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01-10-2009

The relationship between neuropsychological functioning and HAART adherence in HIV-positive adults: a systematic review

Auteurs: Travis I. Lovejoy, Julie A. Suhr

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 5/2009

Abstract

Combination antiretroviral therapy has helped extend the lives of persons infected with HIV; however, the efficacy of highly active antiretroviral therapy (HAART) regimens depends, in part, on the consistency with which the medications are taken. In this paper, we review 11 empirical studies conducted in Western developed nations that utilized psychometrically valid neuropsychological measures to examine the relationship between cognitive functioning and HAART adherence. In general, impaired neuropsychological functioning—particularly within the domains of executive functioning and problem solving, learning and memory, attention and working memory, and global cognitive functioning—was associated with lower medication adherence across studies. However, inconsistent operationalizations of neuropsychological impairment and medication adherence employed in these studies, as well as the paucity of longitudinal data to support temporal relationships, may attenuate these conclusions. We conclude with a set of research recommendations that may help to improve the rigor of future studies and clarify questions left unanswered due to methodological limitations of existing studies.

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Albert, S. M., Flater, S. R., Clouse, R., Todak, G., Stern, Y., & Marder, K. (2003). Medication management skill in HIV: I. Evidence for adaptation of medication management strategies in people with cognitive impairment. II. Evidence for a pervasive lay model of medication efficacy. AIDS and Behavior, 7, 329–338. doi:10.1023/A:1025404105378.PubMedCrossRef

Albert, S. M., Weber, C. M., Todak, G., Polanco, C., Clouse, R., McElhiney, M., et al. (1999). An observed performance test of medication management ability in HIV: Relation to neuropsychological status and medication adherence outcomes. AIDS and Behavior, 3, 121–128. doi:10.1023/A:1025483806464.CrossRef

Ammassari, A., Antinori, A., Aloisi, M. S., Trotta, M. P., Murri, R., Bartoli, L., et al. (2004). Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected patients. Psychosomatics, 45, 394–402. doi:10.1176/appi.psy.45.5.394.PubMedCrossRef

Ammassari, A., Trotta, M. P., Murri, R., Castelli, F., Narciso, P., Noto, P., et al. (2002). Correlates and predictors of adherence to highly active antiretroviral therapy: Overview of published literature. Journal of Acquired Immune Deficiency Syndromes, 31, S123–S127.PubMed

Anthony, I. C., & Bell, J. E. (2008). The neuropathology of HIV/AIDS. International Review of Psychiatry (Abingdon, England), 20, 15–24. doi:10.1080/09540260701862037.CrossRef

Avants, S. K., Margolin, A., Warburton, L. A., Hawkins, K. A., & Shi, J. (2001). Predictors of nonadherence to HIV-related medication regimens during methadone stabilization. The American Journal on Addictions, 10, 69–78. doi:10.1080/105504901750160501.PubMedCrossRef

Bangsberg, D. R., Hecht, F. M., Charlebois, E. D., Zalopa, A. R., Holodniy, M., Sheiner, L., et al. (2000). Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS (London, England), 14, 357–366. doi:10.1097/00002030-200003100-00008.

Barclay, T. R., Hinkin, C. H., Castellon, S. A., Mason, K. I., Reinhard, M. J., Marion, S. D., et al. (2007). Age-associated predictors of medication adherence in HIV-positive adults: Health beliefs, self-efficacy, and neurocognitive status. Health Psychology, 26, 40–49. doi:10.1037/0278-6133.26.1.40.PubMedCrossRef

Benton, A. L., Hamsher, K., & Sivan, A. B. (1983). Multilingual aphasia examination (3rd ed ed.). Iowa City, IA: AJA Associates.

Berg, K. M., & Arnsten, J. H. (2006). Practical and conceptual challenges in measuring antiretroviral adherence. Journal of Acquired Immune Deficiency Syndromes, 43, S79–S87. doi:10.1097/01.qai.0000248337.97814.66.PubMedCrossRef

Brew, B. J. (2004). Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. AIDS (London, England), 18, S75–S78. doi:10.1097/00002030-200401001-00011.

