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Gepubliceerd in: Journal of Autism and Developmental Disorders 10/2013

01-10-2013 | Original Paper

Early Signs of Autism in Toddlers: A Follow-Up Study in the Danish National Birth Cohort

Auteurs: Sanne Lemcke, Svend Juul, Erik T. Parner, Marlene B. Lauritsen, Poul Thorsen

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2013

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Abstract

To identify possible early signs of autism spectrum disorder (ASD) within the Danish National Birth Cohort, we studied prospectively collected interviews from 76,441 mothers about their children’s development and behaviour at 6 and 18 months. In Danish national registries, 720 children with ASD and 231 children with intellectual disability (ID) were identified. At 6 months, associations between early signs and ASD or ID were found only in few areas. At 18 months social, language, and motor skills were delayed, and suspicion of vision and hearing problems were increased for both groups. Signs distinguishing ASD from ID were unclear, and the positive predictive values regarding ASD were below 10 % for individual predictors and aggregated risk scores.
Literatuur
go back to reference Baghdadli, A., Picot, M. C., Pascal, C., Pry, R., & Aussilloux, C. (2003). Relationship between age of recognition of first disturbances and severity in young children with autism. European Child and Adolescent Psychiatry, 12, 122–127.PubMedCrossRef Baghdadli, A., Picot, M. C., Pascal, C., Pry, R., & Aussilloux, C. (2003). Relationship between age of recognition of first disturbances and severity in young children with autism. European Child and Adolescent Psychiatry, 12, 122–127.PubMedCrossRef
go back to reference Bolton, P. F., Golding, J., Emond, A., & Steer, C. D. (2012). Autism spectrum disorder and autistic traits in the avon longitudinal study of parents and children: Precursors and early signs. Journal of the American Academy of Child and Adolescent Psychiatry, 51, 249–260.PubMedCrossRef Bolton, P. F., Golding, J., Emond, A., & Steer, C. D. (2012). Autism spectrum disorder and autistic traits in the avon longitudinal study of parents and children: Precursors and early signs. Journal of the American Academy of Child and Adolescent Psychiatry, 51, 249–260.PubMedCrossRef
go back to reference Bryson, S., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., et al. (2007). A prospective case series of high-risk infants who developed autism. Journal of Autism and Developmental Disorders, 37, 12–24.PubMedCrossRef Bryson, S., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., et al. (2007). A prospective case series of high-risk infants who developed autism. Journal of Autism and Developmental Disorders, 37, 12–24.PubMedCrossRef
go back to reference Chakrabarti, S., & Fombonne, E. (2005). Pervasive developmental disorders in preschool children: Confirmation of high prevalence. American Journal of Psychiatry, 162, 1133–1141.PubMedCrossRef Chakrabarti, S., & Fombonne, E. (2005). Pervasive developmental disorders in preschool children: Confirmation of high prevalence. American Journal of Psychiatry, 162, 1133–1141.PubMedCrossRef
go back to reference Chawarska, K., Paul, R., Klin, A., Hannigen, S., Dichtel, L. E., & Volkmar, F. (2007). Parental recognition of developmental problems in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 62–72.PubMedCrossRef Chawarska, K., Paul, R., Klin, A., Hannigen, S., Dichtel, L. E., & Volkmar, F. (2007). Parental recognition of developmental problems in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 62–72.PubMedCrossRef
go back to reference Clifford, S., Young, R., & Williamson, P. (2007). Assessing the early characteristics of autistic disorder using video analysis. Journal of Autism and Developmental Disorders, 37, 301–313.PubMedCrossRef Clifford, S., Young, R., & Williamson, P. (2007). Assessing the early characteristics of autistic disorder using video analysis. Journal of Autism and Developmental Disorders, 37, 301–313.PubMedCrossRef
go back to reference Dawson, G. (2008). Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder. Development and Psychopathology, 20, 775–803.PubMedCrossRef Dawson, G. (2008). Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder. Development and Psychopathology, 20, 775–803.PubMedCrossRef
