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Journal of Autism and Developmental Disorders

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21-02-2019 | Brief Report

Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism

Auteurs: Emily A. Abel, A. J. Schwichtenberg, Olivia R. Mannin, Kristine Marceau

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2020

Abstract

Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment, melatonin synthesis, and several genetic syndromes. An over-representation analysis identified several enriched pathways that suggest dopamine and serotonin synapses as potential shared SD and ASD mechanisms. This overlapping gene set and the highlighted biological pathways may serve as a preliminary stepping-stone for new genetic investigations of SD and ASD comorbidity.

vorige artikel Brief Report: Evaluating College Students’ Perceptions of a Child Displaying Stereotypic Behaviors: Do Changes in Stereotypy Levels Affect Ratings?

volgende artikel Brief Report: Participation of Black and African-American Families in Autism Research

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Titel: Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism
Auteurs: Emily A. Abel
A. J. Schwichtenberg
Olivia R. Mannin
Kristine Marceau
Publicatiedatum: 21-02-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-03921-5

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