Skip to main content
Top
Gepubliceerd in: Journal of Autism and Developmental Disorders 10/2015

02-06-2015 | Original Paper

Defining Treatment Response and Symptom Remission for Anxiety Disorders in Pediatric Autism Spectrum Disorders Using the Pediatric Anxiety Rating Scale

Auteurs: Carly J. Johnco, Alessandro S. De Nadai, Adam B. Lewin, Jill Ehrenreich-May, Jeffrey J. Wood, Eric A. Storch

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2015

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

This study examined optimal guidelines to assess treatment response and remission for anxiety in youth with autism spectrum disorders (ASD) using the Pediatric Anxiety Rating Scale (PARS). Data was collected for 108 children aged 7–16 years with comorbid anxiety and ASD before and after receiving cognitive behavior therapy. Optimal cut-offs on the PARS were assessed using signal detection analyses using receiver operating characteristic methods. Maximum agreement with response criteria was achieved at 15 % reduction in symptoms on the PARS. Maximum agreement with remission criteria was achieved at 40 % reduction in symptoms, or at a score of 10 or below at post-treatment. Results have implications for standardizing criteria used in research trials and clinical practice.
Literatuur
go back to reference American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed.). Washington, DC: Author. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed.). Washington, DC: Author.
go back to reference Bandelow, B. (2006). Defining response and remission in anxiety disorders: Toward an integrated approach. CNS Spectrums, 11(10 Suppl 12), 21–28.PubMed Bandelow, B. (2006). Defining response and remission in anxiety disorders: Toward an integrated approach. CNS Spectrums, 11(10 Suppl 12), 21–28.PubMed
go back to reference Caporino, N. E., Brodman, D. M., Kendall, P. C., Albano, A. M., Sherrill, J., Piacentini, J., et al. (2013). Defining treatment response and remission in child anxiety: Signal detection analysis using the Pediatric Anxiety Rating Scale. Journal of the American Academy of Child and Adolescent Psychiatry, 52(1), 57–67.PubMedCentralCrossRefPubMed Caporino, N. E., Brodman, D. M., Kendall, P. C., Albano, A. M., Sherrill, J., Piacentini, J., et al. (2013). Defining treatment response and remission in child anxiety: Signal detection analysis using the Pediatric Anxiety Rating Scale. Journal of the American Academy of Child and Adolescent Psychiatry, 52(1), 57–67.PubMedCentralCrossRefPubMed
go back to reference Chalfant, A. M., Rapee, R. M., & Carroll, L. (2007). Treating anxiety disorders in children with high functioning autism spectrum disorders: A controlled trial. Journal of Autism and Developmental Disorders, 37(10), 1842–1857. doi:10.1007/s10803-006-0318-4.CrossRefPubMed Chalfant, A. M., Rapee, R. M., & Carroll, L. (2007). Treating anxiety disorders in children with high functioning autism spectrum disorders: A controlled trial. Journal of Autism and Developmental Disorders, 37(10), 1842–1857. doi:10.​1007/​s10803-006-0318-4.CrossRefPubMed
go back to reference Ehrenreich-May, J., Storch, E. A., Queen, A. H., Hernandez Rodriguez, J., Ghilain, C. S., Alessandri, M., et al. (2014). An open trial of cognitive-behavioral therapy for anxiety disorders in adolescents with autism spectrum disorders. Focus on Autism and Other Developmental Disabilities, 29(3), 145–155. doi:10.1177/1088357614533381.CrossRef Ehrenreich-May, J., Storch, E. A., Queen, A. H., Hernandez Rodriguez, J., Ghilain, C. S., Alessandri, M., et al. (2014). An open trial of cognitive-behavioral therapy for anxiety disorders in adolescents with autism spectrum disorders. Focus on Autism and Other Developmental Disabilities, 29(3), 145–155. doi:10.​1177/​1088357614533381​.CrossRef
go back to reference Ginsburg, G. S., Keeton, C. P., Drazdowski, T. K., & Riddle, M. A. (2011). The utility of clinicians ratings of anxiety using the Pediatric Anxiety Rating Scale (PARS). Child & Youth Care Forum, 40(2), 93–105. doi:10.1007/s10566-010-9125-3.CrossRef Ginsburg, G. S., Keeton, C. P., Drazdowski, T. K., & Riddle, M. A. (2011). The utility of clinicians ratings of anxiety using the Pediatric Anxiety Rating Scale (PARS). Child & Youth Care Forum, 40(2), 93–105. doi:10.​1007/​s10566-010-9125-3.CrossRef
go back to reference Guy, W. (1976). Clinical global impressions ECDEU assessment manual for psychopharmacology. Rockville, MD: National Institute for Mental Health. Guy, W. (1976). Clinical global impressions ECDEU assessment manual for psychopharmacology. Rockville, MD: National Institute for Mental Health.
