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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2008

01-05-2008 | Original Paper

Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder

Auteurs: Mary L. Hediger, Lucinda J. England, Cynthia A. Molloy, Kai F. Yu, Patricia Manning-Courtney, James L. Mills

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2008

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Abstract

Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4–8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (= .02): +3.1 ± 4.7%, −6.5 ± 4.0%, −16.6 ± 3.4%, −19.4 ± 3.7%, −24.1 ± 4.4%, at ages 4–8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of −18.9 ± 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (−10.5 ± 1.3%, < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (< .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets.
Literatuur
go back to reference Aman, M. G., Lam, K. S. L., & Van Bourgondien, M. E. (2005). Medication patterns in patients with autism: Temporal, regional, and demographic influences. Journal of Child and Adolescnt Psychopharmacology, 15, 116–126.CrossRef Aman, M. G., Lam, K. S. L., & Van Bourgondien, M. E. (2005). Medication patterns in patients with autism: Temporal, regional, and demographic influences. Journal of Child and Adolescnt Psychopharmacology, 15, 116–126.CrossRef
go back to reference American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatric Association. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatric Association.
go back to reference Apkon, S. D. (2002). Osteoporosis in children who have disabilities. Physical Medicine and Rehabilitation Clinics of North America, 13, 839–855.PubMedCrossRef Apkon, S. D. (2002). Osteoporosis in children who have disabilities. Physical Medicine and Rehabilitation Clinics of North America, 13, 839–855.PubMedCrossRef
go back to reference Centers for Disease Control and Prevention (CDC). (2007). Prevalence of autism spectrum disorders—Autism and Developmental Disabilities Monitoring Network, six sites, United States, 2000. In: Surveillance Summaries, February 9, 2007. Morbidity and Mortality Weekly Report, 56(No. SS-1), 1–11. Centers for Disease Control and Prevention (CDC). (2007). Prevalence of autism spectrum disorders—Autism and Developmental Disabilities Monitoring Network, six sites, United States, 2000. In: Surveillance Summaries, February 9, 2007. Morbidity and Mortality Weekly Report, 56(No. SS-1), 1–11.
go back to reference Christison, G. W., & Ivany, K. (2006). Elimination diets in autism spectrum disorders: Any wheat amidst the chaff? Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S162–S171.PubMedCrossRef Christison, G. W., & Ivany, K. (2006). Elimination diets in autism spectrum disorders: Any wheat amidst the chaff? Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S162–S171.PubMedCrossRef
go back to reference Davies, J. H., Evans, B. A. J., & Gregory, J. W. (2005). Bone mass acquisition in healthy children. Archives of Diseases in Childhood, 90, 373–378.CrossRef Davies, J. H., Evans, B. A. J., & Gregory, J. W. (2005). Bone mass acquisition in healthy children. Archives of Diseases in Childhood, 90, 373–378.CrossRef
go back to reference Dunn, H. G., & MacLeod, P. M. (2001). Rett syndrome: review of biological abnormalities. Canadian Journal of Neurological Sciences, 28, 16–29.PubMed Dunn, H. G., & MacLeod, P. M. (2001). Rett syndrome: review of biological abnormalities. Canadian Journal of Neurological Sciences, 28, 16–29.PubMed
go back to reference Elder, J. H., Shankar, M., Shuster, J., Theriaque, D., Burns, S., & Sherrill, L. (2006). The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial. Journal of Autism and Developmental Disorders, 36, 413–420.PubMedCrossRef Elder, J. H., Shankar, M., Shuster, J., Theriaque, D., Burns, S., & Sherrill, L. (2006). The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial. Journal of Autism and Developmental Disorders, 36, 413–420.PubMedCrossRef
go back to reference Filipek, P. A., Accardo, P. J., Baranek, G. T., Cook, E. H., Jr., Dawson, G., Gordon, B., et al. (1999). The screening and diagnosis of autistic spectrum disorders. Journal of Autism and Developmental Disorders, 29, 439–484.PubMedCrossRef Filipek, P. A., Accardo, P. J., Baranek, G. T., Cook, E. H., Jr., Dawson, G., Gordon, B., et al. (1999). The screening and diagnosis of autistic spectrum disorders. Journal of Autism and Developmental Disorders, 29, 439–484.PubMedCrossRef
go back to reference Garn, S. M., Poznanski, A. K., & Nagy, J. M. (1971). Bone measurement in the differential diagnosis of osteopenia and osteoporosis. Radiology, 100, 500–518. Garn, S. M., Poznanski, A. K., & Nagy, J. M. (1971). Bone measurement in the differential diagnosis of osteopenia and osteoporosis. Radiology, 100, 500–518.
