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Screening of Broader Autism Phenotype Symptoms in Siblings: Support for a Distinct Model of Symptomatology

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Abstract

Research on siblings of youth with autism spectrum disorder (ASD) suggests that some phenotypic presentation, known as the broader autism phenotype (BAP), is common among siblings without an ASD diagnosis (e.g., Ruzich et al. in Autism Res 9(6):658–665, 2016). Whereas the symptoms that underlie both ASD and the BAP share commonality, the structure of these symptoms in youth with ASD and their siblings may differ. The current study assessed whether differences arise in the factor structure of the Children’s Social Behavior Questionnaire (CSBQ) between youth with ASD and their siblings in a sample of 221 sibling dyads. Results suggest similar factor structures for ASD and BAP; however, number of symptoms endorsed, as opposed to the degree of severity, may better differentiate BAP.

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References

  • Baker, A. R. (2002). The invisible end of the spectrum: Shadows, residues, ‘BAP’, and the female Aspergers experience. Paper presented to Inaugural World Autism Congress “Unity through Diversity”, Melbourne, Australia.

  • Constantino, J. N., & Gruber, C. P. (2005). The social responsiveness scale manual. Los Angeles: Western Psychological Services.

    Google Scholar 

  • Constantino, J. N., Lajonchere, C., Lutz, M., Gray, T., Abbacchi, A., McKenna, K., … & Todd, R. D. (2006). Autistic social impairment in the siblings of children with pervasive developmental disorders. American Journal of Psychiatry, 163(2), 294–296.

  • Daniels, A. M., Rosenberg, R. E., Anderson, C., Law, J. K., Marvin, A. R., & Law, P. A. (2012). Verification of parent-report of child autism spectrum disorder diagnosis to a web-based autism registry. Journal of Autism and Developmental Disorders, 42(2), 257–265.

    Article  Google Scholar 

  • de Bildt, A., Mulder, E. J., Hoekstra, P. J., van Lang, N. D., Minderaa, R. B., & Hartman, C. A. (2009). Validity of the Children’s Social Behavior Questionnaire (CSBQ) in children with intellectual disability: Comparing the CSBQ with ADI-R, ADOS, and clinical DSM-IV-TR classification. Journal of Autism and Developmental Disorders, 39(10), 1464–1470.

    Article  Google Scholar 

  • de Bildt, A., Sytema, S., Ketelaars, C., Kraijer, D., Mulder, E., Volkmar, F., et al. (2004). Interrelationship between autism diagnostic observation schedule-generic (ADOS-G), autism diagnostic interview-revised (ADI-R), and the diagnostic and statistical manual of mental disorders (DSM-IV-TR) classification in children and adolescents with mental retardation. Journal of Autism and Developmental Disorders, 34(2), 129–137.

    Article  Google Scholar 

  • Geluk, C. A., Jansen, L., Vermeiren, R., Doreleijers, T. A., van Domburgh, L., de Bildt, A., … & Hartman, C. A. (2012). Autistic symptoms in childhood arrestees: Longitudinal association with delinquent behavior. Journal of Child Psychology and Psychiatry, 53(2), 160–167.

  • Hartman, C. A., Luteijn, E., Serra, M., & Minderaa, R. (2006). Refinement of the Children’s Social Behavior Questionnaire (CSBQ): An instrument that describes the diverse problems seen in milder forms of PDD. Journal of Autism and Developmental Disorders, 36(3), 325–342.

    Article  Google Scholar 

  • Kline, R. B. (2005). Principles and practice of structural equation modeling (2nd ed.). New York: The Guilford Press.

    Google Scholar 

  • Lee, H., Marvin, A. R., Watson, T., Piggot, J., Law, J. K., Law, P. A., … Nelson, S. F. (2010). Accuracy of phenotyping of autistic children based on Internet implemented parent report. American Journal of Medical Genetics, Part B, 153B(6), 1119–1126.

  • Li, C. H. (2016). Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares. Behavior Research Methods, 48(3), 936–949.

    Article  Google Scholar 

  • Luteijn, E., Luteijn, F., Jackson, S., Volkmar, F., & Minderaa, R. (2000). The Children’s Social Behavior Questionnaire for milder variants of PDD problems: Evaluation of the psychometric characteristics. Journal of Autism and Developmental Disorders, 30(4), 317–330.

