Skip to main content
Top
Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2022

10-04-2021 | Original Paper

Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome

Auteurs: John C. Huston, Robyn P. Thom, Caitlin T. Ravichandran, Jennifer E. Mullett, Carly Moran, Jessica L. Waxler, Barbara R. Pober, Christopher J. McDougle

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2022

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The purpose of the study was to characterize repetitive phenomena in Williams syndrome (WS). The parents of 60 subjects with WS completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or Children’s Y-BOCS, the Yale Global Tic Severity Scale, the Stereotyped Behavior Scale, and the Spence Children’s Anxiety Scale–Parent Version. Nineteen males and 41 females participated in the study. Six subjects (10%) had obsessions only, six (10%) had compulsions only, and eleven (18%) had at least one obsession and at least one compulsion. None of the subjects had tics. Fifty subjects (83.3%) endorsed at least one stereotypy. Increased anxiety was associated with increased severity of obsessions, but not severity of compulsions or stereotypies.
Literatuur
go back to reference American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. (2013) (5th ed.). Arlington, VA: American Psychiatric Association. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. (2013) (5th ed.). Arlington, VA: American Psychiatric Association.
go back to reference Green, T., Avda, S., Dotan, I., Zarchi, O., Basel-Vanagaite, L., Zalsman, G., Weizman, A., & Gothelf, D. (2012). Phenotypic psychiatric characterization of children with Williams syndrome and response of those with ADHD to methylphenidate treatment. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics,. https://doi.org/10.1002/ajmg.b.31247.CrossRef Green, T., Avda, S., Dotan, I., Zarchi, O., Basel-Vanagaite, L., Zalsman, G., Weizman, A., & Gothelf, D. (2012). Phenotypic psychiatric characterization of children with Williams syndrome and response of those with ADHD to methylphenidate treatment. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics,. https://​doi.​org/​10.​1002/​ajmg.​b.​31247.CrossRef
go back to reference Leyfer, O. T., Woodruff-Borden, J., Klein-Tasman, B. P., Fricke, J. S., & Mervis, C. B. (2006). Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 141B(6), 615–622. https://doi.org/10.1002/ajmg.b.30344.CrossRef Leyfer, O. T., Woodruff-Borden, J., Klein-Tasman, B. P., Fricke, J. S., & Mervis, C. B. (2006). Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 141B(6), 615–622. https://​doi.​org/​10.​1002/​ajmg.​b.​30344.CrossRef
go back to reference Long, J., & Ervin, L. (2000). Using heteroscedasticity consistent standard errors in the linear regression model. The American Statistician, 54, 217–224. Long, J., & Ervin, L. (2000). Using heteroscedasticity consistent standard errors in the linear regression model. The American Statistician, 54, 217–224.
go back to reference March, J. S. (2004). Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: The pediatric OCD treatment study (POTS) randomized controlled trial. Journal of the American Medical Association, 292(16), 1969–1976. https://doi.org/10.1001/jama.292.16.1969.CrossRef March, J. S. (2004). Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: The pediatric OCD treatment study (POTS) randomized controlled trial. Journal of the American Medical Association, 292(16), 1969–1976. https://​doi.​org/​10.​1001/​jama.​292.​16.​1969.CrossRef
go back to reference McDougle, C. J., Kresch, L. E., Goodman, W. K., Naylor, S. T., Volkmar, F. R., Cohen, D. J., & Price, L. H. (1995). A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. American Journal of Psychiatry, 152(5), 772–777. https://doi.org/10.1176/ajp.152.5.772.CrossRef McDougle, C. J., Kresch, L. E., Goodman, W. K., Naylor, S. T., Volkmar, F. R., Cohen, D. J., & Price, L. H. (1995). A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. American Journal of Psychiatry, 152(5), 772–777. https://​doi.​org/​10.​1176/​ajp.​152.​5.​772.CrossRef
