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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-07-2013 | Original Paper

Maternal Vitamin D Levels and the Autism Phenotype Among Offspring

Auteurs: Andrew J. O. Whitehouse, Barbara J. Holt, Michael Serralha, Patrick G. Holt, Prue H. Hart, Merci M. H. Kusel

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2013

Abstract

We tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype. Serum 25(OH)-vitamin D concentrations of 929 women were measured at 18 weeks’ pregnancy. The mothers of the three children with a clinical diagnosis of autism spectrum disorder had 25(OH)-vitamin D concentrations above the population mean. The offspring of 406 women completed the Autism-Spectrum Quotient in early adulthood. Maternal 25(OH)-vitamin D concentrations were unrelated to offspring scores on the majority of scales. However, offspring of mothers with low 25(OH)-vitamin D concentrations (<49 nmol/L) were at increased risk for ‘high’ scores (≥2SD above mean) on the Attention Switching subscale (odds ratio: 5.46, 95 % confidence interval: 1.29, 23.05). The involvement of maternal vitamin D during pregnancy in autism requires continued investigation.

volgende artikel Narrowly Versus Broadly Defined Autism Spectrum Disorders: Differences in Pre- and Perinatal Risk Factors

American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Press.

Atif, F., Sayeed, I., Ishrat, T., & Stein, D. G. (2009). Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone. Molecular Medicine, 15, 328–336.PubMedCrossRef

Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The Autism-Spectrum Quotient (AQ): Evidence from Asperger Syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17.PubMedCrossRef

Brown, J., Bianco, J. I., McGrath, J. J., & Eyles, D. W. (2003). 1, 25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neuroscience Letters, 343(2), 139–143.PubMedCrossRef

Camargo, C. A., Rifas-Shiman, S. L., Litonjua, A. A., Rich-Edwards, J. W., Weiss, S. T., Gold, D. R., et al. (2007). Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. The American Journal of Clinical Nutrition, 85(3), 788–795.PubMed

Cannell, J. J. (2008). Autism and vitamin D. Medical Hypotheses, 70(4), 750–759.PubMedCrossRef

Cekic, M., Sayeed, I., & Stein, D. G. (2009). Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease. Frontiers in Neuroendocrinology, 30, 158–172.PubMedCrossRef

Corder, E. H., Guess, H. A., Hulka, B. S., Friedman, G. D., Sadler, M., Vollmer, R. T., et al. (1993). Vitamin D and prostate cancer: A prediagnostic study with stored sera. Cancer Epidemiology, Biomarkers and Prevention, 2(5), 467–472.PubMed

Eyles, D., Brown, J., Mackay-Sim, A., McGrath, J., & Feron, F. (2003). Vitamin D3 and brain development. Neuroscience, 118(3), 641–653.PubMedCrossRef

Gale, C. R., Robinson, S. M., Harvey, N. C., Javaid, M. K., Jiang, B., Martyn, C. N., et al. (2008). Maternal vitamin D status during pregnancy and child outcomes. European Journal of Clinical Nutrition, 62(1), 68–77.PubMedCrossRef

Garcion, E., Wion-Barbot, N., & Montero-Menei, C. N. (2002). New clues about vitamin D functions in the nervous system. Trends in Endocrinology and Metabolism, 13, 100–105.PubMedCrossRef

Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. British Journal of Psychiatry, 195(1), 7–14.PubMedCrossRef

Happé, F., & Ronald, A. (2008). The ‘fractionable autism triad’: A review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychology Review, 18(4), 287–304.PubMedCrossRef

Holick, M. F. (1987). Photosynthesis of vitamin D in the skin: Effect of environmental and life-style variables. Federation Proceedings, 46, 1876–1882.PubMed

Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266–281.PubMedCrossRef

Javaid, M. K., Crozier, S. R., Harvey, N. C., Gale, C. R., Dennison, E. M., Boucher, B. J., et al. (2006). Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: A longitudinal study. Lancet, 367(9504), 36–43.PubMedCrossRef

Kolevzon, A., Weiser, M., Gross, R., Lubin, G., Knobler, H., Schmeidler, J., et al. (2006). Effects of season of birth on autism spectrum disorders: Fact or fiction? American Journal of Psychiatry, 163, 1288–1290.PubMedCrossRef

Landau, E. C., Cicchetti, D. V., Klin, A., & Volkmar, F. R. (1999). Season of birth in autism: A fiction revisited. Journal of Autism and Developmental Disorders, 29(5), 385–393.PubMedCrossRef

