Skip to main content

Advertisement

Log in

Stress-Induced Cardiomyopathy and Psychological Wellbeing 1 Year After an Acute Event

  • Published:
Journal of Clinical Psychology in Medical Settings Aims and scope Submit manuscript

Abstract

Stress cardiomyopathy (SCM) typically presents similar symptoms to acute myocardial infarction (AMI). However, these symptoms differ when it comes to a transient and completely reversible myocardial dysfunction, which is frequently precipitated by acute stressful events, occurring in the absence of plaque rupture and coronary thrombosis. The purpose of this study was to investigate health-related quality of life (HRQL) and emotional burden subsequent to cardiac events in SCM patients. Thirty-seven SCM patients were compared with 37 matched AMI patients. All selected patients were assessed for HRQL and psychological distress at baseline and 1-year after the acute event. After controlling for covariates, scores on the Psychological General Well Being Index indicated that depressed mood had increased in both groups, but the increase for SCM patients was greater than for AMI patients. The AMI group displayed greater decreases than the SCM in physical quality of life and in total cardiac-related health quality of life. The percentage of patients with psychological distress increased significantly more in the SCM group than in the AMI group, and it made no difference whether the triggering event was emotional or physical. Our results suggest that, despite the more favorable medical prognosis of SCM patients, their cardiac condition being transient and resolving completely in few weeks, the psychological impact associated with their condition is more negative 1 year later than in the case of AMI patients whose medical prognosis is less favorable, and this difference is independent of type of trigger event.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

Abbreviations

SCM:

Stress cardiomyopathy

AMI:

Acute myocardial infarction

PGWBI:

Psychological General Well Being Index

HRQL:

Health-related quality of life

References

  • Augustine, D. X., Domanski, A., & Garg, A. (2009). The stress of chest pain: A case of tako-tsubo cardiomyopathy. British Medical Journal Case Reports,. doi:10.1136/bcr.03.2009.1660.

    Google Scholar 

  • Baratta, S., Colorio, C., & Zimmermann-Tansella, C. (1985). Inter-rater reliability of the Italian version of the Paykel Scale of stressful life events. Journal of Affective Disorders, 8, 279–282.

    Article  CAS  PubMed  Google Scholar 

  • Barton, D. A., Dawood, T., Lambert, E. A., Esler, M. D., Haikerwal, D., Brenchley, C., … Lambert, G. W. (2007). Sympathetic activity in major depressive disorder: Identifying those at increased cardiac risk? Journal of hypertension, 25, 2117–2124.

    Google Scholar 

  • Brown, N., Melville, M., Gray, D., Young, T., Munro, J., Skene, A. M., … Hampton, J. R. (1999). Quality of life four years after acute myocardial infarction: Short form 36 scores compared with a normal population. Heart, 81, 352–358.

    Google Scholar 

  • Bybee, K. A., Kara, T., Prasad, A., Lerman, A., Barsness, G. W., Wright, R. S., … Rihal, C. S. (2004). Systematic review: Transient left ventricular apical ballooning: A syndrome that mimics ST-segment elevation myocardial infarction. Annals of Internal Medicine, 141, 858–865.

    Article  PubMed  Google Scholar 

  • Caliendo, M., & Kopeining, S. (2008). Some practical guidance for the implementation of propensity score matching. Journal of Economic Surveys, 22, 31–72.

    Article  Google Scholar 

  • Cevik, C., & Nugent, K. (2008). The role of cardiac autonomic control in the pathogenesis of tako-tsubo cardiomyopathy. American Heart Journal, 156, e31.

    Google Scholar 

  • Chatkoff, D. K., Maier, K. J., & Klein, C. (2010). Nonlinear associations between chronic stress and cardiovascular reactivity and recovery. International Journal of Psychophysiology, 77, 150–156.

    Article  PubMed  Google Scholar 

  • Citro, R., Rigo, F., Previtali, M., Ciampi, Q., Canterin, F. A., Provenza, G., … Bossone, E. (2012). Differences in clinical features and in-hospital outcomes of older adults with tako-tsubo cardiomyopathy. Journal of the American Geriatrics Society, 60, 93–98.