go back to reference Garn, S. M., Rohmann, C. G., & Silverman, F. N. (1967). Radiographic standards for postnatal ossification and tooth calcification. Medical Radiography and Photography, 43, 45–66.PubMed Garn, S. M., Rohmann, C. G., & Silverman, F. N. (1967). Radiographic standards for postnatal ossification and tooth calcification. Medical Radiography and Photography, 43, 45–66.PubMed
go back to reference Gerrior, S. (2001). Nutrient content of the US food supply. Home Economics Research Report no. 53. Washington, DC: United States Department of Agriculture, Center of Nutrition Policy and Promotion. Gerrior, S. (2001). Nutrient content of the US food supply. Home Economics Research Report no. 53. Washington, DC: United States Department of Agriculture, Center of Nutrition Policy and Promotion.
go back to reference Glasson, E. J., Bower, C., Thomson, M. R., Fyfe, S., Leonard, S., Rousham, E., et al. (1998). Diagnosis of Rett syndrome: Can a radiograph help? Developmental Medicine and Child Neurology, 40, 737–742.PubMedCrossRef Glasson, E. J., Bower, C., Thomson, M. R., Fyfe, S., Leonard, S., Rousham, E., et al. (1998). Diagnosis of Rett syndrome: Can a radiograph help? Developmental Medicine and Child Neurology, 40, 737–742.PubMedCrossRef
go back to reference Gordon, C. C., Chumlea, W. C., & Roche, A. F. (1988). Stature, recumbent length, and weight. In: T. G. Lohman, A. F. Roche, & R. Martorell (Eds.), Anthropometric standardization reference manual (pp. 3–8). Champaign: Human Kinetics Books. Gordon, C. C., Chumlea, W. C., & Roche, A. F. (1988). Stature, recumbent length, and weight. In: T. G. Lohman, A. F. Roche, & R. Martorell (Eds.), Anthropometric standardization reference manual (pp. 3–8). Champaign: Human Kinetics Books.
go back to reference Havelock, J. C., Auchus, R. J., & Rainey, W. E. (2004). The rise in adrenal androgen biosynthesis: Adrenarche. Seminars in Reproductive Medicine, 22, 337–347.PubMedCrossRef Havelock, J. C., Auchus, R. J., & Rainey, W. E. (2004). The rise in adrenal androgen biosynthesis: Adrenarche. Seminars in Reproductive Medicine, 22, 337–347.PubMedCrossRef
go back to reference Helelä, T. (1969). Cortical thickness of metacarpal bones as an estimate of mineral content. Annals of Clinical Research, 1, 144–145.PubMed Helelä, T. (1969). Cortical thickness of metacarpal bones as an estimate of mineral content. Annals of Clinical Research, 1, 144–145.PubMed
go back to reference Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tioson, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics, 135, 559–563.PubMedCrossRef Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tioson, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics, 135, 559–563.PubMedCrossRef
go back to reference Hyldstrup, L., & Nielsen, S. P. (2001). Metacarpal index by digital X-ray radiogrammetry: Normative reference values and comparison with dual X-ray absorptiometry. Journal of Clinical Densitometry, 4, 299–306.PubMedCrossRef Hyldstrup, L., & Nielsen, S. P. (2001). Metacarpal index by digital X-ray radiogrammetry: Normative reference values and comparison with dual X-ray absorptiometry. Journal of Clinical Densitometry, 4, 299–306.PubMedCrossRef
go back to reference Isaacs, J. S., Murdock, M., Lane, J., & Percy, A. K. (2003). Eating difficulties in girls with Rett syndrome compared with other developmental disabilities. Journal of the American Dietetic Association, 103, 224–230.PubMedCrossRef Isaacs, J. S., Murdock, M., Lane, J., & Percy, A. K. (2003). Eating difficulties in girls with Rett syndrome compared with other developmental disabilities. Journal of the American Dietetic Association, 103, 224–230.PubMedCrossRef
