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Journal of Autism and Developmental Disorders

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31-08-2017 | Original Paper

Bone Mineral Density in Boys Diagnosed with Autism Spectrum Disorder: A Case-Control Study

Auteurs: Kelly Barnhill, Lucas Ramirez, Alan Gutierrez, Wendy Richardson, C. Nathan Marti, Amy Potts, Rebeca Shearer, Claire Schutte, Laura Hewitson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2017

Abstract

This study compared bone mineral density (BMD) of the spine obtained by dual-energy X-ray absorptiometry (DEXA), nutritional status, biochemical markers, and gastrointestinal (GI) symptoms in 4–8 year old boys with Autism Spectrum Disorder (ASD) with a group of age-matched, healthy boys without ASD. Boys with ASD had significantly lower spine BMD compared to controls but this was not correlated with any biochemical markers, dietary intake of calcium and vitamin D, elimination diet status, or GI symptomology. Reduced BMD in 4–8 year old boys with ASD appears to involve factors other than nutrient intake and GI status, and requires further study.

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American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders. (5th edn.). Arlington, VA: American Psychiatric Association.CrossRef

Baldwin, S. A., Bauer, D. J., Stice, E., & Rohde, P. (2011). Evaluating models for partially clustered designs. Psychological Methods, 16(2), 149–165. doi:10.1037/a0023464.CrossRefPubMedPubMedCentral

Barnhill, K., Gutierrez, A., Ghossainy, M., Marediya, Z., Marti, C. N., & Hewitson, L. (2017). Growth status of children with autism spectrum disorder: A case-control study. Journal of Human Nutrition and Dietetics, 30(1), 59–65. doi:10.1111/jhn.12396.CrossRefPubMed

Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015). Fitting linear mixed-effects models using lme4. Journal of Statistical Software. doi:10.18637/jss.v067.i01.

Bausserman, M., & Michail, S. (2005). The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial. Journal of Pediatrics, 147(2), 197–201.CrossRefPubMed

Bener, A., Khattab, A. O., & Al-Dabbagh, M. M. (2014). Is high prevalence of vitamin D deficiency evidence for autism disorder?: In a highly endogamous population. Journal of Pediatric Neuroscience, 9(3), 227–233. doi:10.4103/1817-1745.147574.CrossRef

Black, C., Kaye, J. A., & Jick, H. (2002). Relation of childhood gastrointestinal disorders to autism: Nested case-control study using data from the UK general practice research database. British Medical Journal, 325(7361), 419–421.CrossRefPubMedPubMedCentral

Buie, T., Campbell, D. B., Fuchs, G. J., Furuta, G. T., Levy, J., Vandewater, J., et al. (2010a). Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: A consensus report. Pediatrics, 125(Suppl 1), S1–S18.

Buie, T., Fuchs, G. J., Furuta, G. T., Kooros, K., Levy, J., Lewis, J. D., et al. (2010b). Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics, 125(Suppl 1), S19–S29. doi:10.1542/peds.2009-1878D.

Calarge, C. A., Burns, T. L., Schlechte, J. A., & Zemel, B. S. (2015). Longitudinal examination of the skeletal effects of selective serotonin reuptake inhibitors and risperidone in boys. Journal of Clinical Psychiatry, 76(5), 607–613. doi:10.4088/JCP.14m09195.CrossRefPubMed

Carter, D. R., Bouxsein, M. L., & Marcus, R. (1992). New approaches for interpreting projected bone densitometry data. Journal of Bone Mineral Research, 7(2), 137–145. doi:10.1002/jbmr.5650070204.CrossRefPubMed

Clark, J. H., Rhoden, D. K., & Turner, D. S. (1993). Symptomatic vitamin A and D deficiencies in an eight-year-old with autism. Journal of Parenteral and Enteral Nutrition, 17(3), 284–286. doi:10.1177/0148607193017003284.CrossRefPubMed

Core-Team, R. (2016). R: A language a nd environment for statistical computing. https://www.R-project.org/. Accessed 14 July 2017.

