Abstract
Patients infected with chronic hepatitis C virus (HCV) commonly suffer from the triad of depression, pain and fatigue. This symptom triad in HCV is likely influenced by additional psychological and interpersonal factors, although the relationship is not clearly understood. This retrospective study aimed to characterize the relationship between attachment style and depressive and physical symptoms in the HCV-infected population. Over 18 months, 99 consecutively referred HCV infected patients were assessed with the Hamilton Depression Rating Scale (HDRS), Fatigue Severity Scale, Patient Health Questionnaire-15 for physical symptoms and the Relationship Questionnaire for attachment style. An ANOVA was used to identify differences between attachment styles and Pearson correlations were used to evaluate the association between depression, fatigue and physical symptoms. Approximately 15 % of patients in the sample had a fearful attachment style. Patients with fearful attachment style had significantly higher depressive symptoms compared to a secure attachment style (p = .025). No differences in physical and fatigue symptoms were observed between attachment styles. Further, HDRS scores were significantly associated with fatigue scores (p < .001) and physical symptoms (p < .001), reinforcing the relationship between these symptom domains in HCV-infected patients. Although depressive, physical and fatigue symptoms are inter-related in HCV-infected patients, our study results suggest that only depressive symptoms were influenced by the extremes of attachment style. Screening of relationship styles may identify at-risk HCV-infected individuals for depression who may have difficulty engaging in care and managing physical symptoms.
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Armstrong, G. L., Wasley, A., Simard, E. P., McQuillan, G. M., Kuhnert, W. L., & Alter, M. J. (2006). The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Annals of Internal Medicine, 144, 705–714.
Barkhuizen, A., Rosen, H. R., Wolf, S., Flora, K., Benner, K., & Bennett, R. M. (1999). Musculoskeletal pain and fatigue are associated with chronic hepatitis C: A report of 239 hepatology clinic patients. American Journal of Gastroenterology, 94, 1355–1360.
Bartholomew, K., & Horowitz, L. M. (1991). Attachment styles among young adults: A test of a four-category model. Journal of Personality and Social Psychology, 61, 226–244.
Bianchi, G., Marchesini, G., Nicolino, F., Graziani, R., Sgarbi, D., & Loguercio, C. (2005). Psychological status and depression in patients with liver cirrhosis. Digestive and Liver Disease: Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 37, 593–600.
Bonkovsky, H. L., & Woolley, J. M. (1999). Reduction of health-related quality of life in chronic hepatitis C and improvement with interferon therapy. Hepatology, 29, 264–270.
Bowlby, J. (1969). Attachment and loss, vol. 1: Attachment. New York: Basic Books.
Bowlby, J. (1973). Attachment and loss, vol. 2: Attachment. New York: Basic Books.
Bowlby, J. (1980). Attachment and loss, vol. 3: Attachment. New York: Basic Books.
Ciechanowski, P. S., Katon, W. J., Russo, J. E., & Dwight-Johnson, M. M. (2002a). Association of attachment style to lifetime medically unexplained symptoms in patients with hepatitis C. Psychosomatics, 43, 206–212.
Ciechanowski, P. S., Russo, J. E., Katon, W. J., Korff, M. V., Simon, G. E., et al. (2006). The association of patient relationship style and outcomes in collaborative care treatment for depression in patients with diabetes. Medical Care, 44, 283–291.
Ciechanowski, P., Russo, J., Katon, W. J., Lin, E. H., Ludman, E., et al. (2010). Relationship styles and mortality in patients with diabetes. Diabetes Care, 33, 539–544.
Ciechanowski, P., Russo, J., Katon, W., Von Korff, M., Ludman, E., Lin, E., et al. (2004). Influence of patient attachment style on self-care and outcomes in diabetes. Psychosomatic Medicine, 66, 720–728.
Ciechanowski, P. S., Walker, E. A., Katon, W. J., & Russo, J. E. (2002b). Attachment theory: A model for health care utilization and somatization. Psychosomatic Medicine, 64, 660–667.
Conradi, H. J., & de Jonge, P. (2009). Recurrent depression and the role of adult attachment: A prospective and a retrospective study. Journal of Affective Disorders, 116, 93–99.
Dantzer, R. (2009). Cytokine, sickness behavior, and depression. Immunology and Allergy Clinics of North America, 29, 247–264.
