Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

24-07-2018 | Original Paper

Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study

Auteurs: Ramkripa Raghavan, M. Daniele Fallin, Xiumei Hong, Guoying Wang, Yuelong Ji, Elizabeth A. Stuart, David Paige, Xiaobin Wang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2019

Abstract

Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms.

vorige artikel Obesity Status and Physical Activity Level in Children and Adults with Autism Spectrum Disorders: A Pilot Study

volgende artikel Reliability and Validity of the Chinese Version of Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F)

Alleen toegankelijk voor geautoriseerde gebruikers

Akintunde, M. E., Rose, M., Krakowiak, P., Heuer, L., Ashwood, P., Hansen, R., et al. (2015). Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma. Journal of Neuroimmunology, 286, 33–41. https://doi.org/10.1016/j.jneuroim.2015.07.003.CrossRefPubMedPubMedCentral

Al-Zaid, F. S., Alhader, A. A., & Al-Ayadhi, L. Y. (2014). Altered ghrelin levels in boys with autism: A novel finding associated with hormonal dysregulation. Scientific Reports, 4, 6478. https://doi.org/10.1038/srep06478.CrossRefPubMedPubMedCentral

Angelidou, A., Asadi, S., Alysandratos, K. D., Karagkouni, A., Kourembanas, S., & Theoharides, T. C. (2012). Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatrics, 12, 89. https://doi.org/10.1186/1471-2431-12-89.CrossRefPubMedPubMedCentral

Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011). Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain, Behavior, and Immunity, 25(1), 40–45. https://doi.org/10.1016/j.bbi.2010.08.003.CrossRefPubMed

Ashwood, P., Kwong, C., Hansen, R., Hertz-Picciotto, I., Croen, L., Krakowiak, P., et al. (2008). Brief report: Plasma leptin levels are elevated in autism: Association with early onset phenotype? Journal of Autism and Developmental Disorders, 38(1), 169–175. https://doi.org/10.1007/s10803-006-0353-1.CrossRefPubMed

Ashwood, P., Wills, S., & Van de Water, J. (2006). The immune response in autism: A new frontier for autism research. Journal of Leukocyte Biology, 80(1), 1–15. https://doi.org/10.1189/jlb.1205707.CrossRefPubMed

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, D.C.: American Psychiatric Association.CrossRef

Baio, J., Wiggins, L., Christensen, D. L., Maenner, M. J., Daniels, J., Warren, Z., et al. (2018). Prevalence of autism spectrum disorder among children aged 8 years—Autism and developmental disabilities monitoring network, 11 sites, United States, 2014. MMWR Surveillance Summaries, 67(6), 1–23. https://doi.org/10.15585/mmwr.ss6706a1.CrossRefPubMedCentral

Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51(6), 1173–1182.CrossRefPubMed

Blardi, P., de Lalla, A., Ceccatelli, L., Vanessa, G., Auteri, A., & Hayek, J. (2010). Variations of plasma leptin and adiponectin levels in autistic patients. Neuroscience Letters, 479(1), 54–57. https://doi.org/10.1016/j.neulet.2010.05.027.CrossRefPubMed

Blardi, P., de Lalla, A., D’Ambrogio, T., Vonella, G., Ceccatelli, L., Auteri, A., et al. (2009). Long-term plasma levels of leptin and adiponectin in Rett syndrome. Clinical Endocrinology, 70(5), 706–709. https://doi.org/10.1111/j.1365-2265.2008.03386.x.CrossRefPubMed

Brochu-Gaudreau, K., Rehfeldt, C., Blouin, R., Bordignon, V., Murphy, B. D., & Palin, M. F. (2010). Adiponectin action from head to toe. Endocrine, 37(1), 11–32. https://doi.org/10.1007/s12020-009-9278-8.CrossRefPubMed

Brucato, M., Ladd-Acosta, C., Li, M., Caruso, D., Hong, X., Kaczaniuk, J., et al. (2017). Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort. Autism Research, 10(11), 1878–1890. https://doi.org/10.1002/aur.1841.CrossRefPubMedPubMedCentral