Brew, B. J., & Gonzalez-Scarano, F. (2007). HIV-associated dementia: An inconvenient truth. Neurology, 68, 324–325. doi:10.1212/01.wnl.0000252803.24176.76.PubMedCrossRef

Butters, N., Grant, I., Haxby, J., Judd, L. L., Martin, A., McClelland, J., et al. (1990). Assessment of AIDS-related cognitive changes: Recommendations of the NIMH workshop on neuropsychological assessment approaches. Journal of Clinical and Experimental Neuropsychology, 12, 963–978. doi:10.1080/01688639008401035.PubMedCrossRef

Casado, J. L., Sabido, R., Perez-Elias, M. J., Antela, A., Oliva, J., Dronda, F., et al. (1999). Percentage of adherence correlates with the risk of protease inhibitor (PI) treatment failure in HIV-infected patients. Antiviral Therapy, 4, 157–161.PubMed

Chander, G., Himelhoch, S., & Moore, R. D. (2006). Substance abuse and psychiatric disorders in HIV-positive patients: Epidemiology and impact on antiretroviral therapy. Drugs, 66, 769–789. doi:10.2165/00003495-200666060-00004.PubMedCrossRef

Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., et al. (2000). Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG adherence instruments. AIDS Care, 12, 255–266. doi:10.1080/09540120050042891.PubMedCrossRef

Cohen, J. (1983). The cost of dichotomization. Applied Psychological Measurement, 7, 249–253. doi:10.1177/014662168300700301.CrossRef

Colfax, G., & Guzman, R. (2006). Club drugs and HIV infection: A review. Clinical Infectious Diseases, 42, 1463–1469. doi:10.1086/503259.PubMedCrossRef

Colfax, G., & Shoptaw, S. (2005). The methamphetamine epidemic: Implications for HIV prevention and treatment. Current HIV/AIDS Reports, 2, 194–199. doi:10.1007/s11904-005-0016-4.PubMedCrossRef

D’Elia, L., Satz, P., Uchiyama, C. L., & White, T. (1996). Color trails 1 and 2. Odessa, FL: Psychological Assessment Resources.

Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (1987). CVLT adult version: California verbal learning test manual, version 1. San Antonio, TX: The Psychological Corporation, Harcourt Brace & Company.

Echemendia, R. J., & Harris, J. G. (2004). Neuropsychological test use with Hispanic/Latino populations in the United States: Part II of a national survey. Applied Neuropsychology, 11, 4–11. doi:10.1207/s15324826an1101_2.PubMedCrossRef

Falagas, M. E., Zarkadoulia, E. A., Pliatsika, P. A., & Panos, G. (2008). Socioeconomic status (SES) as a determinant of adherence to treatment in HIV infected patients: A systematic review of the literature. Retrovirology, 5, 13. doi:10.1186/1742-4690-5-13.PubMedCrossRef

Falutz, J. (2007). Therapy insight: Body-shape changes and metabolic complications associated with HIV and highly active antiretroviral therapy. Nature Clinical Practice. Endocrinology & Metabolism, 3, 651–661. doi:10.1038/ncpendmet0587.CrossRef

Flowers, K. A., & Robertson, C. (1985). The effects of Parkinson’s disease on the ability to maintain a mental set. Journal of Neurology, Neurosurgery, and Neuropsychiatry, 48, 517–529. doi:10.1136/jnnp.48.6.517.CrossRef

Fogarty, L., Roter, D., Larson, S., Burke, J., Gillespie, J., & Levy, R. (2002). Patient adherence to HIV medication regimens: A review of published and abstract reports. Patient Education and Counseling, 46, 93–108. doi:10.1016/S0738-3991(01)00219-1.PubMedCrossRef

Garcia de Olalla, P., Knobel, H., Carmona, A., Gnelar, A., Lopez-Colmes, J. L., & Cayla, J. A. (2002). Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients. Journal of Acquired Immune Deficiency Syndrome, 23, 386–395.

