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05-01-2016 | Brief Report

A randomized controlled pilot study of inflammatory gene expression in response to a stress management intervention for stem cell transplant caregivers

Auteurs: Mark L. Laudenslager, Teresa L. Simoneau, Sam Philips, Patrick Benitez, Crystal Natvig, Steve Cole

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2016

Abstract

Few studies have addressed whether stress-associated physiological changes in caregivers are reversible by psychological interventions mitigating distress. We report on pro-inflammatory, sympathetic, and oxidative stress gene expression in response to stress management for caregivers of allogeneic hematopoietic stem cell transplant (Allo-HSCT) patients. Following randomization by permuted block to either treatment as usual (TAU, n = 11) or a stress management intervention (PsychoEducation, Paced Respiration, and Relaxation, PEPRR, n = 13), twenty-four caregivers were selected at the conclusion of a larger trial of 149 caregivers. PEPRR was provided one-on-one beginning around transplant. Genome-wide transcriptional profiling was conducted on peripheral blood mononuclear cells collected prior to randomization and on completion of PEPRR 3 months post-transplant. Bioinformatics analysis of differentially expressed genes indicated reduced activity of transcription control pathways associated with inflammation (NF-κB), sympathetic nervous system (CREB), and oxidative stress (NRF2) in caregivers receiving PEPRR compared to TAU aligning with reductions in stress, depression, and anxiety. This suggests that PEPRR may alter transcriptomic effects reported for distressed individuals.

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Titel: A randomized controlled pilot study of inflammatory gene expression in response to a stress management intervention for stem cell transplant caregivers
Auteurs: Mark L. Laudenslager
Teresa L. Simoneau
Sam Philips
Patrick Benitez
Crystal Natvig
Steve Cole
Publicatiedatum: 05-01-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 2/2016
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-015-9709-3

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