Burd, I., Balakrishnan, B., & Kannan, S. (2012). Models of fetal brain injury, intrauterine inflammation, and preterm birth. American Journal of Reproductive Immunology, 67(4), 287–294. https://doi.org/10.1111/j.1600-0897.2012.01110.x.CrossRefPubMed

Chez, M. G., Dowling, T., Patel, P. B., Khanna, P., & Kominsky, M. (2007). Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediatric Neurology, 36(6), 361–365. https://doi.org/10.1016/j.pediatrneurol.2007.01.012.CrossRefPubMed

Darcy-Mahoney, A., Minter, B., Higgins, M., Guo, Y., Williams, B., Head Zauche, L. M., et al. (2016). Probability of an autism diagnosis by gestational age. Newborn and Infant Nursing Reviews, 16(4), 322–326. https://doi.org/10.1053/j.nainr.2016.09.019.CrossRefPubMed

Dawczynski, K., de Vries, H., Beck, J. F., Schleussner, E., Wittig, S., & Proquitte, H. (2014). Adiponectin serum concentrations in newborn at delivery appear to be of fetal origin. Journal of Pediatric Endocrinology and Metabolism, 27(3–4), 273–278. https://doi.org/10.1515/jpem-2013-0218.CrossRefPubMed

Erdei, C., & Dammann, O. (2014). The perfect storm: preterm birth, neurodevelopmental mechanisms, and autism causation. Perspectives in Biology and Medicine, 57(4), 470–481. https://doi.org/10.1353/pbm.2014.0036.CrossRefPubMed

Essa, M. M., Braidy, N., Al-Sharbati, M. M., Al-Farsi, Y. M., Ali, A., Waly, M. I., et al. (2011). Elevated plasma leptin levels in autisic children of Sultanate of Oman. International Journal of Biological & Medical Research, 2(3), 803–805.

Fezer, G. F., Matos, M. B., Nau, A. L., Zeigelboim, B. S., Marques, J. M., & Liberalesso, P. B. N. (2017). Perinatal features of children with autism spectrum disorder. Revista Paulista de Pediatria, 35(2), 130–135. https://doi.org/10.1590/1984-0462/;2017;35;2;00003.CrossRefPubMedPubMedCentral

Fiorentino, M., Sapone, A., Senger, S., Camhi, S. S., Kadzielski, S. M., Buie, T. M., et al. (2016). Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Molecular Autism, 7, 49. https://doi.org/10.1186/s13229-016-0110-z.CrossRefPubMedPubMedCentral

Fujita-Shimizu, A., Suzuki, K., Nakamura, K., Miyachi, T., Matsuzaki, H., Kajizuka, M., et al. (2010). Decreased serum levels of adiponectin in subjects with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(3), 455–458. https://doi.org/10.1016/j.pnpbp.2009.12.020.CrossRefPubMed

Ghaffari, M. A., Mousavinejad, E., Riahi, F., Mousavinejad, M., & Afsharmanesh, M. R. (2016). Increased serum levels of tumor necrosis factor-alpha, resistin, and visfatin in the children with autism spectrum disorders: A case-control study. Neurology Research International. https://doi.org/10.1155/2016/9060751.CrossRefPubMedPubMedCentral

Hansen-Pupp, I., Hellgren, G., Hard, A. L., Smith, L., Hellstrom, A., & Lofqvist, C. (2015). Early surge in circulatory adiponectin is associated with improved growth at near term in very preterm infants. The Journal of Clinical Endocrinology and Metabolism, 100(6), 2380–2387. https://doi.org/10.1210/jc.2015-1081.CrossRefPubMed

Hellgren, G., Engstrom, E., Smith, L. E., Lofqvist, C., & Hellstrom, A. (2015). Effect of preterm birth on postnatal apolipoprotein and adipocytokine profiles. Neonatology, 108(1), 16–22. https://doi.org/10.1159/000381278.CrossRefPubMed

Hu, Y., Dong, X., & Chen, J. (2015). Adiponectin and depression: A meta-analysis. Biomedical Reports, 3(1), 38–42. https://doi.org/10.3892/br.2014.372.CrossRefPubMed