Davies, J. H., Evans, B. A., & Gregory, J. W. (2005). Bone mass acquisition in healthy children. Archives of Disease in Childhood, 90(4), 373–378. doi:10.1136/adc.2004.053553.CrossRefPubMedPubMedCentral

Dimenas, E., Carlsson, G., Glise, H., Israelsson, B., & Wiklund, I. (1996). Relevance of norm values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease. Scandinavian Journal of Gastroenterology, 31(Suppl 221), 8–13.CrossRef

Ekhlaspour, L., Baskaran, C., Campoverde, K. J., Sokoloff, N. C., Neumeyer, A. M., & Misra, M. (2016). Bone density in adolescents and young adults with autism spectrum disorders. Journal of Autism and Developmental Disorders. doi:10.1007/s10803-016-2871-9.PubMed

Evans, E. W., Must, A., Anderson, S. E., Curtin, C., Scampini, R., Maslin, M., et al. (2012). Dietary patterns and body mass index in children with autism and typically developing children. Research in Autism Spectrum Disorders, 6(1), 399–405. doi:10.1016/j.rasd.2011.06.014.CrossRefPubMedPubMedCentral

Golden, N. H., & Abrams, S. A.,& Committee on Nutrition. (2014). Optimizing bone health in children and adolescents. Pediatrics, 134(4), e1229–e1243. doi:10.1542/peds.2014-2173.CrossRef

Goodman, S. B., Jiranek, W., Petrow, E., & Yasko, A. W. (2007). The effects of medications on bone. Journal of the American Academy of Orthopedic Surgery, 15(8), 450–460.CrossRef

Gotham, K., Risi, S., Pickles, A., & Lord, C. (2007). The autism diagnostic observation schedule: Revised algorithms for improved diagnostic validity. Journal of Autism and Developmental Disorders, 37(4), 613–627. doi:10.1007/s10803-006-0280-1.CrossRefPubMed

Hartman, C., Eliakim, R., & Shamir, R. (2009). Nutritional status and nutritional therapy in inflammatory bowel diseases. World Journal of Gastroenterology, 15(21), 2570–2578.CrossRefPubMedPubMedCentral

Haubrock, J., Nothlings, U., Volatier, J. L., Dekkers, A., Ocke, M., Harttig, U., et al. (2011). Estimating usual food intake distributions by using the multiple source method in the EPIC-potsdam calibration study. Journal of Nutrition, 141(5), 914–920. doi:10.3945/jn.109.120394.CrossRefPubMed

Hediger, M. L., England, L. J., Molloy, C. A., Yu, K. F., Manning-Courtney, P., & Mills, J. L. (2008). Reduced bone cortical thickness in boys with autism or autism spectrum disorder. Journal of Autism and Developmental Disorders, 38(5), 848–856. doi:10.1007/s10803-007-0453-6.CrossRefPubMed

Herndon, A. C., DiGuiseppi, C., Johnson, S. L., Leiferman, J., & Reynolds, A. (2009). Does nutritional intake differ between children with autism spectrum disorders and children with typical development? Journal of Autism and Developmental Disorders, 39(2), 212–222. doi:10.1007/s10803-008-0606-2.CrossRefPubMed

Hyman, S. L., Stewart, P. A., Schmidt, B., Cain, U., Lemcke, N., Foley, J. T., et al. (2012). Nutrient intake from food in children with autism. Pediatrics, 130(Suppl 2), S145–S153. doi:10.1542/peds.2012-0900L.

Institute of Medicine (2005). Panel on macronutrients standing committee on the scientific evaluation of dietary reference intakes. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, D.C.: National Academies Press.