go back to reference Johnston, F. E., & Watts, E. S. (1969). Endosteal deposition of bone at the midshaft of the second metacarpals of adolescent females. The Anatomical Record, 163, 67–70.PubMedCrossRef Johnston, F. E., & Watts, E. S. (1969). Endosteal deposition of bone at the midshaft of the second metacarpals of adolescent females. The Anatomical Record, 163, 67–70.PubMedCrossRef
go back to reference Jyonouchi, H., Geng, L., Rucy, A., Reedy, C., & Zimmerman-Bier, B. (2005). Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. Journal of Pediatrics, 146, 605–610.PubMedCrossRef Jyonouchi, H., Geng, L., Rucy, A., Reedy, C., & Zimmerman-Bier, B. (2005). Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. Journal of Pediatrics, 146, 605–610.PubMedCrossRef
go back to reference Knivsberg, A. M., Reichelt, K. L., Høien, T., & Nødland, M. (2002). A randomised, controlled study of dietary intervention in autistic syndromes. Nutritional Neuroscience, 5, 251–261.PubMedCrossRef Knivsberg, A. M., Reichelt, K. L., Høien, T., & Nødland, M. (2002). A randomised, controlled study of dietary intervention in autistic syndromes. Nutritional Neuroscience, 5, 251–261.PubMedCrossRef
go back to reference Knivsberg, A. M., Reichelt, K. L., & Nødland, M. (2001). Reports on dietary intervention in autistic disorders. Nutritional Neuroscience, 4, 25–37. Knivsberg, A. M., Reichelt, K. L., & Nødland, M. (2001). Reports on dietary intervention in autistic disorders. Nutritional Neuroscience, 4, 25–37.
go back to reference Kuczmarski, R. J., Ogden, C. L., Grummer-Strawn, L. M., Flegal, K. M., Guo, S. S., Wei, R., et al. (2000). CDC growth charts: United States. Advance data from vital and health statistics; no. 314. Hyattsville, MD: National Center for Health Statistics. URL:http://www.cdc.gov/growthcharts/ Kuczmarski, R. J., Ogden, C. L., Grummer-Strawn, L. M., Flegal, K. M., Guo, S. S., Wei, R., et al. (2000). CDC growth charts: United States. Advance data from vital and health statistics; no. 314. Hyattsville, MD: National Center for Health Statistics. URL:http://​www.​cdc.​gov/​growthcharts/​
go back to reference Kumandas, S., Koklu, E., Gumus, H., Koklu, S., Kurtoglu, S., Karakukcu, M., & Keskin, M. (2006). Effect of carbamezapine and valproic acid on bone mineral density, IGF-I and IGFBP-3. Journal of Pediatric Endocrinology and Metabolism, 19, 529–534.PubMed Kumandas, S., Koklu, E., Gumus, H., Koklu, S., Kurtoglu, S., Karakukcu, M., & Keskin, M. (2006). Effect of carbamezapine and valproic acid on bone mineral density, IGF-I and IGFBP-3. Journal of Pediatric Endocrinology and Metabolism, 19, 529–534.PubMed
go back to reference Lanou, A. J., Berkow, S. E., & Barnard, N. D. (2005). Calcium, dairy products, and bone health in children and young adults: A reevaluation of the evidence. Pediatrics, 115, 736–743.PubMedCrossRef Lanou, A. J., Berkow, S. E., & Barnard, N. D. (2005). Calcium, dairy products, and bone health in children and young adults: A reevaluation of the evidence. Pediatrics, 115, 736–743.PubMedCrossRef
go back to reference Leonard, H., Thomson, M. R., Glasson, E. J., Fyfe, S., Leonard, S., Bower, C., et al. (1999). A population-based approach to the investigation of osteopenia in Rett syndrome. Developmental Medicine and Child Neurology, 41, 323–328.PubMedCrossRef Leonard, H., Thomson, M. R., Glasson, E. J., Fyfe, S., Leonard, S., Bower, C., et al. (1999). A population-based approach to the investigation of osteopenia in Rett syndrome. Developmental Medicine and Child Neurology, 41, 323–328.PubMedCrossRef
