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Journal of Autism and Developmental Disorders

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01-09-2010 | Brief Report

Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder

Auteurs: Kenneth D. Gadow, Jasmin Roohi, Carla J. DeVincent, Sarah Kirsch, Eli Hatchwell

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2010

Abstract

Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.

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Arnold, P. D., Sicard, T., Burroughs, E., Richter, M. A., & Kennedy, J. L. (2006). Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Archives of General Psychiatry, 63, 769–776.CrossRefPubMed

Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009). Vulnerability genes or plasticity genes. Molecular Genetics, 14, 746–754.

Billstedt, E., Gillberg, I. C., & Gillberg, C. (2007). Autism in adult: Symptom patterns and early childhood predictors. Journal of Child Psychology and Psychiatry, 48, 1102–1110.CrossRefPubMed

Bishop, S. L., Richler, J., Cain, A. C., & Lord, C. (2007). Predictors of perceived negative impact in moterhs of children with autism spectrum disorder. American Journal on Mental Retardation, 112, 450–461.CrossRefPubMed

Bolton, P. F., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective and other psychiatric disorders: Patterns of familial aggregation. Psychological Medicine, 28, 385–395.CrossRefPubMed

Brune, C. W., Kim, S.-J., Hanna, G. L., Courchesne, E., Lord, C., Leventhal, B. L., et al. (2008). Family-based association testing of OCD-associated SNPs of SLC1A1 in an autism sample. Autism Research, 1, 108–113.CrossRefPubMed

Brune, C. W., Kim, S. J., Salt, J., Leventhal, B. L., Lord, C., & Cook, E. H. Jr. (2006). 5-HTTLPR genotype-specific phenotype in children and adolescents with autism. American Journal of Psychiatry, 163, 2148–2156.CrossRefPubMed

Carcani-Rathwell, I., Rabe-Hasketh, S., & Santosh, P. J. (2006). Repetitive and stereotyped behaviours in pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 47, 573–581.CrossRefPubMed

Cath, D. C., Ran, N., Smit, J. H., van Balkom, A. J. L. M., & Comijs, H. C. (2008). Symptom overlap between autism spectrum disorder, generalized anxiety disorder and obsessive-compulsive disorder in adults: A preliminary case-controlled study. Psychopahtology, 41, 101–110.CrossRef

Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Mahwah, NJ: Lawrence Erlbaum.

Cohen, J. (1994). The earth is round (p < .05). American Psychologist, 49, 997–1003.CrossRef

Cohen, I. L., Liu, X., Schultz, C., White, B. N., Jenkins, E. C., Brown, W. T., et al. (2003). Association of autism severity with a monoamine oxidase a functional polymorphism. Clinical Genetics, 64, 90–197.CrossRef

Comings, D. E. (1990). Tourette syndrome and human behavior. Duarte, CA: Hope Press.

Comings, D. E., Wu, S., Chiu, C., Ring, R. H., Gade, R., Ahn, C., et al. (1996). Polygenetic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 67B, 264–288.

Coon, H., Dunn, D., Lainhart, J., Miller, J., Hamil, C., Battaglia, A., et al. (2005). Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 135B, 42–46.CrossRef

Cullen, B., Samuels, J., Grados, M., Landa, R., Bienvenu, O. J., Liang, K.-Y., et al. (2008). Social and communication difficulties and obsessive-compulsive disorder. Psychopathology, 41, 194–200.CrossRefPubMed

Dickel, D. E., Veenstra-Vander Weele, J., Cox, N. J., Wu, X., Fischer, D. J., Van Etten-Lee, M., et al. (2006). Association testing of the positional and functional candidate gen SLOC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Archives of General Psychiatry, 63, 778–785.CrossRefPubMed

Feise, R. J. (2002). Do multiple outcome measures require p-value adjustment? BMC Medical Research Methodology, 2.

Flint, J., & Mackay, T. F. C. (2009). Genetic architecture of quantitative traits in mice, flies, and humans. Genome Research, 19, 723–733.CrossRefPubMed

Fong, L., Wilgosh, L., & Sobsey, D. (1993). The experience of parenting an adolescent with autism. International Journal of Disability, Development, and Education, 40, 105–113.CrossRef

Gadow, K.D., DeVincent, C.J., Olvet, D.M., & Hatchwell, E. (2009a). Association of DRD4 polymorphism with severity oppositional defiant, separation anxiety, and repetitive behaviors in children with autism spectrum disorder. Manuscript submitted for publication.