Grant, D. A., & Berg, E. A. (1948). A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. Journal of Experimental Psychology, 38, 404–411. doi:10.1037/h0059831.PubMedCrossRef

Grober, E., & Sliwinski, M. (1991). A prospective study of predictors of adherence to combination antiretroviral medication. Journal of General Internal Medicine, 17, 756–765.

Heaton, R., Grant, I., & Matthews, C. (1991). Comprehensive norms for an expanded Halstead-Reitan battery: Demographic corrections, research findings, and clinical implications. Odessa, FL: Psychological Assessment Resources.

Hinkin, C. H., Castellon, S. A., Durvasula, R. S., Hardy, D. J., Lam, M. N., Mason, K. I., et al. (2002). Medication adherence among HIV+ adults: Effects of cognitive dysfunction and regimen complexity. Neurology, 59, 1944–1950.PubMed

Hinkin, C. H., Hardy, D. J., Mason, K. I., Castellon, S. A., Durvasula, R. S., Lam, M. N., et al. (2004). Medication adherence in HIV-infected adults: Effects of patient age, cognitive status, and substance abuse. AIDS (London, England), 18, S19–S25. doi:10.1097/00002030-200401001-00004.

Hult, B., Chana, G., Masliah, E., & Everall, I. (2008). Neurobiology of HIV. International Review of Psychiatry (Abingdon, England), 20, 3–13. doi:10.1080/09540260701862086.CrossRef

Irwin, J. R., & McClelland, G. H. (2003). Negative consequences of dichotomizing continuous predictor variables. JMR, Journal of Marketing Research, 40, 366–371. doi:10.1509/jmkr.40.3.366.19237.CrossRef

Kalichman, S. C., Amaral, C. M., Stearns, H., White, D., Falnagan, J., Pope, H., et al. (2007). Adherence to antiretroviral therapy assessed by unannounced pill counts conducted by telephone. Journal of General Internal Medicine, 22, 1003–1006. doi:10.1007/s11606-007-0171-y.PubMedCrossRef

Kaufman, A. S., & Kaufman, N. L. (1993). Manual: KAIT Kaufman adolescent & adult intelligence test. Circle Pines, MN: American Guidance Service, Inc.

Klove, H. (1963). Clinical neuropsychology. The Medical Clinics of North America, 46, 1647–1658.

Lert, F., & Kazatchkine, M. D. (2007). Antiretroviral HIV treatment and care for injecting drug users: An evidence-based overview. The International Journal on Drug Policy, 18, 255–261. doi:10.1016/j.drugpo.2007.05.002.PubMedCrossRef

Levine, A. J., Hinkin, C. H., Castellon, S. A., Mason, K. I., Lam, M. N., Perkins, A., et al. (2005). Variations in patterns of highly active antiretroviral therapy (HAART) adherence. AIDS and Behavior, 9, 355–362. doi:10.1007/s10461-005-9009-y.PubMedCrossRef

Levine, A. J., Hinkin, C. H., Marion, S., Keuning, A., Castellon, S. A., Lam, M. N., et al. (2006). Adherence to antiretroviral medications in HIV: Differences in data collected via self-report and electronic monitoring. Health Psychology, 25, 329–335. doi:10.1037/0278-6133.25.3.329.PubMedCrossRef

Lezak, M. D., Howieson, D. B., & Loring, D. W. (2004). Neuropsychological assessment (4th ed.). New York: Oxford University Press.