go back to reference Levy, S. E., Souders, M. C., Ittenbach, R. F., Giarelli, E., Mulberg, A. E., & Pinto-Martin, J. A. (2007). Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biological Psychiatry, 61, 492–497.PubMedCrossRef Levy, S. E., Souders, M. C., Ittenbach, R. F., Giarelli, E., Mulberg, A. E., & Pinto-Martin, J. A. (2007). Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biological Psychiatry, 61, 492–497.PubMedCrossRef
go back to reference Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMedCrossRef Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMedCrossRef
go back to reference Ma, D. Q., & Jones, G. (2003). The association between bone mineral density, metacarpal morphometry, and upper limb fractures in children: a population-based case-control study. Journal of Clinical Endocrinology and Metabolism, 88, 1486–1491.PubMedCrossRef Ma, D. Q., & Jones, G. (2003). The association between bone mineral density, metacarpal morphometry, and upper limb fractures in children: a population-based case-control study. Journal of Clinical Endocrinology and Metabolism, 88, 1486–1491.PubMedCrossRef
go back to reference Mills, J. L., Hediger, M. L., Molloy, C. A., Chrousos, G. P., Manning-Courtney, P., Yu, K. F., Brasington, M., & England, L. J. (2007). Elevated levels of growth-related hormones in autism and autism spectrum disorder. Clinical Endocrinology, 67, 230–237.PubMedCrossRef Mills, J. L., Hediger, M. L., Molloy, C. A., Chrousos, G. P., Manning-Courtney, P., Yu, K. F., Brasington, M., & England, L. J. (2007). Elevated levels of growth-related hormones in autism and autism spectrum disorder. Clinical Endocrinology, 67, 230–237.PubMedCrossRef
go back to reference Millward, C., Ferriter, M., Calver, S., & Connell-Jones, G. (2004). Gluten- and casein free diets for autistic spectrum disorder (review). The Cochrane Database of Systematic Reviews, Issue 2, Art. No. CD003498.pub2. DOI: 10.1002/14651858.CD003498.pub2. Millward, C., Ferriter, M., Calver, S., & Connell-Jones, G. (2004). Gluten- and casein free diets for autistic spectrum disorder (review). The Cochrane Database of Systematic Reviews, Issue 2, Art. No. CD003498.pub2. DOI: 10.1002/14651858.CD003498.pub2.
go back to reference Molloy, C. A., & Manning-Courtney, P. (2003). Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism, 7, 165–171.PubMedCrossRef Molloy, C. A., & Manning-Courtney, P. (2003). Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism, 7, 165–171.PubMedCrossRef
go back to reference Mora, S., Pitukcheewanont, P., Nelson, J. C., & Gilsanz, V. (1999). Serum levels of insulin-like growth factor I and the density, volume, and cross-sectional area of cortical bone in children. Journal of Clinical Endocrinology and Metabolism, 84, 2780–2783.PubMedCrossRef Mora, S., Pitukcheewanont, P., Nelson, J. C., & Gilsanz, V. (1999). Serum levels of insulin-like growth factor I and the density, volume, and cross-sectional area of cortical bone in children. Journal of Clinical Endocrinology and Metabolism, 84, 2780–2783.PubMedCrossRef
go back to reference Murch, S. (2005). Diet, immunity, and autistic spectrum disorders. Journal of Pediatrics, 146, 582–584.PubMedCrossRef Murch, S. (2005). Diet, immunity, and autistic spectrum disorders. Journal of Pediatrics, 146, 582–584.PubMedCrossRef
go back to reference Niehus, R., & Lord, C. (2006). Early medical history of children with autism spectrum disorders. Journal of Developmental and Behavioral Pediatrics, 27, 120–127.CrossRef Niehus, R., & Lord, C. (2006). Early medical history of children with autism spectrum disorders. Journal of Developmental and Behavioral Pediatrics, 27, 120–127.CrossRef
go back to reference Nielsen, S. P. (2001). The metacarpal index revisited: a brief overview. Journal of Clinical Densitometry, 4, 199–207.PubMedCrossRef Nielsen, S. P. (2001). The metacarpal index revisited: a brief overview. Journal of Clinical Densitometry, 4, 199–207.PubMedCrossRef
