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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2008

01-05-2008 | Original Paper

Defining Autism Subgroups: A Taxometric Solution

Auteurs: David G. Ingram, T. Nicole Takahashi, Judith H. Miles

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2008

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Abstract

The purpose of the present study was to determine which behavioral and physical phenotypes would be most likely to divide the ASD population into discrete subgroups. The taxometric methods of Maximum Covariance (MAXCOV) and Minus Mean Below A Cut (MAMBAC) were employed to test for categorical versus continuous variation of each phenotype across the ASD population. Data was retrieved from the Autism Genetic Resource Exchange and the University of Missouri Autism Database. The results of our analyses support subgrouping subjects based on variation in social interaction/communication, intelligence, and essential/complex phenotype; in contrast, subjects varied continuously in insistence on sameness, repetitive sensory motor actions, language acquisition, and, tentatively, adaptive functioning. Stratifying ASD samples based on taxometric results should increase power in gene-finding studies and aid in treatment efficacy research.
Literatuur
go back to reference American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Text revised ed. Washington, DC. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Text revised ed. Washington, DC.
go back to reference Beglinger, L. J., & Smith, T. H. (2001). A review of subtyping in autism and proposed dimensional classification model. Journal of Autism and Developmental Disorders, 31(4), 411–422.PubMedCrossRef Beglinger, L. J., & Smith, T. H. (2001). A review of subtyping in autism and proposed dimensional classification model. Journal of Autism and Developmental Disorders, 31(4), 411–422.PubMedCrossRef
go back to reference Blanchard, J. J., Horan, W. P., & Collins, L. M. (2005). Examining the latent structure of negative symptoms: Is there a distinct subtype of negative symptom schizophrenia? Schizophrenia Research, 77(2–3), 151–165.PubMedCrossRef Blanchard, J. J., Horan, W. P., & Collins, L. M. (2005). Examining the latent structure of negative symptoms: Is there a distinct subtype of negative symptom schizophrenia? Schizophrenia Research, 77(2–3), 151–165.PubMedCrossRef
go back to reference Bolte, S., & Poustka, F., (2002). The relation between general cognitive level and adaptive behavior domains in individuals with autism with and without co-morbid mental retardation. Child Psychiatry and Human Development, 33(2), 165–172.PubMedCrossRef Bolte, S., & Poustka, F., (2002). The relation between general cognitive level and adaptive behavior domains in individuals with autism with and without co-morbid mental retardation. Child Psychiatry and Human Development, 33(2), 165–172.PubMedCrossRef
go back to reference Bolton, P., et al. (1994). A case-control family history study of autism. Journal of Child Psychology and Psychiatry, 35(5), 877–900.PubMedCrossRef Bolton, P., et al. (1994). A case-control family history study of autism. Journal of Child Psychology and Psychiatry, 35(5), 877–900.PubMedCrossRef
go back to reference Bradford, Y., et al. (2001). Incorporating language phenotypes strengthens evidence of linkage to autism. American Journal of Medical Genetics, 105(8), 539–547.PubMedCrossRef Bradford, Y., et al. (2001). Incorporating language phenotypes strengthens evidence of linkage to autism. American Journal of Medical Genetics, 105(8), 539–547.PubMedCrossRef
go back to reference Buxbaum, J. D., et al. (2001). Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity. American Journal of Human Genetics, 68(6), 1514–1520.PubMedCrossRef Buxbaum, J. D., et al. (2001). Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity. American Journal of Human Genetics, 68(6), 1514–1520.PubMedCrossRef
go back to reference Cole, D. A. (2004). Taxometrics in psychopathology research: An introduction to some of the procedures and related methodological issues. Journal of Abnormal Psychology, 113(1), 3–9.PubMedCrossRef Cole, D. A. (2004). Taxometrics in psychopathology research: An introduction to some of the procedures and related methodological issues. Journal of Abnormal Psychology, 113(1), 3–9.PubMedCrossRef
go back to reference Constantino, J. N., & Todd, R. D. (2003). Autistic traits in the general population: A twin study. Archives of General Psychiatry, 60(5), 524–530.PubMedCrossRef Constantino, J. N., & Todd, R. D. (2003). Autistic traits in the general population: A twin study. Archives of General Psychiatry, 60(5), 524–530.PubMedCrossRef