Maggiolo, F., Airoldi, M., Kleinloog, H. D., Callegaro, A., Ravasio, V., Arici, C., et al. (2007). Effect of adherence to HAART on virologic outcome and on the selection of resistance-conferring mutations in NNRTI- or PI-treated patients. HIV Clinical Trials, 8, 282–292. doi:10.1310/hct0805-282.PubMedCrossRef

Maxwell, S. E., & Delaney, H. D. (1993). Bivariate median splits and spurious statistical significance. Psychological Bulletin, 113, 181–190. doi:10.1037/0033-2909.113.1.181.CrossRef

McArthur, J. C. (2004). HIV dementia: An evolving disease. Journal of Neuroimmunology, 157, 3–10. doi:10.1016/j.jneuroim.2004.08.042.PubMedCrossRef

Miller, E. N., Satz, P., & Visscher, B. (1991). Computerized and conventional neuropsychological assessment in HIV-1 infected homosexual men. Neurology, 41, 1608–1616.PubMed

Murphy, E. L., Collier, A. C., Kalish, L. A., Assmann, S. F., Para, M. R., Flanigan, T. P., et al. (2001). Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV disease. Annals of Internal Medicine, 135, 17–26.PubMed

Nicastri, E., Leone, S., Angeletti, C., Palmisano, L., Sarmati, L., Chiesi, A., et al. (2007). Sex issues in HIV-1-infected persons during highly active antiretroviral therapy: A systematic review. The Journal of Antimicrobial Chemotherapy, 60, 724–732. doi:10.1093/jac/dkm302.PubMedCrossRef

Nieuwkerk, P. T., & Oort, F. J. (2005). Self-reported adherence to antiretroviral therapy for HIV-1 infection and virologic treatment response: A meta-analysis. Journal of Acquired Immune Deficiency Syndromes, 38, 445–448. doi:10.1097/01.qai.0000147522.34369.12.PubMedCrossRef

Nieuwkerk, P. T., Sprangers, M. A. G., Burger, D. M., Hoetelmans, R. M. W., Hugen, P. W. H., Danner, S. A., et al. (2001). Limited patient adherence to highly active antiretroviral therapy for HIV-1 infection in an observational cohort study. Archives of Internal Medicine, 161, 1962–1968. doi:10.1001/archinte.161.16.1962.PubMedCrossRef

Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., et al. (2000). Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine, 133, 21–30.PubMed

Price, R. W., & Sidtis, J. J. (1993). AIDS dementia complex and HIV-1 infection: A view from the clinic. Brain Pathology (Zurich, Switzerland), 1, 155–162. doi:10.1111/j.1750-3639.1991.tb00655.x.

Rey, A. (1941). L’examen psychologique dans las cas d’encephalopathie traumatique. Archives de Psychologie, 28, 286–340.

Roberts, K. J. (2000). Barriers to and facilitators of HIV-positive patients’ adherence to antiretroviral treatment regimens. AIDS Patient Care and STDs, 14, 155–168. doi:10.1089/108729100317948.PubMedCrossRef

Sacktor, N. (2002). The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. Journal of Neurovirology, 8, 115–121. doi:10.1080/13550280290101094.PubMedCrossRef

Sacktor, N., McDermott, M. P., Marder, K., Schifitto, G., Selnes, O. A., McArthur, J. C., et al. (2002). HIV-associated cognitive impairment before and after the advent of combination therapy. Journal of Neurovirology, 8, 136–142. doi:10.1080/13550280290101094.PubMedCrossRef

Santos, G., Puga, A. M., & Medina, C. (2004). HAART, adherence, and cultural issues in the US Latino community. The AIDS Reader, 14, S26–S29.PubMed

Selnes, O. A., Jacobson, L., Machado, A. M., Becker, J. T., Wesch, J., Miller, E. N., et al. (1991). Normative data for a brief neuropsychological screening battery. Multicenter AIDS cohort study. Perceptual and Motor Skills, 73, 539–550. doi:10.2466/PMS.73.5.539-550.PubMedCrossRef

Sidtis, J. J., Gatsonis, C., Price, R. W., Singer, E. J., Collier, A. C., Richman, D. D., et al. (1993). Zidovudine treatment of the AIDS dementia complex: Results of a placebo-controlled trial. Annals of Neurology, 33, 343–349. doi:10.1002/ana.410330403.PubMedCrossRef

Simoni, J. M., Kurth, A. E., Pearson, C. R., Pantalone, D. W., Merrill, J. O., & Frick, P. A. (2006). Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management. AIDS and Behavior, 10, 227–245. doi:10.1007/s10461-006-9078-6.PubMedCrossRef

Smith, A. (1982). Symbol digit modalities test (SDMT) manual (revised). Los Angeles, CA: Western Psychological Association.

