Skip to main content
Top
Gepubliceerd in: Journal of Autism and Developmental Disorders 4/2017

03-02-2017 | Original Paper

Quantitative Sensory Testing in adults with Autism Spectrum Disorders

Auteurs: Odette Fründt, Wiebke Grashorn, Daniel Schöttle, Ina Peiker, Nicole David, Andreas K. Engel, Katarina Forkmann, Nathalie Wrobel, Alexander Münchau, Ulrike Bingel

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Altered sensory perception has been found in patients with autism spectrum disorders (ASD) and might be related to aberrant sensory perception thresholds. We used the well-established, standardized Quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain to investigate 13 somatosensory parameters including thermal and tactile detection and pain thresholds in 13 ASD adults and 13 matched healthy controls with normal IQ values. There were no group differences between somatosensory detection and pain thresholds. Two ASD patients showed paradoxical heat sensations and another two ASD subjects presented dynamic mechanical allodynia; somatosensory features that were absent in controls. These findings suggest that central mechanisms during complex stimulus integration rather than peripheral dysfunctions probably determine somatosensory alterations in ASD.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference American Psychiatric Association, A. (2000). Diagnostic and statistical manual of mental disorders Dsm-IV-Tr (Text Revision) (4th ed.). Washington, DC: American Psychiatric Press Inc. American Psychiatric Association, A. (2000). Diagnostic and statistical manual of mental disorders Dsm-IV-Tr (Text Revision) (4th ed.). Washington, DC: American Psychiatric Press Inc.
go back to reference APA (2013). Diagnostic and statistical manual of mental disorders (DSM-5(r)). APA (2013). Diagnostic and statistical manual of mental disorders (DSM-5(r)).
go back to reference Baron, R., & Saguer, M. (1995). Mechanical allodynia in postherpetic neuralgia: evidence for central mechanisms depending on nociceptive C-fiber degeneration. Neurology, 45(12 Suppl 8), S63–65.CrossRefPubMed Baron, R., & Saguer, M. (1995). Mechanical allodynia in postherpetic neuralgia: evidence for central mechanisms depending on nociceptive C-fiber degeneration. Neurology, 45(12 Suppl 8), S63–65.CrossRefPubMed
go back to reference Baron-Cohen, S., Ashwin, E., Ashwin, C., Tavassoli, T., & Chakrabarti, B. (2009). Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 364(1522), 1377–1383. doi:10.1098/rstb.2008.0337.CrossRefPubMedPubMedCentral Baron-Cohen, S., Ashwin, E., Ashwin, C., Tavassoli, T., & Chakrabarti, B. (2009). Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 364(1522), 1377–1383. doi:10.​1098/​rstb.​2008.​0337.CrossRefPubMedPubMedCentral
go back to reference Baron-Cohen, S., Richler, J., Bisarya, D., Gurunathan, N., & Wheelwright, S. (2003). The systemizing quotient: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 358(1430), 361–374. doi:10.1098/rstb.2002.1206.CrossRefPubMedPubMedCentral Baron-Cohen, S., Richler, J., Bisarya, D., Gurunathan, N., & Wheelwright, S. (2003). The systemizing quotient: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 358(1430), 361–374. doi:10.​1098/​rstb.​2002.​1206.CrossRefPubMedPubMedCentral
go back to reference Baron-Cohen, S., & Wheelwright, S. (2004). The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders, 34(2), 163–175.CrossRefPubMed Baron-Cohen, S., & Wheelwright, S. (2004). The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders, 34(2), 163–175.CrossRefPubMed
go back to reference Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.CrossRefPubMed Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.CrossRefPubMed
go back to reference Bird, G., Silani, G., Brindley, R., White, S., Frith, U., & Singer, T. (2010). Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain: A Journal of Neurology, 133(Pt 5), 1515–1525. doi:10.1093/brain/awq060.CrossRef Bird, G., Silani, G., Brindley, R., White, S., Frith, U., & Singer, T. (2010). Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain: A Journal of Neurology, 133(Pt 5), 1515–1525. doi:10.​1093/​brain/​awq060.CrossRef