go back to reference Kerns, C. M., & Kendall, P. C. (2012). The presentation and classification of anxiety in autism spectrum disorder. Clinical Psychology: Science and Practice, 19(4), 323–347. doi:10.1111/cpsp.12009. Kerns, C. M., & Kendall, P. C. (2012). The presentation and classification of anxiety in autism spectrum disorder. Clinical Psychology: Science and Practice, 19(4), 323–347. doi:10.​1111/​cpsp.​12009.
go back to reference Kerns, C. M., Kendall, P. C., Berry, L., Souders, M. C., Franklin, M. E., Schultz, R. T., et al. (2014). Traditional and atypical presentations of anxiety in youth with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(11), 2851–2861. doi:10.1007/s10803-014-2141-7.CrossRefPubMed Kerns, C. M., Kendall, P. C., Berry, L., Souders, M. C., Franklin, M. E., Schultz, R. T., et al. (2014). Traditional and atypical presentations of anxiety in youth with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(11), 2851–2861. doi:10.​1007/​s10803-014-2141-7.CrossRefPubMed
go back to reference Kerns, C. M., Maddox, B. B., Kendall, P. C., Rump, K., Berry, L., Schultz, R. T., et al. (2015). Brief measures of anxiety in non-treatment-seeking youth with autism spectrum disorder. Autism,. doi:10.1177/1362361314558465. Kerns, C. M., Maddox, B. B., Kendall, P. C., Rump, K., Berry, L., Schultz, R. T., et al. (2015). Brief measures of anxiety in non-treatment-seeking youth with autism spectrum disorder. Autism,. doi:10.​1177/​1362361314558465​.
go back to reference Leckman, J. F., Riddle, M. A., Hardin, M. T., Ort, S. I., Swartz, K. L., Stevenson, J., et al. (1989). The Yale Global Tic Severity Scale: Initial testing of a clinician-rated scale of tic severity. Journal of the American Academy of Child and Adolescent Psychiatry, 28(4), 566–573. doi:10.1097/00004583-198907000-00015.CrossRefPubMed Leckman, J. F., Riddle, M. A., Hardin, M. T., Ort, S. I., Swartz, K. L., Stevenson, J., et al. (1989). The Yale Global Tic Severity Scale: Initial testing of a clinician-rated scale of tic severity. Journal of the American Academy of Child and Adolescent Psychiatry, 28(4), 566–573. doi:10.​1097/​00004583-198907000-00015.CrossRefPubMed
go back to reference Lewin, A. B., De Nadai, A. S., Park, J. M., Goodman, W. K., Murphy, T. K., & Storch, E. A. (2011). Refining clinical judgment of treatment outcome in obsessive–compulsive disorder. Psychiatry Research, 185, 394–401.CrossRefPubMed Lewin, A. B., De Nadai, A. S., Park, J. M., Goodman, W. K., Murphy, T. K., & Storch, E. A. (2011). Refining clinical judgment of treatment outcome in obsessive–compulsive disorder. Psychiatry Research, 185, 394–401.CrossRefPubMed
go back to reference Lewin, A. B., & Storch, E. A. (2014). Unpublished data. Lewin, A. B., & Storch, E. A. (2014). Unpublished data.
