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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2018

09-02-2018 | Brief Report

The Co-occurrence of Gender Dysphoria and Autism Spectrum Disorder in Adults: An Analysis of Cross-Sectional and Clinical Chart Data

Auteurs: Gunter Heylens, Lore Aspeslagh, Jesper Dierickx, Kariann Baetens, Birgit Van Hoorde, Griet De Cuypere, Els Elaut

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2018

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Abstract

Quantitative studies indicate an overrepresentation of ASD in individuals with GD. This study aims to determine the prevalence of autistic traits or ASD in adults with GD using two different data collection methods: (1) cross-sectional data using the social responsiveness scale-adults (SRS-A) and the autism quotient (AQ) (n = 63). (2) Clinical chart data (n = 532). Mean SRS-A scores were significantly higher compared to a norm population. Almost 5% of the patients with GD scored above the cut-off as measured by the AQ. In 32 patients (6%), a certain ASD diagnosis was found in the patient files, which is sixfold higher compared to the general population. Significantly more “birth assigned male” were affected compared to “birth assigned female”.
Literatuur
go back to reference Aitken, M., Steensma, T. D., Blanchard, R., VanderLaan, D. P., Wood, H., Fuentes, A., Spegg, C., Wasserman, L., Ames, M., Fitzsimmons, C. L., Leef, J. H., Lishak, V., Reim, E., Takagi, A., Vinik, J., Wreford, J., Cohen-Kettenis, P. T., de Vries, A. L., Kreukels, B. P., & Zucker, K. J. (2014). Evidence for an altered sex ratio in clinic-referred adolescents with gender dysphoria. The Journal of Sexual Medicine, 12, 765–773. Aitken, M., Steensma, T. D., Blanchard, R., VanderLaan, D. P., Wood, H., Fuentes, A., Spegg, C., Wasserman, L., Ames, M., Fitzsimmons, C. L., Leef, J. H., Lishak, V., Reim, E., Takagi, A., Vinik, J., Wreford, J., Cohen-Kettenis, P. T., de Vries, A. L., Kreukels, B. P., & Zucker, K. J. (2014). Evidence for an altered sex ratio in clinic-referred adolescents with gender dysphoria. The Journal of Sexual Medicine, 12, 765–773.
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Press, Washington, DC.CrossRef American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Press, Washington, DC.CrossRef
go back to reference Arcelus, J., Bouman, W. P., Van Den Noortgate, W., Claes, L., Witcomb, G., & Fernandez-Aranda, F. (2015). Systematic review and meta-analysis of prevalence studies in transsexualism. European Psychiatry, 30, 807–815.CrossRefPubMed Arcelus, J., Bouman, W. P., Van Den Noortgate, W., Claes, L., Witcomb, G., & Fernandez-Aranda, F. (2015). Systematic review and meta-analysis of prevalence studies in transsexualism. European Psychiatry, 30, 807–815.CrossRefPubMed
go back to reference Baron-Cohen, S. (2002). The extreme male brain theory of autism. Trends in Cognitive Sciences, 6, 248–254.CrossRefPubMed Baron-Cohen, S. (2002). The extreme male brain theory of autism. Trends in Cognitive Sciences, 6, 248–254.CrossRefPubMed
go back to reference Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger Syndrome/high-functioning autism, males and femals, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.CrossRefPubMed Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger Syndrome/high-functioning autism, males and femals, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.CrossRefPubMed
