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Gepubliceerd in: Journal of Autism and Developmental Disorders 9/2018

11-04-2018 | Brief Report

Brief Report: Autism Spectrum Disorder: A Comprehensive Survey of Randomized Controlled Trials

Auteurs: Samuel Tromans, Clive Adams

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2018

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Abstract

We searched the Cochrane Central Register of Controlled Trials to provide an overview of evidence from randomized controlled trials (RCTs) of therapeutic interventions for autism spectrum disorders. From the final survey (529 RCTs), the mean size was 49 participants (standard deviation 50, range 1–479, median 36, mode 40), with a sharp increase in the number of RCTs from 2008. The most frequently evaluated intervention was antipsychotic treatment (n = 44, 3006 participants). The journal with the most RCTs was the Journal of Autism and Developmental Disorders (N = 104). Most trials were small in size, emphasising the need for research groups to collaborate to generate higher quality data with greater applicability to clinical practice.
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Literatuur
go back to reference Barnard, L., Young, A., Pearson, J., Geddes, J., & O’brien, G. (2002). A systematic review of the use of atypical antipsychotics in autism. Journal of Psychopharmacology, 16(1), 93–101.CrossRefPubMed Barnard, L., Young, A., Pearson, J., Geddes, J., & O’brien, G. (2002). A systematic review of the use of atypical antipsychotics in autism. Journal of Psychopharmacology, 16(1), 93–101.CrossRefPubMed
go back to reference Baxter, A., Brugha, T., Erskine, H., Scheurer, R., Vos, T., & Scott, J. (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 45(3), 601–613.CrossRefPubMed Baxter, A., Brugha, T., Erskine, H., Scheurer, R., Vos, T., & Scott, J. (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 45(3), 601–613.CrossRefPubMed
go back to reference Chalmers, I., Bracken, M. B., Djulbegovic, B., Garattini, S., Grant, J., Gülmezoglu, A. M., et al. (2014). How to increase value and reduce waste when research priorities are set. The Lancet, 383(9912), 156–165.CrossRef Chalmers, I., Bracken, M. B., Djulbegovic, B., Garattini, S., Grant, J., Gülmezoglu, A. M., et al. (2014). How to increase value and reduce waste when research priorities are set. The Lancet, 383(9912), 156–165.CrossRef
go back to reference Cooke, A., Smith, D., & Booth, A. (2012). Beyond PICO: The SPIDER tool for qualitative evidence synthesis. Qualitative Health Research, 22(10), 1435–1443.CrossRefPubMed Cooke, A., Smith, D., & Booth, A. (2012). Beyond PICO: The SPIDER tool for qualitative evidence synthesis. Qualitative Health Research, 22(10), 1435–1443.CrossRefPubMed
go back to reference DSM-5 American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders. Arlington: American Psychiatric Publishing.CrossRef DSM-5 American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders. Arlington: American Psychiatric Publishing.CrossRef
go back to reference Falkmer, T., Anderson, K., Falkmer, M., & Horlin, C. (2013). Diagnostic procedures in autism spectrum disorders: A systematic literature review. European Child & Adolescent Psychiatry, 22(6), 329–340.CrossRef Falkmer, T., Anderson, K., Falkmer, M., & Horlin, C. (2013). Diagnostic procedures in autism spectrum disorders: A systematic literature review. European Child & Adolescent Psychiatry, 22(6), 329–340.CrossRef
go back to reference Gates, J. A., Kang, E., & Lerner, M. D. (2017). Efficacy of group social skills interventions for youth with autism spectrum disorder: A systematic review and meta-analysis. Clinical Psychology Review, 52, 164–181.CrossRefPubMedPubMedCentral Gates, J. A., Kang, E., & Lerner, M. D. (2017). Efficacy of group social skills interventions for youth with autism spectrum disorder: A systematic review and meta-analysis. Clinical Psychology Review, 52, 164–181.CrossRefPubMedPubMedCentral
go back to reference Huang, X., Lin, J., & Demner-Fushman, D. (2006). Evaluation of PICO as a knowledge representation for clinical questions. In AMIA annual symposium proceedings, pp. 359–363. Huang, X., Lin, J., & Demner-Fushman, D. (2006). Evaluation of PICO as a knowledge representation for clinical questions. In AMIA annual symposium proceedings, pp. 359–363.
go back to reference Jang, J., Matson, J. L., Williams, L. W., Tureck, K., Goldin, R. L., & Cervantes, P. E. (2013). Rates of comorbid symptoms in children with ASD, ADHD, and comorbid ASD and ADHD. Research in Developmental Disabilities, 34(8), 2369–2378.CrossRefPubMed Jang, J., Matson, J. L., Williams, L. W., Tureck, K., Goldin, R. L., & Cervantes, P. E. (2013). Rates of comorbid symptoms in children with ASD, ADHD, and comorbid ASD and ADHD. Research in Developmental Disabilities, 34(8), 2369–2378.CrossRefPubMed
go back to reference Postorino, V., Sharp, W. G., McCracken, C. E., Bearss, K., Burrell, T. L., Evans, A. N., et al. (2017). A systematic review and meta-analysis of parent training for disruptive behavior in children with autism spectrum disorder. Clinical Child and Family Psychology Review, 20(4), 391–402.CrossRefPubMed Postorino, V., Sharp, W. G., McCracken, C. E., Bearss, K., Burrell, T. L., Evans, A. N., et al. (2017). A systematic review and meta-analysis of parent training for disruptive behavior in children with autism spectrum disorder. Clinical Child and Family Psychology Review, 20(4), 391–402.CrossRefPubMed
go back to reference Schulz, K. F., Altman, D. G., & Moher, D. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMC Medicine, 8(1), 18.CrossRefPubMedPubMedCentral Schulz, K. F., Altman, D. G., & Moher, D. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMC Medicine, 8(1), 18.CrossRefPubMedPubMedCentral
go back to reference Siegel, M., & Beaulieu, A. A. (2012). Psychotropic medications in children with autism spectrum disorders: A systematic review and synthesis for evidence-based practice. Journal of Autism and Developmental Disorders, 42(8), 1592–1605.CrossRefPubMed Siegel, M., & Beaulieu, A. A. (2012). Psychotropic medications in children with autism spectrum disorders: A systematic review and synthesis for evidence-based practice. Journal of Autism and Developmental Disorders, 42(8), 1592–1605.CrossRefPubMed
go back to reference Trikalinos, T. A., Churchill, R., Ferri, M., Leucht, S., Tuunainen, A., Wahlbeck, K., et al. (2004). Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time. Journal of Clinical Epidemiology, 57(11), 1124–1130.CrossRefPubMed Trikalinos, T. A., Churchill, R., Ferri, M., Leucht, S., Tuunainen, A., Wahlbeck, K., et al. (2004). Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time. Journal of Clinical Epidemiology, 57(11), 1124–1130.CrossRefPubMed
go back to reference Wessely, S. (2007). Randomised, controlled trials. In Choosing methods in mental health research: Mental health research from theory to practice (pp. 85–98). New York: Psychology Press. Wessely, S. (2007). Randomised, controlled trials. In Choosing methods in mental health research: Mental health research from theory to practice (pp. 85–98). New York: Psychology Press.
Metagegevens
Titel
Brief Report: Autism Spectrum Disorder: A Comprehensive Survey of Randomized Controlled Trials
Auteurs
Samuel Tromans
Clive Adams
Publicatiedatum
11-04-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3569-y

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