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Measuring clinical outcomes in neuro-oncology. A battery to evaluate low-grade gliomas (LGG)

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Abstract

We describe how a neuropsychological evaluation in patients with brain tumors should be performed, specifically in the case of low-grade gliomas. Neuropsychological examination is crucial before starting any treatment as well as during the follow-up, since it can improve neurosurgery techniques and reveal potential cognitive effects of chemotherapy and radiotherapy, besides planning rehabilitation. We underline that sensitive and wide-ranging tests are required; specific tasks based on the lesion site should be added. Moreover, some tests can provide additional information about the evolution of the tumor. A careful, thorough examination improves quality of life.

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References

  1. Bennett TL (2001) Neuropsychological evaluation in rehabilitation planning and evaluation of functional skills. Arch Clin Neuropsychol 16:237–253

    PubMed  CAS  Google Scholar 

  2. Meyers CA, Hess KR, Yung WKA, Levin VA (2000) Cognitive function as a predictor of survival in patients with recurrent malignant glioma. J Clin Oncol 18:646–650

    PubMed  CAS  Google Scholar 

  3. Lageman SK, Cerhan JH, Locke DEC, Anderson SK, Wu W, Brown PD (2010) Comparing neuropsychological tasks to optimize brief cognitive batteries for brain tumour clinical trials. J Neuro-Oncol 96:271–276

    Article  Google Scholar 

  4. Duffau H, Gatignol P, Moritz-Gasser S, Mandonnet E (2009) Is the left uncinate fasciculus essential for language? A cerebral stimulation study. J Neurol 256:382–389

    Article  PubMed  Google Scholar 

  5. Damasio H, Grabowsky TJ, Tranel D, Hichwa RD, Damasio AR (1996) A neural basis for lexical retrieval. Nature 380:499–505

    Article  PubMed  CAS  Google Scholar 

  6. Papagno C, Capitani E (1998) Proper name anomia: a case with sparing of the first letter knowledge. Neuropsychologia 36:669–679

    Article  PubMed  CAS  Google Scholar 

  7. Papagno C, Capitani E (2001) Slowly progressive aphasia: a four-year follow-up study. Neuropsychologia 39:678–686

    Article  PubMed  CAS  Google Scholar 

  8. Papagno C, Capasso R, Miceli G (2009) Reversed of concreteness effect for nouns in a subject with semantic dementia. Neuropsychologia 47:1138–1148

    Article  PubMed  Google Scholar 

  9. Papagno C, Miracapillo C, Casarotti A et al (2011) What is the role of the uncinate fasciculus? Surgical removal and proper name retrieval. Brain 134:405–414

    Article  PubMed  Google Scholar 

  10. Påhlson A, Ek L, Ahlström G, Smits A (2003) Pitfalls in the assessment of disability in individuals with low-grade gliomas. J Neuro-Oncol 65:149–158

    Article  Google Scholar 

  11. Tucha O, Steup A, Smely C, Lange KW (1976) Toe agnosia in Gerstmann syndrome. J Neurol Neurosurg Psychiatry 63:399–403

    Article  Google Scholar 

  12. Cohen D, Salanga VD, Hully W, Steinberg MC, Hardy RW (1997) Alexia without agraphia. Neurology 26:455–459

    Article  Google Scholar 

  13. Papagno C, Gallucci M, Casarotti A et al (2011) Connectivity constraints on cortical reorganization of neural circuits involved in object naming. Neuroimage 55:1306–1313

    Article  PubMed  Google Scholar 

  14. Armstrong CL, Goldstein B, Shera D, Ledakis GE, Tallent EM (2003) The predictive value of longitudinal neuropsychologic assessment in the early detection of brain tumor recurrence. Cancer 97:649–656

    Article  PubMed  Google Scholar 

  15. Capitani E (1997) Normative values and neuropsychological assessment. Common problems in clinical practice and research. Neuropsychol Rehabil 7:295–309

    Article  Google Scholar 

  16. Novelli G, Papagno C, Capitani E, Laiacona M, Vallar G, Cappa SF (1986) Tre test clinici di ricerca e produzione lessicale: taratura su soggetti normali. Arch Neurol Psicol Psichiatria 47:477–506

    Google Scholar 

  17. Rizzo S, Venneri A, Papagno C (2002) A normative study of a famous face recognition and naming test. Neurol Sci 23:153–159