    Google Scholar 

  • Compare, A., Bigi, R., Orrego, P. S., Proietti, R., Grossi, E., & Steptoe, A. (2013). Type D personality is associated with the development of stress cardiomyopathy following emotional triggers. Annals of Behavioral Medicine, 45, 299–307.

    Article  PubMed  Google Scholar 

  • Compare, A., Proietti, R., Del Forno, D., Vitelli, A., Grieco, A., Maresca, L., … Giallauria, F. (2011). Vulnerable personality and takotsubo cardiomyopathy consequent to emotional stressful events: A clinical case report. Monaldi Archives for Chest Disease, 76, 99–103.

    PubMed  Google Scholar 

  • Costa, T. N., Cassaro Strunz, C. M., Nicolau, J. C., & Gutierrez, P. S. (2008). Comparison of MB fraction of creatine kinase mass and troponin I serum levels with necropsy findings in acute myocardial infarction. The American Journal of Cardiology, 101, 311–314.

    Article  CAS  PubMed  Google Scholar 

  • Cupples, M. E., Tully, M. A., Dempster, M., Corrigan, M., McCall, D. O., & Downey, B. (2010). Cardiac rehabilitation uptake following myocardial infarction: Cross-sectional study in primary care. British Journal of General Practice, 60, 431–435.

    Article  PubMed  Google Scholar 

  • D’Agostino, R. B. (1998). Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Statistics in Medicine, 17, 2265–2281.

    Article  PubMed  Google Scholar 

  • Del Pace, S., Parodi, G., Bellandi, B., Zampini, L., Venditti, F., Ardito, M., … Gensini, G. F. (2011). Anxiety trait in patients with stress-induced cardiomyopathy: A case–control study. Clinical Research in Cardiology, 100, 523–529.

    Article  PubMed  Google Scholar 

  • Desideri, A., Fioretti, P. M., Cortigiani, L., Gregori, D., Coletta, C., Vigna, C., … Picano, E. (2003). Cost of strategies after myocardial infarction (COSTAMI): A multicentre, international, randomized trial for cost-effective discharge after uncomplicated myocardial infarction. European Heart Journal, 24, 1630–1639.

    Article  PubMed  Google Scholar 

  • Dupuy, H. J. (1984). The Psychological General Well-being (PGWB) Index. In N. K. Wenger, M. E. Mattson, C. F. Furberg, & J. Elinson (Eds.), Assessment of quality of life in clinical trials of cardiovascular therapies (pp. 170–183). New York: Le Jacq Publishing Inc.

    Google Scholar 

  • Eitel, I., von Knobelsdorff-Brenkenhoff, F., Bernhardt, P., Carbone, I., Muellerleile, K., Aldrovandi, A., … Friedrich, M. G. (2011). Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy. JAMA, 306, 277–286.

    CAS  PubMed  Google Scholar 

  • Elesber, A. A., Prasad, A., Lennon, R. J., Wright, R. S., Lerman, A., & Rihal, C. S. (2007). Four-year recurrence rate and prognosis of the apical ballooning syndrome. Journal of the American College of Cardiology, 50, 448–452.

    Article  PubMed  Google Scholar 

  • Fletcher, A. (1995). Quality-of-life measurements in the evaluation of treatment: Proposed guidelines. British Journal of Clinical Pharmacology, 39, 217–222.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Grossi, E., Mosconi, P., Groth, N., Niero, M., & Apolone, G. (2005). Questionario General Well-Being Index—Versione Italiana. Milano: Istituto Mario Negri.

    Google Scholar 

  • Grzybowski, M., Welch, R. D., Parsons, L., Ndumele, C. E., Chen, E., Zalenski, R., … Barron, H. V. (2004). The association between white blood cell count and acute myocardial infarction in-hospital mortality: Findings from the National Registry of Myocardial Infarction. Academic Emergency Medicine, 11, 1049–1060.

  • Hiller, A., Helvik, A. S., Kaasa, S., & Slordahl, S. A. (2010). Psychometric properties of the Norwegian MacNew Heart Disease health-related quality of life inventory. European Journal of Cardiovascular Nursing, 9, 146–152.