go back to reference Cuccaro, M. L., et al. (2003). Factor analysis of restricted and repetitive behaviors in autism using the Autism Diagnostic Interview-R. Child Psychiatry and Human Development, 34(1), 3–17.PubMedCrossRef Cuccaro, M. L., et al. (2003). Factor analysis of restricted and repetitive behaviors in autism using the Autism Diagnostic Interview-R. Child Psychiatry and Human Development, 34(1), 3–17.PubMedCrossRef
go back to reference Georgiades, S., et al. (2007). Structure of the autism symptom phenotype: A proposed multidimensional model. Journal of the Amercian Academy of Child and Adolescent Psychiatry, 46(2), 188–196.CrossRef Georgiades, S., et al. (2007). Structure of the autism symptom phenotype: A proposed multidimensional model. Journal of the Amercian Academy of Child and Adolescent Psychiatry, 46(2), 188–196.CrossRef
go back to reference Haslam, N. (2003). Categorical versus dimensional models of mental disorder: The taxometric evidence. The Australin and New Zealand Journal of Psychiatry, 37(6), 696–704.CrossRef Haslam, N. (2003). Categorical versus dimensional models of mental disorder: The taxometric evidence. The Australin and New Zealand Journal of Psychiatry, 37(6), 696–704.CrossRef
go back to reference Haslam, N., & Beck, A. T. (1994). Subtyping major depression: A taxometric analysis. Journal of Abnormal Psychoogy, 103(4), 686–692.CrossRef Haslam, N., & Beck, A. T. (1994). Subtyping major depression: A taxometric analysis. Journal of Abnormal Psychoogy, 103(4), 686–692.CrossRef
go back to reference Hus, V., et al. (2007). Using the autism diagnostic interview—Revised to increase phenotypic homogeneity in genetic studies of autism. Biological Psychiatry, 61(4), 438–448.PubMedCrossRef Hus, V., et al. (2007). Using the autism diagnostic interview—Revised to increase phenotypic homogeneity in genetic studies of autism. Biological Psychiatry, 61(4), 438–448.PubMedCrossRef
go back to reference Klin, A., et al. (2007). Social and communication abilities and disabilities in higher functioning individuals with autism spectrum disorders: The Vineland and the ADOS. Journal of Autism and Developmental Disorders, 37(4), 748–759.PubMedCrossRef Klin, A., et al. (2007). Social and communication abilities and disabilities in higher functioning individuals with autism spectrum disorders: The Vineland and the ADOS. Journal of Autism and Developmental Disorders, 37(4), 748–759.PubMedCrossRef
go back to reference Lecavalier, L., et al. (2006). Validity of the autism diagnostic interview-revised. American Journal of Mental Retardation, 111(3), 199–215.PubMedCrossRef Lecavalier, L., et al. (2006). Validity of the autism diagnostic interview-revised. American Journal of Mental Retardation, 111(3), 199–215.PubMedCrossRef
go back to reference Meehl, P. E. (1995). Bootstraps taxometrics. Solving the classification problem in psychopathology. The Amercian Psychologist, 50(4), 266–275.CrossRef Meehl, P. E. (1995). Bootstraps taxometrics. Solving the classification problem in psychopathology. The Amercian Psychologist, 50(4), 266–275.CrossRef
go back to reference Miles, J. H., & Hillman, R. E. (2000). Value of a clinical morphology examination in autism. American Journal of Medical Genetics, 91(4), 245–253.PubMedCrossRef Miles, J. H., & Hillman, R. E. (2000). Value of a clinical morphology examination in autism. American Journal of Medical Genetics, 91(4), 245–253.PubMedCrossRef
go back to reference Miles, J. H., et al. (2000). Head circumference is an independent clinical finding associated with autism. American Journal of Medical Genetics, 95, 339–350.PubMedCrossRef Miles, J. H., et al. (2000). Head circumference is an independent clinical finding associated with autism. American Journal of Medical Genetics, 95, 339–350.PubMedCrossRef
go back to reference Miles, J. H., et al. (2005). Essential versus complex autism: Definition of fundamental prognostic subtypes. American Journal of Medical Genetics A, 135(2), 171–180.CrossRef Miles, J. H., et al. (2005). Essential versus complex autism: Definition of fundamental prognostic subtypes. American Journal of Medical Genetics A, 135(2), 171–180.CrossRef
go back to reference Muhle, R., Trentacoste, S. V., & Rapin, I. (2004). The genetics of autism. Pediatrics, 113(5), e472–e486.PubMedCrossRef Muhle, R., Trentacoste, S. V., & Rapin, I. (2004). The genetics of autism. Pediatrics, 113(5), e472–e486.PubMedCrossRef