go back to reference De Giacomo, A., & Fombonne, E. (1998). Parental recognition of developmental abnormalities in autism. European Child and Adolescent Psychiatry, 7, 131–136.PubMedCrossRef De Giacomo, A., & Fombonne, E. (1998). Parental recognition of developmental abnormalities in autism. European Child and Adolescent Psychiatry, 7, 131–136.PubMedCrossRef
go back to reference Esposito, G., & Venuti, P. (2008). Analysis of toddlers’ gait after six months of independent walking to identify autism: A preliminary study. Perceptual and Motor Skills, 106, 259–269.PubMedCrossRef Esposito, G., & Venuti, P. (2008). Analysis of toddlers’ gait after six months of independent walking to identify autism: A preliminary study. Perceptual and Motor Skills, 106, 259–269.PubMedCrossRef
go back to reference Fombonne, E. (2009). Epidemiology of pervasive developmental disorders. [Review]. Pediatric Research, 65, 591–598.PubMedCrossRef Fombonne, E. (2009). Epidemiology of pervasive developmental disorders. [Review]. Pediatric Research, 65, 591–598.PubMedCrossRef
go back to reference Kalbfleisch, J. D., & Prentice, R. L. (2002). The statistical analysis of failure time data (2nd ed.). New York: Wiley.CrossRef Kalbfleisch, J. D., & Prentice, R. L. (2002). The statistical analysis of failure time data (2nd ed.). New York: Wiley.CrossRef
go back to reference Kirkwood, B., & Sterne, J. (2003). Essential medical statistics (2nd ed.). Oxford: Blackwell Science. Kirkwood, B., & Sterne, J. (2003). Essential medical statistics (2nd ed.). Oxford: Blackwell Science.
go back to reference Landa, R., & Garrett-Mayer, E. (2006). Development in infants with autism spectrum disorders: A prospective study. Journal of Child Psychology and Psychiatry, 47, 629–638.PubMedCrossRef Landa, R., & Garrett-Mayer, E. (2006). Development in infants with autism spectrum disorders: A prospective study. Journal of Child Psychology and Psychiatry, 47, 629–638.PubMedCrossRef
go back to reference Landa, R. J. (2008). Diagnosis of autism spectrum disorders in the first 3 years of life. Nature Clinical Practice Neurology, 4, 138–147.PubMedCrossRef Landa, R. J. (2008). Diagnosis of autism spectrum disorders in the first 3 years of life. Nature Clinical Practice Neurology, 4, 138–147.PubMedCrossRef
go back to reference Lauritsen, M. B., Jorgensen, M., Madsen, K. M., Lemcke, S., Toft, S., Grove, J., et al. (2010). Validity of childhood autism in the Danish Psychiatric Central Register: Findings from a cohort sample born 1990–1999. Journal of Autism and Developmental Disorders, 40, 139–148.PubMedCrossRef Lauritsen, M. B., Jorgensen, M., Madsen, K. M., Lemcke, S., Toft, S., Grove, J., et al. (2010). Validity of childhood autism in the Danish Psychiatric Central Register: Findings from a cohort sample born 1990–1999. Journal of Autism and Developmental Disorders, 40, 139–148.PubMedCrossRef
go back to reference Lynge, E., Sandegaard, J. L., & Rebolj, M. (2011). The Danish National Patient Register. Scandinavian Journal of Public Health, 39, 30–33.PubMedCrossRef Lynge, E., Sandegaard, J. L., & Rebolj, M. (2011). The Danish National Patient Register. Scandinavian Journal of Public Health, 39, 30–33.PubMedCrossRef
go back to reference Mors, O., Perto, G. P., & Mortensen, P. B. (2011). The Danish Psychiatric Central Research Register. Scandinavian Journal of Public Health, 39, 54–57.PubMedCrossRef Mors, O., Perto, G. P., & Mortensen, P. B. (2011). The Danish Psychiatric Central Research Register. Scandinavian Journal of Public Health, 39, 54–57.PubMedCrossRef
go back to reference Nohr, E. A., Frydenberg, M., Henriksen, T. B., & Olsen, J. (2006). Does low participation in cohort studies induce bias? Epidemiology, 17, 413–418.PubMedCrossRef Nohr, E. A., Frydenberg, M., Henriksen, T. B., & Olsen, J. (2006). Does low participation in cohort studies induce bias? Epidemiology, 17, 413–418.PubMedCrossRef
go back to reference Olsen, J., Melbye, M., Olsen, S. F., Sorensen, T. I., Aaby, P., Andersen, A. M., et al. (2001). The Danish National Birth Cohort-its background, structure and aim. Scandinavian Journal of Public Health, 29, 300–307.PubMedCrossRef Olsen, J., Melbye, M., Olsen, S. F., Sorensen, T. I., Aaby, P., Andersen, A. M., et al. (2001). The Danish National Birth Cohort-its background, structure and aim. Scandinavian Journal of Public Health, 29, 300–307.PubMedCrossRef