go back to reference Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule. Los Angeles: Western Psychological Services. Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule. Los Angeles: Western Psychological Services.
go back to reference Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.CrossRefPubMed Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.CrossRefPubMed
go back to reference Scahill, L., Riddle, M. A., McSwiggin-Hardin, M., Ort, S. I., King, R. A., Goodman, W. K., et al. (1997). Children’s Yale-Brown Obsessive Compulsive Scale: Reliability and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36(6), 844–852. doi:10.1097/00004583-199706000-00023.CrossRefPubMed Scahill, L., Riddle, M. A., McSwiggin-Hardin, M., Ort, S. I., King, R. A., Goodman, W. K., et al. (1997). Children’s Yale-Brown Obsessive Compulsive Scale: Reliability and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36(6), 844–852. doi:10.​1097/​00004583-199706000-00023.CrossRefPubMed
go back to reference Silverman, W. K., & Albano, A. M. (1996). The anxiety disorders interview schedule for DSM-IV–child and parent versions. London, England: Oxford University Press. Silverman, W. K., & Albano, A. M. (1996). The anxiety disorders interview schedule for DSM-IV–child and parent versions. London, England: Oxford University Press.
go back to reference Storch, E. A., Arnold, E. B., Lewin, A. B., Nadeau, J. M., Jones, A. M., De Nadai, A. S., et al. (2013). The effect of cognitive-behavioral therapy versus treatment as usual for anxiety in children with autism spectrum disorders: a randomized, controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 52(2), 132–142.e132, doi:10.1016/j.jaac.2012.11.007. Storch, E. A., Arnold, E. B., Lewin, A. B., Nadeau, J. M., Jones, A. M., De Nadai, A. S., et al. (2013). The effect of cognitive-behavioral therapy versus treatment as usual for anxiety in children with autism spectrum disorders: a randomized, controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 52(2), 132–142.e132, doi:10.​1016/​j.​jaac.​2012.​11.​007.
go back to reference Storch, E. A., De Nadai, A. S., Lewin, A. B., McGuire, J. F., Jones, A. M., Mutch, P. J., et al. (2011). Defining treatment response in pediatric tic disorders: A signal detection analysis of the Yale Global Tic Severity Scale. Journal of Child and Adolescent Psychopharmacology, 21(6), 621–627. doi:10.1089/cap.2010.0149.PubMedCentralCrossRefPubMed Storch, E. A., De Nadai, A. S., Lewin, A. B., McGuire, J. F., Jones, A. M., Mutch, P. J., et al. (2011). Defining treatment response in pediatric tic disorders: A signal detection analysis of the Yale Global Tic Severity Scale. Journal of Child and Adolescent Psychopharmacology, 21(6), 621–627. doi:10.​1089/​cap.​2010.​0149.PubMedCentralCrossRefPubMed
go back to reference Storch, E. A., Ehrenreich-May, J., Wood, J. J., Jones, A. M., De Nadai, A. S., Lewin, A. B., et al. (2012a). Multiple informant agreement on the anxiety disorders interview schedule in youth with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 22(4), 292–299. doi:10.1089/cap.2011.0114.PubMedCentralCrossRefPubMed Storch, E. A., Ehrenreich-May, J., Wood, J. J., Jones, A. M., De Nadai, A. S., Lewin, A. B., et al. (2012a). Multiple informant agreement on the anxiety disorders interview schedule in youth with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 22(4), 292–299. doi:10.​1089/​cap.​2011.​0114.PubMedCentralCrossRefPubMed