go back to reference Pickles, A., et al. (2000). Variable expression of the autism broader phenotype: Findings from extended pedigrees. Journal of Child Psychology and Psychiatry, 41(4), 491–502.PubMedCrossRef Pickles, A., et al. (2000). Variable expression of the autism broader phenotype: Findings from extended pedigrees. Journal of Child Psychology and Psychiatry, 41(4), 491–502.PubMedCrossRef
go back to reference Raven, J., Raven, J. C., & Court, J. H. (1998). Manual for Raven’s progressive matrices and vocabulary scales. San Antonio: Harcourt Assessment. Raven, J., Raven, J. C., & Court, J. H. (1998). Manual for Raven’s progressive matrices and vocabulary scales. San Antonio: Harcourt Assessment.
go back to reference Ruscio, J., Haslam, N., & Ruscio, A. M. (2006). Introduction to the taxometric method (1st ed.). Mahwah, NJ: Lawrence Erlbaum Associates. Ruscio, J., Haslam, N., & Ruscio, A. M. (2006). Introduction to the taxometric method (1st ed.). Mahwah, NJ: Lawrence Erlbaum Associates.
go back to reference Ruscio, J., & Ruscio, A. M. (2004). Clarifying boundary issues in psychopathology: The role of taxometrics in a comprehensive program of structural research. Journal of Abnormal Psychology, 113(1), 24–38.PubMedCrossRef Ruscio, J., & Ruscio, A. M. (2004). Clarifying boundary issues in psychopathology: The role of taxometrics in a comprehensive program of structural research. Journal of Abnormal Psychology, 113(1), 24–38.PubMedCrossRef
go back to reference Saulnier, C. A., & Klin, A. (2007). Brief report: Social and communication abilities and disabilities in higher functioning individuals with autism and asperger syndrome. Journal of Autism and Developmental Disorders, 37(4), 788–793.PubMedCrossRef Saulnier, C. A., & Klin, A. (2007). Brief report: Social and communication abilities and disabilities in higher functioning individuals with autism and asperger syndrome. Journal of Autism and Developmental Disorders, 37(4), 788–793.PubMedCrossRef
go back to reference Shao, Y., et al. (2003). Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. American Journal of Human Genetics, 72(3), 539–548.PubMedCrossRef Shao, Y., et al. (2003). Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. American Journal of Human Genetics, 72(3), 539–548.PubMedCrossRef
go back to reference Shao, Y., et al. (2002). Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder. American Journal of Human Genetics, 70(4), 1058–1061.PubMedCrossRef Shao, Y., et al. (2002). Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder. American Journal of Human Genetics, 70(4), 1058–1061.PubMedCrossRef
go back to reference Szatmari, P., et al. (2006). Investigating the structure of the restricted, repetitive behaviours and interests domain of autism. Journal of Child Psychology and Psychiatry, 47(6), 582–590.PubMedCrossRef Szatmari, P., et al. (2006). Investigating the structure of the restricted, repetitive behaviours and interests domain of autism. Journal of Child Psychology and Psychiatry, 47(6), 582–590.PubMedCrossRef
go back to reference van Lang, N. D., et al. (2006). Structural equation analysis of a hypothesised symptom model in the autism spectrum. Journal of Child Psychology and Psychiatry, 47(1), 37–44.PubMedCrossRef van Lang, N. D., et al. (2006). Structural equation analysis of a hypothesised symptom model in the autism spectrum. Journal of Child Psychology and Psychiatry, 47(1), 37–44.PubMedCrossRef
go back to reference Waelde, L. C., Silvern, L., & Fairbank, J. A. (2005). A taxometric investigation of dissociation in Vietnam veterans. Journal of Traumatic Stress, 18(4), 359–369.PubMedCrossRef Waelde, L. C., Silvern, L., & Fairbank, J. A. (2005). A taxometric investigation of dissociation in Vietnam veterans. Journal of Traumatic Stress, 18(4), 359–369.PubMedCrossRef
go back to reference Williamson, D. A., Gleaves, D. H., & Stewart, T. M. (2005). Categorical versus dimensional models of eating disorders: An examination of the evidence. The International Journal of Eating Disorders, 37(1), 1–10.PubMedCrossRef Williamson, D. A., Gleaves, D. H., & Stewart, T. M. (2005). Categorical versus dimensional models of eating disorders: An examination of the evidence. The International Journal of Eating Disorders, 37(1), 1–10.PubMedCrossRef
Metagegevens
Titel
Defining Autism Subgroups: A Taxometric Solution
Auteurs
David G. Ingram
T. Nicole Takahashi
Judith H. Miles
Publicatiedatum
01-05-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0469-y

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