go back to reference Cascio, C., McGlone, F., Folger, S., Tannan, V., Baranek, G., Pelphrey, K. A., et al. (2008). Tactile perception in adults with autism: A multidimensional psychophysical study. Journal of Autism and Developmental Disorders, 38(1), 127–137. doi:10.1007/s10803-007-0370-8.CrossRefPubMed Cascio, C., McGlone, F., Folger, S., Tannan, V., Baranek, G., Pelphrey, K. A., et al. (2008). Tactile perception in adults with autism: A multidimensional psychophysical study. Journal of Autism and Developmental Disorders, 38(1), 127–137. doi:10.​1007/​s10803-007-0370-8.CrossRefPubMed
go back to reference Cesaroni, L., & Garber, M. (1991). Exploring the experience of autism through firsthand accounts. Journal of Autism and Developmental Disorders, 21(3), 303–313.CrossRefPubMed Cesaroni, L., & Garber, M. (1991). Exploring the experience of autism through firsthand accounts. Journal of Autism and Developmental Disorders, 21(3), 303–313.CrossRefPubMed
go back to reference Craig, A. D., & Bushnell, M. C. (1994). The thermal grill illusion: Unmasking the burn of cold pain. Science, 265(5169), 252–255.CrossRefPubMed Craig, A. D., & Bushnell, M. C. (1994). The thermal grill illusion: Unmasking the burn of cold pain. Science, 265(5169), 252–255.CrossRefPubMed
go back to reference Di Martino, A., Ross, K., Uddin, L. Q., Sklar, A. B., Castellanos, F. X., & Milham, M. P. (2009). Functional brain correlates of social and nonsocial processes in autism spectrum disorders: an activation likelihood estimation meta-analysis. Biological Psychiatry, 65(1), 63–74. doi:10.1016/j.biopsych.2008.09.022.CrossRefPubMed Di Martino, A., Ross, K., Uddin, L. Q., Sklar, A. B., Castellanos, F. X., & Milham, M. P. (2009). Functional brain correlates of social and nonsocial processes in autism spectrum disorders: an activation likelihood estimation meta-analysis. Biological Psychiatry, 65(1), 63–74. doi:10.​1016/​j.​biopsych.​2008.​09.​022.CrossRefPubMed
go back to reference Duerden, E. G., Taylor, M. J., Lee, M., McGrath, P. A., Davis, K. D., & Roberts, W. (2015). Decreased sensitivity to thermal stimuli in adolescents with autism spectrum disorder: Relation to symptomatology and cognitive ability. The Journal of Pain: Official Journal of the American Pain Society. doi:10.1016/j.jpain.2015.02.001. Duerden, E. G., Taylor, M. J., Lee, M., McGrath, P. A., Davis, K. D., & Roberts, W. (2015). Decreased sensitivity to thermal stimuli in adolescents with autism spectrum disorder: Relation to symptomatology and cognitive ability. The Journal of Pain: Official Journal of the American Pain Society. doi:10.​1016/​j.​jpain.​2015.​02.​001.
go back to reference Fan, Y. T., Chen, C., Chen, S. C., Decety, J., & Cheng, Y. (2014). Empathic arousal and social understanding in individuals with autism: Evidence from fMRI and ERP measurements. Social Cognitive and Affective Neuroscience, 9(8), 1203–1213. doi:10.1093/scan/nst101.CrossRefPubMed Fan, Y. T., Chen, C., Chen, S. C., Decety, J., & Cheng, Y. (2014). Empathic arousal and social understanding in individuals with autism: Evidence from fMRI and ERP measurements. Social Cognitive and Affective Neuroscience, 9(8), 1203–1213. doi:10.​1093/​scan/​nst101.CrossRefPubMed
go back to reference Gierthmühlen, J., & Baron, R. (2013). Vom Symptom zur Therapie. In R. Baron, W. Koppert, M. Strumpf & A. Willweber-Strumpf (Eds.), Praktische Schmerzmedizin - Interdisziplinäre Diagnostik - Multimodale Therapie (Vol. 3, pp. 67–79). Berlin Heidelberg: Springer-Verlag Berlin Heidelberg. Gierthmühlen, J., & Baron, R. (2013). Vom Symptom zur Therapie. In R. Baron, W. Koppert, M. Strumpf & A. Willweber-Strumpf (Eds.), Praktische Schmerzmedizin - Interdisziplinäre Diagnostik - Multimodale Therapie (Vol. 3, pp. 67–79). Berlin Heidelberg: Springer-Verlag Berlin Heidelberg.
go back to reference Grandin, T. (1995). Thinking in pictures; and other reports from my life with autism. New York: Double Day. Grandin, T. (1995). Thinking in pictures; and other reports from my life with autism. New York: Double Day.