go back to reference Pack, A. M., Gidal, B., & Vazquez, B. (2004). Bone disease associated with antiepileptic drugs. Cleveland Clinical Journal of Medicine, 71, S42–S48.CrossRef Pack, A. M., Gidal, B., & Vazquez, B. (2004). Bone disease associated with antiepileptic drugs. Cleveland Clinical Journal of Medicine, 71, S42–S48.CrossRef
go back to reference Poznanski, A. K. (1991). Useful measurements in the evaluation of hand radiographs. Hand Clinics, 7, 21–36.PubMed Poznanski, A. K. (1991). Useful measurements in the evaluation of hand radiographs. Hand Clinics, 7, 21–36.PubMed
go back to reference Remer, T., Boye, K. R., Hartmann, M., Neu, C. M., Schoenau, E., Manz, F., & Wudy, S. A. (2003). Adrenarche and bone modeling and remodeling at the proximal radius: weak androgens make stronger cortical bone in healthy children. Journal of Bone and Mineral Research, 18, 1539–1546.PubMedCrossRef Remer, T., Boye, K. R., Hartmann, M., Neu, C. M., Schoenau, E., Manz, F., & Wudy, S. A. (2003). Adrenarche and bone modeling and remodeling at the proximal radius: weak androgens make stronger cortical bone in healthy children. Journal of Bone and Mineral Research, 18, 1539–1546.PubMedCrossRef
go back to reference Roche A. F., & Malina R. M., Eds. (1983). Manual of physical status and performance in childhood. Volume 1B: physical status (p. 1188). New York: Plenum Press. Roche A. F., & Malina R. M., Eds. (1983). Manual of physical status and performance in childhood. Volume 1B: physical status (p. 1188). New York: Plenum Press.
go back to reference Schoenau, E., Saggese, G., Peter, F., Baroncelli, G. I., Shaw, N. J., Crabtree, N. J., et al. (2004). From bone biology to bone analysis. Hormone Research, 61, 257–269.PubMedCrossRef Schoenau, E., Saggese, G., Peter, F., Baroncelli, G. I., Shaw, N. J., Crabtree, N. J., et al. (2004). From bone biology to bone analysis. Hormone Research, 61, 257–269.PubMedCrossRef
go back to reference Schreck, K. A., Williams, K., & Smith, A. F. (2004). A comparison of eating behaviors between children with and without autism. Journal of Autism and Developmental Disorders, 34, 433–438.PubMedCrossRef Schreck, K. A., Williams, K., & Smith, A. F. (2004). A comparison of eating behaviors between children with and without autism. Journal of Autism and Developmental Disorders, 34, 433–438.PubMedCrossRef
go back to reference Tanner, J. M., Healy, M. J. R., Goldstein, H., & Cameron, N. (2001). Assessment of skeletal maturity and prediction of adult height (TW3 method), 3rd ed. Philadelphia: W. B. Saunders. Tanner, J. M., Healy, M. J. R., Goldstein, H., & Cameron, N. (2001). Assessment of skeletal maturity and prediction of adult height (TW3 method), 3rd ed. Philadelphia: W. B. Saunders.
go back to reference Williams, P. G., Dalrymple, N., & Neal, J. (2000). Eating habits of children with autism. Pediatric Nursing, 26, 259–264.PubMed Williams, P. G., Dalrymple, N., & Neal, J. (2000). Eating habits of children with autism. Pediatric Nursing, 26, 259–264.PubMed
go back to reference Zacharin, M. (2004). Current advances in bone health of disabled children. Current Opinion in Pediatrics, 16, 545–551.PubMedCrossRef Zacharin, M. (2004). Current advances in bone health of disabled children. Current Opinion in Pediatrics, 16, 545–551.PubMedCrossRef
Metagegevens
Titel
Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder
Auteurs
Mary L. Hediger
Lucinda J. England
Cynthia A. Molloy
Kai F. Yu
Patricia Manning-Courtney
James L. Mills
Publicatiedatum
01-05-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0453-6

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