go back to reference Bishop, S. L., & Seltzer, M. M. (2012). Self-reported autism symptoms in adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42, 2354–2363.CrossRefPubMedPubMedCentral Bishop, S. L., & Seltzer, M. M. (2012). Self-reported autism symptoms in adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42, 2354–2363.CrossRefPubMedPubMedCentral
go back to reference Constantino, J. N., & Charman, T. (2016). Diagnosis of autism spectrum disorder: Reconciling the syndrome, its diverse origins, and variation in expression. The Lancet Neurology, 15, 279–291.CrossRefPubMed Constantino, J. N., & Charman, T. (2016). Diagnosis of autism spectrum disorder: Reconciling the syndrome, its diverse origins, and variation in expression. The Lancet Neurology, 15, 279–291.CrossRefPubMed
go back to reference Constantino, J. N., Gruber, C. P., Noens, I., De la Marche, W., & Scholte, E. (2012). SRS-A. Screeningslijst voor autismespectrumstoornissen bij volwassenen. Amsterdam: Hogrefe. Constantino, J. N., Gruber, C. P., Noens, I., De la Marche, W., & Scholte, E. (2012). SRS-A. Screeningslijst voor autismespectrumstoornissen bij volwassenen. Amsterdam: Hogrefe.
go back to reference De Vries, A. L., Noens, I. L., Cohen-Kettenis, P. T., Van Berckelaer-Onnes, I. A., & Doreleijers, T. A. (2010). Autism spectrum disorders in gender dysphoric children and adolescents. Journal of Autism and Developmental Disorders, 40, 930–936.CrossRefPubMedPubMedCentral De Vries, A. L., Noens, I. L., Cohen-Kettenis, P. T., Van Berckelaer-Onnes, I. A., & Doreleijers, T. A. (2010). Autism spectrum disorders in gender dysphoric children and adolescents. Journal of Autism and Developmental Disorders, 40, 930–936.CrossRefPubMedPubMedCentral
go back to reference Fombonne, E. (2005). Epidemiology of autistic disorder and other pervasive developmental disorders. Journal of Clinical Psychiatry, 66, 3–8.PubMed Fombonne, E. (2005). Epidemiology of autistic disorder and other pervasive developmental disorders. Journal of Clinical Psychiatry, 66, 3–8.PubMed
go back to reference Glidden, D., Bouman, W. P., Jones, B. A., & Arcelus, J. (2016). Gender dysphoria and autism spectrum disorder: A systematic review of the literature. Sexual Medicine Reviews, 4, 3–14.CrossRefPubMed Glidden, D., Bouman, W. P., Jones, B. A., & Arcelus, J. (2016). Gender dysphoria and autism spectrum disorder: A systematic review of the literature. Sexual Medicine Reviews, 4, 3–14.CrossRefPubMed
go back to reference Hoekstra, R. A., Bartels, M., Cath, D. C., & Boomsma, D. I. (2008). Factor structure, reliability and criterion validity of the autism spectrum quotient (AQ): A study in Dutch population and patient groups. Journal of Autism and Developmental Disorders, 38, 1555–1566.CrossRefPubMedPubMedCentral Hoekstra, R. A., Bartels, M., Cath, D. C., & Boomsma, D. I. (2008). Factor structure, reliability and criterion validity of the autism spectrum quotient (AQ): A study in Dutch population and patient groups. Journal of Autism and Developmental Disorders, 38, 1555–1566.CrossRefPubMedPubMedCentral
go back to reference Hus, V., Bishop, S., Gotham, K., Huerta, M., & Lord, C. (2013). Factors influencing scores on the social responsiveness scale. Journal of Child Psychology and Psychiatry, 54, 216–224.CrossRefPubMed Hus, V., Bishop, S., Gotham, K., Huerta, M., & Lord, C. (2013). Factors influencing scores on the social responsiveness scale. Journal of Child Psychology and Psychiatry, 54, 216–224.CrossRefPubMed