go back to reference Osterling, J. A., Dawson, G., & Munson, J. A. (2002). Early recognition of 1-year-old infants with autism spectrum disorder versus mental retardation. Development and Psychopathology, 14, 239–251.PubMedCrossRef Osterling, J. A., Dawson, G., & Munson, J. A. (2002). Early recognition of 1-year-old infants with autism spectrum disorder versus mental retardation. Development and Psychopathology, 14, 239–251.PubMedCrossRef
go back to reference Ozonoff, S., Iosif, A. M., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., et al. (2010). A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 256–266.PubMed Ozonoff, S., Iosif, A. M., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., et al. (2010). A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 256–266.PubMed
go back to reference Ozonoff, S., Young, G. S., Goldring, S., Greiss-Hess, L., Herrera, A. M., Steele, J., et al. (2008). Gross motor development, movement abnormalities, and early identification of autism. Journal of Autism and Developmental Disorders, 38, 644–656.PubMedCrossRef Ozonoff, S., Young, G. S., Goldring, S., Greiss-Hess, L., Herrera, A. M., Steele, J., et al. (2008). Gross motor development, movement abnormalities, and early identification of autism. Journal of Autism and Developmental Disorders, 38, 644–656.PubMedCrossRef
go back to reference Palomo, R., Belinchon, M., & Ozonoff, S. (2006). Autism and family home movies: A comprehensive review. Journal of Developmental and Behavioral Pediatrics, 27, S59–S68.PubMedCrossRef Palomo, R., Belinchon, M., & Ozonoff, S. (2006). Autism and family home movies: A comprehensive review. Journal of Developmental and Behavioral Pediatrics, 27, S59–S68.PubMedCrossRef
go back to reference Parner, E. T., Schendel, D. E., & Thorsen, P. (2008). Autism prevalence trends over time in Denmark: Changes in prevalence and age at diagnosis. Archives of Pediatrics Adolescent Medicine, 162, 1150–1156.PubMedCrossRef Parner, E. T., Schendel, D. E., & Thorsen, P. (2008). Autism prevalence trends over time in Denmark: Changes in prevalence and age at diagnosis. Archives of Pediatrics Adolescent Medicine, 162, 1150–1156.PubMedCrossRef
go back to reference Pedersen, C. B., Gotzsche, H., Moller, J. O., & Mortensen, P. B. (2006). The Danish Civil Registration System. A cohort of eight million persons. Danish Medical Bulletin, 53, 441–449.PubMed Pedersen, C. B., Gotzsche, H., Moller, J. O., & Mortensen, P. B. (2006). The Danish Civil Registration System. A cohort of eight million persons. Danish Medical Bulletin, 53, 441–449.PubMed
go back to reference Petersen, D., Bilenberg, N., Hoerder, K., & Gillberg, C. (2006). The population prevalence of child psychiatric disorders in Danish 8 to 9 year old children. European Child and Adolescent Psychiatry, 15, 71–78.PubMedCrossRef Petersen, D., Bilenberg, N., Hoerder, K., & Gillberg, C. (2006). The population prevalence of child psychiatric disorders in Danish 8 to 9 year old children. European Child and Adolescent Psychiatry, 15, 71–78.PubMedCrossRef
go back to reference Sivberg, B. (2003). Parents’ detection of early signs in their children having an autistic spectrum disorder. Journal of Pediatric Nursing, 18, 433–439.PubMedCrossRef Sivberg, B. (2003). Parents’ detection of early signs in their children having an autistic spectrum disorder. Journal of Pediatric Nursing, 18, 433–439.PubMedCrossRef
go back to reference Vostanis, P., Smith, B., Corbett, J., Sungum-Paliwal, R., Edwards, A., Gingell, K., et al. (1998). Parental concerns of early development in children with autism and related disorders. Autism: International journal of research, 2, 229–242.CrossRef Vostanis, P., Smith, B., Corbett, J., Sungum-Paliwal, R., Edwards, A., Gingell, K., et al. (1998). Parental concerns of early development in children with autism and related disorders. Autism: International journal of research, 2, 229–242.CrossRef
go back to reference Warren, Z., McPheeters, M. L., Sathe, N., Foss-Feig, J. H., Glasser, A., & Veenstra-Vanderweele, J. (2011). A systematic review of early intensive intervention for autism spectrum disorders. Pediatrics, 127, e1303–e1311.PubMedCrossRef Warren, Z., McPheeters, M. L., Sathe, N., Foss-Feig, J. H., Glasser, A., & Veenstra-Vanderweele, J. (2011). A systematic review of early intensive intervention for autism spectrum disorders. Pediatrics, 127, e1303–e1311.PubMedCrossRef