go back to reference Grone, E., Crispin, A., Fleckenstein, J., Irnich, D., Treede, R. D., & Lang, P. M. (2012). Test order of quantitative sensory testing facilitates mechanical hyperalgesia in healthy volunteers. The Journal of Pain: Official Journal of the American Pain Society, 13(1), 73–80. doi:10.1016/j.jpain.2011.10.005.CrossRef Grone, E., Crispin, A., Fleckenstein, J., Irnich, D., Treede, R. D., & Lang, P. M. (2012). Test order of quantitative sensory testing facilitates mechanical hyperalgesia in healthy volunteers. The Journal of Pain: Official Journal of the American Pain Society, 13(1), 73–80. doi:10.​1016/​j.​jpain.​2011.​10.​005.CrossRef
go back to reference Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., et al. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: a comparative study. Journal of Autism and Developmental Disorders, 43(6), 1314–1325. doi:10.1007/s10803-012-1679-5.CrossRefPubMed Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., et al. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: a comparative study. Journal of Autism and Developmental Disorders, 43(6), 1314–1325. doi:10.​1007/​s10803-012-1679-5.CrossRefPubMed
go back to reference Kientz, M. A., & Dunn, W. (1997). A comparison of the performance of children with and without autism on the Sensory Profile. The American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association, 51(7), 530–537.CrossRef Kientz, M. A., & Dunn, W. (1997). A comparison of the performance of children with and without autism on the Sensory Profile. The American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association, 51(7), 530–537.CrossRef
go back to reference Lehrl, S. (2005). Mehrfachwach-Wortschatz-Intelligenztest MWT-B (5th edition ed.). Balingen: Spitta Verlag. Lehrl, S. (2005). Mehrfachwach-Wortschatz-Intelligenztest MWT-B (5th edition ed.). Balingen: Spitta Verlag.
go back to reference Magerl, W., & Klein, T. (2006). Experimental human models of neuropathic pain. In F. Cervero, & T. S. Jensen (Ed.), Handbook of clinical neurology (Vol. 81 Pain, pp. 503–516). Edinburgh: Elsevier. Magerl, W., & Klein, T. (2006). Experimental human models of neuropathic pain. In F. Cervero, & T. S. Jensen (Ed.), Handbook of clinical neurology (Vol. 81 Pain, pp. 503–516). Edinburgh: Elsevier.
go back to reference Magerl, W., Krumova, E. K., Baron, R., Tolle, T., Treede, R. D., & Maier, C. (2010). Reference data for quantitative sensory testing (QST): Refined stratification for age and a novel method for statistical comparison of group data. Pain, 151(3), 598–605. doi:10.1016/j.pain.2010.07.026.CrossRefPubMed Magerl, W., Krumova, E. K., Baron, R., Tolle, T., Treede, R. D., & Maier, C. (2010). Reference data for quantitative sensory testing (QST): Refined stratification for age and a novel method for statistical comparison of group data. Pain, 151(3), 598–605. doi:10.​1016/​j.​pain.​2010.​07.​026.CrossRefPubMed
go back to reference Rolke, R., Andrews, K., Magerl, W., & Treede, R. -D. (2010). Investigator’s Brochure: A standardized battery of quantitative sensory testing according to the protocol of the German Research Network on neuropathic pain (DFNS) - Version 2.1. Rolke, R., Andrews, K., Magerl, W., & Treede, R. -D. (2010). Investigator’s Brochure: A standardized battery of quantitative sensory testing according to the protocol of the German Research Network on neuropathic pain (DFNS) - Version 2.1.