go back to reference Nicita, F., Garone, G., Spalice, A., Savasta, S., Striano, P., Pantaleoni, C., et al. (2016). Epilepsy is a possible feature in Williams-Beuren syndrome patients harboring typical deletions of the 7q1123 critical region. American Journal of Medical Genetics, Part A, 170(1), 148–155. https://doi.org/10.1002/ajmg.a.37410.CrossRef Nicita, F., Garone, G., Spalice, A., Savasta, S., Striano, P., Pantaleoni, C., et al. (2016). Epilepsy is a possible feature in Williams-Beuren syndrome patients harboring typical deletions of the 7q1123 critical region. American Journal of Medical Genetics, Part A, 170(1), 148–155. https://​doi.​org/​10.​1002/​ajmg.​a.​37410.CrossRef
go back to reference Royston, R., Oliver, C., Moss, J., Adams, D., Berg, K., Burbidge, C., Howlin, P., Nelson, L., Stinton, C., & Waite, J. (2018). Brief report: repetitive behaviour profiles in Williams syndrome: cross syndrome comparisons with Prader-Willi and down syndromes. Journal of Autism and Developmental Disorders, 48(1), 326–331. https://doi.org/10.1007/s10803-017-3319-6.CrossRefPubMed Royston, R., Oliver, C., Moss, J., Adams, D., Berg, K., Burbidge, C., Howlin, P., Nelson, L., Stinton, C., & Waite, J. (2018). Brief report: repetitive behaviour profiles in Williams syndrome: cross syndrome comparisons with Prader-Willi and down syndromes. Journal of Autism and Developmental Disorders, 48(1), 326–331. https://​doi.​org/​10.​1007/​s10803-017-3319-6.CrossRefPubMed
go back to reference Smith, V., Preisser, J., Neelon, B., & Maciejewski, M. (2014). A marginalized two-part model for semicontinuous data. Statistics in Medicine, 33(28), 4891–4903.CrossRef Smith, V., Preisser, J., Neelon, B., & Maciejewski, M. (2014). A marginalized two-part model for semicontinuous data. Statistics in Medicine, 33(28), 4891–4903.CrossRef
go back to reference Thom, R. P., & McDougle, C. J. (2021). A comprehensive review of the assessment and differential diagnosis of repetitive thoughts and behaviors in autism spectrum and other neuropsychiatric disorders. Review Journal of Autism and Developmental Disorders. Submitted. Thom, R. P., & McDougle, C. J. (2021). A comprehensive review of the assessment and differential diagnosis of repetitive thoughts and behaviors in autism spectrum and other neuropsychiatric disorders. Review Journal of Autism and Developmental Disorders. Submitted.
go back to reference Woodruff-Borden, J., Kistler, D. J., Henderson, D. R., Crawford, N. A., & Mervis, C. B. (2010). Longitudinal course of anxiety in children and adolescents with Williams syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 154C(2), 277–290. https://doi.org/10.1002/ajmg.c.30259.CrossRef Woodruff-Borden, J., Kistler, D. J., Henderson, D. R., Crawford, N. A., & Mervis, C. B. (2010). Longitudinal course of anxiety in children and adolescents with Williams syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 154C(2), 277–290. https://​doi.​org/​10.​1002/​ajmg.​c.​30259.CrossRef
go back to reference Zainal, H., Magiati, I., Tan, J. W. L., Sung, M., Fung, D. S. S., & Howlin, P. (2014). A preliminary investigation of the Spence children’s anxiety parent scale as a screening tool for anxiety in young people with autism spectrum disorders. Journal of Autism and Developmental Disorders, 44(8), 1982–1994. https://doi.org/10.1007/s10803-014-2075-0.CrossRefPubMed Zainal, H., Magiati, I., Tan, J. W. L., Sung, M., Fung, D. S. S., & Howlin, P. (2014). A preliminary investigation of the Spence children’s anxiety parent scale as a screening tool for anxiety in young people with autism spectrum disorders. Journal of Autism and Developmental Disorders, 44(8), 1982–1994. https://​doi.​org/​10.​1007/​s10803-014-2075-0.CrossRefPubMed
Metagegevens
Titel
Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome
Auteurs
John C. Huston
Robyn P. Thom
Caitlin T. Ravichandran
Jennifer E. Mullett
Carly Moran
Jessica L. Waxler
Barbara R. Pober
Christopher J. McDougle
Publicatiedatum
10-04-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-04979-w

Andere artikelen Uitgave 2/2022

Journal of Autism and Developmental Disorders 2/2022 Naar de uitgave