    Article  PubMed  Google Scholar 

  • Hofer, S., Lim, L., Guyatt, G., & Oldridge, N. (2004). The MacNew Heart Disease health-related quality of life instrument: A summary. Health Related Quality of Life Outcomes, 2, 3.

    Article  Google Scholar 

  • Klocek, M., Kubinyi, A., Bacior, B., & Kawecka-Jaszcz, K. (2005). Effect of physical training on quality of life and oxygen consumption in patients with congestive heart failure. International Journal of Cardiology, 103, 323–329.

    Article  PubMed  Google Scholar 

  • Komesaroff, P. A., Esler, M. D., & Sudhir, K. (1999). Estrogen supplementation attenuates glucocorticoid and catecholamine responses to mental stress in perimenopausal women. Journal of Clinical Endocrinology and Metabolism, 84, 606–610.

    CAS  PubMed  Google Scholar 

  • Leuven, E., & Sianesi, B. (2003). PSMATCH2: Stata module to perform full Mahalanobis and propensity score matching, common support graphing, and covariate imbalance testing. http://ideas.repec.org/c/boc/bocode/s432001.html. Version 4.0.4.

  • Lim, L. L., Johnson, N. A., O’Connell, R. L., & Heller, R. F. (1998). Quality of life and later adverse health outcomes in patients with suspected heart attack. Australian and New Zealand Journal of Public Health, 22, 540–546.

    Article  CAS  PubMed  Google Scholar 

  • Lim, L. L., Valenti, L. A., Knapp, J. C., Dobson, A. J., Plotnikoff, R., Higginbotham, N., … Heller, R. F. (1993). A self-administered quality-of-life questionnaire after acute myocardial infarction. Journal of Clinical Epidemiology, 46, 1249–1256.

    Article  CAS  PubMed  Google Scholar 

  • Madhavan, M., Rihal, C. S., Lerman, A., & Prasad, A. (2011). Acute heart failure in apical ballooning syndrome (takotsubo/stress cardiomyopathy): Clinical correlates and Mayo Clinic risk score. Journal of the American College of Cardiology, 57, 1400–1401.

    Article  PubMed  Google Scholar 

  • Mahajan, V. S., & Jarolim, P. (2011). How to interpret elevated cardiac troponin levels. Circulation, 21, 2350–2354.

    Article  Google Scholar 

  • Manzoni, G. M., Villa, V., Compare, A., Castelnuovo, G., Nibbio, F., Titon, A. M., … Gondoni, L. A. (2011). Short-term effects of a multi-disciplinary cardiac rehabilitation programme on psychological well-being, exercise capacity and weight in a sample of obese in-patients with coronary heart disease: A practice-level study. Psychology, Health & Medicine, 16, 178–189.

    Article  Google Scholar 

  • Martin, E. A., Prasad, A., Rihal, C. S., Lerman, L. O., & Lerman, A. (2010). Endothelial function and vascular response to mental stress are impaired in patients with apical ballooning syndrome. Journal of the American College of Cardiology, 56, 1840–1846.

    Article  PubMed Central  PubMed  Google Scholar 

  • Mittleman, M. A., & Mostofsky, E. (2011). Physical, psychological and chemical triggers of acute cardiovascular events: Preventive strategies. Circulation, 124, 346–354.

    Article  PubMed Central  PubMed  Google Scholar 

  • Mudd, J. O., Kapur, N. K., Champion, H. C., Schulman, S. P., & Wittstein, I. S. (2007). Patients with stress-induced (takotsubo) cardiomyopathy have an increased prevalence of mood disorders and antidepressant use compared to patients with acute myocardial infarction. Journal of Cardiac Failure, 13, S176.

    Article  Google Scholar 

  • Nunez-Gil, I. J., Fernandez-Ortiz, A., Perez-Isla, L., Luaces, M., Garcia-Rubira, J. C., Vivas, D., … Macaya, C. (2008). Clinical and prognostic comparison between left ventricular transient dyskinesia and a first non-ST-segment elevation acute coronary syndrome. Coronary Artery Disease, 19, 449–453.

  • Ogura, R., Hiasa, Y., Takahashi, T., Yamaguchi, K., Fujiwara, K., Ohara, Y., … Ohtani R. (2003). Specific findings of the standard 12-lead ECG in patients with ‘takotsubo’ cardiomyopathy: Comparison with the findings of acute anterior myocardial infarction. Circulation Journal: Official Journal of the Japanese Circulation Society, 67, 687–690.