go back to reference Rolke, R., Baron, R., Maier, C., Tolle, T. R., Treede, R. D., Beyer, A., et al. (2006). Quantitative sensory testing in the German research network on neuropathic pain (DFNS): standardized protocol and reference values. Pain, 123(3), 231–243. doi:10.1016/j.pain.2006.01.041.CrossRefPubMed Rolke, R., Baron, R., Maier, C., Tolle, T. R., Treede, R. D., Beyer, A., et al. (2006). Quantitative sensory testing in the German research network on neuropathic pain (DFNS): standardized protocol and reference values. Pain, 123(3), 231–243. doi:10.​1016/​j.​pain.​2006.​01.​041.CrossRefPubMed
go back to reference Schneider, G., Pogatzki-Zahn, E., Marziniak, M., Stumpf, A., & Ständer, S. (2015). Cutaneous sensory function is not related to depression and anxiety in patients with chronic pruritus with dysesthetic subqualities. Acta Dermato Venereologica, 95, 289–293.CrossRefPubMed Schneider, G., Pogatzki-Zahn, E., Marziniak, M., Stumpf, A., & Ständer, S. (2015). Cutaneous sensory function is not related to depression and anxiety in patients with chronic pruritus with dysesthetic subqualities. Acta Dermato Venereologica, 95, 289–293.CrossRefPubMed
go back to reference Siegel, D. J., Minshew, N. J., & Goldstein, G. (1996). Wechsler IQ profiles in diagnosis of high-functioning autism. Journal of Autism and Developmental Disorders, 26(4), 389–406.CrossRefPubMed Siegel, D. J., Minshew, N. J., & Goldstein, G. (1996). Wechsler IQ profiles in diagnosis of high-functioning autism. Journal of Autism and Developmental Disorders, 26(4), 389–406.CrossRefPubMed
go back to reference Silva, L. M., & Schalock, M. (2012). Sense and self-regulation checklist, a measure of comorbid autism symptoms: initial psychometric evidence. The American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association, 66(2), 177–186. doi:10.5014/ajot.2012.001578.CrossRef Silva, L. M., & Schalock, M. (2012). Sense and self-regulation checklist, a measure of comorbid autism symptoms: initial psychometric evidence. The American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association, 66(2), 177–186. doi:10.​5014/​ajot.​2012.​001578.CrossRef
go back to reference Silva, L. M., & Schalock, M. (2013). Prevalence and significance of abnormal tactile responses in young children with autism. North American Journal of Medicine and Science, 6 (No.3), 121–127. Silva, L. M., & Schalock, M. (2013). Prevalence and significance of abnormal tactile responses in young children with autism. North American Journal of Medicine and Science, 6 (No.3), 121–127.
go back to reference Susser, E., Sprecher, E., & Yarnitsky, D. (1999). Paradoxical heat sensation in healthy subjects: Peripherally conducted by A delta or C fibres? Brain, 122 (Pt 2), 239–246.CrossRefPubMed Susser, E., Sprecher, E., & Yarnitsky, D. (1999). Paradoxical heat sensation in healthy subjects: Peripherally conducted by A delta or C fibres? Brain, 122 (Pt 2), 239–246.CrossRefPubMed
go back to reference Tavassoli, T., Bellesheim, K., Tommerdahl, M., Holden, J. M., Kolevzon, A., & Buxbaum, J. D. (2015). Altered tactile processing in children with autism spectrum disorder. Autism Research. doi:10.1002/aur.1563.PubMed Tavassoli, T., Bellesheim, K., Tommerdahl, M., Holden, J. M., Kolevzon, A., & Buxbaum, J. D. (2015). Altered tactile processing in children with autism spectrum disorder. Autism Research. doi:10.​1002/​aur.​1563.PubMed
go back to reference Tonacci, A., Billeci, L., Tartarisco, G., Ruta, L., Muratori, F., Pioggia, G., et al. (2017). [Formula: see text] Olfaction in autism spectrum disorders: A systematic review. Child neuropsychology: A Journal on Normal and Abnormal Development in Childhood and Adolescence, 23(1), 1–25. doi:10.1080/09297049.2015.1081678.CrossRef Tonacci, A., Billeci, L., Tartarisco, G., Ruta, L., Muratori, F., Pioggia, G., et al. (2017). [Formula: see text] Olfaction in autism spectrum disorders: A systematic review. Child neuropsychology: A Journal on Normal and Abnormal Development in Childhood and Adolescence, 23(1), 1–25. doi:10.​1080/​09297049.​2015.​1081678.CrossRef
go back to reference Wahren, L. K., Torebjork, E., & Jorum, E. (1989). Central suppression of cold-induced C fibre pain by myelinated fibre input. Pain, 38(3), 313–319.CrossRefPubMed Wahren, L. K., Torebjork, E., & Jorum, E. (1989). Central suppression of cold-induced C fibre pain by myelinated fibre input. Pain, 38(3), 313–319.CrossRefPubMed
Metagegevens
Titel
Quantitative Sensory Testing in adults with Autism Spectrum Disorders
Auteurs
Odette Fründt
Wiebke Grashorn
Daniel Schöttle
Ina Peiker
Nicole David
Andreas K. Engel
Katarina Forkmann
Nathalie Wrobel
Alexander Münchau
Ulrike Bingel
Publicatiedatum
03-02-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3041-4

Andere artikelen Uitgave 4/2017

Journal of Autism and Developmental Disorders 4/2017 Naar de uitgave