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Journal of Autism and Developmental Disorders

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03-05-2019 | Original Paper

Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder

Auteurs: Maayan Huberman Samuel, Gal Meiri, Ilan Dinstein, Hagit Flusser, Analiya Michaelovski, Asher Bashiri, Idan Menashe

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2019

Abstract

Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026–2.302, and aOR = 1.692; 95% CI 1.057–2.709, p_diff = 0.865). We therefore suggest that exposure to GA during CS may explain the association between CS and ASD.

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Titel: Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder
Auteurs: Maayan Huberman Samuel
Gal Meiri
Ilan Dinstein
Hagit Flusser
Analiya Michaelovski
Asher Bashiri
Idan Menashe
Publicatiedatum: 03-05-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-04034-9

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