10.1001/jama.285.11.1466.

    Article  CAS  PubMed  Google Scholar 

  • Jenkins, R., Baingana, F., Belkin, G., Borowitz, M., Daly, A., Francis, P., et al. (2010). Mental health and the development agenda in Sub-Saharan Africa. Psychiatric Services, 61, 229–234. doi:10.1176/appi.ps.61.3.229.

    Article  PubMed  Google Scholar 

  • Johnson, J. A., Lee, A., Vinson, D., & Seale, J. P. (2013). Use of AUDIT-based measures to identify unhealthy alcohol use and alcohol dependence in primary care: A validation study. Alcoholism-Clinical and Experimental Research, 37, E253–E259. doi:10.1111/j.1530-0277.2012.01898.x.

    Article  Google Scholar 

  • Kaharazu, F. M., Bunnell, R., Moss, S., Purcell, D. W., Bikaakp-Kajura, W., Wamai, N., et al. (2006). Depression and CD4 cell count among persons with HIV infection in Uganda. AIDS and Behavior, 10, S105–S111. doi:10.1007/s10461-006-9142-2.

    Article  Google Scholar 

  • Kalichman, S. C., Simbayi, L. C., Jooste, S., Cain, D., & Cherry, C. (2006). Sensation seeking, alcohol use, and sexual behaviors among sexually transmitted infection clinic patients in Cape Town, South Africa. Psychology of Addictive Behaviors, 20, 298–304. doi:10.1037/0893-164x.20.3.298.

    Article  PubMed  Google Scholar 

  • Kidder, D. P., Bachanas, P., Medley, A. M., Pals, S., Nuwagaba-Biribonwhoa, H., Ackers, M., et al.(2013). HIV prevention with people living with HIV/AIDS: Baseline sample of an intervention evaluation for HIV care and treatment settings. PLoS ONE, 8, e57215. doi:10.1371/journal.pone.0057215.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kinyanda, E., Woodburn, P., Tugumisirize, J., Kagugube, J., Ndyanabangi, S., & Patel, V. (2011). Poverty, life events and the risk for depression in Uganda. Social Psychiatry and Psychiatric Epidemiology, 46, 35–44. doi:10.1007/s00127-009-0164-8.

    Article  PubMed Central  PubMed  Google Scholar 

  • Lawler, K., Mosepele, M., Seloilwe, E., Ratcliffe, S., Steele, K., Nthobatsang, R., et al. (2011). Depression among HIV-positive individuals in Botswana: A behavioral surveillance. AIDS and Behavior, 15, 204–208. doi:10.1007/s10461-009-9622-2.

    Article  PubMed  Google Scholar 

  • Leserman, J. (2008). Role of depression, stress, and trauma in HIV disease progression. Psychosomatic Medicine, 70, 539–545. doi:10.1097/PSY.0b013e3181777a5f.

    Article  PubMed  Google Scholar 

  • Longmire-Avital, B., Holder, C. A., Golub, S. A., & Parsons, J. T. (2012). Risk factors for drinking among HIV-positive African American adults: The depression–gender interaction. American Journal of Drug and Alcohol Abuse, 38, 260–266. doi:10.3109/00952990.2011.653425.

    Article  PubMed Central  PubMed  Google Scholar 

  • Luchters, S., Geibel, S., Syengo, M., Lango, D., Kingóla, N., Temmerman, M., et al. (2011). Use of AUDIT and measures of drinking frequency and patterns to detect associations between alcohol and sexual behavior in male sex workers in Kenya. BMC Public Health, 11, 384–392. doi:10.1186/1471-2458-11-384.

    Article  PubMed Central  PubMed  Google Scholar 

  • Makoae, L. N., Seboni, N. M., Molosiwa, K., Moleko, M., Human, S., Sukati, N. A., et al. (2005). The symptom experience of people living with HIV/AIDS in Southern Africa. Journal of the Association of Nurses in AIDS Care, 16, 22–32. doi:10.1016/j.jana.2005.03.005.