Knivsberg, A. M., Reichelt, K. L., Hoien, T., & Nodland, M. (2002). A randomised, controlled study of dietary intervention in autistic syndromes. Nutritional Neuroscience, 5(4), 251–261. doi:10.1080/10284150290028945.CrossRefPubMed

Kushak, R. I., Buie, T. M., Murray, K. F., Newburg, D. S., Chen, C., Nestoridi, E., et al. (2016). Evaluation of intestinal function in children with autism and gastrointestinal symptoms. Journal of Pediatric Gastroenterology and Nutrition, 62(5), 687–691. doi:10.1097/MPG.0000000000001174.CrossRefPubMed

Lionetti, E., Miniello, V. L., Castellaneta, S. P., Magista, A. M., de Canio, A., Maurogiovanni, G., et al. (2006). Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: A randomized placebo controlled trial. Alimentary Pharmacology & Therapeutics, 24(10), 1461–1468. doi:10.1111/j.1365-2036.2006.03145.x.[pii].CrossRef

Lopes, L. H., Sdepanian, V. L., Szejnfeld, V. L., de Morais, M. B., & Fagundes-Neto, U. (2008). Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease. Digestive Diseases and Sciences, 53(10), 2746–2753. doi:10.1007/s10620-008-0223-0.CrossRefPubMed

Macdonald, M., Esposito, P., & Ulrich, D. (2011). The physical activity patterns of children with autism. BMC Research Notes, 4, 422. doi:10.1186/1756-0500-4-422.CrossRefPubMedPubMedCentral

Mahan, K. L., & Escott-Stump, S. (2008). Krause’s Food and Nutrition Therapy. (12th edn.). St Louis, MO: Saunders.

Mari-Bauset, S., Llopis-González, A., Zazpe, I., Mari-Sanchís, A., & Suárez-Varela, M. M. (2015). Anthropometric measures of Spanish children with autism spectrum disorder. Research in Autism Spectrum Disorders, 9, 26–33.CrossRef

Mari-Bauset, S., Zazpe, I., Mari-Sanchis, A., Llopis-González, A., & Suárez-Varela, M. M. (2012). Are there anthropometric differences between autistic and healthy children? Journal of Child Neurology, 28, 1226–1232.CrossRef

Meguid, N. A., Kandeel, W. A., Wakeel, K. E., & El-Nofely, A. A. (2014). Anthropometric assessment of a middle eastern group of autistic children. World Journal of Pediatrics, 10(4), 318–323. doi:10.1007/s12519-014-0510-0.CrossRefPubMed

Millward, C., Ferriter, M., Calver, S., & Connell-Jones, G. (2004). Gluten- and casein-free diets for autistic spectrum disorder. The Cochrane Database of Systematic Reviews, 2:CD003498. doi:10.1002/14651858.CD003498.pub2.

Molloy, C. A., Kalkwarf, H. J., Manning-Courtney, P., Mills, J. L., & Hediger, M. L. (2010). Plasma 25(OH) D concentration in children with autism spectrum disorder. Developmental Medicine & Child Neurology, 52(10), 969–971. doi:10.1111/j.1469-8749.2010.03704.x.CrossRef

Neumeyer, A. M., Gates, A., Ferrone, C., Lee, H., & Misra, M. (2013). Bone density in peripubertal boys with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(7), 1623–1629. doi:10.1007/s10803-012-1709-3.CrossRefPubMedPubMedCentral

Neumeyer, A. M., Sokoloff, N. C., McDonnell, E., Macklin, E. A., McDougle, C. J., & Misra, M. (2017a). Bone accrual in males with autism spectrum disorder. Journal of Pediatrics, 181, 195–201. doi:10.1016/j.jpeds.2016.10.080.CrossRefPubMed

Neumeyer, A. M., Sokoloff, N. C., McDonnell, E., Macklin, E. A., McDougle, C. J., & Misra, M. (2017b). Bone microarchitecture in adolescent boys with autism spectrum disorder. Bone, 97, 139–146. doi:10.1016/j.bone.2017.01.009.CrossRefPubMed

Palacios, C. (2006). The role of nutrients in bone health, from A to Z. Critical Reviews in Food Science and Nutrition, 46, 621–628.CrossRefPubMed

Porter, R. S., & Kaplan, J. L. (2011). The Merck Manual of Diagnosis and Therapy. (19th edn.). Whitehouse Station: Merck Research Laboratories.

Roche, A. F., & Malina, R. M. (Eds.). (1983). Manual of Physical Status and Performance in Childhood: Physical Status (Vol. 1B). New York: Plenum Press.

