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01-12-2014

What keeps a body moving? The brain-derived neurotrophic factor val66met polymorphism and intrinsic motivation to exercise in humans

Auteurs: Ann E. Caldwell Hooper, Angela D. Bryan, Martin S. Hagger

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2014

Abstract

Individuals who are intrinsically motivated to exercise are more likely to do so consistently. In previous research, those with at least one copy of the methionine (met) allele in the brain-derived neurotrophic factor gene (BDNF; rs6265) had greater increases in positive mood and lower perceived exertion during exercise. This study examined whether genotype for BDNF is also related to intrinsic motivation, measured by self-report during a treadmill exercise session and a free-choice behavioral measure (continuing to exercise given the option to stop) among 89 regular exercisers (age M = 23.58, SD = 3.95). Those with at least one copy of the met allele reported greater increases in intrinsic motivation during exercise and were more likely to continue exercising when given the option to stop (55 vs. 33 %). Results suggest that underlying genetic factors may partially influence perceptions of inherent rewards associated with exercise and might inform the development of individually targeted interventions.

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We consider physical activity as a global, generic term referring to all activities that have a raised level of energy expenditure above resting metabolic rate and includes incidental activity like walking to work and occupational physical activities as well as other non-sedentary behaviors. Exercise refers to formal, purposive activities with the goal of raising energy expenditure with a particular focus on improving health-related outcomes such as cardiovascular fitness or strength. In the current article, we mainly focus on exercise as a formal, purposive activity, but recognize that the literature on genetic correlates tends to focus on overall and leisure time physical activity.

Non-parametric tests were used because several of the dependent measures were not normally distributed in the current sample.

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Titel: What keeps a body moving? The brain-derived neurotrophic factor val66met polymorphism and intrinsic motivation to exercise in humans
Auteurs: Ann E. Caldwell Hooper
Angela D. Bryan
Martin S. Hagger
Publicatiedatum: 01-12-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 6/2014
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-014-9567-4

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