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Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2020

31-01-2020 | Original Paper

Autism Spectrum Disorder Symptoms are Associated with Connectivity Between Large-Scale Neural Networks and Brain Regions Involved in Social Processing

Auteurs: Korey P. Wylie, Jason R. Tregellas, Joshua J. Bear, Kristina T. Legget

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2020

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Abstract

The neurobiology of autism spectrum disorder remains poorly understood. The present study addresses this knowledge gap by examining the relationship between functional brain connectivity and Autism Diagnostic Observation Schedule (ADOS) scores using publicly available data from the Autism Brain Imaging Data Exchange (ABIDE) database (N = 107). This relationship was tested across all brain voxels, without a priori assumptions, using a novel statistical approach. ADOS scores were primarily associated with decreased connectivity to right temporoparietal junction, right anterior insula, and left fusiform gyrus (p < 0.05, corrected). Seven large-scale brain networks influenced these associations. Findings largely encompassed brain regions involved in processing socially relevant information, highlighting the importance of these processes in autism spectrum disorder.
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Metagegevens
Titel
Autism Spectrum Disorder Symptoms are Associated with Connectivity Between Large-Scale Neural Networks and Brain Regions Involved in Social Processing
Auteurs
Korey P. Wylie
Jason R. Tregellas
Joshua J. Bear
Kristina T. Legget
Publicatiedatum
31-01-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04383-w

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