    Google Scholar 

  • Oldridge, N., Gottlieb, M., Guyatt, G., Jones, N., Streiner, D., & Feeny, D. (1998). Predictors of health-related quality of life with cardiac rehabilitation after acute myocardial infarction. Journal of Cardiopulmonary Rehabilitation, 18, 95–103.

    Article  CAS  PubMed  Google Scholar 

  • Oldridge, N., Perkins, A., & Hodes, Z. (2002). Comparison of three heart disease specific health-related quality of life instruments. Monaldi Archives for Chest Disease, 58, 10–18.

    CAS  PubMed  Google Scholar 

  • Omvik, P., Thaulow, E., Herland, O. B., Eide, I., Midha, R., & Turner, R. R. (1993). Double-blind, parallel, comparative study on quality of life during treatment with amlodipine or enalapril in mild or moderate hypertensive patients: A multicentre study. Journal of Hypertension, 11, 103–113.

    Article  CAS  PubMed  Google Scholar 

  • Parodi, G., Del Pace, S., Carrabba, N., Salvadori, C., Memisha, G., Simonetti, I., … Gensini, G. F. (2007). Incidence, clinical findings, and outcome of women with left ventricular apical ballooning syndrome. American Journal of Cardiology, 99, 182–185.

  • Paykel, E. (1997). The interview for recent life events. Psychological Medicine, 27, 301–310.

    Article  CAS  PubMed  Google Scholar 

  • Paykel, E. (2003). Life events: Effects and genesis. Psychological Medicine, 33, 1145–1148.

    Article  PubMed  Google Scholar 

  • Pilgrim, T. M., & Wyss, T. R. (2008). Takotsubo cardiomyopathy or transient left ventricular apical ballooning syndrome: A systematic review. International Journal of Cardiology, 124, 283–292.

    Article  PubMed  Google Scholar 

  • Plevier, C. M., Mooy, J. M., Marang-Van de Mheen, P. J., Stouthard, M. E., Visser, M. C., Grobbee, D. E., … Gunning-Schepers, L. J. (2001). Persistent impaired emotional functioning in survivors of a myocardial infarction? Quality of Life Research, 10, 123–132.

    Google Scholar 

  • Prasad, A., Lerman, A., & Rihal, C. S. (2008). Apical ballooning syndrome (tako-tsubo or stress cardiomyopathy): A mimic of acute myocardial infarction. American Heart Journal, 155, 408–417.

    Article  PubMed  Google Scholar 

  • Previtali, M., Repetto, A., Camporotondo, R., Citro, R., Faggiano, P., Bovelli, D., … Klersy, C. (2011). Clinical characteristics and outcome of left ventricular ballooning syndrome in a European population. American Journal of Cardiology, 107, 120–125.

    Google Scholar 

  • Regnante, R. A., Zuzek, R. W., Weinsier, S. B., Latif, S. R., Linsky, R. A., Ahmed, H. N., … Sadiq, I. (2009). Clinical characteristics and four-year outcomes of patients in the Rhode Island Takotsubo Cardiomyopathy Registry. American Journal of Cardiology, 103, 1015–1019.

  • Rosenbaum, P. R., & Rubin, D. B. (1985). Constructing a control group using multivariate matched sampling methods that incorporate the propensity. American Statistician, 39, 33–38.

    Google Scholar 

  • Rubin, D. B. (1997). Estimating causal effects from large data sets using propensity scores. Annals of Internal Medicine, 127, 757–763.

    Article  CAS  PubMed  Google Scholar 

  • Sato, H., Tateishi, H., & Uchida, T. (1990). Takotsubo-type cardiomyopathy due to multivessel spasm. In K. Kodama, K. Haze, & M. Hon (Eds.), Clinical aspect of myocardial injury: From ischemia to heart failure (pp. 56–64). Tokyo: Kagakuhyouronsya Co (in Japanese).