go back to reference Storch, E. A., Lewin, A. B., Collier, A. B., Arnold, E., De Nadai, A. S., Dane, B. F., et al. (2014). A randomized controlled trial of cognitive-behavioral therapy versus treatment as usual for adolescents with autism spectrum disorders and comorbid anxiety. Depression and Anxiety, 32(3), 174–181. doi:10.1002/da.22332.CrossRefPubMed Storch, E. A., Lewin, A. B., Collier, A. B., Arnold, E., De Nadai, A. S., Dane, B. F., et al. (2014). A randomized controlled trial of cognitive-behavioral therapy versus treatment as usual for adolescents with autism spectrum disorders and comorbid anxiety. Depression and Anxiety, 32(3), 174–181. doi:10.​1002/​da.​22332.CrossRefPubMed
go back to reference Storch, E. A., Lewin, A. B., De Nadai, A. S., & Murphy, T. K. (2010). Defining treatment response and remission in obsessive–compulsive disorder: A signal detection analysis of the children’s yale-brown obsessive compulsive scale. Journal of the American Academy of Child and Adolescent Psychiatry, 49(7), 708–717. doi:10.1016/j.jaac.2010.04.005.PubMed Storch, E. A., Lewin, A. B., De Nadai, A. S., & Murphy, T. K. (2010). Defining treatment response and remission in obsessive–compulsive disorder: A signal detection analysis of the children’s yale-brown obsessive compulsive scale. Journal of the American Academy of Child and Adolescent Psychiatry, 49(7), 708–717. doi:10.​1016/​j.​jaac.​2010.​04.​005.PubMed
go back to reference Storch, E. A., Wood, J. J., Ehrenreich-May, J., Jones, A. M., Park, J. M., Lewin, A. B., et al. (2012b). Convergent and discriminant validity and reliability of the pediatric anxiety rating scale in youth with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(11), 2374–2382. doi:10.1007/s10803-012-1489-9.CrossRefPubMed Storch, E. A., Wood, J. J., Ehrenreich-May, J., Jones, A. M., Park, J. M., Lewin, A. B., et al. (2012b). Convergent and discriminant validity and reliability of the pediatric anxiety rating scale in youth with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(11), 2374–2382. doi:10.​1007/​s10803-012-1489-9.CrossRefPubMed
go back to reference Tolin, D. F., Abramowitz, J. S., & Diefenbach, G. J. (2005). Defining response in clinical trials for obsessive–compulsive disorder: A signal detection analysis of the Yale-Brown obsessive compulsive scale. Journal of Clinical Psychiatry, 66(12), 1549–1557.CrossRefPubMed Tolin, D. F., Abramowitz, J. S., & Diefenbach, G. J. (2005). Defining response in clinical trials for obsessive–compulsive disorder: A signal detection analysis of the Yale-Brown obsessive compulsive scale. Journal of Clinical Psychiatry, 66(12), 1549–1557.CrossRefPubMed
go back to reference Ung, D., Arnold, E., De Nadai, A., Lewin, A., Phares, V., Murphy, T., et al. (2014). Inter-rater reliability of the anxiety disorders interview schedule for DSM-IV in high-functioning youth with autism spectrum disorder. Journal of Developmental and Physical Disabilities, 26(1), 53–65. doi:10.1007/s10882-013-9343-3.PubMedCentralCrossRefPubMed Ung, D., Arnold, E., De Nadai, A., Lewin, A., Phares, V., Murphy, T., et al. (2014). Inter-rater reliability of the anxiety disorders interview schedule for DSM-IV in high-functioning youth with autism spectrum disorder. Journal of Developmental and Physical Disabilities, 26(1), 53–65. doi:10.​1007/​s10882-013-9343-3.PubMedCentralCrossRefPubMed
go back to reference Vasa, R. A., Carroll, L. M., Nozzolillo, A. A., Mahajan, R., Mazurek, M. O., Bennett, A. E., et al. (2014). A Systematic Review of Treatments for Anxiety in Youth with Autism Spectrum Disorders. Journal of Autism and Developmental Disorders, 1–15, doi:10.1007/s10803-014-2184-9. Vasa, R. A., Carroll, L. M., Nozzolillo, A. A., Mahajan, R., Mazurek, M. O., Bennett, A. E., et al. (2014). A Systematic Review of Treatments for Anxiety in Youth with Autism Spectrum Disorders. Journal of Autism and Developmental Disorders, 1–15, doi:10.​1007/​s10803-014-2184-9.