Inami, I., Okada, T., Fujita, H., Makimoto, M., Hosono, S., Minato, M., et al. (2007). Impact of serum adiponectin concentration on birth size and early postnatal growth. Pediatric Research, 61(5 Pt 1), 604–606. https://doi.org/10.1203/pdr.0b013e3180459f8a.CrossRefPubMed

Inoue, M., Maehata, E., Yano, M., Taniyama, M., & Suzuki, S. (2005). Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism, 54(3), 281–286. https://doi.org/10.1016/j.metabol.2004.09.006.CrossRefPubMed

Ito, H., Morishita, R., & Nagata, K. I. (2017). Autism spectrum disorder-associated genes and the development of dentate granule cells. Medical Molecular Morphology, 50(3), 123–129. https://doi.org/10.1007/s00795-017-0161-z.CrossRefPubMed

Kajantie, E., Hytinantti, T., Hovi, P., & Andersson, S. (2004). Cord plasma adiponectin: A 20-fold rise between 24 weeks gestation and term. The Journal of Clinical Endocrinology and Metabolism, 89(8), 4031–4036. https://doi.org/10.1210/jc.2004-0018.CrossRefPubMed

Kotani, Y., Yokota, I., Kitamura, S., Matsuda, J., Naito, E., & Kuroda, Y. (2004). Plasma adiponectin levels in newborns are higher than those in adults and positively correlated with birth weight. Clinical Endocrinology, 61(4), 418–423. https://doi.org/10.1111/j.1365-2265.2004.02041.x.CrossRefPubMed

Kuzniewicz, M. W., Wi, S., Qian, Y., Walsh, E. M., Armstrong, M. A., & Croen, L. A. (2014). Prevalence and neonatal factors associated with autism spectrum disorders in preterm infants. The Journal of Pediatrics, 164(1), 20–25. https://doi.org/10.1016/j.jpeds.2013.09.021.CrossRefPubMed

Lehto, S. M., Huotari, A., Niskanen, L., Tolmunen, T., Koivumaa-Honkanen, H., Honkalampi, K., et al. (2010). Serum adiponectin and resistin levels in major depressive disorder. Acta Psychiatrica Scandinavica, 121(3), 209–215. https://doi.org/10.1111/j.1600-0447.2009.01463.x.CrossRefPubMed

Lenz, A. M., & Diamond, F. (2012). The importance of the adiponectin and leptin relationship in in utero and infant growth. New York: Springer.CrossRef

Li, M., Fallin, M. D., Riley, A., Landa, R., Walker, S. O., Silverstein, M., et al. (2016). The association of maternal obesity and diabetes with autism and other developmental disabilities. Pediatrics, 137(2), e20152206. https://doi.org/10.1542/peds.2015-2206.CrossRefPubMedPubMedCentral

Lindsay, R. S., Walker, J. D., Havel, P. J., Hamilton, B. A., Calder, A. A., Johnstone, F. D., et al. (2003). Adiponectin is present in cord blood but is unrelated to birth weight. Diabetes Care, 26(8), 2244–2249.CrossRefPubMed

Lisik, M. Z., Gutmajster, E., & Sieron, A. L. (2016). Plasma levels of leptin and adiponectin in fragile X syndrome. Neuroimmunomodulation, 23(4), 239–243. https://doi.org/10.1159/000452336.CrossRefPubMed

Lyall, K., Croen, L., Daniels, J., Fallin, M. D., Ladd-Acosta, C., Lee, B. K., et al. (2017). The changing epidemiology of autism spectrum disorders. Annual Review of Public Health, 38, 81–102. https://doi.org/10.1146/annurev-publhealth-031816-044318.CrossRefPubMed

Machado-Vieira, R., Gold, P. W., Luckenbaugh, D. A., Ballard, E. D., Richards, E. M., Henter, I. D., et al. (2017). The role of adipokines in the rapid antidepressant effects of ketamine. Molecular Psychiatry, 22(1), 127–133. https://doi.org/10.1038/mp.2016.36.CrossRefPubMed

Mansur, R. B., Rizzo, L. B., Santos, C. M., Asevedo, E., Cunha, G. R., Noto, M. N., et al. (2016). Adipokines, metabolic dysfunction and illness course in bipolar disorder. Journal of Psychiatric Research, 74, 63–69. https://doi.org/10.1016/j.jpsychires.2015.12.003.CrossRefPubMed