    Article  PubMed  Google Scholar 

  • Maman, S., Mbwambo, J. K., Hogan, N. M., Kilonzo, G. P., Campbell, J. C., Weiss, E., et al. (2002). HIV-positive women report more lifetime partner violence: Findings from a voluntary counseling and testing clinic in Dar es Salaam, Tanzania. American Journal of Public Health, 92, 1331–1337. doi:10.2105/AJPH.92.8.1331.

    Article  PubMed Central  PubMed  Google Scholar 

  • Martinez, P., Andia, I., Emenyonu, N., Hahn, J. A., Hauff, E., Pepper, L., et al. (2008). Alcohol use, depressive symptoms and the receipt of antiretroviral therapy in southwest Uganda. AIDS and Behavior, 12, 602–612. doi:10.1007/s10461-007-9312-x.

    Article  Google Scholar 

  • Marwick, K. F. M., & Kaaya, S. F. (2010). Prevalence of depression and anxiety disorders in HIV-positive outpatients in rural Tanzania. AIDS Care, 22, 415–419. doi:10.1080/09540120903253981.

    Article  PubMed  Google Scholar 

  • McInerney, P. A., Neama, B. P., Wantland, D., Bhengu, B. R., McGibbon, C., Davis, S. M., et al. (2008). Quality of life and physical functioning in HIV-infected individuals receiving antiretroviral therapy in KwaZulu-Natal, South Africa. Nursing and Health Sciences, 10, 266–272. doi:10.1111/j.1442-2018.2008.00410.x.

    Article  PubMed  Google Scholar 

  • Meyer, J. P., Springer, S. A., & Altice, F. L. (2011). Substance abuse, violence, and HIV in women: A literature review of the syndemic. Journal of Women's Health, 20, 991–1006. doi:10.1089/jwh.2010.2328.

    Article  PubMed Central  PubMed  Google Scholar 

  • Monahan, P. O., Shacham, E., Reece, M., Kroenke, K., Ongór, W. O., Omollo, O., et al. (2008). Validity/reliability of PHQ-9 and PHQ-2 depression scales among adults living with HIV/AIDS in Western Kenya. Journal of General Internal Medicine, 24, 189–197. doi:10.1007/s11606-008-0846-z.

    Article  PubMed Central  PubMed  Google Scholar 

  • Myer, L., Smit, J., Liezel, L. R., Parker, S., Sein, D. J., & Seedat, S. (2008). Common mental disorders among HIV-infected individuals in South Africa: Prevalence, predictors, and validation of brief psychiatric rating scales. AIDS Patient Care and STDs, 22, 147–158. doi:10.1089/apc.2007.0102.

    Article  PubMed  Google Scholar 

  • Nakasujja, N., Skolasky, R. L., Musisi, S., Allebeck, P., Robertson, K., Ronald, A., et al. (2010). Depression symptoms and cognitive function among individuals with advanced HIV infection initiating HAART in Uganda. BMC Psychiatry, 10, 44. doi:10.1186/1471-244X-10-44.

    Article  PubMed Central  PubMed  Google Scholar 

  • Nakimuli-Mpungu, E., Bass, J. K., Alexandre, P., Mills, E. J., Musisi, S., Ram, M., et al. (2012). Depression, alcohol use and adherence to antiretroviral therapy in Sub-Saharan Africa: A systematic review. AIDS and Behavior, 16, 2101–2118. doi:10.1007/s10461-011-0087-8.

    Article  PubMed  Google Scholar 

  • National AIDS Control Council, & National AIDS and STI Control Programme. (2012). The Kenya AIDS epidemic: 2011 update. from http://www.unaids.org/en/dataanalysis/knowyourresponse/countryprogressreports/2012countries/ce_KE_Narrative_Report.pdf. Accessed 15 Mar 2013.