Solomon, T. M., & Halkitis, P. N. (2008). Cognitive executive functioning in relation to HIV medication adherence among gay, bisexual, and other men who have sex with men. AIDS and Behavior, 12, 68–77. doi:10.1007/s10461-007-9273-0.PubMedCrossRef

Starace, F., Ammassari, A., Trotta, M. P., Murri, R., De Longis, P., Izzo, C., et al. (2002). Depression is a risk factor for suboptimal adherence to highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 31, S136–S139.PubMed

Stuss, D. T., Stethem, L. L., & Pelchat, G. (1988). Three tests of attention and rapid information processing: An extension. The Clinical Neuropsychologist, 2, 246–250. doi:10.1080/13854048808520107.CrossRef

Tiffin, J. (1968). Purdue Pegboard: Examiner manual. Chicago, IL: Science Research Associates.

Uldall, K. K., Palmer, N. B., Whetten, K., Mellins, C., & Mellins, C. (2004). Adherence in people living with HIV/AIDS, mental illness, and chemical dependency: A review of the literature. AIDS Care, 16, S71–S96. doi:10.1080/09540120412331315277.PubMedCrossRef

Wagner, G. J. (2002). Predictors of antiretroviral adherence as measured by self-report, electronic monitoring, and medication diaries. AIDS Patient Care and STDs, 16, 599–608. doi:10.1089/108729102761882134.PubMedCrossRef

Wagner, G. J. (2003). Does discontinuing the use of pill boxes to facilitate electronic monitoring impede adherence? International Journal of STD & AIDS, 14, 64–65. doi:10.1258/095646203321043327.CrossRef

Wagner, G. J., Kanouse, D. E., Koegel, P., & Sullivan, G. (2004). Correlates of HIV antiretroviral adherence in persons with serious mental illness. AIDS Care, 16, 501–506. doi:10.1080/09540120410001683420.PubMedCrossRef

Waldrop-Valverde, D., Ownby, R. L., Wilkie, F. L., Mack, A., Kumar, M., & Metsch, L. (2006). Neurocognitive aspects of medication adherence in HIV-positive injecting drug users. AIDS and Behavior, 10, 287–297. doi:10.1007/s10461-005-9062-6.PubMedCrossRef

Wechsler, D. (1981). Wechsler adult intelligence scale-revised. New York, NY: The Psychological Corporation.

Wechsler, D. (1997). Wechsler adult intelligence scale manual (3rd ed.). New York, NY: The Psychological Corporation.

Wetzel, L., & Boll, T. J. (1987). Short category test, booklet format. Los Angeles, CA: Western Psychological Association.

Woods, S. P., Moran, L. M., Carey, C. L., Dawson, M. S., Iudicello, J. E., Gibson, S., et al. (2008). Prospective memory in HIV infection: is “remembering to remember” a unique predictor of self-reported medication management? Archives of Clinical Neuropsychology, 23, 257–270. doi:10.1016/j.acn.2007.12.006.PubMedCrossRef

World Health Organization. (2008). A global view of HIV infection: 2006. Retrieved December 7, 2008, from http://gamapserver.who.int/mapLibrary/Files/Maps/HIVPrevalenceGlobal.2006.png.

Titel: The relationship between neuropsychological functioning and HAART adherence in HIV-positive adults: a systematic review
Auteurs: Travis I. Lovejoy
Julie A. Suhr
Publicatiedatum: 01-10-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 5/2009
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-009-9212-9

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