Mantzoros, C. S., Rifas-Shiman, S. L., Williams, C. J., Fargnoli, J. L., Kelesidis, T., & Gillman, M. W. (2009). Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: A prospective cohort study. Pediatrics, 123(2), 682–689. https://doi.org/10.1542/peds.2008-0343.CrossRefPubMed

Martos-Moreno, G. A., Barrios, V., Saenz de Pipaon, M., Pozo, J., Dorronsoro, I., Martinez-Biarge, M., et al. (2009). Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: Relationship with glucose metabolism. European Journal of Endocrinology, 161(3), 381–389. https://doi.org/10.1530/EJE-09-0193.CrossRefPubMed

Mazaki-Tovi, S., Kanety, H., Pariente, C., Hemi, R., Efraty, Y., Schiff, E., et al. (2007). Determining the source of fetal adiponectin. The Journal of Reproductive Medicine, 52(9), 774–778.PubMed

Mazaki-Tovi, S., Romero, R., Vaisbuch, E., Erez, O., Mittal, P., Chaiworapongsa, T., et al. (2009). Dysregulation of maternal serum adiponectin in preterm labor. Journal of Maternal-Fetal and Neonatal Medicine, 22(10), 887–904. https://doi.org/10.1080/14767050902994655.CrossRefPubMed

Meyer, D. M., Brei, C., Stecher, L., Much, D., Brunner, S., & Hauner, H. (2017). Cord blood and child plasma adiponectin levels in relation to childhood obesity risk and fat distribution up to 5 y. Pediatric Research, 81(5), 745–751. https://doi.org/10.1038/pr.2016.275.CrossRefPubMed

Molloy, C. A., Morrow, A. L., Meinzen-Derr, J., Schleifer, K., Dienger, K., Manning-Courtney, P., et al. (2006). Elevated cytokine levels in children with autism spectrum disorder. Journal of Neuroimmunology, 172(1–2), 198–205. https://doi.org/10.1016/j.jneuroim.2005.11.007.CrossRefPubMed

Movsas, T. Z., & Paneth, N. (2012). The effect of gestational age on symptom severity in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 42(11), 2431–2439. https://doi.org/10.1007/s10803-012-1501-4.CrossRefPubMed

Nakano, Y., Itabashi, K., Sakurai, M., Aizawa, M., Dobashi, K., & Mizuno, K. (2013). Preterm infants have altered adiponectin levels at term-equivalent age even if they do not present with extrauterine growth restriction. Hormone Research in Paediatrics, 80(3), 147–153. https://doi.org/10.1159/000354037.CrossRefPubMed

Ng, R. C., & Chan, K. H. (2017). Potential neuroprotective effects of adiponectin in Alzheimer’s disease. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18030592.CrossRefPubMedPubMedCentral

Oberthuer, A., Donmez, F., Oberhauser, F., Hahn, M., Hoppenz, M., Hoehn, T., et al. (2012). Hypoadiponectinemia in extremely low gestational age newborns with severe hyperglycemia—A matched-paired analysis. PLoS ONE, 7(6), e38481. https://doi.org/10.1371/journal.pone.0038481.CrossRefPubMedPubMedCentral

Pardo, I. M., Geloneze, B., Tambascia, M. A., & Barros-Filho, A. A. (2004). Hyperadiponectinemia in newborns: Relationship with leptin levels and birth weight. Obesity Research, 12(3), 521–524. https://doi.org/10.1038/oby.2004.59.CrossRefPubMed

Raghavan, R., Riley, A. W., Volk, H., Caruso, D., Hironaka, L., Sices, L., et al. (2018). Maternal multivitamin intake, plasma folate and vitamin B₁₂ levels and autism spectrum disorder risk in offspring. Paediatric and Perinatal Epidemiology. https://doi.org/10.1111/ppe.12414.CrossRefPubMed

Rodrigues, D. H., Rocha, N. P., Sousa, L. F., Barbosa, I. G., Kummer, A., & Teixeira, A. L. (2014). Changes in adipokine levels in autism spectrum disorders. Neuropsychobiology, 69(1), 6–10. https://doi.org/10.1159/000356234.CrossRefPubMed