  • Nduna, M., Jewkes, R. K., Dunkle, K. L., Shai, N. P., & Colman, I. (2010). Associations between depressive symptoms, sexual behaviour and relationship characteristics: A prospective cohort study of young women and men in the Eastern Cape, South Africa. Journal of the International AIDS Society, 13, 44–51. doi:10.1186/1758-2652-13-44.

    Article  PubMed Central  PubMed  Google Scholar 

  • Peltzer, K., & Ramlagan, S. (2009). Alcohol use trends in South Africa. Journal of Social Sciences, 18, 1–12.

    Google Scholar 

  • Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385–401. doi:10.1177/014662167700100306.

    Article  Google Scholar 

  • Ramadhani, H. O., Thielman, N. M., Landman, K. Z., Ndosi, E. M., Gao, F., Kirchherr, J. L., et al. (2007). Predictors of incomplete adherence, virologic failure, and antiviral drug resistance among HIV-infected adults receiving antiretroviral therapy in Tanzania. Clinical Infectious Diseases, 45, 1492–1498. doi:10.1086/522991.

    Article  PubMed  Google Scholar 

  • Reinert, D. F., & Allen, J. P. (2007). The Alcohol Use Disorders Identification Test: An update of research findings. Alcoholism: Clinical and Experimental Research, 31, 185–199. doi:10.1111/j.1530-0277.2006.00295.x.

    Article  Google Scholar 

  • Remien, R. H., & Mellins, C. A. (2007). Long-term psychosocial challenges for people living with HIV: Let's not forget the individual in our global response to the pandemic. AIDS, 21, S55–S63.

    Article  PubMed  Google Scholar 

  • Republic of Namibia Ministry of Health and Social Services (MOHSS). (2012). Global AIDS response progress reporting 2012: monitoring the 2011 political declaration on HIV/AIDS. from http://www.unaids.org/en/dataanalysis/knowyourresponse/countryprogressreports/2012countries/ce_NA_Narrative_Report[1].pdf. Accessed 15 Mar 2013.

  • Reynolds, N. R., Sun, J., Nagaraja, H. N., Gifford, A. L., Wu, A. W., & Chesney, M. A. (2007). Optimizing measurement of self-reported adherence with the ACTG Adherence Questionnaire: A cross-protocol analysis. Journal of Acquired Immune Deficiency Syndromes, 46, 402–409.

    Article  PubMed  Google Scholar 

  • Roberts, B., Browne, J., Ocaka, K. F., Oyok, T., & Sondorp, E. (2008). The reliability and validity of the SF-8 with a conflict-affected population in northern Uganda. Health and Quality of Life Outcomes, 6, 108. doi:10.1186/1477-7525-6-108.

    Article  PubMed Central  PubMed  Google Scholar 

  • Roberts, B., Damundu, E. Y., Lomoro, O., & Sondorp, E. (2010). The influence of demographic characteristics, living conditions, and trauma exposure on the overall health of a conflict-affected population in Southern Sudan. BMC Public Health, 10, 518. doi:10.1186/1471-2458-10-518.

    Article  PubMed Central  PubMed  Google Scholar 

  • SAS Institute Inc. (2008). SAS/STAT Software for PC (version 9.2). Cary: SAS Institute.

    Google Scholar 

  • Siziya, S., & Fylkesnes, K. (2005). Impact of HIV infection on self-rated health in a high-prevalence population with low awareness of own HIV status. Norsk Epidemiologi, 15, 165–173.

    Google Scholar 

  • Stirratt, M. J., Remien, R. H., Smith, A., Copeland, O. Q., Dolezal, C., Krieger, D., et al. (2006). The role of HIV serostatus disclosure in antiretroviral medication adherence. AIDS and Behavior, 10, 483–493. doi:10.1007/s10461-006-9106-6.

    Article  PubMed  Google Scholar 

  • Tanzania Commission for AIDS, National Bureau of Statistics, Office of the Chief Government Statistician, & Macro Internation, Inc. (2008). Tanzania HIV/AIDS and malaria indicator survey 2007–08. from http://www.tacaids.go.tz/dmdocuments/THMIS%202007-08.pdf. Accessed 15 Mar 2013.