Dieperink, E., Ho, S. B., Tetrick, L., Thuras, P., Dua, K., & Willenbring, M. L. (2004). Suicidal ideation during interferon-alpha2b and ribavirin treatment of patients with chronic hepatitis C. General Hospital Psychiatry, 26, 237–240.
El-Sarag, H. B., Kunik, M., Richardson, P., & Rabaneck, L. (2002). Psychiatric disorders among veterans with hepatitis C infection. Gastroenterology, 123, 476–482.
Golden, J., Conroy, R. M., O’Dwyer, A. M., Golden, D., & Hardouin, J. B. (2006). Illness-related stigma, mood and adjustment illness in persons with hepatitis C. Social Science and Medicine, 63, 3188–3198.
Golden, J., O’Dwyer, A. M., & Conroy, R. M. (2005). Depression and anxiety in patients with hepatitis C: Prevalence, detection rates and risk factors. General Hospital Psychiatry, 27, 431–438.
Griffin, D. W., & Bartholomew, K. (1994). The metaphysics of measurement: The case of adult attachment. In K. Bartholomew & D. Perlman (Eds.), Advances in personal relationships (Vol. 5, pp. 17–52)., Attachment processes in adulthood London: Jessica Kingsley Publishers.
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.
Hilsabeck, R. C., Hassanein, T. I., & Perry, W. (2005). Biopsychosocial predictors of fatigue in chronic hepatitis C. Journal of Psychosomatic Research, 58, 173–178.
Hoge, C. W., McGurk, D., Thomas, J. L., Cox, A. L., Engel, C. C., & Castro, C. A. (2008). Mild traumatic brain injury in U.S. soldiers returning from Iraq. New England Journal of Medicine, 358, 453–463.
Horikawa, N., Yamazaki, T., Izumi, N., & Uchihara, M. (2003). Incidence and clinical course of major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy: A prospective study. General Hospital Psychiatry, 25, 34–38.
Hunter, J. J., & Maunder, R. G. (2001). Using attachment theory to understand illness behavior. General Hospital Psychiatry, 23, 177–182.
Kalaitzakis, E., Josefsson, A., Castedal, M., Henfridsson, P., Bengtsson, M., et al. (2012). Factors related to fatigue in patients with cirrhosis before and after liver transplantation. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 10, 174–181.
Kallman, J., O’Neil, M. M., Larive, B., Boparai, N., Calabrese, L., & Younossi, Z. M. (2007). Fatigue and health-related quality of life (HRQOL) in chronic hepatitis C virus infection. Digestive Diseases and Sciences, 52, 2531–2539.
Kirkova, J., Rybicki, L., Walsh, D., Aktas, A., Davis, M. P., & Karafa, M. T. (2011). The relationship between symptom prevalence and severity and cancer primary site in 796 patients with advanced cancer. American Journal of Hospice & Palliative Care, 28, 350–355.
Kleinman, L., Zodet, M. W., Hakim, Z., Aledort, J., Barker, C., Chan, K., et al. (2000). Psychometric evaluation of the Fatigue Severity Scale for use in chronic hepatitis C. Quality of Life Research, 9, 499–508.
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2002). The PHQ-15: Validity of a new measure for evaluating severity of somatic symptoms. Psychosomatic Medicine, 64, 258–266.
Krupp, L. B., LaRocca, N. G., Muir-Nash, J., & Steinberg, A. D. (1989). The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology, 46, 1121–1123.
Lang, C. A., Conrad, S., Garrett, L., Battistutta, D., Cooksley, W. G., Dunne, M. P., et al. (2006). Symptom prevalence and clustering of symptoms in people living with chronic hepatitis C infection. Journal of Pain and Symptom Management, 31, 335–344.
Lotrich, F. E., Rabinovitz, M., Gironda, P., & Pollock, B. G. (2007). Depression following pegylated interferon-alpha: Characteristics and vulnerability. Journal of Psychosomatic Research, 63, 131–135.
Majer, M., Welberg, L. A., Capuron, L., Pagnoni, G., Raison, C. L., & Miller, A. H. (2008). IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C. Brain, Behavior, and Immunity, 22, 870–880.
Maunder, R. G., Panzer, A., Viljoen, M., Owen, J., Human, S., & Hunter, J. J. (2006). Physicians’ difficulty with emergency department patients is related to patients’ attachment style. Social Science and Medicine, 63, 552–562.