go back to reference Watson, L. R., Baranek, G. T., Crais, E. R., Steven, R. J., Dykstra, J., & Perryman, T. (2007). The first year inventory: retrospective parent responses to a questionnaire designed to identify one-year-olds at risk for autism. Journal of Autism and Developmental Disorders, 37, 49–61.PubMedCrossRef Watson, L. R., Baranek, G. T., Crais, E. R., Steven, R. J., Dykstra, J., & Perryman, T. (2007). The first year inventory: retrospective parent responses to a questionnaire designed to identify one-year-olds at risk for autism. Journal of Autism and Developmental Disorders, 37, 49–61.PubMedCrossRef
go back to reference Werner, E., & Dawson, G. (2005). Validation of the phenomenon of autistic regression using home videotapes. Archives of General Psychiatry, 62, 889–895.PubMedCrossRef Werner, E., & Dawson, G. (2005). Validation of the phenomenon of autistic regression using home videotapes. Archives of General Psychiatry, 62, 889–895.PubMedCrossRef
go back to reference Werner, E., Dawson, G., Munson, J., & Osterling, J. (2005). Variation in early developmental course in autism and its relation with behavioral outcome at 3–4 years of age. Journal of Autism and Developmental Disorders, 35, 337–350.PubMedCrossRef Werner, E., Dawson, G., Munson, J., & Osterling, J. (2005). Variation in early developmental course in autism and its relation with behavioral outcome at 3–4 years of age. Journal of Autism and Developmental Disorders, 35, 337–350.PubMedCrossRef
go back to reference Wetherby, A. M., Watt, N., Morgan, L., & Shumway, S. (2007). Social communication profiles of children with autism spectrum disorders late in the second year of life. Journal of Autism and Developmental Disorders, 37, 960–975.PubMedCrossRef Wetherby, A. M., Watt, N., Morgan, L., & Shumway, S. (2007). Social communication profiles of children with autism spectrum disorders late in the second year of life. Journal of Autism and Developmental Disorders, 37, 960–975.PubMedCrossRef
go back to reference Wiggins, L. D., Baio, J., & Rice, C. (2006). Examination of the time between first evaluation and first autism spectrum diagnosis in a population-based sample. Journal of Developmental and Behavioral Pediatrics, 27, S79–S87.PubMedCrossRef Wiggins, L. D., Baio, J., & Rice, C. (2006). Examination of the time between first evaluation and first autism spectrum diagnosis in a population-based sample. Journal of Developmental and Behavioral Pediatrics, 27, S79–S87.PubMedCrossRef
go back to reference Wiggins, L. D., Rice, C. E., & Baio, J. (2009). Developmental regression in children with an autism spectrum disorder identified by a population-based surveillance system. Autism, 13, 357–374.PubMedCrossRef Wiggins, L. D., Rice, C. E., & Baio, J. (2009). Developmental regression in children with an autism spectrum disorder identified by a population-based surveillance system. Autism, 13, 357–374.PubMedCrossRef
go back to reference Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. The journal of the American Medical Association, 289, 49–55.CrossRef Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. The journal of the American Medical Association, 289, 49–55.CrossRef
go back to reference Yirmiya, N., & Charman, T. (2010). The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics. Journal of Child Psychology and Psychiatry, 51, 432–458.PubMedCrossRef Yirmiya, N., & Charman, T. (2010). The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics. Journal of Child Psychology and Psychiatry, 51, 432–458.PubMedCrossRef
go back to reference Young, R. L., Brewer, N., & Pattison, C. (2003). Parental identification of early behavioural abnormalities in children with autistic disorder. Autism, 7, 125–143.PubMedCrossRef Young, R. L., Brewer, N., & Pattison, C. (2003). Parental identification of early behavioural abnormalities in children with autistic disorder. Autism, 7, 125–143.PubMedCrossRef
Metagegevens
Titel
Early Signs of Autism in Toddlers: A Follow-Up Study in the Danish National Birth Cohort
Auteurs
Sanne Lemcke
Svend Juul
Erik T. Parner
Marlene B. Lauritsen
Poul Thorsen
Publicatiedatum
01-10-2013
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 10/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1785-z

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