go back to reference Jones, R. M., Wheelwright, S., Farrell, K., Martin, E., Green, R., Di Ceglie, D., & Baron-Cohen, S. (2012). Brief report: Female-to-male transsexual people and autistic traits. Journal of Autism and Developmental Disorders, 42, 301–306.CrossRefPubMed Jones, R. M., Wheelwright, S., Farrell, K., Martin, E., Green, R., Di Ceglie, D., & Baron-Cohen, S. (2012). Brief report: Female-to-male transsexual people and autistic traits. Journal of Autism and Developmental Disorders, 42, 301–306.CrossRefPubMed
go back to reference Kreukels, B. P., Haraldsen, I. R., De Cuypere, G., Richter-Appelt, H., Gijs, L., & Cohen-Kettenis, P. T. (2012). A European network for the investigation of gender incongruence: The ENIGI initiative. European Psychiatry, 27, 445–450.CrossRefPubMed Kreukels, B. P., Haraldsen, I. R., De Cuypere, G., Richter-Appelt, H., Gijs, L., & Cohen-Kettenis, P. T. (2012). A European network for the investigation of gender incongruence: The ENIGI initiative. European Psychiatry, 27, 445–450.CrossRefPubMed
go back to reference Kung, K. T., Spencer, D., Pasterski, V., Neufeld, S., Glover, V., O’Connor, T. G., Hindmarsh, P. C., Hughes, I. A., Acerini, C. L., & Hines, M. (2016). No relationship between prenatal androgen exposure and autistic traits: Convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children. Journal of Child Psychology and Psychiatry, 57, 1455–1462.CrossRefPubMed Kung, K. T., Spencer, D., Pasterski, V., Neufeld, S., Glover, V., O’Connor, T. G., Hindmarsh, P. C., Hughes, I. A., Acerini, C. L., & Hines, M. (2016). No relationship between prenatal androgen exposure and autistic traits: Convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children. Journal of Child Psychology and Psychiatry, 57, 1455–1462.CrossRefPubMed
go back to reference Pasterski, V., Gilligan, L., & Curtis, R. (2014). Traits of autism spectrum disorders in adults with gender dysphoria. Archives of Sexual Behavior, 43, 387–393.CrossRefPubMed Pasterski, V., Gilligan, L., & Curtis, R. (2014). Traits of autism spectrum disorders in adults with gender dysphoria. Archives of Sexual Behavior, 43, 387–393.CrossRefPubMed
go back to reference Richards, C., Bouman, W. P., Seal, L., Barker, M. J., Nieder, T. O., & T’Sjoen, G. (2016). Non-binary or genderqueer genders. International Review of Psychiatry, 8, 95–102.CrossRef Richards, C., Bouman, W. P., Seal, L., Barker, M. J., Nieder, T. O., & T’Sjoen, G. (2016). Non-binary or genderqueer genders. International Review of Psychiatry, 8, 95–102.CrossRef
go back to reference Schaafsma, S. M., & Pfaff, D. W. (2014). Etiologies underlying sex differences in autism spectrum disorders. Frontiers in Neuroendocrinology, 35, 255–271.CrossRefPubMed Schaafsma, S. M., & Pfaff, D. W. (2014). Etiologies underlying sex differences in autism spectrum disorders. Frontiers in Neuroendocrinology, 35, 255–271.CrossRefPubMed
go back to reference Schneider, C., Cerwenka, S., Nieder, T. O., Briken, P., Cohen-Kettenis, P. T., De Cuypere, G., Haraldsen, I. R., Kreukels, B. P., & Richter-Appelt, H. (2016). Measuring gender dysphoria: A multicenter examination and comparison of the utrecht gender dysphoria scale and the gender identity/gender dysphoria questionnaire for adolescents and adults. Archives of Sexual Behaviour, 45, 551–558.CrossRef Schneider, C., Cerwenka, S., Nieder, T. O., Briken, P., Cohen-Kettenis, P. T., De Cuypere, G., Haraldsen, I. R., Kreukels, B. P., & Richter-Appelt, H. (2016). Measuring gender dysphoria: A multicenter examination and comparison of the utrecht gender dysphoria scale and the gender identity/gender dysphoria questionnaire for adolescents and adults. Archives of Sexual Behaviour, 45, 551–558.CrossRef