Gadow, K. D., DeVincent, C. J., Pomeroy, J., & Azizian, A. (2005). Comparison of DSM-IV symptoms in elementary school-aged children with PDD versus clinic and community samples. Autism, 9, 392–415.CrossRefPubMed

Gadow, K. D., Nolan, E. E., Sprafkin, J., & Schwartz, J. (2002). Tics and psychiatric comorbidity in children and adolescents. Developmental Medicine and Child Neurology, 44, 330–338.CrossRefPubMed

Gadow, K. D., Roohi, J., DeVincent, C. J., & Hatchwell, E. (2008a). Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder. Journal of Child Psychology and Psychiatry, 49, 1331–1338.CrossRefPubMed

Gadow, K.D., Roohi, J., DeVincent, C.J., Kirsch, S., & Hatchwell, E. (2009b). Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 67–74.

Gadow, K. D., Schwartz, J., DeVincent, C., Strong, G., & Cuva, S. (2008b). Clinical utility of autism spectrum disorder scoring algorithms for the child symptom inventory. Journal of Autism and Developmental Disorders, 38, 419–427.CrossRefPubMed

Gadow, K. D., & Sprafkin, J. (1986). Stony Brook Child Psychiatric Checklist-3. Stony Brook: Department of Psychiatry, State University of New York.

Gadow, K. D., & Sprafkin, J. (2002). Child Symptom Inventory-4 Screening and Norms Manual. Checkmate Plus: Stony Brook, NY.

Gadow, K. D, Sprafkin, J. (2008). The symptom inventories: An annotated bibliography [On-line]. Stony Brook, NY: Checkmate Plus. Available: www.checkmateplus.com.

Grados, M. A., Mathews, C. A., & Tourette Syndrome Association International Consortium for Genetics. (2008). Latent class analysis of Gilles de la Tourette syndrome using comorbidities: Clinical and genetic implications. Biological Psychiatry, 64, 219–225.CrossRefPubMed

Hollingshead, A. B. (1975). Four Factor Index of Social Status. Department of Sociology, Yale University: New Haven, CT.

Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004). Adult outcome for children with autism. Journal of Child Psychology and Psychiatry, 45, 212–229.CrossRefPubMed

Lam, K. S. L., Bodfish, J. W., & Piven, J. (2008). Evidence for three subtypes of repetitive behavior in autism that differ in familiarity and association with other symptoms. Journal of Child Psychology and Psychiatry, 49, 1193–1200.PubMed

Lecavalier, L., Gadow, K. D., DeVincent, C. J., & Edwards, M. C. (2009a). Validation of DSM-IV model of psychiatric syndromes in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 278–289.CrossRefPubMed

Lecavalier, L., Gadow, K. D., DeVincent, C. J., Houts, C., & Edwards, M. C. (2009b). Deconstructing the PDD clinical phenotype: Internal validity of the DSM-IV. Journal of Child Psychology and Psychiatry, 50, 1246–1254.CrossRefPubMed

Lecavalier, L., Leone, S., & Wiltz, J. (2006). The impact of behaviour problems on caregiver stress in young people with autism spectrum disorders. Journal of Intellectual Disability Research, 50, 172–183.CrossRefPubMed

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.CrossRefPubMed

Mandy, W. P. L., & Skuse, D. H. (2008). Research review: What is the association between the social-communication element of autism and repetitive interests, behaviours and activities? Child Psychology and Psychiatry, 49, 795–808.CrossRef

Matson, J. L., & Dempsey, T. (2009). The nature and treatment of compulsions, obsessions, and rituals in people with developmental disabilities. Research in Developmental Disabilities, 30, 603–611.CrossRefPubMed

Moss, J., Oliver, C., Arron, K., Burbidge, C., & Berg, K. (2009). The prevelance and phenomenology of repetitive behavior in genetic syndromes. Journal of Autism and Developmental Disorders, 39, 572–588.CrossRefPubMed

Mulder, E. J., Anderson, G. M., Kema, I. P., Brugman, A. M., Ketelaars, C. E. J., de Bildt, A., et al. (2005). Serotonin transporter intron 2 polymorphism associated with rigid-compulsive behaviors in Dutch individuals with pervasive developmental disorder. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, B133, 93–96.CrossRef

