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Journal of Autism and Developmental Disorders

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01-09-2012 | Original Paper

Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica

Auteurs: Mohammad H. Rahbar, Maureen Samms-Vaughan, Katherine A. Loveland, Deborah A. Pearson, Jan Bressler, Zhongxue Chen, Manouchehr Ardjomand-Hessabi, Sydonnie Shakespeare-Pellington, Megan L. Grove, Compton Beecher, Kari Bloom, Eric Boerwinkle

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2012

Abstract

Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM.

vorige artikel Autonomic Arousal to Direct Gaze Correlates with Social Impairments Among Children with ASD

volgende artikel Developmental Profiles of Infants and Toddlers with Autism Spectrum Disorders Identified Prospectively in a Community-Based Setting

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Titel: Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica
Auteurs: Mohammad H. Rahbar
Maureen Samms-Vaughan
Katherine A. Loveland
Deborah A. Pearson
Jan Bressler
Zhongxue Chen
Manouchehr Ardjomand-Hessabi
Sydonnie Shakespeare-Pellington
Megan L. Grove
Compton Beecher
Kari Bloom
Eric Boerwinkle
Publicatiedatum: 01-09-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1438-z

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