    Article  PubMed  CAS  Google Scholar 

  18. Catricalà E, Ginex V, Della Rosa P, Cappa SF (2008) CaGi: a new battery to investigate semantic memory deficits. SIN, Napoli

  19. Parisi D, Pizzamiglio L (1970) Syntactic comprehension in aphasia. Cortex 6:204–215

    PubMed  CAS  Google Scholar 

  20. De Renzi E, Faglioni P (1978) Normative data and screening power of a shortened version of the token test. Cortex 14:41–49

    PubMed  Google Scholar 

  21. Miceli G, Capasso R, Laudanna A, Burani C (1994) Batteria per l’analisi dei deficit afasici. CEPSAG, Roma

    Google Scholar 

  22. Orsini A, Grossi D, Capitani E, Laiacona M, Papagno C, Vallar G (1987) Verbal and spatial immediate memory span: normative data from 1355 adults and 1112 children. Ital J Neurol Sci 8:539–548

    Article  PubMed  CAS  Google Scholar 

  23. Carlesimo GA, Caltagirone C, Gainotti G, Fadda L, Gallassi R, Lorusso S, Marfia G, Marra C, Nocentini U, Parnetti L (1996) The mental deterioration battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. Eur Neurol 36:378–384

    Article  PubMed  CAS  Google Scholar 

  24. Capitani E, Laiacona M, Ciceri E, Gruppo Italiano per lo Studio Neuropsicologico dell’Invecchiamento (1991) Sex differences in spatial memory: a reanalysis of block tapping long-term memory according to the short-term memory level. Ital J Neurol Sci 12:461–466

    Google Scholar 

  25. Caffarra P, Vezzadini G, Dieci F, Zonato F, Venneri A (2002) Rey–Osterrieth complex figure: normative values in an Italian population sample. Neurol Sci 22:443–447

    Article  PubMed  CAS  Google Scholar 

  26. Basso A, Capitani E, Laiacona M (1987) Raven’s coloured progressive matrices: normative values on 305 normal adults controls. Funct Neurol 2:189–194

    PubMed  CAS  Google Scholar 

  27. Spinnler H, Tognoni G (1987) Standardizzazione e taratura italiana di test neuropsicologici [Italian standardization of neuropsychological tests]. Ital J Neurol Sci Suppl 8:1–120

    Google Scholar 

  28. Laiacona M, Inzaghi MG, De Tanti A, Capitani E (2000) Wisconsin card sorting test: a new global score, with Italian norms, and its relationship with the Weigl sorting test. Neurol Sci 21:279–291

    Article  PubMed  CAS  Google Scholar 

  29. Caffarra P, Vezzadini G, Dieci F, Zonato A, Venneri A (2002) Una versione abbreviata del test di Stroop: dati normative nella popolazione italiana. Nuova Riv Neurol 12:111–115

    Google Scholar 

  30. Giovagnoli AR, Del Pesce M, Mascheroni S, Simoncelli M, Laiacona M, Capitani E (1996) Trail making test: normative values from 287 normal adult controls. Ital J Neurol Sci 17:305–309

    Article  PubMed  CAS  Google Scholar 

  31. De Renzi E, Motti F, Nichelli P (1980) Imitating gestures: a quantitative approach to ideomotor apraxia. Arch Neurol 37:6–10

    Article  PubMed  Google Scholar 

  32. Ronchi R, Posteraro L, Fortis P, Bricolo E, Vallar G (2009) Perseveration in left spatial neglect; drawing and cancellation tasks. Cortex 45:300–312

    Article  PubMed  Google Scholar 

  33. Bechara A, Damasio AR, Damasio H, Anderson S (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50:7–12

    Article  PubMed  CAS  Google Scholar 

  34. Ekman P (1999) Facial expressions. Wiley, Sussex

    Google Scholar 

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Correspondence to Costanza Papagno.

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Papagno, C., Casarotti, A., Comi, A. et al. Measuring clinical outcomes in neuro-oncology. A battery to evaluate low-grade gliomas (LGG). J Neurooncol 108, 269–275 (2012). https://doi.org/10.1007/s11060-012-0824-5

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  • DOI: https://doi.org/10.1007/s11060-012-0824-5

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