Saito, M., Nishimura, K., Nozue, H., Miyazono, Y., & Kamoda, T. (2011). Changes in serum adiponectin levels from birth to term-equivalent age are associated with postnatal weight gain in preterm infants. Neonatology, 100(1), 93–98. https://doi.org/10.1159/000322654.CrossRefPubMed

Schendel, D., & Bhasin, T. K. (2008). Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities. Pediatrics, 121(6), 1155–1164. https://doi.org/10.1542/peds.2007-1049.CrossRefPubMed

Siahanidou, T., Mandyla, H., Papassotiriou, G. P., Papassotiriou, I., & Chrousos, G. (2007). Circulating levels of adiponectin in preterm infants. Archives of Disease in Childhood-Fetal and Neonatal Edition, 92(4), F286–F290. https://doi.org/10.1136/adc.2006.106112.CrossRefPubMed

Song, J., Kang, S. M., Kim, E., Kim, C. H., Song, H. T., & Lee, J. E. (2015). Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: An in vivo and in vitro study. Cell Death & Differentiation, 6, e1844. https://doi.org/10.1038/cddis.2015.220.CrossRef

Stefan, N., Bunt, J. C., Salbe, A. D., Funahashi, T., Matsuzawa, Y., & Tataranni, P. A. (2002). Plasma adiponectin concentrations in children: Relationships with obesity and insulinemia. The Journal of Clinical Endocrinology and Metabolism, 87(10), 4652–4656. https://doi.org/10.1210/jc.2002-020694.CrossRefPubMed

Terrazzan, A. C., Procianoy, R. S., & Silveira, R. C. (2014). Neonatal cord blood adiponectin and insulin levels in very low birth weight preterm and healthy full-term infants. Journal of Maternal-Fetal and Neonatal Medicine, 27(6), 616–620. https://doi.org/10.3109/14767058.2013.823939.CrossRefPubMed

Thundyil, J., Pavlovski, D., Sobey, C. G., & Arumugam, T. V. (2012). Adiponectin receptor signalling in the brain. British Journal of Pharmacology, 165(2), 313–327. https://doi.org/10.1111/j.1476-5381.2011.01560.x.CrossRefPubMedPubMedCentral

Tsai, P. J., Yu, C. H., Hsu, S. P., Lee, Y. H., Chiou, C. H., Hsu, Y. W., et al. (2004). Cord plasma concentrations of adiponectin and leptin in healthy term neonates: Positive correlation with birthweight and neonatal adiposity. Clinical Endocrinology, 61(1), 88–93. https://doi.org/10.1111/j.1365-2265.2004.02057.x.CrossRefPubMed

Villarreal-Molina, M. T., & Antuna-Puente, B. (2012). Adiponectin: Anti-inflammatory and cardioprotective effects. Biochimie, 94(10), 2143–2149. https://doi.org/10.1016/j.biochi.2012.06.030.CrossRefPubMed

Wang, G., Divall, S., Radovick, S., Paige, D., Ning, Y., Chen, Z., et al. (2014). Preterm birth and random plasma insulin levels at birth and in early childhood. JAMA, 311(6), 587–596. https://doi.org/10.1001/jama.2014.1.CrossRefPubMedPubMedCentral

Wang, G., Hu, F. B., Mistry, K. B., Zhang, C., Ren, F., Huo, Y., et al. (2016a). Association between maternal prepregnancy body mass index and plasma folate concentrations with child metabolic health. JAMA Pediatrics, 170(8), e160845. https://doi.org/10.1001/jamapediatrics.2016.0845.CrossRefPubMedPubMedCentral

Wang, G., Johnson, S., Gong, Y., Polk, S., Divall, S., Radovick, S., et al. (2016b). Weight gain in infancy and overweight or obesity in childhood across the gestational spectrum: A prospective birth cohort study. Scientific Reports, 6, 29867. https://doi.org/10.1038/srep29867.CrossRefPubMedPubMedCentral

Wang, X., Zuckerman, B., Pearson, C., Kaufman, G., Chen, C., Wang, G., et al. (2002). Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. JAMA, 287(2), 195–202.CrossRefPubMed