go back to reference Walkup, J. T., Albano, A. M., Piacentini, J., Birmaher, B., Compton, S. N., Sherrill, J. T., et al. (2008). Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. New England Journal of Medicine, 359(26), 2753–2766. doi:10.1056/NEJMoa0804633.PubMedCentralCrossRefPubMed Walkup, J. T., Albano, A. M., Piacentini, J., Birmaher, B., Compton, S. N., Sherrill, J. T., et al. (2008). Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. New England Journal of Medicine, 359(26), 2753–2766. doi:10.​1056/​NEJMoa0804633.PubMedCentralCrossRefPubMed
go back to reference White, S. W., Ollendick, T., Albano, A. M., Oswald, D., Johnson, C., Southam-Gerow, M. A., et al. (2013). Randomized controlled trial: multimodal anxiety and social skill intervention for adolescents with autism spectrum disorder. Journal of Autism and Developmental Disorders, 43(2), 382–394. doi:10.1007/s10803-012-1577-x.PubMedCentralCrossRefPubMed White, S. W., Ollendick, T., Albano, A. M., Oswald, D., Johnson, C., Southam-Gerow, M. A., et al. (2013). Randomized controlled trial: multimodal anxiety and social skill intervention for adolescents with autism spectrum disorder. Journal of Autism and Developmental Disorders, 43(2), 382–394. doi:10.​1007/​s10803-012-1577-x.PubMedCentralCrossRefPubMed
go back to reference Williams, K., Wheeler, D. M., Silove, N., & Hazell, P. (2010). Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Cochrane Database Systematic Review, 8, CD004677. doi:10.1002/14651858.CD004677.pub2. Williams, K., Wheeler, D. M., Silove, N., & Hazell, P. (2010). Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Cochrane Database Systematic Review, 8, CD004677. doi:10.​1002/​14651858.​CD004677.​pub2.
go back to reference Wood, J. J., & Drahota, A. (2005). Behavioral interventions for anxiety in children with autism. Los Angeles, CA: University of California-Los Angeles. Wood, J. J., & Drahota, A. (2005). Behavioral interventions for anxiety in children with autism. Los Angeles, CA: University of California-Los Angeles.
go back to reference Wood, J. J., Ehrenreich-May, J., Alessandri, M., Fujii, C., Renno, P., Laugeson, E., et al. (2015). Cognitive behavioral therapy for early adolescents with autism spectrum disorders and clinical anxiety: A randomized, controlled trial. Behavior Therapy, 46(1), 7–19. doi:10.1016/j.beth.2014.01.002.CrossRefPubMed Wood, J. J., Ehrenreich-May, J., Alessandri, M., Fujii, C., Renno, P., Laugeson, E., et al. (2015). Cognitive behavioral therapy for early adolescents with autism spectrum disorders and clinical anxiety: A randomized, controlled trial. Behavior Therapy, 46(1), 7–19. doi:10.​1016/​j.​beth.​2014.​01.​002.CrossRefPubMed
Metagegevens
Titel
Defining Treatment Response and Symptom Remission for Anxiety Disorders in Pediatric Autism Spectrum Disorders Using the Pediatric Anxiety Rating Scale
Auteurs
Carly J. Johnco
Alessandro S. De Nadai
Adam B. Lewin
Jill Ehrenreich-May
Jeffrey J. Wood
Eric A. Storch
Publicatiedatum
02-06-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 10/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2483-9

Andere artikelen Uitgave 10/2015

Journal of Autism and Developmental Disorders 10/2015 Naar de uitgave