Roke, Y., van Harten, P. N., Buitelaar, J. K., Tenback, D. E., Quekel, L. G., de Rijke, Y. B., et al. (2012). Bone mineral density in male adolescents with autism spectrum disorders and disruptive behavior disorder with or without antipsychotic treatment. European Journal of Endocrinology, 167(6), 855–863. doi:10.1530/EJE-12-0521.CrossRefPubMed

Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview–revised (ADI–R) manual. Los Angeles: Western Psychological Services.

Schaafsma, A., de Vries, P. J., & Saris, W. H. (2001). Delay of natural bone loss by higher intakes of specific minerals and vitamins. Critical Reviews in Food Science and Nutrition, 41(4), 225–249.CrossRefPubMed

Schieve, L. A., Gonzalez, V., Boulet, S. L., Visser, S. N., Rice, C. E., Van Naarden Braun, K., et al. (2012). Concurrent medical conditions and health care use and needs among children with learning and behavioral developmental disabilities, National Health Interview Survey, 2006–2010. Research in Developmental Disabilities, 33(2), 467–476. doi:10.1016/j.ridd.2011.10.008.CrossRefPubMed

Schreck, K. A., Williams, K., & Smith, A. F. (2004). A comparison of eating behaviors between children with and without autism. Journal of Autism and Developmental Disorders, 34(4), 433–438.CrossRefPubMed

Srinivasan, S., O’Rourke, J., Bersche Golas S., Neumeyer, A., & Misra, M. (2016). Calcium and vitamin D supplement prescribing practices among providers caring for children with autism spectrum disorders: Are we addressing bone health?. Autism Research and Treatment, 2016, 6763205. doi:10.1155/2016/6763205.CrossRefPubMedPubMedCentral

Stewart, P. A., Hyman, S. L., Schmidt, B. L., Macklin, E. A., Reynolds, A., Johnson, C. R., et al. (2015). Dietary supplementation in children with autism spectrum disorders: Common, insufficient, and excessive. Journal of the Academy of Nutrition and Dietetics, 115(8), 1237–1248. doi:10.1016/j.jand.2015.03.026.CrossRefPubMed

Svedlund, J., Sjodin, I., & Dotevall, G. (1988). GSRS—a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Digests in Disability Science, 33(2), 129–134.CrossRef

Thangarajah, D., Hyde, M. J., Konteti, V. K., Santhakumaran, S., Frost, G., & Fell, J. M. (2015). Systematic review: Body composition in children with inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 42(2), 142–157. doi:10.1111/apt.13218.CrossRef

Thomson, M., Fritscher-Ravens, A., Hall, S., Afzal, N., Ashwood, P., & Swain, C. P. (2004). Endoluminal gastroplication in children with significant gastro-oesophageal reflux disease. Gut, 53(12), 1745–1750, doi:10.1136/gut.2004.041921.CrossRefPubMedPubMedCentral

Valicenti-McDermott, M., McVicar, K., Rapin, I., Wershil, B. K., Cohen, H., & Shinnar, S. (2006). Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S128–S136.

Weisshof, R., & Chermesh, I. (2015). Micronutrient deficiencies in inflammatory bowel disease. Current Opinion in Clinical Nutrition & Metabolic Care, 18(6), 576–581. doi:10.1097/MCO.0000000000000226.CrossRef

Williams, P. G., Dalrymple, N., & Neal, J. (2000). Eating habits of children with autism. Pediatric Nursing, 26(3), 259–264.PubMed

Wong, H. H., & Smith, R. G. (2006). Patterns of complementary and alternative medical therapy use in children diagnosed with autism spectrum disorders. Journal of Autism and Developmental Disorders, 36(7), 901–909. doi:10.1007/s10803-006-0131-0.CrossRefPubMed

Titel: Bone Mineral Density in Boys Diagnosed with Autism Spectrum Disorder: A Case-Control Study
Auteurs: Kelly Barnhill
Lucas Ramirez
Alan Gutierrez
Wendy Richardson
C. Nathan Marti
Amy Potts
Rebeca Shearer
Claire Schutte
Laura Hewitson
Publicatiedatum: 31-08-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3277-z

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