    Article  Google Scholar 

  • MacCallum, R. C., Widaman, K. F., Zhang, S., & Hong, S. (1999). Sample size in factor analysis. Psychological Methods, 4(1), 84–99.

    Article  Google Scholar 

  • Marvin, A. R., Law, P. A., Law, J. K., Arthur, E. M., Mortenson, E. L., Abbacchi, A. M., … Constantino, J. N. (2014). Non-verbal children with ASD (NV-ASD): Validating a registry and characterizing a population. Presentation at the International Meeting for Autism Research (Atlanta, GA).

  • Meyer, K. A., Ingersoll, B., & Hambrick, D. Z. (2011). Factors influencing adjustment in siblings of children with autism spectrum disorders. Research in Autism Spectrum Disorders, 5(4), 1413–1420.

    Article  Google Scholar 

  • Nijmeijer, J. S., Hoekstra, P. J., Minderaa, R. B., Buitelaar, J. K., Altink, M. E., Buschgens, C. J. M., … & Hartman, C. A. (2009). PDD symptoms in ADHD, an independent familial trait? Journal of Abnormal Child Psychology, 37(3), 443–453.

  • Noordhof, A., Krueger, R. F., Ormel, J., Oldehinkel, A. J., & Hartman, C. A. (2015). Integrating autism-related symptoms into the dimensional internalizing and externalizing model of psychopathology. The TRAILS Study. Journal of Abnormal Child Psychology, 43(3), 577–587.

    Article  Google Scholar 

  • Norris, M., & Lecavalier, L. (2010). Screening accuracy of level 2 autism spectrum disorder rating scales: A review of selected instruments. Autism, 14(4), 263–284.

    Article  Google Scholar 

  • Qualtrics. (2018). Online sample. Retrieved from https://success.qualtrics.com/request-pricing-online-sample.html?_ga=2.217136342.1915722433.1533347627-436553940.1533347627.

  • Rankin, J. A., Tomeny, T. S., & Barry, T. D. (2017). Multi-informant assessment of siblings of youth with autism spectrum disorder: Parent-child discrepancies in at-risk classification. Research in Developmental Disabilities, 68, 78–87.

    Article  Google Scholar 

  • Rhemtulla, M., Brosseau-Liard, P. É., & Savalei, V. (2012). When can categorical variables be treated as continuous? A comparison of robust continuous and categorical SEM estimation methods under suboptimal conditions. Psychological Methods, 17(3), 354.

    Article  Google Scholar 

  • Rosseel, Y. (2012). Lavaan: An R package for structural equation modeling and more, version 0.5–12 (BETA). Journal of Statistical Software, 48(2), 1–36.

    Article  Google Scholar 

  • Rutter, M., Bailey, A., & Lord, C. (2003). Manual for the Social Communication Questionnaire. Los Angeles: Western Psychological Services.

    Google Scholar 

  • Ruzich, E., Allison, C., Smith, P., Watson, P., Auyeung, B., Ring, H., et al. (2016). Subgrouping siblings of people with autism: Identifying the broader autism phenotype. Autism Research, 9(6), 658–665.

    Article  Google Scholar 

  • van Dongen, E. V., von Rhein, D., O’Dwyer, L., Franke, B., Hartman, C. A., Heslenfeld, D. J., … & Buitelaar, J. (2015). Distinct effects of ASD and ADHD symptoms on reward anticipation in participants with ADHD, their unaffected siblings and healthy controls: A cross-sectional study. Molecular Autism, 6(1), 48–60.

  • van Steensel, F. J., Bögels, S. M., & de Bruin, E. I. (2015). DSM-IV versus DSM-5 autism spectrum disorder and social anxiety disorder in childhood: Similarities and differences. Journal of Child and Family Studies, 24(9), 2752–2756.

    Article  Google Scholar 

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Acknowledgments

This research did not receive any specific Grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors declare that there is no conflict of interest regarding the publication of this article.

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  1. Department of Psychology, The University of Alabama, Box 870348, Tuscaloosa, AL, 35487, USA

    James A. Rankin & Theodore S. Tomeny

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  1. James A. Rankin
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  2. Theodore S. Tomeny
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Correspondence to James A. Rankin.

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Rankin, J.A., Tomeny, T.S. Screening of Broader Autism Phenotype Symptoms in Siblings: Support for a Distinct Model of Symptomatology. J Autism Dev Disord 49, 4686–4690 (2019). https://doi.org/10.1007/s10803-019-04157-z

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