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Health-Related Quality of Life and Treatment Satisfaction in North American Patients with Primary Immunedeficiency Diseases Receiving Subcutaneous IgG Self-Infusions at Home

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Abstract

The lifelong IgG replacement therapy for patients with primary immunedeficiencies (PIDD) may be provided by intravenous (IVIG) or by subcutaneous IgG (SCIG) infusions. We investigated the impact of weekly SCIG self-infusions at home on the health-related quality of life, treatment satisfaction, and preferences in patients treated with IVIG at the hospital/doctor's office (Group A) or at home (Group B) before the study started. Forty-four adult North American PIDD patients were included in the study, 28 patients in Group A and 16 in Group B. Patients in Group A reported significantly less limitations with their work/daily activities, a significantly improved vitality, and better general health. Treatment satisfaction was significantly improved in Group A. The preference for the subcutaneous route and for home therapy was respectively 81% and 90% in Group A. In Group B, 69% preferred the subcutaneous route and 92% home therapy.

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Authors and Affiliations

  1. Section of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden

    Uwe Nicolay & Ann Gardulf

  2. Clinical Research, ZLB Behring GmbH, Marburg, Germany

    Peter Kiessling & Stefan Haag

  3. Division of Allergy, Immunology and Rheumatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio

    Melvin Berger

  4. Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California

    Sudhir Gupta & Leman Yel

  5. The Hospital for Sick Children, Toronto, Ontario, Canada

    Chaim M. Roifman

  6. Kendle International Inc., Munich, Germany

    Florian Eichmann

  7. Department of Biostatistics, Accovion GmbH, Marburg, Germany

    Cordula Massion

  8. Department of Pediatrics, University of Washington, Seattle, Washington

    Hans D. Ochs

  9. M96, Section of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, SE-14186, Sweden

    Uwe Nicolay

Authors
  1. Uwe Nicolay
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  2. Peter Kiessling
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  3. Melvin Berger
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  4. Sudhir Gupta
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  5. Leman Yel
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  6. Chaim M. Roifman
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  7. Ann Gardulf
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  8. Florian Eichmann
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  9. Stefan Haag
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  10. Cordula Massion
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  11. Hans D. Ochs
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Correspondence to Uwe Nicolay.

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Nicolay, U., Kiessling, P., Berger, M. et al. Health-Related Quality of Life and Treatment Satisfaction in North American Patients with Primary Immunedeficiency Diseases Receiving Subcutaneous IgG Self-Infusions at Home. J Clin Immunol 26, 65–72 (2006). https://doi.org/10.1007/s10875-006-8905-x

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  • DOI: https://doi.org/10.1007/s10875-006-8905-x

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