go back to reference Skagerberg, E., Di Ceglie, D., & Carmichael, P. (2015). Brief report: Autistic features in children and adolescents with gender dysphoria. Journal of Autism Developmental Disorders, 45, 2628–2632.CrossRefPubMed Skagerberg, E., Di Ceglie, D., & Carmichael, P. (2015). Brief report: Autistic features in children and adolescents with gender dysphoria. Journal of Autism Developmental Disorders, 45, 2628–2632.CrossRefPubMed
go back to reference South, M., Carr, A. W., Stephenson, K. G., Maisel, M. E., & Cox, J. C. (2017). Symptom overlap on the SRS-2 adult self-report between adults with asd and adults with high anxiety. Autism Research, 10, 1215–1220.CrossRefPubMed South, M., Carr, A. W., Stephenson, K. G., Maisel, M. E., & Cox, J. C. (2017). Symptom overlap on the SRS-2 adult self-report between adults with asd and adults with high anxiety. Autism Research, 10, 1215–1220.CrossRefPubMed
go back to reference Strang, J. F., Meagher, H., Kenworthy, L., de Vries, A. L., Menvielle, E., Leibowitz, S., Janssen, A., Cohen-Kettenis, P., Shumer, D. E., Edwards-Leeper, L., Pleak, R. R., Spack, N., Karasic, D. H., Schreier, H., Balleur, A., Tishelman, A., Ehrensaft, D., Rodnan, L., Kuschner, E. S., Mandel, F., Caretto, A., Lewis, H. C., & Anthony, L. G. (2016). Initial clinical guidelines for co-occurring autism spectrum disorder and gender dysphoria or Incongruence in adolescents. Journal of Clinical Child & Adolescent Psychology, 24, 1–11. [Epub ahead of print]. Strang, J. F., Meagher, H., Kenworthy, L., de Vries, A. L., Menvielle, E., Leibowitz, S., Janssen, A., Cohen-Kettenis, P., Shumer, D. E., Edwards-Leeper, L., Pleak, R. R., Spack, N., Karasic, D. H., Schreier, H., Balleur, A., Tishelman, A., Ehrensaft, D., Rodnan, L., Kuschner, E. S., Mandel, F., Caretto, A., Lewis, H. C., & Anthony, L. G. (2016). Initial clinical guidelines for co-occurring autism spectrum disorder and gender dysphoria or Incongruence in adolescents. Journal of Clinical Child & Adolescent Psychology, 24, 1–11. [Epub ahead of print].
go back to reference Van der Miesen, A. I., Hurley, H., & De Vries, A. L. (2016). Gender dysphoria and autism spectrum disorder: A narrative review. International Review of Psychiatry, 28, 70–80.CrossRef Van der Miesen, A. I., Hurley, H., & De Vries, A. L. (2016). Gender dysphoria and autism spectrum disorder: A narrative review. International Review of Psychiatry, 28, 70–80.CrossRef
go back to reference van Schalkwyk, G. I., Klingensmith, K., & Volkmar, F. R. (2015). Gender identity and autism spectrum disorders. The Yale Journal of Biology and Medicine, 88, 81–83.PubMedPubMedCentral van Schalkwyk, G. I., Klingensmith, K., & Volkmar, F. R. (2015). Gender identity and autism spectrum disorders. The Yale Journal of Biology and Medicine, 88, 81–83.PubMedPubMedCentral
go back to reference VanderLaan, D. P., Leef, H. L., Wood, H., Hughes, S. K., & Zucker, K. J. (2015). Autism spectrum disorder risk factors and autistic traits in gender dysphoric children. Journal of Autism and Developmental Disorders, 45, 1742–1750.CrossRefPubMed VanderLaan, D. P., Leef, H. L., Wood, H., Hughes, S. K., & Zucker, K. J. (2015). Autism spectrum disorder risk factors and autistic traits in gender dysphoric children. Journal of Autism and Developmental Disorders, 45, 1742–1750.CrossRefPubMed
Metagegevens
Titel
The Co-occurrence of Gender Dysphoria and Autism Spectrum Disorder in Adults: An Analysis of Cross-Sectional and Clinical Chart Data
Auteurs
Gunter Heylens
Lore Aspeslagh
Jesper Dierickx
Kariann Baetens
Birgit Van Hoorde
Griet De Cuypere
Els Elaut
Publicatiedatum
09-02-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3480-6

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