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Post-traumatic stress disorders in patients with low-grade glioma and its association with survival

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Abstract

Purpose

The primary objective of this study was to investigate the incidence of PTSD at 3 months postoperatively in patients who were newly diagnosed with LGGs, and its association with 5-year survival. Moreover, QoL and other psychiatric disorders like depression and anxiety were also evaluated.

Methods

From February 2011 to April 2013, patients who underwent low-grade glioma surgery at our hospital and come back for reexamination at 3-month follow-up were considered for this study. Interviews, HADS-A, HADS-D, and SF-36 scales were used for evaluating PTSD, anxiety, depression, and quality of life. Participants were asked to complete these assessments at 3 months after surgery. Followed-ups on survival status were made for 5 years.

Results

A total of 219 subjects comprising 83 women and 136 men with a mean age of 41.5 years were included in this study. At 3 months after surgery, 35 (16%) patients were diagnosed with PTSD. Younger age (OR = 2.23, [95% CI 1.02–4.84], P = 0.04) and frontal lobe involvement of tumor (OR = 2.57, [95% CI 1.06–6.23], P = 0.04) predicted PTSD. Patients with PTSD had higher anxiety and depression level, and had worse QoL in all eight dimensions of SF-36. Kaplan–Meier analyses demonstrated that diagnosis of PTSD was associated with shorter overall survival in LGG patients (Log-rank = 7.45, P = 0.01). After adjusting for other variables, PTSD remained associated with elevated 5-year overall mortality risk of LGG patients (HR = 2.98 [95% CI 1.10–8.05], P = 0.03).

Conclusions

The results showed that newly diagnosed LGG patients suffering from PTSD at 3 months after surgery had lower rates of 5-year survival. In clinical practice, psychological evaluation is suggested for LGG patients and proper psychotherapy should be considered for those with PTSD.

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Authors and Affiliations

  1. Department of Neurology, General Hospital of Southern Theatre Command, 111 Liuhua Road, Guangzhou, Guangdong Province, China

    Che Jiang & Jiajia Wang

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  1. Che Jiang
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  2. Jiajia Wang
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Correspondence to Che Jiang.

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Che Jiang and Jiajia Wang declared no conflict of interest. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Jiang, C., Wang, J. Post-traumatic stress disorders in patients with low-grade glioma and its association with survival. J Neurooncol 142, 385–392 (2019). https://doi.org/10.1007/s11060-019-03112-3

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  • DOI: https://doi.org/10.1007/s11060-019-03112-3

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