  • Tanzania Commission for AIDS, & Zanzibar AIDS Commission. (2012). The United Republic of Tanzania: Country Progress Reporting. from http://www.unaids.org/en/dataanalysis/knowyourresponse/countryprogressreports/2012countries/ce_TZ_Narrative_Report[1].pdf. Accessed 15 Mar 2013.

  • Turner-Bowker, D. M., Bayliss, M. S., Ware, J. E., & Kosinski, M. (2003). Usefulness of the SF-8 Health Survey for comparing the impact of migraine and other conditions. Quality of Life Research, 12, 1003–1012.

    Article  PubMed  Google Scholar 

  • UN Joint Programme on HIV/AIDS (UNAIDS). (2010a). Fact sheet: Sub-Saharan Africa Retrieved July 22, 2011, from http://www.unaids.org/en/media/unaids/contentassets/documents/factsheet/2010/20101123_FS_SSA_em_en.pdf.

  • UN Joint Programme on HIV/AIDS (UNAIDS). (2010b). UNAIDS Report on the Global AIDS Epidemic Retrieved May 5, 2011, from http://www.unaids.org/globalreport/Global_report.htm.

  • Ware, J. E., Kosinski, M., Dewey, J. E., & Gandek, B. (2001). How to score and interpret single-item health status measures: A manual for users of the SF-8 health survey. Lincoln: Quality Metric Incorporated.

    Google Scholar 

  • Wong, F. Y., Huang, Z. J., DiGangi, J. A., Thompson, E. E., & Smith, B. D. (2008). Gender differences in intimate partner violence on substance abuse, sexual risks, and depression among a sample of South Africans in Cape Town, South Africa. AIDS Education and Prevention, 20, 56–64. doi:10.1521/aeap.2008.20.1.56.

    Article  PubMed  Google Scholar 

  • Wouters, E., van Loon, F., van Rensburg, D., & Meulemans, H. (2009). Community support and disclosure of HIV serostatus to family members by public-sector antiretroviral treatment patients in the free state province of South Africa. AIDS Patient Care and STDs, 23, 357–364. doi:10.1089/apc.2008.0201.

    Article  PubMed  Google Scholar 

  • Zachariah, R., Ford, N., Philips, M., Lynch, S., Massaquoi, M., Janssens, V., et al. (2009). Task shifting in HIV/AIDS: Opportunities, challenges and proposed actions for sub-Saharan Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103, 549–558. doi:10.1016/j.trstmh.2008.09.019.

    Article  CAS  PubMed  Google Scholar 

  • Zetola, N. M., Modongo, C., Kip, E. C., Gross, R., Bisson, G. P., & Collman, R. G. (2012). Alcohol use and abuse among patients with multi-drug resistant tuberculosis in Botswana. International Journal of Tuberculosis and Lung Disease, 16, 1529–1534.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Zich, J. M., Attkisson, C. C., & Greenfield, T. K. (1990). Screening for depression in primary care clinics: the CES-D and the BDI. International Journal of Psychiatry in Medicine, 20, 259–277. doi:10.2190/LYKR-7VHP-YJEM-MKM2.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors would like to express their gratitude to the study interviewers, program coordinators, and data management staff in the three countries without whom this study could not have been completed. The authors would also like to thank the Ministries of Health in Kenya, Tanzania, and Namibia, as well as ICAP and CDC staff in these three countries for all the support they provided to this project. Finally, the authors would like to thank all of the health care providers, lay counselors, and clinic patients that participated in this study for their willingness to share their experiences with us. This research has been supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) through CDC.

Disclaimer

The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Puja Seth.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seth, P., Kidder, D., Pals, S. et al. Psychosocial Functioning and Depressive Symptoms Among HIV-Positive Persons Receiving Care and Treatment in Kenya, Namibia, and Tanzania. Prev Sci 15, 318–328 (2014). https://doi.org/10.1007/s11121-013-0420-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11121-013-0420-8

Keywords

Navigation