Abstract
To determine the relative validity of parent-assessed and self-assessed symptoms of Generalised Anxiety Disorder (GAD) in boys with an Autism Spectrum Disorder (ASD). 140 boys with an Autism Spectrum Disorder (ASD) were assessed for GAD by their parents and by themselves, and gave a sample of cortisol during the afternoon of these assessments. There were significant differences between self-assessments and parents’ assessments for the total GAD score and on four of the eight individual GAD symptoms. Using cortisol concentrations as a validation index, the two key GAD items were most validly assessed via boys’ self-ratings. Key GAD symptoms in boys with an ASD may be best assessed from their self-reports rather than by their parents’ reports. Implications for clinical practice are discussed.
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References
Achenbach, T., McConaughty, S., & Howell, C. (1987). Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. Psychological Bulletin, 101, 213–32.
APA. (2013). Diagnostic and Statistical Manual of Mental Disorders-5. Washington, DC: American Psychiatric Association.
Bender, R., & Lange, S. (2001). Adjusting for multiple testing—when and how? Journal of Clinical Epidemiology, 54, 343–9.
Bitsika, V., Sharpley, C., Andronicos, N., & Agnew, L. (2015). Hypothalamus-piutuitary-adrenal axis daily fluctuation, anxiety and age interact to rpedict cortisol concentrations in boys with an autism spectrum disorder. Physiology and Behavior, 138, 200–7.
Brosnan, M., Turner-Cobb, J., Munro-Naan, Z., & Jessop, D. (2009). Absence of a normal cortisol awakening response (CAR) in adolescent males with asperger syndrome (AS). Psychoneuroendocrinology, 34, 1095–100.
Chida, Y., & Steptoe, A. (2009). Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biological Psychology, 80(3), 265–78.
Corbett, B., Mendoza, S., Abdullah, M., Wegelin, J., & Levine, S. (2006). Cortisol circadian rhythms and response to stress in children with autism. Psychoneuroendocrinology, 31, 59–66.
Feise, R. (2002). Do multiple outcome measures require p-value adjustment? BMC Medical research Methodology. Epub 17 June 2002.
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009). The cortisol awakening response (CAR): facts and future directions. International Journal of Psychophysiology, 72, 67–73.
Gadow, K., & Sprafkin, J. (2010). Child and adolescent symptom inventory 4R: Screening and norms manual. Stony Brook: Checkmate Plus.
Gadow, K., Devincent, C., Pomeroy, J., & Azizian, A. (2005). Comparison of DSM-IV symptoms in elementary school-age children with PDD versus clinic and community samples. Autism, 9, 392–415.
Greaves-Lord, K., Ferdinand, R., Oldehinkel, A., Sondeijker, F., Ormel, J., & Verhulst, F. (2007). Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiatrica Scandinavia., 116, 137–44.
Insel T. Transforming diagnosis. (2013). USA: National Institute of Mental Health [cited 2013 May 27]; Post]. Available from: www.nimh.nih.gov/about/director/2013/transforming-diagnosis-shtml.
Kidd S, Corbett B, Granger D, Boyce W, Anders T, Tager I. (2012). Daytime secretion of salivary cortisol and alpha-amylase in preschool-aged children with autism and typically developing children. Journal of Autism and Developmental Disorders.;42:2648–58. Epub 04 April, 2012.
Kim, J., Szatmari, P., Bryson, S., Streiner, D., & Wilson, F. (2000). The prevalence of anxiety and mood problems among children with autism and aspergers syndrome. Autism, 4, 117–32.
Lanni, K., Schup, C., Simon, D., & Corbett, B. (2012). Verbal ability, social stress, and anxiety in children with an autistic disorder. Autism: the international journal of research and practice., 16, 123–8.
Lecavalier, L., Wood, J., Halliday, A., Jones, N., Aman, M., Cook, E., et al. (2014). Measuring anxiety as a treatment endpoint in youth with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44, 1128–43.
Marnovic-Curin, J., Marinovic-Terzic, I., Bujas-Petkovic, Z., Zekan, L., Skrabic, V., Dogas, Z., et al. (2008). Slower cortisol response during ACTH stimulation test in autistic children. European Child and Adolescent Psychiatry, 17, 39–43.
Matson, J., & Nebel-Schwalm, M. (2007). Comorbid psychopathology with autism spectrum disorder in children: an overview. Research in Developmental Disabilities, 28, 341–52.
Meyer, J., Mundy, P., Van Hecke, V., & Durocher, J. (2006). Social attribution processes and comorbid psychiatric symptoms in children with asperger syndrome. Autism, 10, 383–402.
Montgomery, E. (2008). Self- and parent assessment of mental health: disagreement on externalizing and internalizing behaviour in young refugees from the middle east. Clinical Child Psychology and Psychiatry, 13(1), 49–63.
Rothman, K. (1990). No adjustments are neede for multiple comparisons. Epidemiology, 1, 43–6.
Saklofske, D., Caravan, G., & Schwartz, C. (2000). Concurrent validity of the Wechsler abbreviated scale of intelligence (WASI) with a sample of Canadian children. Canadian Journal of School Psychology, 16, 87–94.
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000). How Do glucocorticoids influence stress responses? integrating permissive, supressive, stimulatory, and preparative actions. Endocrine Reviews, 21(1), 55–89.
Streiner, D., & Norman, G. (2011). Correction for multiple testing. Chest, 140, 16–8.
Taylor, J., & Corbett, B. (2014). A review of rhythm and responsiveness of cortisol in individuals with autism disorders. Psychoneuroendocrinology, 49, 207–28.
van Steensel, F., Bogels, S., & Perrin, S. (2011). Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis. Clinical Child and Family Psychology Review, 14, 302–17.
Vasa, R., Carroll, L., Nozzolillo, A., Mahajan, R., Mazurek, M., Bennett, A., et al. (2014). A systematic review of treatment for anxiety in youth with autism spectrum disorders. Journal of Autism and Developmental Disorders, 44, 3215–29.
Vreeberg, S., Zitman, F., Van Pelt, J., DeRijk, R., Verhagen, J., Van Dyck, R., et al. (2010). Salivary cortisol levels in persons with and without different anxiety disorders. Psychosomatic Medicine, 72, 340–7.
White, S. W., Oswald, D., Ollendick, T., & Scahill, L. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29(3), 216–29.
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Bitsika, V., Sharpley, C.F., Andronicos, N.M. et al. Agreement Between self- vs Parent-Ratings of General Anxiety Disorder Symptoms and Salivary Cortisol in boys with an ASD. J Dev Phys Disabil 27, 467–477 (2015). https://doi.org/10.1007/s10882-015-9431-7
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DOI: https://doi.org/10.1007/s10882-015-9431-7