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Quantitative assessment of a second-generation cryoballoon ablation catheter with new cooling technology—a perspective on potential implications on outcome

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Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study was to assess the differences in cooling behavior between the first-generation cryoballoon (CB-1G) and the second-generation cryoballoon (CB-2G) quantitatively to understand the freezing capabilities and to benefit from the improved efficacy of the CB-2G in patients with atrial fibrillation.

Methods

We analyzed quantitatively the ice formation of the CB-1G and CB-2G catheters in vitro in a 37 °C warm water bath during freezing for 60, 120, 180, 240, and 300 s, respectively.

Results

The mean-covered surface area and the relative coverage of the ice spots on the CB-2G were significantly different from the spots on the CB-1G for the 28-mm CBs but not for the 23-mm CBs. Whereas for the CB-1G, the ice formation was discontiguous with four isolated ice spots; the CB-2G showed a contiguous ice cap covering the entire distal part including the pole of the balloon. No homogeneous cooling behavior could be observed at the equatorial level with both catheters. Temporal differences on the ice formation could be observed for the 28-mm CB-2G but not for the 23-mm CB-2G.

Conclusion

The new-generation CB-2G showed more powerful and homogeneous cooling behavior, especially for the 28-mm CB. Whether this translates into higher long-term success rates is currently unknown. The impact of the more effective cooling and the longer dissolving duration of the ice cap of the new-generation CB-2G on procedural safety needs to be investigated.

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References

  1. Knecht, S., Kühne, M., Altmann, D., Ammann, P., Schaer, B., Osswald, S., & Sticherling, C. (2013). Anatomical predictors for acute and mid-term success of cryoballoon ablation of atrial fibrillation using the 28mm balloon. Journal of Cardiovascular Electrophysiology, 24, 132–138.

    Article  PubMed  Google Scholar 

  2. URL [Internet]. Available from: http://www.medtronic.com/for-healthcare-professionals/products-therapies/cardiac-rhythm/ablation-products-for-atrial-fibrillation/arctic-front/index.htm#tab1, Accessed 24th of July 2013.

  3. Andrade, J. G., Dubuc, M., Guerra, P. G., Landry, E., Coulombe, N., Leduc, H., Rivard, L., Macle, L., Thibault, B., Talajic, M., Roy, D., & Khairy, P. (2013). Pulmonary vein isolation using a second-generation cryoballoon catheter: a randomized comparison of ablation duration and method of deflation. Journal of Cardiovascular Electrophysiology, 24, 692–698.

    Article  PubMed  Google Scholar 

  4. Coulombe, N., Paulin, J., & Su, W. (2013). Improved in vivo performance of second-generation cryoballoon for pulmonary vein isolation. Journal of Cardiovascular Electrophysiology, 24, 919–925.

    Article  PubMed  Google Scholar 

  5. Fürnkranz, A., Bordignon, S., Schmidt, B., Gunawardene, M., Schulte-Hahn, B., Urban, V., Bode, F., Nowak, B., & Chun, J. K. R. (2013). Improved procedural efficacy of pulmonary vein isolation using the novel second-generation cryoballoon. Journal of Cardiovascular Electrophysiology, 24, 492–497.

    Article  PubMed  Google Scholar 

  6. Hussain, S. K., & Ferguson, J. D. (2013). Cool enough-halving pulmonary vein isolation time with the cryoballoon catheter. Journal of Cardiovascular Electrophysiology, 24, 699–700.

    Article  PubMed  Google Scholar 

  7. Andrade, J. G., Dubuc, M., Guerra, P. G., Macle, L., Mondésert, B., Rivard, L., Roy, D., Talajic, M., Thibault, B., & Khairy, P. (2012). The biophysics and biomechanics of cryoballoon ablation. Pacing and Clinical Electrophysiology, 35, 1162–1168.

    Article  PubMed  Google Scholar 

  8. Available from: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=19003, Accessed 17th of September 2013.

  9. Kühne, M., Knecht, S., Altmann, D., Kawel, N., Ammann, P., Schaer, B., Osswald, S., & Sticherling, C. (2013). Phrenic nerve palsy during ablation of atrial fibrillation using a 28-mm cryoballoon catheter: predictors and prevention. Journal of Interventional Cardiac Electrophysiology, 36, 47–54.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Cardiology/Electrophysiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland

    Sven Knecht, Michael Kühne, Stefan Osswald & Christian Sticherling

Authors
  1. Sven Knecht
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  2. Michael Kühne
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  3. Stefan Osswald
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  4. Christian Sticherling
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Corresponding author

Correspondence to Sven Knecht.

Additional information

Sven Knecht and Michael Kühne contributed equally to this manuscript

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Knecht, S., Kühne, M., Osswald, S. et al. Quantitative assessment of a second-generation cryoballoon ablation catheter with new cooling technology—a perspective on potential implications on outcome. J Interv Card Electrophysiol 40, 17–21 (2014). https://doi.org/10.1007/s10840-014-9883-1

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  • DOI: https://doi.org/10.1007/s10840-014-9883-1

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