  • Sharkey, S. W., Lesser, J. R., Menon, M., Parpart, M., Maron, M. S., & Maron, B. J. (2008). Spectrum and significance of electrocardiographic patterns, troponin levels, and thrombolysis in myocardial infarction frame count in patients with stress (tako-tsubo) cardiomyopathy and comparison to those in patients with ST-elevation anterior wall myocardial infarction. American Journal of Cardiology, 101, 1723–1728.

    Article  PubMed  Google Scholar 

  • Sharkey, S. W., Windenburg, D. C., Lesser, J. R., Maron, M. S., Hauser, R. G., Lesser, J. N., … Maron, B. J. (2010). Natural history and expansive clinical profile of stress (tako-tsubo) cardiomyopathy. Journal of the American College of Cardiology, 55, 333–341.

    Google Scholar 

  • Singh, N. K., Rumman, S., Mikell, F. L., Nallamothu, N., & Rangaswamy, C. (2010). Stress cardiomyopathy: Clinical and ventriculographic characteristics in 107 North American subjects. International Journal of Cardiology, 141, 297–303.

    Article  PubMed  Google Scholar 

  • Sobnosky, S., Shah, A., Aharonian, V. J., Mansukhani, P., Moore, N., Shen, A. Y., … Somjot, S. B. (2010). Abstract 20134: Frequency of psychiatric disorders in persons with stress induced cardiomyopathy. Circulation, 122, A20134.

  • Summers, M. R., Lennon, R. J., & Prasad, A. (2010). Pre-morbid psychiatric and cardiovascular diseases in apical ballooning syndrome (tako-tsubo/stress-induced cardiomyopathy): Potential pre-disposing factors? Journal of the American College of Cardiology, 55, 700–701.

    Article  PubMed  Google Scholar 

  • Sung, B. H., Ching, M., Izzo, J. L., Jr., Dandona, P., & Wilson, M. F. (1999). Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal women. Journal of Hypertension, 17, 523–528.

    Article  CAS  PubMed  Google Scholar 

  • Thygesen, K., Alpert, J. S., White, H. D., Jaffe, A. S., Apple, F. S., Galvani, M., … Al-Attar, N. (2007). Universal definition of myocardial infarction. Circulation, 116, 2634–2653.

    Google Scholar 

  • Valenti, L., Lim, L., Heller, R. F., & Knapp, J. (1996). An improved questionnaire for assessing quality of life after acute myocardial infarction. Quality of Life Research, 5, 151–161.

    Article  CAS  PubMed  Google Scholar 

  • Vidi, V., Rajesh, V., Singh, P. P., Mukherjee, J. T., Lago, R. M., Venesy, D. M., … Nesto, R. W. (2009). Clinical characteristics of tako-tsubo cardiomyopathy. American Journal of Cardiology, 104, 578–582.

    Google Scholar 

  • Wiklund, I., & Karlberg, J. (1991). Evaluation of quality of life in clinical trials. Selecting quality-of-life measures. Controlled Clinical Trials, 12, 204S–216S.

    Article  CAS  PubMed  Google Scholar 

  • Wittstein, I. S. (2012). Stress cardiomyopathy: A syndrome of catecholamine-mediated myocardial stunning? Cellular and Molecular Neurobiology, 32, 847–857.

    Article  CAS  PubMed  Google Scholar 

  • Wittstein, I. S., Thiemann, D. R., Lima, J. A., Baughman, K. L., Schulman, S. P., Gerstenblith, G., … Champion, H. C. (2005). Neurohumoral features of myocardial stunning due to sudden emotional stress. New England Journal of Medicine, 352, 539–548.

    Google Scholar 

Download references

Acknowledgments

We thank the primary health care practitioners who took part in this study.

Conflict of interest

Angelo Compare, Enzo Grossi, Riccardo Bigi, Riccardo Proietti, Edo Shonin, Pedro Silva Orrego, and Lydia Poole declare that they have no conflict of interest.

Ethical standard

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients prior to being included in the study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Angelo Compare.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Compare, A., Grossi, E., Bigi, R. et al. Stress-Induced Cardiomyopathy and Psychological Wellbeing 1 Year After an Acute Event. J Clin Psychol Med Settings 21, 81–91 (2014). https://doi.org/10.1007/s10880-013-9380-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10880-013-9380-1

Keywords

Navigation