Meredith, P. J., Strong, J., & Feeney, J. A. (2006). The relationship of adult attachment to emotion, catastrophizing, control, threshold and tolerance, in experimentally-induced pain. Pain, 120, 44–52.
Mickelson, K. D., Kessler, R. C., & Shaver, P. R. (1997). Adult attachment in a nationally representative sample. Journal of Personality and Social Psychology, 73, 1092–1106.
Morasco, B. J., Rifai, M. A., Loftis, J. M., Indest, D. W., Moles, J. K., & Hauser, P. (2007). A randomized trial of paroxetine to prevent interferon-alpha-induced depression in patients with hepatitis C. Journal of Affective Disorders, 103, 83–90.
Naess, H., Lunde, L., & Brogger, J. (2012). The triad of pain, fatigue and depression in ischemic stroke patients: The Bergen Stroke Study. Cerebrovascular Diseases, 33, 461–465.
Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., et al. (2009). Activation of central nervous system inflammatory pathways by interferon-alpha: Relationship to monoamines and depression. Biological Psychiatry, 65, 296–303.
Sha, M. C., Callahan, C. M., Counsell, S. R., Westmoreland, G. R., Stump, T. E., & Kroenke, K. (2005). Physical symptoms as a predictor of health care use and mortality among older adults. American Journal of Medicine, 118, 301–306.
Sockalingam, S., Blank, D., Al Jarad, A., Alosaimi, F., Hirschfield, G., & Abbey, S. E. (2011a). A comparison of depression screening instruments in hepatitis C and the impact of depression on somatic symptoms. Psychosomatics, 52, 433–440.
Sockalingam, S., Links, P. S., & Abbey, S. E. (2011b). Suicide risk in hepatitis C and during interferon-alpha therapy: A review and clinical update. Journal of Viral Hepatitis, 18, 153–160.
Stewart, C. A., Enders, F. T., Mitchell, M. M., Felmlee-Devine, D., & Smith, G. E. (2011). The cognitive profile of depressed patients with cirrhosis. Primary care companion to CNS disorders, 13, PCC.10m01090.
Tremblay, I., & Sullivan, M. J. (2010). Attachment and pain outcomes in adolescents: The mediating role of pain catastrophizing and anxiety. Journal of Pain: Official Journal of the American Pain Society, 11, 160–171.
Verne, G. N., Soldevia-Pico, C., Robinson, M. E., Spicer, K. M., & Reuben, A. (2004). Autonomic dysfunction and gastroparesis in cirrhosis. Journal of Clinical Gastroenterology, 38, 72–76.
Waters, E., Hamilton, C. E., & Weinfield, N. S. (2000). The stability of attachment security from infancy to adolescence and early adulthood: General introduction. Child Development, 71, 678–683.
Whitehead, A. J., Dobscha, S. K., Morasco, B. J., Ruimy, S., Bussell, C., & Hauser, P. (2008). Pain, substance use disorders and opioid analgesic prescription patterns in veterans with hepatitis C. Journal of Pain and Symptom Management, 36, 39–45.
WHO. (1997). Hepatitis C: Global prevalence. Weekly Epidemiology Record, 72, 341–344.
Wichers, M. C., Kenis, G., Leue, C., Koek, G., Robaeys, G., & Maes, M. (2006). Baseline immune activation as a risk factor for the onset of depression during interferon-alpha treatment. Biological Psychiatry, 60, 77–79.
Yovtcheva, S. P., Rifai, M. A., Moles, J. K., & Van der Linden, B. J. (2001). Psychiatric comorbidity among hepatitis C-positive patients. Psychosomatics, 42, 411–415.
Zickmund, S. L., Bryce, C. L., Blasiole, J. A., Shinkunas, L., LaBrecque, D. R., & Arnold, R. M. (2006). Majority of patients with hepatitis C express physical, mental, and social difficulties with antiviral treatment. European Journal of Gastroenterology and Hepatology, 18, 381–388.
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Sockalingam, S., Blank, D., Jarad, A.A. et al. The Role of Attachment Style and Depression in Patients with Hepatitis C. J Clin Psychol Med Settings 20, 227–233 (2013). https://doi.org/10.1007/s10880-012-9335-y
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DOI: https://doi.org/10.1007/s10880-012-9335-y