Wei, H., Alberts, I., & Li, X. (2013). Brain IL-6 and autism. Neuroscience, 252, 320–325. https://doi.org/10.1016/j.neuroscience.2013.08.025.CrossRefPubMed

Weyermann, M., Beermann, C., Brenner, H., & Rothenbacher, D. (2006). Adiponectin and leptin in maternal serum, cord blood, and breast milk. Clinical Chemistry, 52(11), 2095–2102. https://doi.org/10.1373/clinchem.2006.071019.CrossRefPubMed

Wozniak, R. H., Leezenbaum, N. B., Northrup, J. B., West, K. L., & Iverson, J. M. (2017). The development of autism spectrum disorders: Variability and causal complexity. Wiley Interdisciplinary Reviews: Cognitive Science, 8(1–2), e1426. https://doi.org/10.1002/wcs.1426.CrossRef

Yeung, E. H., McLain, A. C., Anderson, N., Lawrence, D., Boghossian, N. S., Druschel, C., et al. (2015). Newborn adipokines and birth outcomes. Paediatric and Perinatal Epidemiology, 29(4), 317–325. https://doi.org/10.1111/ppe.12203.CrossRefPubMedPubMedCentral

Yoshida, T., Nagasaki, H., Asato, Y., & Ohta, T. (2009). The ratio of high-molecular weight adiponectin and total adiponectin differs in preterm and term infants. Pediatric Research, 65(5), 580–583. https://doi.org/10.1203/PDR.0b013e3181995103.CrossRefPubMed

Young, A. M., Campbell, E., Lynch, S., Suckling, J., & Powis, S. J. (2011). Aberrant NF-kappaB expression in autism spectrum condition: A mechanism for neuroinflammation. Frontiers in Psychiatry, 2, 27. https://doi.org/10.3389/fpsyt.2011.00027.CrossRefPubMedPubMedCentral

Zerbo, O., Yoshida, C., Grether, J. K., Van de Water, J., Ashwood, P., Delorenze, G. N., et al. (2014). Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: The Early Markers for Autism (EMA) study: A case-control study. Journal of Neuroinflammation, 11, 113. https://doi.org/10.1186/1742-2094-11-113.CrossRefPubMedPubMedCentral

Zhang, D., Wang, X., Wang, B., Garza, J. C., Fang, X., Wang, J., et al. (2017). Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors. Molecular Psychiatry, 22(7), 1044–1055. https://doi.org/10.1038/mp.2016.58.CrossRefPubMed

Zhang, D., Wang, X., & Lu, X. Y. (2016a). Adiponectin exerts neurotrophic effects on dendritic arborization, spinogenesis, and neurogenesis of the dentate gyrus of male mice. Endocrinology, 157(7), 2853–2869. https://doi.org/10.1210/en.2015-2078.CrossRefPubMedPubMedCentral

Zhang, Z. Q., Lu, Q. G., Huang, J., Jiao, C. Y., Huang, S. M., & Mao, L. M. (2016b). Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: A prospective study. BMC Pregnancy and Childbirth, 16(1), 189. https://doi.org/10.1186/s12884-016-0978-9.CrossRefPubMedPubMedCentral

Titel: Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study
Auteurs: Ramkripa Raghavan
M. Daniele Fallin
Xiumei Hong
Guoying Wang
Yuelong Ji
Elizabeth A. Stuart
David Paige
Xiaobin Wang
Publicatiedatum: 24-07-2018
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-018-3688-5

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 1/2019

The Relation Between Vocal Pitch and Vocal Emotion Recognition Abilities in People with Autism Spectrum Disorder and Typical Development

Autism Traits, Sensory Over-Responsivity, Anxiety, and Stress: A Test of Explanatory Models

Brief Report: Differences in Multisensory Integration Covary with Sensory Responsiveness in Children with and without Autism Spectrum Disorder

Do Beliefs About Whether Others Can See Modulate Social Seeking in Autism?

Brief Report: Sibling Feelings Toward their Brother or Sister With or Without Autism or Intellectual Disability

Diagnostic and Therapeutic Misconception: Parental Expectations and Perspectives Regarding Genetic Testing for Developmental Disorders