Levis, S., Gomez, A., Jimenez, C., Veras, L., Ma, F., Lai, S., et al. (2005). Vitamin D deficiency and seasonal variation in an adult South Florida population. Journal of Clinical Endocrinology and Metabolism, 90(3), 1557–1562.PubMedCrossRef

Lundström, S., Chang, Z., Rastam, M., Gillberg, C., Larsson, H., Anckarsater, H., et al. (2012). Autism Spectrum Disorders and autistic-like traits: Similar etiology in the extreme end and the normal variation. Archives of General Psychiatry, 69(1), 46–52.PubMedCrossRef

Marini, F., Bartoccini, E., Cascianelli, G., Voccoli, V., Baviglia, M. G., Magni, M. V., et al. (2010). Effect of 1α, 25-dihydroxyvitamin D3 in embryonic hippocampal cells. Hippocampus, 20(6), 696–705.PubMed

Morley, R., Carlin, J. B., Pasco, J. A., & Wark, J. D. (2006). Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. Journal of Clinical Endocrinology and Metabolism, 91(3), 906–912.PubMedCrossRef

Neveu, I., Naveilhan, P., Jehan, F., Baudet, C., Wion, D., De Luca, H. F., et al. (1994). 1, 25-Dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Molecular Brain Research, 24(1–4), 70–76.PubMedCrossRef

Newnham, J. P., Evans, S. F., Michael, C. A., Stanley, F. J., & Landau, L. I. (1993). Effects of frequent ultrasound during pregnancy: A randomized controlled trial. Lancet, 342(8876), 887–891.PubMedCrossRef

Nomura, A. M. Y., Stemmermann, G. N., Lee, J., Kolonel, L. N., Chen, T. C., Turner, A., et al. (1998). Serum vitamin D metabolite levels and the subsequent development of prostate cancer (Hawaii, United States). Cancer Causes and Control, 9(4), 425–432.PubMedCrossRef

O’Loan, J., Eyles, D. W., Kesby, J., Ko, P., McGrath, J. J., & Burne, T. H. J. (2007). Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring. Psychoneuroendocrinology, 32(3), 227–234.PubMedCrossRef

Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., et al. (2011). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics, 128(3), e488–e495.

Rice, D., & Barone, S. (2000). Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models. Environmental Health Perspectives, 108, 511–533.PubMed

Robinson, E. B., Koenen, K. C., McCormick, M. C., Munir, K., Hallett, V., Happé, F., et al. (2011). Evidence that autistic traits show the same etiology in the general population and at the quantitative extremes (5 %, 2.5 %, and 1 %). Archives of General Psychiatry, 68(11), 1113–1121.PubMedCrossRef

Whitehouse, A. J. O., Hickey, M., Stanley, F. J., Newnham, J. P., & Pennell, C. E. (2011). A preliminary study of fetal head circumference growth in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 41, 122–129.PubMedCrossRef

Whitehouse, A. J. O., Holt, B. J., Serralha, M., Holt, P. G., Kusel, M. M. H., & Hart, P. H. (2012). Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics, 129(3), 485–493.PubMedCrossRef

Wilkinson, R. J., Llewelyn, M., Toossi, Z., Patel, P., Pasvol, G., Lalvani, A., et al. (2000). Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: A case-control study. The Lancet, 355(9204), 618–621.CrossRef

Wion, D., Macgrogan, D., Neveu, I., Jehan, F., Houlgatte, R., & Brachet, P. (1991). 1, 25-Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis. Journal of Neuroscience Research, 28(1), 110–114.PubMedCrossRef

Wolke, D., Waylen, A., Samara, M., Steer, C., Goodman, R., Ford, T., et al. (2009). Selective drop-out in longitudinal studies and non-biased prediction of behaviour disorders. The British Journal of Psychiatry, 195(3), 249–256.PubMedCrossRef

Zosky, G. R., Berry, L. J., Elliot, J. G., James, A. L., Gorman, S., & Hart, P. H. (2011). Vitamin D deficiency causes deficits in lung function and alters lung structure. American Journal of Respiratory and Critical Care Medicine, 183(10), 1336–1343.PubMedCrossRef

Titel: Maternal Vitamin D Levels and the Autism Phenotype Among Offspring
Auteurs: Andrew J. O. Whitehouse
Barbara J. Holt
Michael Serralha
Patrick G. Holt
Prue H. Hart
Merci M. H. Kusel
Publicatiedatum: 01-07-2013
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-012-1676-8

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