Perneger, T. V. (1998). What’s wrong with Bonferroni adjustments. BMJ, 316, 1236–1238.PubMed

Piven, J., & Palmer, P. (1999). Psychiatric disorder and the broad autism phenotype: Evidence from family study of multiple-incidence autistic families. American Journal of Psychiatry, 156, 557–563.PubMed

Roohi, J., DeVincent, C. J., Hatchwell, E., & Gadow, K. D. (2009). Association of a monoamine oxidase-A gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 67–74.CrossRefPubMed

Rothman, K. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1, 43–46.CrossRefPubMed

Rowe, D. C., Stever, C., Gard, J. M. C., Cleveland, H. H., Sanders, M. L., Abramowitz, A., et al. (1998). The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behavior Genetics, 28, 215–225.CrossRefPubMed

Rutter, M., LeCouteur, A., & Lord, C. (2003). Autism Diagnostic Interview-Revised. Western Psychological Services: Los Angeles, CA.

Sacco, R., Papaleo, V., Hager, J., Rousseau, F., Moessner, R., Militerni, R., et al. (2007). Case-control and family-based association studies of candidate gene in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC Medical Genetics, 8, 11.CrossRefPubMed

Sakurai, T., Reichert, J., Hoffman, E. J., Cai, G., Jones, H. B., Faham, M., et al. (2008). A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders. Autism Research, 1, 251–257.CrossRefPubMed

Stewart, S. E., Fagerness, J. A., Platko, J., Smoller, J. W., Scharf, J. M., Illmann, C., et al. (2007). Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. American Journal of Medical Genetics Part B Neurospychiatric Genetics, 144B, 1027–1033.CrossRef

Sutcliffe, J. S., Delahanty, R. J., Prasad, H. C., McCauley, J. L., Han, Q., Jiang, L., et al. (2005). Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. American Journal of Human Genetics, 77, 265–279.CrossRefPubMed

Tordjman, S., Gutknecht, L., Carlier, M., Spitz, E., Antoine, C., Slama, F., et al. (2001). Role of the serotonin transporter gene in the behavioral expression of autism. Molecular Psychiatry, 6, 434–439.CrossRefPubMed

Wang, Y., Adamczyk, A., Shugart, Y.Y., Samuels, J.F., Grados, M.A., Greenberg, B.D., et al. (2009). A screen of SLC1A1 for OCD-related alleles. American Journal of Medical Genetics Part B. doi 10.1002/ajmg.b.31001.

Wendland, J. R., Moya, P. R., Timpano, K. R., Anavitarte, A. P., Kruse, M. R., Wheaton, M. G., et al. (2009). A haplotype containing quantitative trait loci for SLC 1A1 gene expression and its association with obsessive-compulsive disorder. Archives of General Psychiatry, 66, 408–416.CrossRefPubMed

White, S.W., Oswald, D., Ollendick, T., & Scahill, L. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29, 216–229.

Wood, J.J., Drahota, A., Sze, K., Har, K., Chiu, A., & Langer, D.A. (2008). Cognitive behavioural therapy for anxiety in children with autism Spectrum disorders: a randomized, controlled trial. Journal of Child Psychology and Psychiatry, 50, 224–234.

Zandt, F., Prior, M., & Kyrios, M. (2007). Repetitive behaviour in children with high functioning autism and obsessive compulsive disorder. Journal of Autism and Developmental Disorders, 37, 251–259.CrossRefPubMed

Zhang, J., Quan, H., Ng, J., & Stepanavage, M. E. (1997). Some statistical methods for multiple endpoints in clinical trials. Controlled Clinical Trials, 18, 204–221.CrossRefPubMed

Zhou, L., Myers, A. N., Vandersteen, J. G., Wang, L., & Wittwer, C. T. (2004). Closed-tube genotyping with unlabeled oligonucleotide probes and a saturating DNA dye. Clinical Chemistry, 50, 328–335. Epub 2004 May 27.CrossRef

Titel: Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder
Auteurs: Kenneth D. Gadow
Jasmin Roohi
Carla J. DeVincent
Sarah Kirsch
Eli Hatchwell
Publicatiedatum: 01-09-2010
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-010-0961-7

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